Entry |
|
Name |
serine C-palmitoyltransferase;
serine palmitoyltransferase;
SPT;
3-oxosphinganine synthetase;
acyl-CoA:serine C-2 acyltransferase decarboxylating
|
Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
 |
Sysname |
palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)
|
Reaction(IUBMB) |
palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2 [RN: R01281]
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Reaction(KEGG) |
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Substrate |
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Product |
|
Comment |
A pyridoxal-phosphate protein.
|
History |
EC 2.3.1.50 created 1976, modified 1982
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Pathway |
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Orthology |
K00654 | serine palmitoyltransferase |
|
Genes |
» show all
 |
Reference |
|
Authors |
Brady RN, Di Mari SJ, Snell EE. |
Title |
Biosynthesis of sphingolipid bases. 3. Isolation and characterization of ketonic intermediates in the synthesis of sphingosine and dihydrosphingosine by cell-free extracts of Hansenula ciferri. |
Journal |
J Biol Chem 244:491-6 (1969) |
Reference |
|
Authors |
Stoffel W, LeKim D, Sticht G. |
Title |
Biosynthesis of dihydrosphingosine in vitro. |
Journal |
Hoppe Seylers Z Physiol Chem 349:664-70 (1968) |
Other DBs |
ExplorEnz - The Enzyme Database: | 2.3.1.50 |
ExPASy - ENZYME nomenclature database: | 2.3.1.50 |
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