KEGG   ENZYME: 2.4.1.122Help
Entry
EC 2.4.1.122                Enzyme                                 

Name
N-acetylgalactosaminide beta-1,3-galactosyltransferase;
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase;
uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase;
UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase;
UDP-Gal:alpha-D-GalNAc-1,3-alpha-D-GalNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase;
wbnJ (gene name);
wbiP (gene name);
C1GALT1 (gene name);
UDP-alpha-D-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-alpha-D-galactosaminyl-R beta-1,3-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [RN:R05908]
Reaction(KEGG)
R05908(G);
(other) R10436
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-alpha-D-galactosaminyl-R [CPD:C04387]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [CPD:C04750]
Comment
The eukaryotic enzyme can act on non-reducing O-serine-linked N-acetylgalactosamine residues in mucin glycoproteins, forming the T-antigen. The bacterial enzyme, found in some pathogenic strains, is involved in biosynthesis of the O-antigen repeating unit.
History
EC 2.4.1.122 created 1984 (EC 2.4.1.307 created 2013, incorporated 2016), modified 2016
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00731  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
K21366  N-acetylgalactosaminide beta-1,3-galactosyltransferase
Genes
HSA: 56913(C1GALT1)
PTR: 472288(C1GALT1)
PPS: 100977740(C1GALT1)
GGO: 101145951(C1GALT1)
PON: 100452461(C1GALT1)
NLE: 100583301(C1GALT1)
MCC: 696870(C1GALT1)
MCF: 102137839(C1GALT1)
CSAB: 103226504(C1GALT1)
RRO: 104668754(C1GALT1)
RBB: 108543414(C1GALT1)
CJC: 100406487(C1GALT1)
SBQ: 101029936(C1GALT1)
MMU: 94192(C1galt1)
RNO: 65044(C1galt1)
CGE: 100761169(C1galt1)
NGI: 103751705(C1galt1)
HGL: 101704643(C1galt1)
CCAN: 109703122(C1galt1)
OCU: 100359047(C1GALT1)
TUP: 102479007(C1GALT1)
CFA: 482314(C1GALT1)
AML: 100483848(C1GALT1)
UMR: 103658758(C1GALT1)
ORO: 101378420(C1GALT1)
FCA: 101096459(C1GALT1)
PTG: 102965358(C1GALT1)
AJU: 106970015(C1GALT1)
BTA: 539417(C1GALT1)
BOM: 102287025(C1GALT1)
BIU: 109558238(C1GALT1)
PHD: 102335545
CHX: 102169248(C1GALT1)
OAS: 101120567(C1GALT1) 105612683
SSC: 100525767(C1GALT1)
CFR: 102514986(C1GALT1)
CDK: 105088713(C1GALT1)
BACU: 103001219(C1GALT1)
LVE: 103071088(C1GALT1)
OOR: 101282789(C1GALT1)
ECB: 100063865(C1GALT1)
EPZ: 103540682(C1GALT1)
EAI: 106839569(C1GALT1)
MYB: 102244854(C1GALT1) 102250159
MYD: 102754234(C1GALT1)
HAI: 109394810(C1GALT1)
RSS: 109446411(C1GALT1)
PALE: 102883390(C1GALT1)
LAV: 100670784(C1GALT1)
TMU: 101357588
SHR: 100932643(C1GALT1)
OAA: 100075856
GGA: 420575(C1GALT1)
MGP: 100542429(C1GALT1)
CJO: 107309116(C1GALT1)
APLA: 101797632(C1GALT1)
ACYG: 106037532(C1GALT1)
TGU: 100221974(C1GALT1)
GFR: 102032158(C1GALT1)
FAB: 101810221(C1GALT1)
PHI: 102103229(C1GALT1) 102104490
PMAJ: 107199204 107200786(C1GALT1)
CCW: 104689153(C1GALT1)
FPG: 101923797(C1GALT1)
FCH: 102059381(C1GALT1)
CLV: 102088254(C1GALT1)
EGZ: 104129130(C1GALT1)
AAM: 106483404(C1GALT1) 106492776
AMJ: 102558826(C1GALT1) 102575907
PSS: 102460792(C1GALT1)
CPIC: 101931210 101942937(C1GALT1) 101945118
ACS: 100554192 100562160(c1galt1)
PVT: 110070539 110073023(C1GALT1)
