KEGG   ENZYME: 2.4.1.135Help
Entry
EC 2.4.1.135                Enzyme                                 

Name
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase;
glucuronosyltransferase I;
uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase;
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase;
UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein D-glucuronosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucuronate:[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine D-glucuronosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine [RN:R04607 R05928]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
[protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine [CPD:C04825]
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine [CPD:C04903]
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates). Requires Mn2+.
History
EC 2.4.1.135 created 1984, modified 2002, modified 2016
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00735  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
K10157  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
K10158  galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
K10812  beta-1,3-glucuronyltransferase
Genes
HSA: 135152(B3GAT2) 26229(B3GAT3) 27087(B3GAT1)
PTR: 462813(B3GAT2) 466859(B3GAT1) 740388(B3GAT3)
PPS: 100980067(B3GAT1) 100993761(B3GAT2) 103783318(B3GAT3)
GGO: 101132051(B3GAT2) 101142201(B3GAT1) 109028750(B3GAT3)
PON: 100448790(B3GAT1) 100449395(B3GAT2) 100458701(B3GAT3)
NLE: 100584249(B3GAT1) 100592146(B3GAT3) 100603558(B3GAT2)
MCC: 695293(B3GAT1) 717157(B3GAT2) 718744(B3GAT3)
MCF: 101867087(B3GAT3) 102118326(B3GAT2) 102142387(B3GAT1)
CSAB: 103234006(B3GAT3) 103243928(B3GAT2) 103248899(B3GAT1)
RRO: 104661430(B3GAT1) 104668762(B3GAT2) 104679349(B3GAT3)
RBB: 108529217(B3GAT2) 108529702(B3GAT1) 108533582(B3GAT3)
CJC: 100391738(B3GAT1) 100395367(B3GAT3) 100401353(B3GAT2)
SBQ: 101029437(B3GAT2) 101034661(B3GAT3) 101037144(B3GAT1)
MMU: 280645(B3gat2) 72727(B3gat3) 76898(B3gat1)
RNO: 117108(B3gat1) 293722(B3gat3) 64544(B3gat2)
CGE: 100689419(B3gat3) 100750701(B3gat1) 100756696(B3gat2)
NGI: 103737681(B3gat3) 103750906(B3gat1) 103752492(B3gat2)
HGL: 101709113(B3gat2) 101710890(B3gat1) 101717898(B3gat3)
CCAN: 109674376(B3gat1) 109681240(B3gat3) 109688753(B3gat2)
OCU: 100345204(B3GAT1) 100349666(B3GAT2) 100350294(B3GAT3)
TUP: 102471121 102471547(B3GAT1) 102472891(B3GAT3) 102483923(B3GAT2)
CFA: 481875(B3GAT2) 483785(B3GAT3) 489265(B3GAT1)
AML: 100467358(B3GAT3) 100468570(B3GAT1) 100474997(B3GAT2)
UMR: 103657469(B3GAT2) 103660755(B3GAT1) 103678187(B3GAT3)
ORO: 101371974(B3GAT2) 101373124(B3GAT3) 101374853(B3GAT1)
FCA: 101087404(B3GAT2) 101089044(B3GAT3) 101096760(B3GAT1)
PTG: 102948861(B3GAT3) 102956846(B3GAT1) 102970934(B3GAT2)
