KEGG   ENZYME: 2.3.3.4Help
Entry
EC 2.3.3.4                  Enzyme                                 

Name
decylhomocitrate synthase;
2-decylhomocitrate synthase;
3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating)
Class
Transferases;
Acyltransferases;
Acyl groups converted into alkyl groups on transfer
BRITE hierarchy
Sysname
dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)
Reaction(IUBMB)
dodecanoyl-CoA + H2O + 2-oxoglutarate = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA [RN:R03859]
Reaction(KEGG)
Substrate
dodecanoyl-CoA [CPD:C01832];
H2O [CPD:C00001];
2-oxoglutarate [CPD:C00026]
Product
(3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate [CPD:C04529];
CoA [CPD:C00010]
Comment
Decanoyl-CoA can act instead of dodecanoyl-CoA, but 2-oxoglutarate cannot be replaced by oxaloacetate or pyruvate.
History
EC 2.3.3.4 created 1976 as EC 4.1.3.29, transferred 2002 to EC 2.3.3.4
Reference
1  [PMID:4774124]
  Authors
Mahlen A.
  Title
Purification and some properties of 2-decylhomocitrate synthase from Penicillium spiculisporum.
  Journal
Eur J Biochem 38:32-9 (1973)
DOI:10.1111/j.1432-1033.1973.tb03029.x
Reference
2
  Authors
Brandage, S., Dahlman, O., Lindqvist, B., Maahlen, A. and Morch, L.
  Title
Absolute configuration and enantiospecific synthesis of spiculisporic acid.
  Journal
Acta Chem Scand 38B:837-844 (1984)
Other DBs
ExplorEnz - The Enzyme Database: 2.3.3.4
IUBMB Enzyme Nomenclature: 2.3.3.4
ExPASy - ENZYME nomenclature database: 2.3.3.4
BRENDA, the Enzyme Database: 2.3.3.4
CAS: 51845-40-0

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