KEGG   ENZYME: 2.3.1.86Help
Entry
EC 2.3.1.86                 Enzyme                                 

Name
fatty-acyl-CoA synthase;
yeast fatty acid synthase;
FAS1 (gene name);
FAS2 (gene name)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)
Reaction(IUBMB)
acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H+ = long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP+ [RN:R05190]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Product
long-chain-acyl-CoA;
CoA [CPD:C00010];
CO2 [CPD:C00011];
NADP+ [CPD:C00006]
Comment
The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC 1.1.1.100, 3-oxoacyl-[acyl-carrier-protein] reductase and EC 2.3.1.41, 3-oxoacyl-[acyl-carrier-protein] synthase, while the other subunit catalyses the reactions of EC 2.3.1.38, [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39, [acyl-carrier-protein] S-malonyltransferase, EC 4.2.1.59, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.10, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC 1.1.1.279, (R)-3-hydroxyacid ester dehydrogenase. The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
History
EC 2.3.1.86 created 1984, modified 2003, modified 2013
Pathway
ec00061  Fatty acid biosynthesis
ec01100  Metabolic pathways
Orthology
K00667  fatty acid synthase subunit alpha, fungi type
K00668  fatty acid synthase subunit beta, fungi type
Genes
PXB: 103941732
SCE: YKL182W(FAS1) YPL231W(FAS2)
AGO: AGOS_AER085C AGOS_AFL138W
ERC: Ecym_2158 Ecym_3239
KLA: KLLA0_B02717g KLLA0_C15983g
KMX: KLMA_40526(FAS1) KLMA_70219(FAS2)
LTH: KLTH0D15070g KLTH0G09526g KLTH0H03190g
VPO: Kpol_1002p24 Kpol_1055p60
ZRO: ZYRO0B13068g ZYRO0E07766g
CGR: CAGL0D00528g CAGL0E06138g
NCS: NCAS_0G01260(NCAS0G01260) NCAS_0J01680(NCAS0J01680)
NDI: NDAI_0F01390(NDAI0F01390) NDAI_0J02670(NDAI0J02670)
TPF: TPHA_0B02040(TPHA0B02040) TPHA_0H01860(TPHA0H01860)
TBL: TBLA_0C02010(TBLA0C02010) TBLA_0I03120(TBLA0I03120)
TDL: TDEL_0A06700(TDEL0A06700) TDEL_0C04130(TDEL0C04130) TDEL_0E00900(TDEL0E00900)
KAF: KAFR_0A05730(KAFR0A05730) KAFR_0F01200(KAFR0F01200)
PIC: PICST_80966(FAS2) PICST_85125(FAS1)
SLB: AWJ20_164(FAS2) AWJ20_861(FAS1)
NCR: NCU07307(cel-2) NCU07308(cel-1)
NTE: NEUTE1DRAFT61252(NEUTE1DRAFT_61252) NEUTE1DRAFT61255(NEUTE1DRAFT_61255)
ANG: ANI_1_1114084(An09g01740) ANI_1_1156084(An09g02010) ANI_1_1466104(An12g01980) ANI_1_1468104(An12g01990) ANI_1_202174(An10g00630) ANI_1_204174(An10g00650) ANI_1_2056014(An01g00050) ANI_1_2488074(An08g10860) ANI_1_2494074(An08g10930) ANI_1_6014(An01g00060)
SPO: SPAC4A8.11c(fas2) SPAC926.09c(fas1)
LBC: LACBIDRAFT_296983(FAS-2)
ABP: AGABI1DRAFT134019(AGABI1DRAFT_134019)
ABV: AGABI2DRAFT146869(AGABI2DRAFT_146869)
 » show all
Taxonomy
Reference
1  [PMID:4590449]
  Authors
Schweizer E, Kniep B, Castorph H, Holzner U.
  Title
Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
  Journal
Eur J Biochem 39:353-62 (1973)
DOI:10.1111/j.1432-1033.1973.tb03133.x
Reference
2  [PMID:6137188]
  Authors
Wakil SJ, Stoops JK, Joshi VC.
  Title
Fatty acid synthesis and its regulation.
  Journal
Annu Rev Biochem 52:537-79 (1983)
DOI:10.1146/annurev.bi.52.070183.002541
Reference
3  [PMID:16950653]
  Authors
Tehlivets O, Scheuringer K, Kohlwein SD
  Title
Fatty acid synthesis and elongation in yeast.
  Journal
Biochim Biophys Acta 1771:255-70 (2007)
DOI:10.1016/j.bbalip.2006.07.004
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.86
IUBMB Enzyme Nomenclature: 2.3.1.86
ExPASy - ENZYME nomenclature database: 2.3.1.86
BRENDA, the Enzyme Database: 2.3.1.86
CAS: 94219-29-1

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