KEGG   ENZYME: 2.4.1.109Help
Entry
EC 2.4.1.109                Enzyme                                 

Name
dolichyl-phosphate-mannose---protein mannosyltransferase;
dolichol phosphomannose-protein mannosyltransferase;
protein O-D-mannosyltransferase;
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase;
dolichyl-phosphate-mannose-protein mannosyltransferase;
dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-mannosyl-phosphate:L-threonyl/L-seryl-[protein] O-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
(1) dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [RN:R11399];
(2) dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = dolichyl phosphate + 3-O-(alpha-D-mannosyl)-L-seryl-[protein] [RN:R04072 R07620]
Reaction(KEGG)
Substrate
dolichyl beta-D-mannosyl phosphate [CPD:C03862];
L-threonyl-[protein];
L-seryl-[protein]
Product
dolichyl phosphate [CPD:C00110];
3-O-(alpha-D-mannosyl)-L-threonyl-[protein] [CPD:C20722];
3-O-(alpha-D-mannosyl)-L-seryl-[protein]
Comment
The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain alpha-dihydropolyprenyl derivatives, larger than C35.
History
EC 2.4.1.109 created 1983, modified 2014
Pathway
ec00514  Other types of O-glycan biosynthesis
ec00515  Mannose type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00728  dolichyl-phosphate-mannose-protein mannosyltransferase
Genes
HSA: 10585(POMT1) 29954(POMT2)
PTR: 453067(POMT2) 473076(POMT1)
PPS: 100969666(POMT1) 100991424(POMT2)
GGO: 101129927(POMT1) 101140993(POMT2)
PON: 100437813(POMT2)
NLE: 100583229(POMT1) 100597409(POMT2)
MCC: 106993586(POMT1) 705604(POMT2) 722387(POMT1)
MCF: 102136913(POMT2) 102140167(POMT1)
CSAB: 103229387(POMT2) 103239729(POMT1)
RRO: 104669759(POMT1) 104677614(POMT2)
RBB: 108513932(POMT1) 108534960(POMT2)
CJC: 100400916(POMT2) 100401935(POMT1)
SBQ: 101029111(POMT2) 101050475(POMT1)
MMU: 217734(Pomt2) 99011(Pomt1)
RNO: 688673(Pomt2) 84430(Pomt1)
CGE: 100755033(Pomt1) 100764752(Pomt2)
NGI: 103727607(Pomt1) 103739582(Pomt2)
HGL: 101706534(Pomt2) 101719016(Pomt1)
CCAN: 109691897(Pomt1) 109697387(Pomt2)
OCU: 100357260(POMT2) 100357781(POMT1)
TUP: 102470633(POMT2) 102491271(POMT1)
CFA: 480400(POMT2) 608039(POMT1)
AML: 100465937(POMT2) 100467979(POMT1)
UMR: 103670255(POMT1) 103674072(POMT2)
ORO: 101367697(POMT1) 101384613(POMT2)
FCA: 101088629(POMT1) 101101141(POMT2)
PTG: 102962030(POMT1) 102968434(POMT2)
AJU: 106974345(POMT2) 106985332(POMT1)
