KEGG   ENZYME: 2.4.1.133Help
Entry
EC 2.4.1.133                Enzyme                                 

Name
xylosylprotein 4-beta-galactosyltransferase;
UDP-D-galactose:D-xylose galactosyltransferase;
UDP-D-galactose:xylose galactosyltransferase;
galactosyltransferase I;
uridine diphosphogalactose-xylose galactosyltransferase;
UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase;
UDP-alpha-D-galactose:O-beta-D-xylosyl-[protein] 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:[protein]-3-O-(beta-D-xylosyl)-L-serine 4-beta-D-galactosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-galactose + [protein]-3-O-(beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [RN:R05926]
Reaction(KEGG)
R05926(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
[protein]-3-O-(beta-D-xylosyl)-L-serine
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.133 created 1984, modified 2002
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00733  xylosylprotein 4-beta-galactosyltransferase
Genes
HSA: 11285(B4GALT7)
PTR: 664711(B4GALT7)
PPS: 100969443(B4GALT7)
GGO: 109025277(B4GALT7)
PON: 100438606(B4GALT7)
NLE: 100593744(B4GALT7)
MCC: 701000(B4GALT7)
MCF: 102134376(B4GALT7)
CSAB: 103245067(B4GALT7)
RRO: 104680468(B4GALT7)
RBB: 108544793(B4GALT7)
CJC: 100397629(B4GALT7)
SBQ: 101049094(B4GALT7)
MMU: 218271(B4galt7)
RNO: 364675(B4galt7)
CGE: 100769652(B4galt7)
NGI: 103732252(B4galt7)
HGL: 101713013(B4galt7)
CCAN: 109685754(B4galt7)
OCU: 100358677(B4GALT7)
TUP: 102469216 102469641(B4GALT7)
CFA: 481445(B4GALT7)
AML: 100466599(B4GALT7)
UMR: 103680002(B4GALT7)
ORO: 101362992(B4GALT7)
FCA: 101099172(B4GALT7)
PTG: 102949589(B4GALT7)
AJU: 106970084(B4GALT7)
BTA: 507559(B4GALT7)
BOM: 102274604(B4GALT7)
BIU: 109561915(B4GALT7)
PHD: 102324782(B4GALT7)
CHX: 102189205(B4GALT7)
OAS: 100316848(B4GALT7)
SSC: 100316855(B4GALT7)
CFR: 102509297(B4GALT7)
CDK: 105099602(B4GALT7)
BACU: 102998185(B4GALT7)
LVE: 103085357(B4GALT7)
OOR: 101274084(B4GALT7)
ECB: 100058225(B4GALT7)
EPZ: 103541731(B4GALT7)
EAI: 106827174(B4GALT7)
MYB: 102252387(B4GALT7)
MYD: 102753871(B4GALT7)
HAI: 109389791(B4GALT7)
RSS: 109434251(B4GALT7)
PALE: 102884700(B4GALT7)
LAV: 100674198(B4GALT7)
TMU: 101361238
MDO: 100027902(B4GALT7)
SHR: 100922950(B4GALT7)
OAA: 100088745(B4GALT7)
GGA: 416359(B4GALT7)
MGP: 100549378(B4GALT7)
CJO: 107320474(B4GALT7)
APLA: 101799322(B4GALT7)
ACYG: 106042753(B4GALT7)
TGU: 100217536(B4GALT7)
GFR: 102032323(B4GALT7)
FAB: 101809350(B4GALT7)
PHI: 102110580(B4GALT7)
PMAJ: 107210581(B4GALT7)
CCW: 104689658(B4GALT7)
FPG: 101912431(B4GALT7)
FCH: 102053514(B4GALT7)
CLV: 102098527(B4GALT7)
EGZ: 104135892(B4GALT7)
AAM: 106489923(B4GALT7)
ASN: 112547986(B4GALT7)
AMJ: 102571339(B4GALT7)
PSS: 102455627(B4GALT7)
CMY: 102946711(B4GALT7)
CPIC: 101942960(B4GALT7)
ACS: 100556890(b4galt7)
PVT: 110077329(B4GALT7)
PBI: 103051226(B4GALT7)
GJA: 107111554(B4GALT7) 107125262
XLA: 108710989(b4galt7.L) 495369(b4galt7.S)
XTR: 100144979(b4galt7)
NPR: 108798025(B4GALT7)
DRE: 445022(b4galt7)
IPU: 100528903(b4galt7)
AMEX: 103030020(b4galt7)
TRU: 778009(b4galt7)
LCO: 104934784(b4galt7)
NCC: 104941972(b4galt7)
MZE: 101464985(b4galt7)
OLA: 100049391(b4galt7)
XMA: 102234949(b4galt7)
NFU: 107380813(b4galt7)
CSEM: 103391078(b4galt7)
LCF: 108889683(b4galt7)
HCQ: 109516649(b4galt7)
BPEC: 110166076(b4galt7)
SASA: 106604202(b4galt7) 106612238
ELS: 105026158(b4galt7)
SFM: 108923004(b4galt7)
LCM: 102365042(B4GALT7)
CIN: 779002(b4gal-t7)
SPU: 100893036
APLC: 110982496
SKO: 100370356
DME: Dmel_CG11780(beta4GalT7)
DAN: Dana_GF16319(Dana_beta4GalT7)
DER: Dere_GG11346(Dere_beta4GalT7)
DSE: Dsec_GM17784(Dsec_beta4GalT7) Dsec_GM17785
DSI: Dsimw501_GD21157(Dsim_beta4GalT7)
DYA: Dyak_GE23542(Dyak_beta4GalT7)
DMO: Dmoj_GI22222(Dmoj_beta4GalT7)
MDE: 101901029
AAG: 5569772
AME: 551662
BIM: 100740220
BTER: 100644684
SOC: 105199296
AEC: 105152211
ACEP: 105621491
PBAR: 105432394
HST: 105184864
CFO: 105259486
LHU: 105672626
PGC: 109861759
NVI: 100120002
TCA: 662423
DPA: 109542053
NVL: 108563065
PMAC: 106715865
PRAP: 110991476
PXY: 105398823
API: 100159143
DNX: 107164425
ZNE: 110834722
FCD: 110848119
TUT: 107362732
CEL: CELE_R10E11.4(sqv-3)
CBR: CBG09970(Cbr-sqv-3)
BMY: Bm1_44360
TSP: Tsp_04693
CRG: 105349030
OBI: 106876853
SHX: MS3_11035
ADF: 107327698
HMG: 100206713
APRO: F751_6798
 » show all
Taxonomy
Reference
1  [PMID:1150655]
  Authors
Schwartz NB, Roden L.
  Title
Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans.
  Journal
J Biol Chem 250:5200-7 (1975)
Reference
2  [PMID:10438455]
  Authors
Okajima T, Yoshida K, Kondo T, Furukawa K.
  Title
Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
  Journal
J Biol Chem 274:22915-8 (1999)
DOI:10.1074/jbc.274.33.22915
  Sequence
[hsa:11285]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.133
IUBMB Enzyme Nomenclature: 2.4.1.133
ExPASy - ENZYME nomenclature database: 2.4.1.133
BRENDA, the Enzyme Database: 2.4.1.133
CAS: 52227-72-2

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