KEGG   ENZYME: 2.3.1.87
Entry
EC 2.3.1.87                 Enzyme                                 
Name
aralkylamine N-acetyltransferase;
serotonin acetyltransferase;
serotonin acetylase;
arylalkylamine N-acetyltransferase;
serotonin N-acetyltransferase;
AANAT;
melatonin rhythm enzyme
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:2-arylethylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a 2-arylethylamine = CoA + an N-acetyl-2-arylethylamine [RN:R03760]
Reaction(KEGG)
R03760 > R02911
Substrate
acetyl-CoA [CPD:C00024];
2-arylethylamine [CPD:C15534]
Product
CoA [CPD:C00010];
N-acetyl-2-arylethylamine [CPD:C15535]
Comment
Narrow specificity towards 2-arylethylamines, including serotonin (5-hydroxytryptamine), tryptamine, 5-methoxytryptamine and phenylethylamine. This is the penultimate enzyme in the production of melatonin (5-methoxy-N-acetyltryptamine) and controls its synthesis (cf. EC 2.1.1.4, acetylserotonin O-methyltransferase). Differs from EC 2.3.1.5 arylamine N-acetyltransferase.
History
EC 2.3.1.87 created 1986, modified 2005
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00669  arylalkylamine N-acetyltransferase
K22450  aralkylamine N-acetyltransferase
Genes
HSA15(AANAT)
PTR503504(AANAT)
PPS100977321(AANAT)
GGO101129527(AANAT)
PON100433977(AANAT)
NLE100600128(AANAT)
HMH116484181(AANAT)
MCC706924(AANAT)
MCF102127968(AANAT)
MTHB126939239
MNI105469202(AANAT)
CSAB103242991(AANAT)
CATY105577688(AANAT)
PANU101021111(AANAT)
TGE112610080(AANAT)
MLEU105542397(AANAT)
RRO104681272(AANAT)
RBB108537333(AANAT)
TFN117066724(AANAT)
PTEH111542384(AANAT)
CANG105517583(AANAT)
CJC100406947(AANAT)
SBQ101027986(AANAT)
CIMI108309467(AANAT)
CSYR103250644(AANAT)
MMUR105878976(AANAT)
LCAT123620487(AANAT)
PCOQ105824783(AANAT)
OGA100966018(AANAT)
MMU11298(Aanat)
MCAL110304584(Aanat)
MPAH110332666(Aanat)
RNO25120(Aanat)
MCOC116077976(Aanat)
ANU117711177(Aanat)
MUN110542260(Aanat)
CGE100755392(Aanat)
MAUA101834092(Aanat)
PROB127221552(Aanat)
PLEU114707082(Aanat)
MORG121436288(Aanat)
MFOT126500454
AAMP119813655(Aanat)
NGI103732690(Aanat)
HGL101713893(Aanat)
CPOC100724241(Aanat)
CCAN109685598(Aanat)
DORD106003068(Aanat)
DSP122094967(Aanat)
PLOP125365967(Aanat)
NCAR124981032
OCU100357535
OPI101525294(AANAT)
TUP102470373(AANAT)
GVR103605509(AANAT)
CFA483331(AANAT)
CLUD112672836(AANAT)
VVP112920613(AANAT)
VLG121473674(AANAT)
NPO129508128(AANAT)
AML100482847(AANAT)
UMR103665763(AANAT)
UAH113244682(AANAT)
UAR123802940(AANAT)
ELK111160461
LLV125087596
MPUF101672101(AANAT)
NVS122907529(AANAT)
ORO101375231(AANAT)
EJU114216050(AANAT)
ZCA113939291(AANAT)
MLX118024237(AANAT)
NSU110572512(AANAT)
LWW102750097(AANAT)
FCA101098178(AANAT)
PYU121017956(AANAT)
PCOO112864704(AANAT)
PBG122486123(AANAT)
LRUF124513228
PTG102953543(AANAT)
PPAD109276895(AANAT)