BTA: 537054(POMT2) 617609(POMT1)
BOM: 102279725(POMT2) 102286979(POMT1)
BIU: 109565378(POMT2) 109566559(POMT1)
CHX: 102169594(POMT2) 102176050(POMT1)
OAS: 101110065(POMT2) 101121672(POMT1)
SSC: 100155173(POMT2) 100525803(POMT1)
CFR: 102514392(POMT2) 102521239(POMT1)
CDK: 105085167(POMT1) 105086065(POMT2)
BACU: 103008355(POMT2) 103018656(POMT1)
LVE: 103069264(POMT1) 103089885(POMT2)
OOR: 101271550(POMT2) 101278802(POMT1)
ECB: 100059121(POMT2) 100069575(POMT1)
EPZ: 103553652(POMT1) 103561839(POMT2)
EAI: 106830956(POMT2) 106845381(POMT1)
MYB: 102250898(POMT1) 102261340(POMT2)
MYD: 102756063(POMT1) 102763673(POMT2)
HAI: 109380785(POMT1) 109381536(POMT2)
RSS: 109445951(POMT1) 109448318(POMT2)
PALE: 102881991(POMT1) 102896335(POMT2)
LAV: 100655255(POMT2) 100663873(POMT1)
MDO: 100016377(POMT1) 100022191(POMT2)
SHR: 100924792 100927549(POMT2) 100931363(POMT1)
OAA: 100075192(POMT1) 100077316(POMT2)
GGA: 417175(POMT1) 423373(POMT2)
MGP: 100541989(POMT1) 100545733(POMT2)
CJO: 107315136(POMT2) 107321761(POMT1)
APLA: 101796417(POMT1) 101803424(POMT2)
ACYG: 106038853(POMT2) 106044127(POMT1)
TGU: 100221491(POMT1) 100227792(POMT2)
GFR: 102036515(POMT2) 102041735(POMT1)
FAB: 101818924(POMT1) 101820143(POMT2)
PHI: 102099802(POMT2) 102101108(POMT1)
PMAJ: 107205785(POMT2) 107211976(POMT1)
CCAE: 111922377(POMT1) 111929944(POMT2)
CCW: 104685384(POMT2) 104688312(POMT1)
FPG: 101914245(POMT2) 101920099(POMT1)
FCH: 102051602(POMT1) 102052371(POMT2)
CLV: 102089813(POMT2) 102092682(POMT1)
EGZ: 104129823(POMT1) 104133270(POMT2)
AAM: 106482890(POMT2) 106490319(POMT1)
ASN: 102373766(POMT2) 102375614(POMT1)
AMJ: 102567821(POMT1) 102569546(POMT2)
PSS: 102459251(POMT1) 102463352(POMT2)
CMY: 102942390(POMT1) 102945073(POMT2)
CPIC: 101946329(POMT2) 101953904(POMT1)
ACS: 100566915(pomt2) 103282313(pomt1)
PVT: 110079366(POMT2) 110079663(POMT1)
PBI: 103056094(POMT2) 103063082(POMT1)
GJA: 107109055(POMT1) 107116470(POMT2)
XLA: 108698684(pomt2.L) 108699937(pomt1.S)
XTR: 100490100(pomt2) 448433(pomt1)
NPR: 108794321(POMT1) 108803877
DRE: 563878(pomt2) 569769(pomt1)
IPU: 108255768(pomt1) 108270454(pomt2)
AMEX: 103034447(pomt1) 103041800(pomt2)
TRU: 101064230(pomt2) 101067746(pomt1)
LCO: 104921339(pomt2) 104939485(pomt1)
NCC: 104963643(pomt2)
MZE: 101469889(pomt1) 101479092(pomt2)
OLA: 101157138(pomt1) 101167160(pomt2)
XMA: 102217411(pomt2) 102221622(pomt1)
PRET: 103458498(pomt2) 103460403(pomt1)
NFU: 107386213(pomt1) 107392419(pomt2)
