KEGG   ENZYME: 2.4.1.102Help
Entry
EC 2.4.1.102                Enzyme                                 

Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I;
beta6-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase;
core 2 acetylglucosaminyltransferase;
core 6-beta-GlcNAc-transferase A;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase;
GCNT1;
GCNT3;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R) 6-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein] = UDP + O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein] [RN:R04575 R05912]
Reaction(KEGG)
R04575 R05912(G);
(other) R05910(G)
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
O3-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl/threonyl-[protein]
Product
UDP [CPD:C00015];
O3-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl/threonyl-[protein]
Comment
The enzyme catalyses the addition of N-acetyl-alpha-D-glucosamine to the core 1 structure of O-glycans forming core 2.
History
EC 2.4.1.102 created 1983, modified 2018
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00727  beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
Genes
HSA: 2650(GCNT1)
PTR: 472959(GCNT1)
PPS: 100990909(GCNT1)
GGO: 101144738(GCNT1)
PON: 100453351(GCNT1)
NLE: 100590764(GCNT1)
MCC: 704639(GCNT1)
MCF: 102121951(GCNT1)
CSAB: 103219612(GCNT1)
RRO: 104682177(GCNT1)
RBB: 108542654(GCNT1)
CJC: 100397450(GCNT1)
SBQ: 101041046(GCNT1)
MMU: 14537(Gcnt1)
RNO: 64043(Gcnt1)
CGE: 100767124(Gcnt1)
HGL: 101713056(Gcnt1)
CCAN: 109693363(Gcnt1)
OCU: 100347030(GCNT1)
TUP: 102474618(GCNT1)
CFA: 484158(GCNT1)
AML: 100481771(GCNT1)
UMR: 103663275(GCNT1)
ORO: 101386761(GCNT1)
FCA: 101093969(GCNT1)
PTG: 102952027(GCNT1)
AJU: 106975313(GCNT1)
BTA: 281778(GCNT1)
BOM: 102285997(GCNT1)
BIU: 109562970(GCNT1)
PHD: 102317499(GCNT1)
CHX: 102187590(GCNT1)
OAS: 101121316(GCNT1)
SSC: 106508649(GCNT1)
CFR: 102509033(GCNT1)
CDK: 105087407(GCNT1)
BACU: 103015488(GCNT1)
LVE: 103084201(GCNT1)
OOR: 101290151(GCNT1)
ECB: 100061416(GCNT1)
EPZ: 103548068(GCNT1)
EAI: 106825720(GCNT1)
MYB: 102248045(GCNT1)
MYD: 102759783(GCNT1)
HAI: 109385744(GCNT1)
RSS: 109449945(GCNT1)
PALE: 102898105(GCNT1)
LAV: 100658096(GCNT1)
TMU: 101353425
MDO: 100011966(GCNT1)
SHR: 100921847(GCNT1)
OAA: 100075656(GCNT1)
GGA: 427260(GCNT1)
MGP: 100544057(GCNT1)
CJO: 107306219(GCNT1)
APLA: 101796875(GCNT1)
ACYG: 106044482(GCNT1)
TGU: 100221628(GCNT1)
GFR: 102041616(GCNT1)
FAB: 101808578(GCNT1)
PHI: 102103854(GCNT1)
PMAJ: 107198206(GCNT1)
CCAE: 111940833(GCNT1)
CCW: 104691986(GCNT1)
FPG: 101912116(GCNT1)
FCH: 102047162(GCNT1)
CLV: 102085044(GCNT1)
EGZ: 104123222(GCNT1)
AAM: 106489914
ASN: 102385228(GCNT1)
AMJ: 102563225(GCNT1)
PSS: 102449351
CMY: 102941735(GCNT1)
CPIC: 101952241(GCNT1)
ACS: 100565751(gcnt1)
PVT: 110076011(GCNT1)
PBI: 103048092(GCNT1)
GJA: 107108744(GCNT1)
XLA: 380501(gcnt1.L) 495090
XTR: 100490337(gcnt1)
NPR: 108788489(GCNT1)
IPU: 108265617(gcnt1)
AMEX: 103024919(gcnt1) 111189883
TRU: 101066002(gcnt1)
OLA: 101157299(gcnt1)
XMA: 102217069
PRET: 103470242(gcnt1)
LCF: 108878093(gcnt1)
HCQ: 109520688(gcnt1)
SASA: 106585626(gcnt1)
SFM: 108938500(gcnt1)
LCM: 102357208(GCNT1)
CMK: 103186097(gcnt1) 103188128
APLC: 110984114
CEL: CELE_C54C8.11(gly-15) CELE_T15D6.2(gly-16)
CBR: CBG04363(Cbr-gly-15)
EGL: EGR_09263
 » show all
Taxonomy
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:6449508]
  Authors
Williams D, Longmore G, Matta KL, Schachter H.
  Title
Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 255:11253-61 (1980)
Reference
3  [PMID:6449507]
  Authors
Williams D, Schachter H.
  Title
Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates.
  Journal
J Biol Chem 255:11247-52 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.102
IUBMB Enzyme Nomenclature: 2.4.1.102
ExPASy - ENZYME nomenclature database: 2.4.1.102
BRENDA, the Enzyme Database: 2.4.1.102
CAS: 95978-15-7

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