PBI: 103050549(C1GALT1) 103063573
XLA: 108707741 108708597 108708598 108709868 108709869 108718847(c1galt1.L) 108719911(c1galt1.S) 444326(LOC100496837.L)
DRE: 337131(c1galt1b) 555344(si:dkey-202e17.1) 557675(c1galt1a)
IPU: 108272220(c1galt1b) 108276279
PRET: 103465384 103467345 103471939(c1galt1)
CSEM: 103385080 103385956 103394502(c1galt1)
BPEC: 110161213(c1galt1) 110164964 110168386
SFM: 108918317 108935659(c1galt1)
CIN: 100182788
SPU: 581429
DME: Dmel_CG2975(CG2975) Dmel_CG2983(CG2983) Dmel_CG3119(CG3119) Dmel_CG34056(CG34056) Dmel_CG34057(CG34057) Dmel_CG34451(CG34451) Dmel_CG34452(CG34452) Dmel_CG7440(tgy) Dmel_CG8708(CG8708) Dmel_CG9520(C1GalTA)
DSI: Dsimw501_GD10181(Dsim_GD10181) Dsimw501_GD12540(Dsim_GD12540) Dsimw501_GD12541(Dsim_GD12541) Dsimw501_GD13582(Dsim_GD13582) Dsimw501_GD22375(Dsim_GD22375) Dsimw501_GD22798(Dsim_GD22798) Dsimw501_GD23186(Dsim_GD23186) Dsimw501_GD23187(Dsim_GD23187) Dsimw501_GD24465(Dsim_GD24465) Dsimw501_GD27301(Dsim_GD27301)
AAG: 5569374
AME: 409263
BIM: 100742738
BTER: 100644092
SOC: 105202750
AEC: 105153414
ACEP: 105619515
PBAR: 105422802
HST: 105181555
CFO: 105258145
LHU: 105678429
PGC: 109856374
NVI: 100120600
BMOR: 101746328
PMAC: 106709178
PRAP: 110993263
API: 100168660
DNX: 107167669
ZNE: 110837984
CEL: CELE_C38H2.2(C38H2.2)
CBR: CBG18398
TSP: Tsp_00464
ADF: 107348169
NGD: NGA_0449900(C1GALT1)
ECG: E2348C_2172(wbiP)
PLU: plu4819(wblT)
 » show all
Taxonomy
Reference
1  [PMID:6789880]
  Authors
Hesford FJ, Berger EG, Van den Eijnden DH.
  Title
Identification of the product formed by human erythrocyte galactosyltransferase.
  Journal
Biochim Biophys Acta 659:302-11 (1981)
DOI:10.1016/0005-2744(81)90056-5
Reference
2  [PMID:6801057]
  Authors
Mendicino J, Sivakami S, Davila M, Chandrasekaran EV.
  Title
Purification and properties of UDP-gal:N-acetylgalactosaminide mucin: beta 1,3-galactosyltransferase from swine trachea mucosa.
  Journal
J Biol Chem 257:3987-94 (1982)
Reference
3  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
Reference
4  [PMID:11677243]
  Authors
Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM
  Title
Cloning and expression of human core 1 beta1,3-galactosyltransferase.
  Journal
J Biol Chem 277:178-86 (2002)
DOI:10.1074/jbc.M109060200
  Sequence
[hsa:56913] [mmu:94192] [rno:65044] [cel:CELE_C38H2.2] [dme:Dmel_CG9520 Dmel_CG8708]
Reference
5  [PMID:18179256]
  Authors
Yi W, Perali RS, Eguchi H, Motari E, Woodward R, Wang PG
  Title
Characterization of a bacterial beta-1,3-galactosyltransferase with application in the synthesis of tumor-associated T-antigen mimics.
  Journal
Biochemistry 47:1241-8 (2008)
DOI:10.1021/bi7020712
Reference
6  [PMID:20418877]
  Authors
Woodward R, Yi W, Li L, Zhao G, Eguchi H, Sridhar PR, Guo H, Song JK, Motari E, Cai L, Kelleher P, Liu X, Han W, Zhang W, Ding Y, Li M, Wang PG
  Title
In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz.
  Journal
Nat Chem Biol 6:418-23 (2010)
DOI:10.1038/nchembio.351
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.122
IUBMB Enzyme Nomenclature: 2.4.1.122
ExPASy - ENZYME nomenclature database: 2.4.1.122
BRENDA, the Enzyme Database: 2.4.1.122
CAS: 97089-61-7

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