KEGG   ENZYME: 2.3.1.85Help
Entry
EC 2.3.1.85                 Enzyme                                 

Name
fatty-acid synthase;
FASN (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+ [RN:R05188]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain fatty acid [CPD:C00638];
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase. cf. EC 2.3.1.86, fatty-acyl-CoA synthase.
History
EC 2.3.1.85 created 1984
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K00665  fatty acid synthase, animal type
Genes
HSA: 2194(FASN)
PTR: 454986(FASN)
PPS: 100985873(FASN)
GGO: 101151060(FASN)
PON: 100456558(FASN)
NLE: 100596750 100597701(FASN)
MCC: 715708(FASN)
MCF: 102119674(FASN)
CSAB: 103243754(FASN)
RRO: 104654984(FASN)
RBB: 108525064 108534089(FASN)
CJC: 100402953(FASN)
SBQ: 101045175(FASN)
MMU: 14104(Fasn)
RNO: 50671(Fasn)
CGE: 100689207(Fasn)
NGI: 103730050(Fasn)
HGL: 101698314(Fasn)
CCAN: 109702407(Fasn)
TUP: 102481635(FASN)
CFA: 483378(FASN)
AML: 100468470(FASN)
UMR: 103666012(FASN)
ORO: 101372296(FASN)
FCA: 100270775(FASN)
PTG: 102956933(FASN)
AJU: 106986313(FASN)
BTA: 281152(FASN)
BOM: 102278267(FASN)
BIU: 109573330(FASN)
PHD: 102336161(FASN)
CHX: 100861286(FASN)
OAS: 100170327(FASN)
SSC: 397561(FASN)
CFR: 102509439(FASN)
CDK: 105102220(FASN)
BACU: 103017465
LVE: 103077747(FASN)
OOR: 101279575(FASN)
ECB: 100057311(FASN)
EPZ: 103545808 103551124(FASN)
EAI: 106846150
MYB: 102251003(FASN)
MYD: 102761714(FASN)
HAI: 109393056(FASN)
RSS: 109449422(FASN)
PALE: 102887167(FASN)
LAV: 100674176(FASN)
TMU: 101361851
MDO: 100025176(FASN)
SHR: 100924144(FASN)
OAA: 100091954
GGA: 396061(FASN)
MGP: 100542651(FASN)
CJO: 107322058(FASN)
APLA: 101796973(FASN)
ACYG: 106046771(FASN)
TGU: 100226957(FASN)
GFR: 102043163(FASN)
FAB: 101820764(FASN)
PHI: 102102393(FASN)
PMAJ: 107212310(FASN)
CCW: 104698180(FASN)
FPG: 101924649(FASN)
FCH: 102046127(FASN)
CLV: 102086015(FASN)
EGZ: 104131108(FASN)
AAM: 106487141(FASN)
ASN: 102384493(FASN)
AMJ: 102571811(FASN)
PSS: 102458578(FASN)
CMY: 102933656(FASN)
CPIC: 101942965(FASN)
ACS: 100563002(fasn)
PVT: 110090820(FASN)
PBI: 103062560(FASN)
GJA: 107118129(FASN)
XLA: 108701000
XTR: 100487052(fasn)
NPR: 108791330(FASN)
DRE: 559001(fasn)
SRX: 107722180 107755500(fasn)
IPU: 108273998(fasn)
AMEX: 103030617(fasn)
TRU: 101069108(fasn) 105418859
LCO: 104927028(fasn)
OLA: 101171365(fasn)
XMA: 102232393(fasn)
PRET: 103482177(fasn)
NFU: 107396699(fasn)
CSEM: 103381833(fasn)
HCQ: 109513269(fasn)
BPEC: 110154166(fasn)
ELS: 105021150(fasn)
SFM: 108939982(fasn)
LCM: 102352909(FASN)
CMK: 103175468(fasn)
CIN: 100181277
SPU: 105440011
DME: Dmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2)
DSI: Dsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207)
CEL: CELE_F32H2.5(fasn-1)
CBR: CBG12408(Cbr-fasn-1)
BMY: Bm1_35180
TSP: Tsp_06638
EPA: 110240069
ADF: 107350794
 » show all
Taxonomy
Reference
1  [PMID:457689]
  Authors
Stoops JK, Ross P, Arslanian MJ, Aune KC, Wakil SJ, Oliver RM.
  Title
Physicochemical studies of the rat liver and adipose fatty acid synthetases.
  Journal
J Biol Chem 254:7418-26 (1979)
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu Rev Biochem 52:537-79 (1983)
DOI:10.1146/annurev.bi.52.070183.002541
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.85
IUBMB Enzyme Nomenclature: 2.3.1.85
ExPASy - ENZYME nomenclature database: 2.3.1.85
BRENDA, the Enzyme Database: 2.3.1.85
CAS: 9045-77-6

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