KEGG   ENZYME: 2.3.1.60Help
Entry
EC 2.3.1.60                 Enzyme                                 

Name
gentamicin 3-N-acetyltransferase;
gentamycin acetyltransferase I;
aminoglycoside acetyltransferase AAC(3)-1;
gentamycin 3-N-acetyltransferase;
acetyl-CoA:gentamycin-C N3-acetyltransferase;
acetyl-CoA:gentamicin-C N3'-acetyltransferase (incorrect);
gentamicin 3'-N-acetyltransferase (incorrect)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:gentamicin-C N3-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C [RN:R03767]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
gentamicin C [CPD:C01918]
Product
CoA [CPD:C00010];
N3-acetylgentamicin C [CPD:C03297]
Comment
Also acetylates sisomicin.
History
EC 2.3.1.60 created 1976, modified 2015
Orthology
K03395  aminoglycoside 3-N-acetyltransferase I
Genes
ECLE: ECNIH2_24920
KPZ: KPNIH27_26715
CFD: CFNIH1_26030
LEI: C2U54_26560(aac(3)-I)
LEH: C3F35_26175(aac(3)-I)
PANT: PSNIH1_20595
PANP: PSNIH2_21655
PMY: Pmen_3087
ABY: ABAYE3573(aacC1)
ABX: ABK1_1589
ABD: ABTW07_3898(aacC1)
SDE: Sde_1840
TGR: Tgr7_1824
TKM: TK90_1523
HCH: HCH_06852
ADI: B5T_01209
HYB: Q5W_22495
MEX: Mext_3943
MDI: METDI4935
MCH: Mchl_4311
METD: C0214_21740(aac(3)-I)
PYE: A6J80_10650(aac(3)-I)
PZH: CX676_10170(aac(3)-I)
PMUT: DPM13_08945(aac(3)-I)
SAL: Sala_0626
SPHP: LH20_01610
HHG: XM38_051250(aacC1)
DFO: Dform_01321(aac3-I)
 » show all
Taxonomy
Reference
1  [PMID:6281224]
  Authors
Angelatou F, Litsas SB, Kontomichalou P.
  Title
Purification and properties of two gentamicin-modifying enzymes, coded by a single plasmid pPK237 originating from Pseudomonas aeruginosa.
  Journal
J Antibiot (Tokyo) 35:235-44 (1982)
Reference
2  [PMID:820250]
  Authors
Biddlecome S, Haas M, Davies J, Miller GH, Rane DF, Daniels PJ.
  Title
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
  Journal
Antimicrob Agents Chemother 9:951-5 (1976)
Reference
3  [PMID:764855]
  Authors
Williams JW, Northrop DB.
  Title
Purification and properties of gentamicin acetyltransferase I.
  Journal
Biochemistry 15:125-31 (1976)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.60
IUBMB Enzyme Nomenclature: 2.3.1.60
ExPASy - ENZYME nomenclature database: 2.3.1.60
BRENDA, the Enzyme Database: 2.3.1.60
CAS: 58500-58-6

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