AJU: 106975157(B3GAT1) 106981737(B3GAT3)
BTA: 404162(B3GAT3) 541595(B3GAT2) 541596(B3GAT1)
BOM: 102265083(B3GAT1) 102269297(B3GAT3) 102276804(B3GAT2)
BIU: 109554349(B3GAT3) 109563701(B3GAT2) 109569771(B3GAT1)
PHD: 102318873(B3GAT2) 102320142(B3GAT1) 102342113(B3GAT3)
CHX: 102172516(B3GAT3) 102174927(B3GAT1) 102180686(B3GAT2)
OAS: 101102248(B3GAT2) 101111917(B3GAT3) 101116508(B3GAT1)
SSC: 100520760(B3GAT1) 100526195(B3GAT2) 397642(B3GAT3)
CFR: 102503662(B3GAT2) 102505052(B3GAT1) 102505525(B3GAT3)
CDK: 105085061(B3GAT2) 105091529(B3GAT3) 105104231(B3GAT1)
BACU: 103002629(B3GAT3) 103005848(B3GAT1) 103012910(B3GAT2)
LVE: 103078862(B3GAT3) 103085675(B3GAT1) 103090698(B3GAT2)
OOR: 101270376(B3GAT2) 101272042(B3GAT1) 101279944(B3GAT3)
ECB: 100063587(B3GAT3) 100071000(B3GAT2) 100072914(B3GAT1)
EPZ: 103541648(B3GAT2) 103558932(B3GAT3) 103565179(B3GAT1)
EAI: 106826833(B3GAT3) 106834293(B3GAT2) 106846908(B3GAT1)
MYB: 102238806(B3GAT2) 102248586(B3GAT1) 102260939(B3GAT3) 106724844
MYD: 102752313(B3GAT3) 102763619(B3GAT2) 102768404(B3GAT1)
HAI: 109374153(B3GAT1) 109384098(B3GAT3) 109394168(B3GAT2)
RSS: 109435830(B3GAT3) 109438141(B3GAT1) 109456839(B3GAT2)
PALE: 102886975(B3GAT2) 102890779(B3GAT1) 102891455(B3GAT3)
LAV: 100653777(B3GAT1) 100661019(B3GAT2) 100672369(B3GAT3)
MDO: 100010236(B3GAT3) 100016092(B3GAT2) 100017866(B3GAT1)
SHR: 100913671(B3GAT1) 100917776(B3GAT2) 100935255(B3GAT3)
OAA: 100075413(B3GAT3) 100090509
GGA: 373949(B3GAT1) 408180(B3GAT1L) 428638(B3GAT2)
MGP: 100548173 100550564(B3GAT1) 100550793(B3GAT2)
CJO: 107312060(B3GAT2) 107320417 107324164(B3GAT1)
APLA: 101791983 101796136(B3GAT2) 101802219 101803867(B3GAT1)
ACYG: 106030374(B3GAT2) 106037591 106040589(B3GAT1)
TGU: 100224397(B3GAT1) 100227480 100230653(B3GAT2)
GFR: 102034447 102036701(B3GAT2) 102039444(B3GAT1)
FAB: 101805893(B3GAT1) 101808720(B3GAT2) 101809294
PHI: 102105592(B3GAT3) 102107435(B3GAT1) 102108514 102109761(B3GAT2)
PMAJ: 107201433(B3GAT2) 107212820 107214391(B3GAT1)
CCAE: 111926021(B3GAT2) 111939130 111939336(B3GAT1)
CCW: 104687055 104692121(B3GAT1) 104693116(B3GAT2)
FPG: 101912858(B3GAT1) 101915992 101921056(B3GAT2)
FCH: 102051462 102056555(B3GAT1) 102060053(B3GAT2)
CLV: 102085686(B3GAT2) 102089787 102094135 102096632(B3GAT1)
EGZ: 104125158(B3GAT2) 104126495 104129214(B3GAT1)
AAM: 106490243(B3GAT1) 106490700 106492517(B3GAT2) 106493921
ASN: 102369484 102369978(B3GAT1) 102375316(B3GAT3) 102385987(B3GAT2)
AMJ: 102561089(B3GAT2) 102563043(B3GAT3) 102568198(B3GAT1) 102570391
PSS: 102452466 102453546 102455157(B3GAT2) 102460502(B3GAT3)
CMY: 102933583(B3GAT1) 102934293(B3GAT2) 102937420 102941550(B3GAT3)
CPIC: 101940176(B3GAT3) 101946238(B3GAT1) 101949948(B3GAT2) 101952321
ACS: 100556963 100565010(b3gat1) 100567109(b3gat3) 100567640(b3gat2)
