KEGG   ENZYME: 2.4.1.131Help
Entry
EC 2.4.1.131                Enzyme                                 

Name
GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase;
ALG11;
ALG11 mannosyltransferase;
LEW3 (gene name);
At2G40190 (gene name);
gmd3 (gene name);
galactomannan deficiency protein 3;
GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase;
glycolipid 2-alpha-mannosyltransferase;
GDP-mannose:glycolipid 2-alpha-D-mannosyltransferase;
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase;
GDP-alpha-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 2-alpha-D-mannosyltransferase (configuration-retaining)
Reaction(IUBMB)
2 GDP-alpha-D-mannose + alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol [RN:R06127 R06128]
Reaction(KEGG)
R06127(G) R06128(G)
Show
Substrate
GDP-alpha-D-mannose [CPD:C00096];
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
GDP [CPD:C00035];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Comment
The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in alpha(1->2) linkages to the nascent oligosaccharide.
History
EC 2.4.1.131 created 1984, modified 2011, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03844  alpha-1,2-mannosyltransferase
Genes
HSA: 440138(ALG11)
PTR: 452735(ALG11)
PPS: 103782702(ALG11)
GGO: 101123814(ALG11)
PON: 100173205(ALG11)
NLE: 101177074(ALG11)
MCC: 100498659(ALG11)
MCF: 102145860(ALG11)
CSAB: 103214468(ALG11)
RRO: 104653861(ALG11)
RBB: 108519343(ALG11)
CJC: 100387786(ALG11)
SBQ: 101029990(ALG11)
MMU: 207958(Alg11)
RNO: 361174(Alg11)
CGE: 100765573 100771009(Alg11)
NGI: 103745442(Alg11)
HGL: 101712342(Alg11)
CCAN: 109676480(Alg11)
OCU: 100340094(ALG11)
TUP: 102475258(ALG11)
CFA: 100682632(ALG11)
AML: 100469498(ALG11)
UMR: 103677631(ALG11)
ORO: 101375850(ALG11)
FCA: 101091245(ALG11)
PTG: 102956830(ALG11)
AJU: 106972659(ALG11)
BTA: 540845(ALG11)
BOM: 102286251(ALG11)
BIU: 109566746(ALG11)
PHD: 102336218(ALG11)
CHX: 102190970(ALG11)
OAS: 101120844(ALG11)
SSC: 100152645(ALG11)
CFR: 102506887(ALG11)
CDK: 105090994(ALG11)
BACU: 103002538(ALG11)
LVE: 103089951(ALG11)
OOR: 101279400(ALG11)
ECB: 100049892(ALG11)
EPZ: 103564320(ALG11)
EAI: 106837702(ALG11)
MYB: 102255926(ALG11)
MYD: 102762995(ALG11)
HAI: 109396766(ALG11)
RSS: 109458454(ALG11)
PALE: 102887410(ALG11)
LAV: 100672340(ALG11)
TMU: 101350642
MDO: 100028147(ALG11)
OAA: 100082628(ALG11)
GGA: 418880(ALG11)
MGP: 100541393(ALG11)
CJO: 107308190(ALG11)
APLA: 101796223(ALG11)
ACYG: 106035080(ALG11)
TGU: 100231100(ALG11)
GFR: 102038557(ALG11)
FAB: 101818493(ALG11)
PHI: 102101256(ALG11)
PMAJ: 107208055(ALG11)
CCAE: 111945568(ALG11)
CCW: 104690001(ALG11)
FPG: 101910543(ALG11)
FCH: 102056572(ALG11)
CLV: 102086030(ALG11)
EGZ: 104129662(ALG11)
AAM: 106489229(ALG11)
ASN: 102370078(ALG11)
AMJ: 102577351(ALG11)
PSS: 102453750(ALG11)
CMY: 102937670(ALG11)
CPIC: 101944769(ALG11)
ACS: 100552965(alg11)
PVT: 110076145(ALG11)
PBI: 103061317(ALG11)
GJA: 107125627(ALG11)
XLA: 108709929(alg11.S) 733388(alg11.L)
XTR: 394898(alg11)
NPR: 108787024(ALG11)
DRE: 407614(alg11)
SRX: 107707840(alg11) 107719740
CCAR: 109067313(alg11) 109096248
IPU: 108258497(alg11)
AMEX: 103039495(alg11)
TRU: 101079741(alg11)
LCO: 104934533(alg11)
NCC: 104964312(alg11)
PRET: 103460209 103475530(alg11)
KMR: 108246705(alg11) 108248628
CSEM: 103389882(alg11)
LCF: 108872993(alg11) 108896321
HCQ: 109520924(alg11)
BPEC: 110162928(alg11)
MALB: 109955804(alg11) 109972602
SASA: 100380802(alg11) 106586488
SFM: 108926843(alg11)
LCM: 102363993(ALG11)
CMK: 103177168(alg11)
CIN: 100180498
SPU: 582224(alg11)
APLC: 110979818
SKO: 100378532
DME: Dmel_CG11306(CG11306)
DSI: Dsimw501_GD14979(Dsim_GD14979)
MDE: 101901555
AAG: 5563668
AME: 552533
