KEGG   ENZYME: 2.4.1.115Help
Entry
EC 2.4.1.115                Enzyme                                 

Name
anthocyanidin 3-O-glucosyltransferase;
uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase;
UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase;
UDP-glucose:cyanidin-3-O-glucosyltransferase;
UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase;
3-GT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase
Reaction(IUBMB)
UDP-D-glucose + an anthocyanidin = UDP + an anthocyanidin-3-O-beta-D-glucoside [RN:R03797]
Reaction(KEGG)
Substrate
UDP-D-glucose [CPD:C00029];
anthocyanidin [CPD:C02003]
Product
UDP [CPD:C00015];
anthocyanidin-3-O-beta-D-glucoside
Comment
The anthocyanidin compounds cyanidin, delphinidin, peonidin and to a lesser extent pelargonidin can act as substrates. The enzyme does not catalyse glucosylation of the 5-position of cyanidin and does not act on flavanols such as quercetin and kaempferol (cf. EC 2.4.1.91 flavonol 3-O-glucosyltransferase). In conjunction with EC 1.14.20.4, anthocyanidin oxygenase, it is involved in the conversion of leucoanthocyanidin into anthocyanidin 3-glucoside. It may act on the pseudobase precursor of the anthocyanidin rather than on the anthocyanidin itself [3].
History
EC 2.4.1.115 created 1984 (EC 2.4.1.233 created 2004, incorporated 2005), modified 2005
Pathway
ec00942  Anthocyanin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12930  anthocyanidin 3-O-glucosyltransferase
Genes
CIT: 102609299
CIC: CICLE_v10019770mg
EGR: 104450379
FVE: 101300000
RCU: 8283075
JCU: 105649015
VVI: 100233099(UFGT)
OSA: 4340373
DOSA: Os06t0192100-00(Os06g0192100)
BDI: 100841090
SBI: 8065445
ZMA: 732800(BZ1)
SITA: 101786047
PDA: 103718397
EGU: 105039612
 » show all
Taxonomy
Reference
1  [PMID:751640]
  Authors
Kamsteeg J, van Brederode J, van Nigtevecht G.
  Title
Identification and properties of UDP-glucose: cyanidin-3-O-glucosyltransferase isolated from petals of the red campion (Silene dioica).
  Journal
Biochem Genet 16:1045-58 (1978)
Reference
2  [PMID:9535914]
  Authors
Ford CM, Boss PK, Hoj PB.
  Title
Cloning and characterization of Vitis vinifera UDP-glucose:flavonoid 3-O-glucosyltransferase, a homologue of the enzyme encoded by the maize Bronze-1 locus that may primarily serve to glucosylate anthocyanidins in vivo.
  Journal
J Biol Chem 273:9224-33 (1998)
DOI:10.1074/jbc.273.15.9224
  Sequence
[vvi:100233099]
Reference
3  [PMID:11316805]
  Authors
Nakajima  J, Tanaka Y, Yamazaki M, Saito K.
  Title
Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis.
  Journal
J Biol Chem 276:25797-803 (2001)
DOI:10.1074/jbc.M100744200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.115
IUBMB Enzyme Nomenclature: 2.4.1.115
ExPASy - ENZYME nomenclature database: 2.4.1.115
BRENDA, the Enzyme Database: 2.4.1.115
CAS: 65607-32-1

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