KMR: 108232734(pomt2) 108248072(pomt1)
LCF: 108892589(pomt2) 108894458(pomt1)
SDU: 111225625(pomt2) 111237441(pomt1)
HCQ: 109519276(pomt1) 109526152(pomt2)
BPEC: 110155631(pomt2) 110156989(pomt1)
MALB: 109957274(pomt1) 109967993(pomt2)
SASA: 106580122(pomt1) 106600350 106611062(pomt2)
OTW: 112256683(pomt2) 112263305(pomt1)
ELS: 105014665(pomt1) 105015693(pomt2)
SFM: 108920122(pomt1) 108930726(pomt2)
LCM: 102356244(POMT2) 102357324(POMT1)
CMK: 103183034(pomt1) 103189968(pomt2)
SPU: 580971(pomt2) 588991(pomt1)
DSI: Dsimw501_GD12795(Dsim_GD12795) Dsimw501_GD16529(Dsim_GD16529)
SCE: YAL023C(PMT2) YDL093W(PMT5) YDL095W(PMT1) YDR307W(PMT7) YGR199W(PMT6) YJR143C(PMT4) YOR321W(PMT3)
KMX: KLMA_20657(PMT1) KLMA_30233(PMT2) KLMA_30539(PMT7) KLMA_40257(PMT6) KLMA_40486(PMT4)
NCS: NCAS_0A07260(NCAS0A07260) NCAS_0B05850(NCAS0B05850) NCAS_0B05860(NCAS0B05860) NCAS_0F01660(NCAS0F01660) NCAS_0F02750(NCAS0F02750) NCAS_0I00420(NCAS0I00420) NCAS_0J02260(NCAS0J02260)
NDI: NDAI_0A08600(NDAI0A08600) NDAI_0B03160(NDAI0B03160) NDAI_0B03170(NDAI0B03170) NDAI_0C04210(NDAI0C04210) NDAI_0D02240(NDAI0D02240) NDAI_0H02540(NDAI0H02540) NDAI_0J02980(NDAI0J02980)
TPF: TPHA_0A04800(TPHA0A04800) TPHA_0B00290(TPHA0B00290) TPHA_0C03750(TPHA0C03750) TPHA_0E01230(TPHA0E01230) TPHA_0G01950(TPHA0G01950) TPHA_0H02700(TPHA0H02700) TPHA_0L00440(TPHA0L00440)
TBL: TBLA_0A02990(TBLA0A02990) TBLA_0A04640(TBLA0A04640) TBLA_0A10670(TBLA0A10670) TBLA_0B05710(TBLA0B05710) TBLA_0B07650(TBLA0B07650) TBLA_0B09470(TBLA0B09470) TBLA_0E02320(TBLA0E02320)
TDL: TDEL_0D00380(TDEL0D00380) TDEL_0E02980(TDEL0E02980) TDEL_0E04890(TDEL0E04890) TDEL_0G02920(TDEL0G02920) TDEL_0H03750(TDEL0H03750)
KAF: KAFR_0B00800(KAFR0B00800) KAFR_0D01190(KAFR0D01190) KAFR_0E04460(KAFR0E04460) KAFR_0G01180(KAFR0G01180) KAFR_0K00650(KAFR0K00650) KAFR_0K02390(KAFR0K02390) KAFR_0K02400(KAFR0K02400)
SLB: AWJ20_2541(PMT1) AWJ20_3481(PMT2) AWJ20_3725(PMT1) AWJ20_4793(PMT4)
NTE: NEUTE1DRAFT105770(NEUTE1DRAFT_105770) NEUTE1DRAFT122991(NEUTE1DRAFT_122991) NEUTE1DRAFT70939(NEUTE1DRAFT_70939)
BFU: BCIN_01g02310(Bcpmt1) BCIN_02g01980(Bcpmt4) BCIN_15g03420(Bcpmt2)
ANG: ANI_1_1134144(An16g08490) ANI_1_1278094(An11g09890) ANI_1_1328064(An07g10350)
SPO: SPAC22A12.07c(ogm1) SPAPB1E7.09(ogm2) SPBC16C6.09(ogm4)
ABP: AGABI1DRAFT118848(AGABI1DRAFT_118848) AGABI1DRAFT119690(AGABI1DRAFT_119690) AGABI1DRAFT35577(AGABI1DRAFT_35577)