PUC125926331
AJU113596985
HHV120228269(AANAT)
BTA112442710(AANAT) 281583(AANAT)
BOM102279792 102285681
BIU109573499 109573505
BBUB102401346 102412521(AANAT)
BBIS105000375
CHX100860947(AANAT) 102190991(AANAT)
OAS105601853 443531(AANAT)
BTAX128065506 128065508
ODA120859233 120859234 120866544(AANAT)
CCAD122424699 122442155
MBEZ129544688 129544691
SSC100518330 110255264
CFR102522698 116669211 116669239
CBAI105065622(AANAT)
CDK105092185(AANAT)
VPC102540360(AANAT)
BACU103011665(AANAT)
LVE103071739(AANAT)
OOR101286550(AANAT)
DLE111182937(AANAT)
PCAD102993089(AANAT)
PSIU116746215(AANAT)
NASI112410182(AANAT)
ECB100058770(AANAT)
EPZ103565530(AANAT)
EAI106830333(AANAT)
MYB102257691(AANAT)
MMYO118672357(AANAT)
MNA107536593(AANAT)
PKL118704556(AANAT)
HAI109383638(AANAT)
DRO112298834(AANAT)
SHON119000101(AANAT)
AJM119058577(AANAT)
PDIC114504159(AANAT)
PHAS123817386(AANAT)
MMF118634540(AANAT)
RFQ117013054(AANAT)
PALE102898841(AANAT)
PGIG120599975(AANAT)
PVP105293433(AANAT)
RAY107510038(AANAT)
MJV108398665(AANAT)
TOD119231650(AANAT)
SARA101553717(AANAT)
LAV100667906(AANAT)
ETF101656083(AANAT)
MDO100026619(AANAT)
GAS123247143(AANAT)
SHR100924836(AANAT)
AFZ127560436
PCW110219333(AANAT)
OAA100076568(AANAT)
GGA396066(AANAT)
PCOC116232615(AANAT)
MGP100549848(AANAT)
CJO107322266(AANAT)
TPAI128083092(AANAT)
NMEL110407363(AANAT)
APLA101798734(AANAT)
ACYG106034630(AANAT)
AFUL116496655(AANAT)
TGU100228432(AANAT)
LSR110476573(AANAT)
SCAN103820004(AANAT)
PMOA120505532(AANAT)
OTC121338384(AANAT)
PRUF121363880(AANAT)
GFR102044523(AANAT)
FAB101817679(AANAT)
PHI102107121(AANAT)
PMAJ107212354(AANAT)
CCAE111937273(AANAT)
CCW104694394(AANAT)
CBRC103621763(AANAT)
ETL114058599(AANAT)
ACHL103798751(AANAT)
SVG106861012(AANAT)
FPG101917150(AANAT)
FCH102045840(AANAT)
CLV102097087(AANAT)
EGZ104125379(AANAT)
NNI104022838(AANAT)
PCRI104034687(AANAT)
ACUN113486749(AANAT)
TALA116964028(AANAT)
PADL103921009(AANAT)
AFOR103899024(AANAT)
ACHC115340961(AANAT)
HLE104839203(AANAT)
AGEN126044047
GCL127024165
CCRI104160913(AANAT)
MUI104540984(AANAT)
LDI104351342(AANAT)
SHAB115616703(AANAT)
DPUB104298011(AANAT)
PGUU104469399(AANAT)
ACAR104517843(AANAT)
CPEA104387780(AANAT)
AVIT104270956(AANAT)
CVF104284129(AANAT)
CUCA104068672(AANAT)
TEO104376464(AANAT)
BRHI104495970(AANAT)
AAM106485386(AANAT)
AROW112977768(AANAT)
NPD112957705(AANAT)
TGT104577592(AANAT)
DNE112985340(AANAT)
ASN102385650(AANAT)
AMJ102558329(AANAT)
CPOO109315105(AANAT)
GGN109286971(AANAT)
PSS102454343(AANAT)
CMY102939980(AANAT)
DCC119843400(AANAT)
CPIC101949766(AANAT)
TST117887303(AANAT)
CABI116832292(AANAT)
MRV120383350(AANAT)
ACS100560631(aanat)
PVT110085911(AANAT)
SUND121922887(AANAT)
PBI103059427(AANAT)
PMUR107290061(AANAT)
CTIG120301161(AANAT)
TSR106554544(AANAT)
PGUT117660475(AANAT)
PTEX113437174(AANAT)
