KEGG   ENZYME: 2.3.1.59Help
Entry
EC 2.3.1.59                 Enzyme                                 

Name
gentamicin 2'-N-acetyltransferase;
gentamycin acetyltransferase II;
gentamycin 2'-N-acetyltransferase;
acetyl-CoA:gentamycin-C1a N2'-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:gentamicin-C1a N2'-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C1a = CoA + N2'-acetylgentamicin C1a [RN:R03056]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C1a [CPD:C00908]
Product
CoA [CPD:C00010];
N2'-acetylgentamicin C1a [CPD:C03524]
Comment
The antibiotics gentamicin A, sisomicin, tobramycin, paromomycin, neomycin B, kanamycin B and kanamycin C can also act as acceptors.
History
EC 2.3.1.59 created 1976
Orthology
K17840  aminoglycoside 2'-N-acetyltransferase I
Genes
PSI: S70_17610
PSX: DR96_2475
PSTA: BGK56_19845
PRG: RB151_031910(aac)
PAEU: BN889_06966(aac)
CVC: BKX93_13790
CHRO: CXB49_21390
MTU: Rv0262c(aac)
MTV: RVBD_0262c
MTC: MT0275(aac)
MRA: MRA_0270(aac)
MTUR: CFBS_0279(aac)
MTO: MTCTRI2_0267(aac)
MTD: UDA_0262c(aac)
MTN: ERDMAN_0290(aac)
MTUE: J114_01420
MTUH: I917_01870
MTUL: TBHG_00262
MTUT: HKBT1_0279(aac)
MTUU: HKBT2_0279(aac)
MTQ: HKBS1_0279(aac)
MBO: BQ2027_MB0268C(aac)
MBB: BCG_0300c(aac)
MBT: JTY_0269(aac)
MBM: BCGMEX_0269c(aac)
MBX: BCGT_0027
MAF: MAF_02630(aac)
MMIC: RN08_0294
MCE: MCAN_02691(aac)
MCQ: BN44_10301(aac)
MCV: BN43_10296(aac)
MCX: BN42_10308(aac)
MCZ: BN45_10288(aac)
MLE: ML2551(aac)
MLB: MLBr02551(aac)
MUL: MUL_1185(aac)
MMC: Mmcs_0265
MKM: Mkms_0275
MJL: Mjls_0255
MMI: MMAR_0522(aac)
MMAE: MMARE11_04790(aac)
MLI: MULP_00526(aac)
MHAD: B586_00975
MVA: Mvan_0302
MGI: Mflv_0379
MPHL: MPHLCCUG_04827(aac)
MVQ: MYVA_0296
MTHN: 4412656_00273(aac)
MAB: MAB_4395
MABB: MASS_4433
MSTE: MSTE_04563
MTER: 4434518_00231(aac)
RHU: A3Q40_02318(aac)
SMA: SAVERM_2721(aac1)
SGR: SGR_1985
SGB: WQO_25540
SBH: SBI_09091
SHY: SHJG_6618
SVE: SVEN_5199
SFI: SFUL_5379
SALU: DC74_5946
SALL: SAZ_12180
STRE: GZL_02854
SLD: T261_2154
STRM: M444_24330
SAMB: SAM23877_5271(aac)
SRW: TUE45_06019(aac_2)
SLE: sle_21330(sle_21330)
SRN: A4G23_04081(aac_2)
SALF: SMD44_06140(aac)
SALJ: SMD11_1742(aac)
SLX: SLAV_12125(aac)
SFK: KY5_5685
KSK: KSE_68370
NCA: Noca_3357
NDK: I601_2761
MMAR: MODMU_5198
AOI: AORI_7879
PSEA: WY02_28020
PSEE: FRP1_14705
PSEH: XF36_14960
SESP: BN6_71470
ASE: ACPL_6034(aac)
ACTS: ACWT_5902
 » show all
Taxonomy
Reference
1  [PMID:4209515]
  Authors
Benveniste R, Davies J.
  Title
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
  Journal
Proc Natl Acad Sci U S A 70:2276-80 (1973)
DOI:10.1073/pnas.70.8.2276
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.59
IUBMB Enzyme Nomenclature: 2.3.1.59
ExPASy - ENZYME nomenclature database: 2.3.1.59
BRENDA, the Enzyme Database: 2.3.1.59
CAS: 50864-40-9

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