ABV: AGABI2DRAFT205019(AGABI2DRAFT_205019) AGABI2DRAFT205915(AGABI2DRAFT_205915) AGABI2DRAFT67868(AGABI2DRAFT_67868)
CJA: CJA_3156(gt39A)
SAGA: M5M_04960
MCA: MCA2192
GEO: Geob_0316
GEB: GM18_0616
BJA: blr2412
BRA: BRADO1891
BBT: BBta_2206
BRS: S23_55950
AOL: S58_56670
BRAD: BF49_2387
HBA: Hbal_0832
NAR: Saro_2664
STAX: MC45_10015
SPHI: TS85_03370
SSAN: NX02_08895
SSY: SLG_25770
ELI: ELI_08325
AAY: WYH_01164(pmt)
ANH: A6F65_01286(pmt)
ADO: A6F68_01256(pmt)
PSAB: PSAB_02965
PRI: PRIO_0763
CTH: Cthe_3095
HSC: HVS_12060(pmt)
CCE: Ccel_2417
ELM: ELI_2321
CSC: Csac_1081
ATE: Athe_1864
MTU: Rv1002c
MTC: MT1031
MRA: MRA_1011
MTUR: CFBS_1056
MTD: UDA_1002c
MTUE: J114_05400
MTUL: TBHG_00986
MTUT: HKBT1_1054
MTUU: HKBT2_1059
MBB: BCG_1059c
MBT: JTY_1031
MBX: BCGT_0818
MAF: MAF_10120
MMIC: RN08_1120
MLE: ML0192
MLB: MLBr00192
MPA: MAP_0943c
MAO: MAP4_2917
MAVI: RC58_14480
MAVU: RE97_14505
MAV: MAV_1126
MIT: OCO_09980
MIA: OCU_09990
MID: MIP_01638
MYO: OEM_10150
MIR: OCQ_10080
MLP: MLM_1078
MUL: MUL_4663
MMC: Mmcs_4274
MKM: Mkms_4360
MJL: Mjls_4653
MMI: MMAR_4491
MMM: W7S_04970
MHAD: B586_06550
MVA: Mvan_4809
MGI: Mflv_1924
MPHL: MPHLCCUG_04390(pmt)
MVQ: MYVA_4630
MAB: MAB_1122c
MABB: MASS_1119
MCHE: BB28_05510
MSTE: MSTE_01076
ASD: AS9A_3507
CGL: NCgl0854(Cgl0890)
CGB: cg1014
CGU: WA5_0854(Pmt)
CGT: cgR_1003
CGM: cgp_1014(pmt)
CGJ: AR0_05005
CEF: CE0964
CDI: DIP0868
CJK: jk1519
CUR: cu0557
COP: Cp31_0678
CPSE: CPTA_01224
CPSU: CPTB_00307
CPSF: CPTC_01215
CRD: CRES_1653
CVA: CVAR_2062
CTER: A606_08245
COA: DR71_591
CSX: CSING_04705(pmt)
CMQ: B840_03500(pmt)
CKU: UL82_08335(pmt)
CCJ: UL81_03865(pmt)
CMV: CMUST_05060(pmt)
CEI: CEPID_04075(pmt)
CUT: CUTER_03515(pmt)
CDX: CDES_04460(pmt)
CSP: WM42_0525
CPHO: CPHO_08725
CGV: CGLAU_03895(pmt)
CAQU: CAQU_03925
CAMG: CAMM_09310
NFA: NFA_49110
RER: RER_43700(pmt)
REY: O5Y_20495
ROP: ROP_57220(pmt)
REQ: REQ_11950
RHB: NY08_2357
RFA: A3L23_00545(pmt)
RHS: A3Q41_02808(pmt)
RHU: A3Q40_02559(pmt)
GBR: Gbro_1486
GOR: KTR9_1415
TPR: Tpau_3241
SRT: Srot_0846
SCO: SCO3154(SCE87.05)
SALB: XNR_2092
SGR: SGR_4346
SGB: WQO_13800
SCT: SCAT_2155
SFA: Sfla_3742
SBH: SBI_04375
SVE: SVEN_2974
SALS: SLNWT_4436
STRP: F750_2997
SFI: SFUL_2788
SALU: DC74_3597
SALL: SAZ_19120
STRE: GZL_05299
SLD: T261_4934
STRM: M444_14805
SPRI: SPRI_4392
SRW: TUE45_04504(pmt)
SLE: sle_41320(sle_41320)
SRN: A4G23_02180(pmt)
STRD: NI25_23030
SMAL: SMALA_4723
SLAU: SLA_2926
SALJ: SMD11_4062
SLX: SLAV_22320(pmt)
SFK: KY5_3355
KSK: KSE_24310(pmt2) KSE_46200(pmt1)