NSS113412100(AANAT)
VKO123035638(AANAT)
PMUA114590653(AANAT)
ZVI118079864(AANAT)
HCG128343243(AANAT)
GJA107121146(AANAT)
STOW125428195(AANAT)
XLA100335045(aanat.S) 100335046(aanat.L)
XTR100497589(aanat)
NPR108796857(AANAT)
RTEM120918502(AANAT)
BBUF121005313(AANAT)
BGAR122942559(AANAT)
DRE30685(aanat2) 393677(aanat1)
SRX107711187 107715487(aanat) 107742556 107754039
SANH107670449 107672440 107702983(aanat)
SGH107561337(aanat) 107588006 107596820
CCAR109056260 109056933 109059207
CAUA113042439 113050725(aanat) 113082008 113095415
CGIB127952843 127953320 128016227
PTET122339818(aanat2) 122347060(aanat1)
LROH127162811(aanat2) 127167246(aanat1)
PPRM120466727(aanat1) 120489294(aanat2)
MAMB125268979(aanat2) 125273287(aanat1)
CIDE127509052 127513808
MASI127449031 127449977 127452121
IPU108257103(aanat2) 108273103(aanat1)
PHYP113536007 113538260(aanat)
SMEO124376137(aanat2) 124383978(aanat1)
TFD113634427(aanat1) 113640464(aanat2)
AMEX103029239 103031094(aanat)
CMAO118805779(aanat2) 118807506(aanat1)
EEE113571837 113583276
CHAR105898567 105900207(aanat1) 105907855(aanat2) 116222096
TRU101065059 101069944(aanat) 101071652
TNGGSTEN00007250G001 GSTEN00010408G001 GSTEN00032513G001
LCO104918698 104932979(aanat) 104938975
NCC104953103 104955756
CGOB115009663(aanat) 115011759 115012355
ELY117254966(aanat1) 117268622(aanat2) 117268670
EFO125879145 125879210(aanat2) 125884970(aanat1)
PLEP121939806 121941854(aanat1) 121956108(aanat2)
SLUC116042642(aanat1) 116059525(aanat2) 116065468
ECRA117957840 117958329(aanat2) 117960910(aanat1)
ESP116700109(aanat) 116703094 116703551
PFLV114569609 114569801 114569809
GAT120825377(aanat1) 120827539 120827719(aanat2)
PPUG119218418(aanat1) 119220452 119220746(aanat2)
MSAM119883952 119891562(aanat2) 119899313(aanat1)
SCHU122868535(aanat2) 122869406 122873583(aanat1)
CUD121503573 121503576(aanat2) 121508637(aanat1)
ALAT119014348(aanat2) 119014811 119026957(aanat1)
MZE101470946 101472579(aanat) 101479147
ONL100689833 100690180 100706826(aanat)
OAU116310830(aanat1) 116318401(aanat2) 116327149
OLA100049467(aanat) 100049488(aanat2) 100049507(aanat1b)
OML112146110 112146445(aanat2) 112157294(aanat1)
XMA102226079 102233098 102235970(aanat)
XCO114145405 114159590 114160189
XHE116720846 116735180 116735883
PRET103468403 103468705 103469693
PFOR103143668 103143768 103143770 103153197
PLAI106937025 106942159 106950860 106964066
PMEI106911672 106918968 106934031 106934060
GAF122821519(aanat2) 122822124 122830249(aanat1)
CVG107083117 107100582(aanat) 107104616
CTUL119771323(aanat1) 119785324(aanat2) 119797287
GMU124862532 124863331 124864628 124865019 124868481(aanat1)
NFU107376253 107378383 107382246
KMR108236158 108243703(aanat2) 108248779(aanat1)
ALIM106518761 106523853 106528835
NWH119421791(aanat2) 119422146 119423194(aanat1)
