KEGG   ENZYME: 2.3.2.10Help
Entry
EC 2.3.2.10                 Enzyme                                 

Name
UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase;
alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase;
UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase;
uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase;
L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
L-alanyl-tRNAAla:UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase
Reaction(IUBMB)
L-alanyl-tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine = tRNAAla + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine [RN:R04613]
Reaction(KEGG)
R04613;
(other) R08779
Show
Substrate
L-alanyl-tRNA(Ala) [CPD:C00886];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
Product
tRNA(Ala) [CPD:C01635];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine
Comment
Also acts on L-seryl-tRNASer.
History
EC 2.3.2.10 created 1972, modified 2013
Pathway
ec00550  Peptidoglycan biosynthesis
Orthology
K05363  serine/alanine adding enzyme
Genes
BACO: OXB_0272
GMO: NCTC11323_00057(femB_1)
SPOR: SporoP33_05385
SPOP: SporoP37_05875
SURE: SporoP32a_05895
SPOS: DV702_09585
LLK: LLKF_2319(murM)
LLX: NCDO2118_2181(murM)
LLC: LACR_2372
LLM: llmg_2352(murM)
LLR: llh_12055
LLI: uc509_2051(murM)
LLW: kw2_2131(murM)
LGR: LCGT_0589
LGV: LCGL_0608
SPY: SPy_0616(murM) SPy_1205
SPYA: A20_0553c(murM) A20_0956c(murM)
SPG: SpyM3_0435(murM.1) SpyM3_0846(murM.2)
SPF: SpyM50878(murM) SpyM51352(murM)
SOZ: Spy49_0518c(murM.1) Spy49_0951c(murM2)
SPN: SP_0615(fibA)
SPD: SPD_0535(murM_fibA)
SPR: spr0540(murM)
SPW: SPCG_0575(murM)
SJJ: SPJ_0566
SNV: SPNINV200_05420(murM)
SPX: SPG_0558
SNT: SPT_0640
SND: MYY_0664
SPNN: T308_02900
SNE: SPN23F05540(murM)
SPV: SPH_0708
SPP: SPP_0629
SNI: INV104_05130(murM)
SNP: SPAP_0601
SNX: SPNOXC05610(murM)
SNU: SPNA45_01491(murM)
SPNE: SPN034156_16110(murM)
SPNU: SPN034183_05640(murM)
SPNM: SPN994038_05520(murM)
SPNO: SPN994039_05530(murM)
SAG: SAG0509(fibA) SAG0510
SGC: A964_0540(murM) A964_0541(murM)
SAGP: V193_02835
SAGC: DN94_02835
SMU: SMU_717(murM)
SMC: SmuNN2025_1280(murM)
SMJ: SMULJ23_1281(murM)
SMUA: SMUFR_0625(murM)
STC: str1155(murM)
STL: stu1155(murM)
STE: STER_1112
STN: STND_1074
STU: STH8232_1341(murM)
STW: Y1U_C0774
STHE: T303_06625
SSA: SSA_0862(murM)
SSUI: T15_0381(murM)
SGO: SGO_1623(murM)
SEZ: Sez_1015(murM) Sez_1319(murM)
SUB: SUB0607(murM)
SDS: SDEG_0637(murM) SDEG_0947
SDA: GGS_0612(murM) GGS_0917(murM)
SDC: SDSE_0678(murM) SDSE_0983 SDSE_0984(murM)
SGG: SGGBAA2069_c15300(murM)
SGT: SGGB_1503(murM)
SMB: smi_1584(fibA)
SOR: SOR_1963(murM)
STK: STP_0096 STP_0414(murM)
STB: SGPB_1404(murM)
SCF: Spaf_1436
SSR: SALIVB_1141(femX)
STF: Ssal_01216(murM)
STJ: SALIVA_0993(murM)
SSAH: HSISS4_00840(murM)
SMN: SMA_1515
SIF: Sinf_1329
SIE: SCIM_0530(murM)
SIB: SIR_1111(murM)
SIU: SII_1132(murM)
SANG: SAIN_0586(murM)
SANC: SANR_0598(murM)
SANS: DK43_07235
SCG: SCI_0623(murM)
SCON: SCRE_0603(murM)
SCOS: SCR2_0603(murM)
SLU: KE3_1458
LSN: LSA_00260
EFA: EF2658
EFL: EF62_2819(murM)
EFI: OG1RF_12030(fibA)
EFD: EFD32_2218(murM)
EFS: EFS1_2129
EFN: DENG_02594(murM)
EFQ: DR75_1359
MPS: MPTP_1602
MPX: MPD5_0449
OOE: OEOE_1444
LME: LEUM_1773
LMM: MI1_07685
LMK: LMES_1540
LCI: LCK_01455
LKI: LKI_07255
WKO: WKK_02350
WCE: WS08_1006
WCT: WS74_1072
APR: Apre_0286
AHE: Arch_0164
TPYO: X956_02825
BAST: BAST_1252
 » show all
Taxonomy
Reference
1  [PMID:4248527]
  Authors
Plapp R, Strominger JL.
  Title
Biosynthesis of the peptidoglycan of bacterial cell walls. 18. Purification and properties of L-alanyl transfer ribonucleic acid-uridine diphosphate-N-acetylmuramyl-pentapeptide transferase from Lactobacillus viridescens.
  Journal
J Biol Chem 245:3675-82 (1970)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.2.10
IUBMB Enzyme Nomenclature: 2.3.2.10
ExPASy - ENZYME nomenclature database: 2.3.2.10
BRENDA, the Enzyme Database: 2.3.2.10
CAS: 37257-26-4

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