TWH: TWT_121
TWS: TW132
LXX: Lxx17570
CMI: CMM_2398
CMS: CMS2336
CMC: CMN_02353
MTS: MTES_2930
AUW: AURUGA1_00333(pmt)
ARM: ART_3983
AAU: AAur_1329
ACH: Achl_1275
BCV: Bcav_0950
JDE: Jden_1964
LMOI: VV02_08605
XCE: Xcel_2736
IDO: I598_3166(pmt)
CFL: Cfla_0843
CFI: Celf_3080
SERJ: SGUI_1368
BLIN: BLSMQ_3038
PAC: PPA0523
PACC: PAC1_02710
PACH: PAGK_0542
CACN: RN83_03140
PFRE: RM25_1665
ACIJ: JS278_02337(pmt)
MPH: MLP_45140
NCA: Noca_3861
NDK: I601_0548(pmt)
KFL: Kfla_5735
PSIM: KR76_05555
NDA: Ndas_4076
NAL: B005_1253
TCU: Tcur_0972
SRO: Sros_8627
NML: Namu_4565
GOB: Gobs_0896
MMAR: MODMU_0940(pmt)
KRA: Krad_3667
SEN: SACE_0791
AMD: AMED_8260
AMN: RAM_42420
AMM: AMES_8133
AMZ: B737_8134
AOI: AORI_7053
AJA: AJAP_03880(pmt)
PDX: Psed_0826
PSEA: WY02_20355
PSEE: FRP1_22840
PSEH: XF36_21210
AMI: Amir_0636
SESP: BN6_06920(gtuS39-1)
ACTI: UA75_03510
ACAD: UA74_03415
AHG: AHOG_03270(pmt)
SAQ: Sare_0720
CAI: Caci_0582
SNA: Snas_5721
TPYO: X956_01785
BLA: BLA_0889
BBB: BIF_00930
BBC: BLC1_1491
BLV: BalV_1495
BLW: W7Y_1541
BLS: W91_1575
BANI: Bl12_1445
BANL: BLAC_07700
BANM: EN10_07810
BDE: BDP_2125
BDN: BBDE_1996
BAST: BAST_0192
BTP: D805_1667
BCOR: BCOR_0166
BPSP: AH67_08225
SIJ: SCIP_1417
PDO: PSDT_1523
TBI: Tbis_3175
SYN: slr1050
SYZ: MYO_14650
SYY: SYNGTS_0459(slr1050)
SYT: SYNGTI_0459(slr1050)
SYS: SYNPCCN_0459(slr1050)
SYQ: SYNPCCP_0459(slr1050)
CYA: CYA_1457
CYB: CYB_0649
TEL: tlr2437
LET: O77CONTIG1_00321(pmt)
HHG: XM38_017900(pmt)
AMR: AM1_4355
MAR: MAE_24320
CYT: cce_2033
TER: Tery_0870
ANA: alr3150
AVA: Ava_3845
NAZ: Aazo_4868
CALH: IJ00_00880
NSP: BMF81_01216(pmt)
CTHE: Chro_3528
TTR: Tter_0359
SACI: Sinac_1715
PYR: P186_2360
POG: Pogu_2369
 » show all
Taxonomy
Reference
1  [PMID:6989607]
  Authors
Babczinski P, Haselbeck A, Tanner W.
  Title
Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme.
  Journal
Eur J Biochem 105:509-15 (1980)
DOI:10.1111/j.1432-1033.1980.tb04526.x
Reference
2  [PMID:6445267]
  Authors
Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W.
  Title
Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives.
  Journal
Eur J Biochem 105:517-23 (1980)
DOI:10.1111/j.1432-1033.1980.tb04527.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.109
IUBMB Enzyme Nomenclature: 2.4.1.109
ExPASy - ENZYME nomenclature database: 2.4.1.109
BRENDA, the Enzyme Database: 2.4.1.109
CAS: 74315-99-4

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