KEGG   ENZYME: 2.3.1.78Help
Entry
EC 2.3.1.78                 Enzyme                                 

Name
heparan-alpha-glucosaminide N-acetyltransferase;
acetyl-CoA:alpha-glucosaminide N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide [RN:R04466 R07815]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
heparan sulfate alpha-D-glucosaminide [CPD:C04384]
Product
CoA [CPD:C00010];
heparan sulfate N-acetyl-alpha-D-glucosaminide [CPD:C04649]
Comment
Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.
History
EC 2.3.1.78 created 1984
Pathway
ec00531  Glycosaminoglycan degradation
ec01100  Metabolic pathways
Orthology
K10532  heparan-alpha-glucosaminide N-acetyltransferase
Genes
HSA: 138050(HGSNAT)
PTR: 464155(HGSNAT)
PPS: 100984595(HGSNAT)
GGO: 101149295(HGSNAT)
PON: 100447325(HGSNAT)
NLE: 100606132(HGSNAT)
MCC: 720331(HGSNAT)
MCF: 102129964 102146857(HGSNAT)
CSAB: 103215704(HGSNAT)
RRO: 104668313(HGSNAT)
RBB: 108534354(HGSNAT)
CJC: 100403479(HGSNAT)
SBQ: 101052325(HGSNAT)
MMU: 52120(Hgsnat)
CGE: 100752593(Hgsnat)
NGI: 103734216(Hgsnat)
HGL: 101698026(Hgsnat)
OCU: 100355407(HGSNAT)
TUP: 102478224(HGSNAT)
CFA: 482833(HGSNAT)
AML: 100466980(HGSNAT)
UMR: 103677041(HGSNAT)
ORO: 101370676(HGSNAT)
FCA: 101101049(HGSNAT)
PTG: 102958238(HGSNAT)
AJU: 106978258(HGSNAT)
BTA: 511607(HGSNAT)
BOM: 102272015(HGSNAT)
BIU: 109553469(HGSNAT)
PHD: 102332946(HGSNAT)
CHX: 102179068(HGSNAT)
OAS: 101102037(HGSNAT)
SSC: 100517562(HGSNAT)
CFR: 102515446(HGSNAT)
CDK: 105094298(HGSNAT)
BACU: 103014371(HGSNAT) 103016171
LVE: 103085420(HGSNAT)
OOR: 101269692(HGSNAT)
ECB: 100053359(HGSNAT)
EPZ: 103540950(HGSNAT)
EAI: 106828971(HGSNAT)
MYB: 102255817(HGSNAT)
MYD: 102753313(HGSNAT)
HAI: 109386280(HGSNAT)
RSS: 109452804(HGSNAT)
PALE: 102898024(HGSNAT)
LAV: 100668824(HGSNAT)
TMU: 101344649
MDO: 100015953 100033053(HGSNAT)
SHR: 100926947 100930224(HGSNAT)
OAA: 100086649(HGSNAT)
GGA: 422490(HGSNAT)
MGP: 100540377(HGSNAT)
CJO: 107313211(HGSNAT)
APLA: 101798941(HGSNAT)
ACYG: 106035184(HGSNAT)
TGU: 100228309(HGSNAT)
GFR: 102033589(HGSNAT)
FAB: 101811325(HGSNAT)
PHI: 102113040(HGSNAT)
PMAJ: 107203298(HGSNAT)
CCW: 104697135(HGSNAT)
FPG: 101916028(HGSNAT)
FCH: 102048397(HGSNAT)
CLV: 102088426(HGSNAT)
EGZ: 104135512(HGSNAT)
AAM: 106484356(HGSNAT)
ASN: 102367842 102380180(HGSNAT)
AMJ: 102558169(BMS1) 102567230(HGSNAT)
PSS: 102446451(HGSNAT)
CMY: 102929508(HGSNAT)
CPIC: 101949968(HGSNAT)
ACS: 100567269(hgsnat) 103279643
PVT: 110083669 110086321(HGSNAT)
PBI: 103067626(HGSNAT)
GJA: 107107429(HGSNAT)
XLA: 108695792 108712227(hgsnat.L)
XTR: 100485725(hgsnat) 100496969
NPR: 108786592 108804914(HGSNAT)
DRE: 100329505(hgsnat) 565246(si:dkey-192p21.6)
CCAR: 109068429
IPU: 108260558(hgsnat) 108263840
AMEX: 103035691(hgsnat) 103038051
LCO: 104921898 104930930(hgsnat)
NCC: 104951383(hgsnat) 104952735
MZE: 101474778 101485947(hgsnat)
OLA: 101155794 101166687(hgsnat)
PRET: 103469275(hgsnat) 103477188
NFU: 107372418(hgsnat) 107375363
CSEM: 103383737(hgsnat) 103387461
HCQ: 109511354(hgsnat) 109523168
BPEC: 110162343 110172620(hgsnat)
ELS: 105007438(hgsnat)
SFM: 108925690(hgsnat) 108932733
CMK: 103180601(hgsnat)
CIN: 100185618
APLC: 110987515
SKO: 102806658
DME: Dmel_CG6903(CG6903)
DSI: Dsimw501_GD16714(Dsim_GD16714)
MDE: 101898084
AAG: 5567477
API: 100159605
DNX: 107170094
TUT: 107364433
HMG: 100199128
AQU: 100639521
ATH: AT5G27730
CRB: 111830078
BRP: 103854670
BOE: 106322966
THJ: 104818720
LJA: Lj1g3v4626570.1(Lj1g3v4626570.1) Lj5g3v1601890.1(Lj5g3v1601890.1)
DOSA: Os05t0155700-01(Os05g0155700)
ATS: 109755387(LOC109755387) 109774972(LOC109774972) 109783785(LOC109783785)
DFA: DFA_08785
 » show all
Taxonomy
Reference
1  [PMID:33384]
  Authors
Klein U, Kresse H, von Figura K.
  Title
Sanfilippo syndrome type C: deficiency of acetyl-CoA:alpha-glucosaminide N-acetyltransferase in skin fibroblasts.
  Journal
Proc Natl Acad Sci U S A 75:5185-9 (1978)
DOI:10.1073/pnas.75.10.5185
Reference
2  [PMID:7346380]
  Authors
Pohlmann R, Klein U, Fromme HG, von Figura K.
  Title
Localisation of acetyl-CoA: alpha-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver.
  Journal
Hoppe Seylers Z Physiol Chem 362:1199-207 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.78
IUBMB Enzyme Nomenclature: 2.3.1.78
ExPASy - ENZYME nomenclature database: 2.3.1.78
BRENDA, the Enzyme Database: 2.3.1.78
CAS: 79955-83-2

DBGET integrated database retrieval system