AOCE111564217(aanat) 111567914 111574835
MCEP124997602(aanat2) 124997799 125003790(aanat1)
CSEM103383775 103392596 103393389
POV109627400 109634267 109644751
SSEN122763909(aanat2) 122770985(aanat1)
HHIP117763112(aanat1) 117766279 117766473(aanat2)
HSP118119218(aanat1) 118123053(aanat2) 118123157
LCF108875852(aanat1) 108879348 108898703 108902966
SDU111217515 111236294(aanat) 111238089
SLAL111659761 111660619 111673755
XGL120787793(aanat2) 120787961(aanat1)
HCQ109513811 109516440 109519790(aanat)
SSCV125969559 125983907 125984168
BPEC110166218(aanat) 110170029 110172214
MALB109966005 109966258(aanat) 109974664
BSPL114855511(aanat1) 114860298 114860556(aanat2)
SASA106588571(aanat) 106601142 106601410 106607000 106607367
STRU115170616 115170622 115178176 115201927 115203761
OTW112230148(aanat1) 112234611 112246025 112258719 112259441
OMY100135782 100135881(aanat-2) 110487522(aanat1) 110538456 110538513
OGO123999575 124000370 124015435 124016078(aanat1) 124016278
ONE115103555 115103628 115103642 115109882 115110646
SALP111955129 111980399 111981627
SNH120032934 120034461 120034465 120044556 120044615
CCLU121550932 121551145 121570396 121570428
ELS105013156 105013380 105021627(aanat)
SFM108935849 108939955(aanat)
PKI111843224 111848397(aanat)
AANG118219646(aanat1) 118221224(aanat2)
LOC102683533(aanat) 102686229
PSPA121295719 121296561(aanat1) 121330940(aanat2)
ARUT117418367 117423197(aanat1) 117424323 117431354
PSEX120517232(aanat1) 120542384(aanat2)
LCM102349438(AANAT)
CMK103188407(aanat2)
RTP109931923(aanat)
CPLA122560493
BFO118414177
BBEL109471522
APLC110985521
DMEDmel_CG3318(speck)
DER6547970
DSE6613030
DSIDsimw501_GD15464(Dsim_Dat)
DYADyak_GE14383
DAN6494240
DSR110191728
DPO4804331
DPE6592468
DMN108160778 117190948
DWI6652169
DGR6560444
DMODmoj_GI20262
DAZ108616403
DNV108653929
DHE111600616 115482737
CCAT101459162
BOD106618444
RZE108366425
MDE101895265
SCAC106084825
LCQ111674574
LSQ119616228
HIS119653936
AGAAgaP_AGAP010142
ACOZ120955644
AARA120900650
AMER121596297
ASTE118511119
AALI118456883
AAG5574368
AALB109404734 109414420
CQUCpipJ_CPIJ015282
CPII120425442
CNS116342447 116350849
BCOO119073769
PFUC122524744
NPT124221578
NFB124184231 124184793
NLO107219468 107223418
NVG124306636
SOY115890348
AGRG126738117
CSET123309990
AGB108911237
LDC111505099 111505728 111509399
APLN108743952
PPYR116169540 116169784 116169786
OTU111427395 111427414 111427421
BANY112046690
PMAC106713943
PPOT106100879
PXU106121608
PRAP110992527 111002558
SLIU111356569
OFU114362544
FOC113201897 113218248
TPAL117643620 117644122 117654200
CSEC111874952
DMK116917990
PJA122245523
PPOI119104624 119104828 119104873
MYI110466687
MMER123558797
LAK106163577 106178530
TADTRIADDRAFT_56876
ATHAT1G26220 AT1G32070(NSI)
ALY9326732 9327030
CRB17897055 17900932