PVT: 110074027 110075006(B3GAT2) 110078243(B3GAT1) 110081006(B3GAT3)
PBI: 103050021 103050571(B3GAT2) 103057546(B3GAT3) 103062783(B3GAT1)
GJA: 107106043 107111644(B3GAT2) 107116871(B3GAT1) 107120072(B3GAT3)
XTR: 100037907(b3gat1) 100493713 594895(b3gat3) 594896(b3gat1) 594928(b3gat2)
DRE: 192334(b3gat3) 445060(b3gat2) 548607(b3gat1a)
IPU: 108263352(b3gat2) 108263969 108268305(b3gat3) 108276863
AMEX: 103028547(b3gat3) 103033187(b3gat2) 103036350 103039617(b3gat1)
TRU: 654312(b3gat3) 654313(b3gat1) 654316(b3gat2)
LCO: 104917661(b3gat2) 104918106(b3gat3) 104933912 104940504
MZE: 101480695(b3gat3) 101481864 101484521(b3gat2) 101487321
OLA: 100049460(b3gat3) 100302419(b3gat1) 100302420(b3gat2) 101158332
XMA: 102235338 102237884 102238000(b3gat3) 102238009(b3gat2)
PRET: 103474772 103476133 103477310(b3gat2) 103480760(b3gat3)
NFU: 107376425(b3gat2) 107377135(b3gat3) 107380714 107386313
KMR: 108238185 108239122(b3gat2) 108242856(b3gat3) 108244718
CSEM: 103377670(b3gat1) 103384246(b3gat3) 103386917(b3gat2) 103394811 103399064
LCF: 108888787(b3gat3) 108893453 108895748(b3gat2) 108898828
SDU: 111220566(b3gat2) 111222183 111231304(b3gat3) 111233438
HCQ: 109512903(b3gat1) 109515067(b3gat3) 109523236(b3gat2)
ELS: 105005687(b3gat3) 105006566 105010636(b3gat2) 105023813
LCM: 102348408 102350544(B3GAT1) 102364469(B3GAT2) 102364764(B3GAT3)
CMK: 103171591(b3gat3) 103180285(b3gat1) 103183513 103185598(b3gat2)
CIN: 778533(uglcat1)
SPU: 579023
DME: Dmel_CG32775 Dmel_CG3881(GlcAT-S) Dmel_CG6207(GlcAT-P)
DPE: 6598968
DSI: Dsimw501_GD12815(Dsim_GD12815) Dsimw501_GD16673(Dsim_GD16673) Dsimw501_GD23619(Dsim_GD23619)
DYA: Dyak_GE16334(Dyak_GlcAT-I) Dyak_GE18858(Dyak_GlcAT-S) Dyak_GE20229(Dyak_GlcAT-P)
NVI: 100123025(B3gat)
CLEC: 106661064
CEL: CELE_ZK1307.5(sqv-8)
CBR: CBG01067(Cbr-sqv-8)
BMY: Bm1_42955
CRG: 105326288
MYI: 110466531
OBI: 106873166
LAK: 106166698
SHX: MS3_09360
HMG: 100200928
 » show all
Taxonomy
Reference
1  [PMID:5770003]
  Authors
Helting T, Roden L.
  Title
Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate-protein linkage region.
  Journal
J Biol Chem 244:2799-805 (1969)
Reference
2  [PMID:4260846]
  Authors
Helting T.
  Title
Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma.
  Journal
J Biol Chem 247:4327-32 (1972)
Reference
3  [PMID:9506957]
  Authors
Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K.
  Title
Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans.
  Journal
J Biol Chem 273:6615-8 (1998)
DOI:10.1074/jbc.273.12.6615
  Sequence
[hsa:26229]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.135
IUBMB Enzyme Nomenclature: 2.4.1.135
ExPASy - ENZYME nomenclature database: 2.4.1.135
BRENDA, the Enzyme Database: 2.4.1.135
CAS: 227184-75-0

DBGET integrated database retrieval system