BIM: 100748818
BTER: 100642267
SOC: 105201585
AEC: 105143841
ACEP: 105620062
PBAR: 105432151
HST: 105181610
DQU: 106740824
CFO: 105249537
LHU: 105678417
PGC: 109855896
PCF: 106790948
NVI: 100119778
MDL: 103578913
TCA: 657970
DPA: 109542160
NVL: 108569916
PMAC: 106715098
PRAP: 111000061
HAW: 110380318
API: 100168497
DNX: 107161329
CLEC: 106672682
ZNE: 110833065
TUT: 107369689
CEL: CELE_B0361.8(algn-11)
CBR: CBG15348
BMY: Bm1_22890
CRG: 105324377
MYI: 110461837
OBI: 106869257
LAK: 106172291
SHX: MS3_07428
EGL: EGR_04314
ADF: 107349468
HMG: 100198257
AQU: 105316734
ATH: AT2G40190(LEW3)
CRB: 17888154
BOE: 106337364
THJ: 104810111
CPAP: 110810740
CIT: 102624638
TCC: 18585830
GRA: 105782703
DZI: 111297064
EGR: 104454408
VRA: 106754940
CCAJ: 109816395
CAM: 101496921
LJA: Lj3g3v2441820.1(Lj3g3v2441820.1) Lj3g3v2441820.2(Lj3g3v2441820.2)
AIP: 107617989
LANG: 109336738
FVE: 101306568
PPER: 18785438
PMUM: 103332802
PAVI: 110749776
CSV: 101207680
CMO: 103495121
MCHA: 111015919
CMAX: 111491140
CMOS: 111447815
CPEP: 111811686
RCU: 8265373
JCU: 105645965
POP: 7454543
JRE: 108991924
VVI: 100250164
SLY: 101250940
SPEN: 107032214
SOT: 102586948
SIND: 105167032
HAN: 110904886
LSV: 111879843
CCAV: 112517745
SOE: 110798636
NNU: 104610277
OSA: 4352649
DOSA: Os12t0583000-01(Os12g0583000)
OBR: 102720847
BDI: 100841990
ATS: 109757324(LOC109757324)
SBI: 8069702
ZMA: 100274516
SITA: 101769051
PDA: 103704436
DCT: 110100471
PEQ: 110033276
ATR: 18435261
SMO: SELMODRAFT_80274(GT4A6)
PPP: 112290918
CRE: CHLREDRAFT_19999(GTR6)
MNG: MNEG_1379
APRO: F751_3225
SCE: YNL048W(ALG11)
ERC: Ecym_3304
KMX: KLMA_80151(ALG11)
NCS: NCAS_0G03240(NCAS0G03240)
NDI: NDAI_0D01260(NDAI0D01260)
TPF: TPHA_0D01640(TPHA0D01640)
TBL: TBLA_0B05860(TBLA0B05860)
TDL: TDEL_0C03950(TDEL0C03950)
KAF: KAFR_0H03470(KAFR0H03470)
PIC: PICST_83561(ALG11)
CAL: CAALFM_C602270CA(ALG11)
CAUR: QG37_07724
SLB: AWJ20_4533(ALG11)
NCR: NCU06779
NTE: NEUTE1DRAFT123179(NEUTE1DRAFT_123179)
MGR: MGG_03883
SSCK: SPSK_01090
MAW: MAC_03551
MAJ: MAA_02636
CMT: CCM_02472
MBE: MBM_04997
ANI: AN5725.2
ANG: ANI_1_792164(An18g05910)
ABE: ARB_00023
TVE: TRV_07801
PTE: PTT_15916
SPO: SPCC330.08(alg11)
CNE: CNJ00210
CNB: CNBJ3290
LBC: LACBIDRAFT_399402(ALG11)
ABP: AGABI1DRAFT123007(AGABI1DRAFT_123007)
ABV: AGABI2DRAFT202169(AGABI2DRAFT_202169)
MGL: MGL_1160
DDI: DDB_G0292118(alg11)
DFA: DFA_11738(alg11)
EHI: EHI_093950(3.t00023)
CPV: cgd4_2990
SMIN: v1.2.001761.t1(symbB.v1.2.001761.t1)
SPAR: SPRG_13743
TCR: 506885.10
LMA: LMJF_35_5250(ALG11)
 » show all
Taxonomy
Reference
1  [PMID:16878994]
  Authors
O'Reilly MK, Zhang G, Imperiali B
  Title
In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.
  Journal
Biochemistry 45:9593-603 (2006)
DOI:10.1021/bi060878o
  Sequence
[sce:YNL048W]
Reference
2  [PMID:19929855]
  Authors
Absmanner B, Schmeiser V, Kampf M, Lehle L
  Title
Biochemical characterization, membrane association and identification of amino acids essential for the function of Alg11 from Saccharomyces cerevisiae, an alpha1,2-mannosyltransferase catalysing two sequential glycosylation steps in the formation of the lipid-linked core oligosaccharide.
  Journal
Biochem J 426:205-17 (2010)
DOI:10.1042/BJ20091121
  Sequence
[sce:YNL048W]
Reference
3  [PMID:6154707]
  Authors
Schutzbach JS, Springfield JD, Jensen JW.
  Title
The biosynthesis of oligosaccharide-lipids. Formation of an alpha-1,2-mannosyl-mannose linkage.
  Journal
J Biol Chem 255:4170-5 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.131
IUBMB Enzyme Nomenclature: 2.4.1.131
ExPASy - ENZYME nomenclature database: 2.4.1.131
BRENDA, the Enzyme Database: 2.4.1.131
CAS: 74506-43-7

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