CSAT104741233 104741234 104741802 104756917 104757576 104776667 104777238
EUSEUTSA_v10008400mg EUTSA_v10008844mg
BRP103835481 103868913
BNA106361844 106361908(BNACNNG04490D) 106365605 106451742
BOE106295341 106328614
RSZ108819205 108862864
THJ104806235 104821982
CPAP110812909 110814677
CIT102610413 102615047
CICCICLE_v10012371mg CICLE_v10032841mg
PVY116105203 116119522 116136492
MINC123212972 123214469
TCC18602183 18610130
GRA105783853 105793933
GHI107888830 107895041 107918288 107951054
GAB108463383 108487392
DZI111288139 111307603 111318209
EGR104425125 104435581
GMX100778613 100799333(TAP1)
GSJ114388175 114396786 114425700
PVUPHAVU_006G034800g PHAVU_006G035000g PHAVU_008G079900g
VRA106758671 106774536
VAR108321317 108341856
VUN114183845 114187217
CCAJ109788951 109789881
APRC113861492 113869644
MTR11417190 11430066
TPRA123892756 123892842 123911603
CAM101505938 101507363
PSAT127119068 127127271
LJALj1g3v2536100.1(Lj1g3v2536100.1)
ADU107470795 107479042 107485362
AIP107634137 107639732
AHF112716098 112736334 112743881 112790407 112797253
LANG109352699 109355807
PCIN129287640 129322998
FVE101296483 101299392
RCN112193361 112198548
PPER18775586 18793399
PMUM103341987 103342676
PAVI110757692 110771956
PDUL117613562 117616364 117631846
MDM103450782 103451714
MSYL126594347 126594923
PXB103930236 103947313
ZJU107429139 107429150 107431393
MNT112092023 21409181
CSAV115716162 115725561
CSV101204410 101208854
CMO103489215 103501481
BHJ120072585 120081819
MCHA111017595 111025811
CMAX111478297 111484466
CMOS111432339 111452951 111458741
CPEP111781059 111803110 111807119
RCU8264622 8271695
JCU105640713 105649077
HBR110639106 110642611 110667725
MESC110621806 110630270
POP7472491 7483916
PEU105108867 105123398
PALZ118039988 118047196
JRE108986255 108989416
CILL122275624 122310679
QSU111989041 112017082
QLO115951903 115954184 115957693
TWL119981981 119990980
VVI100241027 100250235
VRI117911157 117920732
SLY101247616 101262573
SPEN107002224 107020508
SOT102591080 102597415
SSTN125866395 125869265
CANN107845856 107852754
NTA107779554 107789648 107817186 107819409
NSY104224393 104229486
NTO104104574 104107124
NAU109215540 109219467
INI109146806 109182093
ITR116006235 116025762
SIND105161683 105174689
OEU111398653 111403886
EGT105953212 105967673
SSPL121767538 121795666 121799307
APAN127251634 127261644
HAN110910062 110941941
ECAD122582973 122587407
LSV111918409 111919310
CCAV112513390 112515951
DCR108193511 108201876
CSIN114268185 114297586
BVG104896286 104898120
SOE110804144 110804344
CQI110686034 110690742 110721014 110731833
NNU104588375 104597826
MING122057651 122062521 122091214
TSS122651590 122652924
PSOM113273943 113277521 113283619 113357903
OSA4339123 4344423
DOSAOs05t0481000-01(Os05g0481000) Os08t0102000-01(Os08g0102000)
OBR102701448 102708173
