KEGG   ENZYME: 2.3.1.74Help
Entry
EC 2.3.1.74                 Enzyme                                 

Name
chalcone synthase;
naringenin-chalcone synthase;
flavanone synthase;
6'-deoxychalcone synthase;
chalcone synthetase;
DOCS;
CHS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 [RN:R01613]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product
CoA [CPD:C00010];
naringenin chalcone [CPD:C06561];
CO2 [CPD:C00011]
Comment
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
History
EC 2.3.1.74 created 1984, modified 2018
Pathway
ec00941  Flavonoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00660  chalcone synthase
Genes
ATH: AT5G13930(TT4)
ALY: ARALYDRAFT_488219
CSAT: 104705657 104735408 104769619
EUS: EUTSA_v10013745mg
BRP: 103836794 103846527(CHS-BR-1) 103850907(CHS5) 103854548(CHS-BR-2) 103856040
BNA: 106367233 106372253 106378767 106381815 106382265 106382267 106425116 106431192 111204286
BOE: 106312851 106313587 106324440 106324842 106327741 106328481
THJ: 104801099 104801109 104803980 104822426
CPAP: 110813035 110814000
CIT: 102606708 102607309 102612856 102613437 102616330 102616623 102620619 102626778 102626876 102629616
LJA: Lj0g3v0107259.1(Lj0g3v0107259.1) Lj0g3v0129339.1(Lj0g3v0129339.1) Lj1g3v0116650.1(Lj1g3v0116650.1) Lj1g3v0116650.2(Lj1g3v0116650.2) Lj1g3v0898770.1(Lj1g3v0898770.1) Lj1g3v0898850.1(Lj1g3v0898850.1) Lj1g3v2626180.1(Lj1g3v2626180.1) Lj1g3v2626190.1(Lj1g3v2626190.1) Lj1g3v2626200.1(Lj1g3v2626200.1) Lj1g3v2626210.1(Lj1g3v2626210.1) Lj1g3v3918040.1(Lj1g3v3918040.1) Lj1g3v3918050.1(Lj1g3v3918050.1) Lj2g3v2124310.1(Lj2g3v2124310.1) Lj2g3v2124320.1(Lj2g3v2124320.1) Lj2g3v2124320.2(Lj2g3v2124320.2) Lj4g3v2574990.1(Lj4g3v2574990.1) Lj6g3v0933570.1(Lj6g3v0933570.1)
MDM: 103421794(CHS) 103443512(CHS-2) 103443513(MdCHS)
CSV: 101205211
CMO: 103491706
MCHA: 111009641
INI: 109161594(CHS-E) 109176547(CHS-D) 109189176(CHSB) 109189177(CHSA) 109189178
DOSA: Os07t0214900-00(Os07g0214900) Os11t0530600-01(Os11g0530600)
BDI: 100829639
ATS: 109739868(LOC109739868) 109739869(LOC109739869) 109743740(LOC109743740) 109743836(LOC109743836) 109752472(LOC109752472) 109752473(LOC109752473) 109752474(LOC109752474) 109758766(LOC109758766) 109768285(LOC109768285) 109768286(LOC109768286) 109775497(LOC109775497) 109775499(LOC109775499) 109775501(LOC109775501) 109780460(LOC109780460) 109787049(LOC109787049)
 » show all
Taxonomy
Reference
1  [PMID:3355160]
  Authors
Ayabe S, Udagawa A, Furuya T.
  Title
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
  Journal
Arch Biochem Biophys 261:458-62 (1988)
DOI:10.1016/0003-9861(88)90362-1
Reference
2  [PMID:7436427]
  Authors
Heller W, Hahlbrock K.
  Title
Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone.
  Journal
Arch Biochem Biophys 200:617-9 (1980)
DOI:10.1016/0003-9861(80)90395-1
Reference
3  [PMID:28482241]
  Authors
Yahyaa M, Ali S, Davidovich-Rikanati R, Ibdah M, Shachtier A, Eyal Y, Lewinsohn E, Ibdah M
  Title
Characterization of three chalcone synthase-like genes from apple (Malus x domestica Borkh.).
  Journal
Phytochemistry 140:125-133 (2017)
DOI:10.1016/j.phytochem.2017.04.022
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.74
IUBMB Enzyme Nomenclature: 2.3.1.74
ExPASy - ENZYME nomenclature database: 2.3.1.74
BRENDA, the Enzyme Database: 2.3.1.74
CAS: 56803-04-4

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