OGL127772585 127781620
BDI100837085 100846403
ATS109752019 109764125
TDC119284027 119331884 119340732 119348706
TAES123060198 123137124 123147684 123162459 123169053 123182379
TUA125521785 125525307
LPER127313597 127318898
SBI8064146 8064317
ZMA100194006 100276761
SITA101767823 101777356
SVS117850339 117860518
PVIR120665135 120678457 120698338 120711072
PHAI112887367 112896668
PDA103702403 103716703
EGU105046017 105050664 109504744
MUS103972784 103986056
ZOF121973620 121977966 122009012 122014621
DCT110092647 110110969
PEQ110022031 110032620
AOF109822178
NCOL116254480 116263430
ATR18432408 18433148
SMOSELMODRAFT_126619 SELMODRAFT_271611 SELMODRAFT_432148 SELMODRAFT_449074
PPP112275116 112285609 112288166
CRECHLRE_01g002250v5
VCNVOLCADRAFT_107031 VOLCADRAFT_64094
MNGMNEG_0842 MNEG_7477
CSLCOCSUDRAFT_20526 COCSUDRAFT_8782
CVRCHLNCDRAFT_143824 CHLNCDRAFT_57286
APROF751_1318 F751_1688
OLUOSTLU_43627 OSTLU_7981
OTAOT_ostta09g02380 OT_ostta14g00170
BPGBathy07g04480 Bathy10g02160
MISMICPUN_58705 MICPUN_72029
MPPMICPUCDRAFT_33987 MICPUCDRAFT_6518
CMECYME_CMK299C
GSLGasu_52950
CCPCHC_T00003174001
ENRH650_08120
ENFAKI40_1403
RORRORB6_06255
RPLNB1209_13265
RAODSD31_12815
KSAC813_22330
KORAWR26_07085
KRDA3780_16860
KPSEIP581_16390
KOOO9K67_06925
SRRSerAS9_3686
SRLSOD_c34120
SRYM621_18550
SPLYQ5A_018555
SRSSerAS12_3687
SRASerAS13_3688
SMAFD781_3274
SLQM495_18030
EAMEGXP68_21665
BGJAWC36_13950
FPPFPB0191_01811
DFLDFE_0046
DSADesal_3052
DAFDesaf_0496
PPRFDPRO_3122
DTOTOL2_C19160
DOVDSCO28_11060
DWDDSCW_20980
DALKDSCA_18470
SSPSSP2346
SXYBE24_13175
SXLSXYLSMQ121_2387
SXOSXYL_02546
PSTEPSTEL_08850
PDHB9T62_22365
JEPBW721_00135
JEHEJN90_02805
JARG7057_02175
CSRCspa_c14020
DSLDacsa_3409
HAOPCC7418_3859
ENNFRE64_10465
VBCC5Q97_12290
PEPAQ505_19430
PCMAY601_2531
PSTYBFS30_00850
PEKFFJ24_003525
MHORMSHOH_3193
MPYMpsy_1118
 » show all
Reference
1  [PMID:6469990]
  Authors
Voisin P, Namboodiri MA, Klein DC.
  Title
Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.
  Journal
J Biol Chem 259:10913-8 (1984)
Reference
2  [PMID:10722724]
  Authors
Ferry G, Loynel A, Kucharczyk N, Bertin S, Rodriguez M, Delagrange P, Galizzi JP, Jacoby E, Volland JP, Lesieur D, Renard P, Canet E, Fauchere JL, Boutin JA.
  Title
Substrate specificity and inhibition studies of human serotonin N-acetyltransferase.
  Journal
J Biol Chem 275:8794-805 (2000)
DOI:10.1074/jbc.275.12.8794
Reference
3
  Authors
Khalil, E.M. and Cole, P.A.
  Title
A potent inhibitor of the melatonin rhythm enzyme.
  Journal
J Am Chem Soc 120:6195-6196 (1998)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.87
IUBMB Enzyme Nomenclature: 2.3.1.87
ExPASy - ENZYME nomenclature database: 2.3.1.87
BRENDA, the Enzyme Database: 2.3.1.87
CAS: 92941-56-5

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