KEGG   ENZYME: 2.4.1.142Help
Entry
EC 2.4.1.142                Enzyme                                 

Name
chitobiosyldiphosphodolichol beta-mannosyltransferase;
guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase;
GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-alpha-D-mannose:N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol 4-beta-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
GDP-alpha-D-mannose + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol = GDP + beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol [RN:R04502 R05972]
Reaction(KEGG)
Substrate
GDP-alpha-D-mannose [CPD:C00096];
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
Product
GDP [CPD:C00035];
beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
History
EC 2.4.1.142 created 1984, modified 2001
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03842  beta-1,4-mannosyltransferase
Genes
HSA: 56052(ALG1)
PTR: 453895(ALG1)
PPS: 100977123 100978344(ALG1L2) 100982195(ALG1) 100992801 100992948
GGO: 101138177(ALG1L) 101139524(ALG1L2) 101140257(ALG1) 101143532 109023085
PON: 100173370(ALG1)
NLE: 100581207 100602863(ALG1) 100603769
MCC: 710713(ALG1)
MCF: 101865928(ALG1)
CSAB: 103227830(ALG1)
RRO: 104654665(ALG1)
RBB: 108538315(ALG1)
CJC: 100400085(ALG1)
SBQ: 101032945(ALG1)
MMU: 208211(Alg1)
RNO: 360475(Alg1)
CGE: 100773731(Alg1)
NGI: 103744783(Alg1)
HGL: 101706108(Alg1)
CCAN: 109698326(Alg1)
OCU: 100353396(ALG1)
TUP: 102498955(ALG1)
CFA: 490017(ALG1)
AML: 100474990(ALG1)
UMR: 103668569(ALG1)
ORO: 101374118(ALG1)
FCA: 101091331(ALG1)
PTG: 102966396(ALG1) 102968537
AJU: 106978824(ALG1)
BTA: 507210(ALG1)
BOM: 102269961(ALG1)
BIU: 109578685(ALG1)
PHD: 102333777(ALG1)
CHX: 102187731(ALG1)
OAS: 101104800(ALG1)
SSC: 100524193(ALG1)
CFR: 102503439(ALG1)
CDK: 105098401(ALG1)
BACU: 103007281(ALG1)
LVE: 103086066(ALG1)
OOR: 101274998(ALG1)
ECB: 100147524(ALG1)
EPZ: 103563126(ALG1)
EAI: 106826034(ALG1)
MYB: 102247170(ALG1)
MYD: 102770836(ALG1)
HAI: 109392138(ALG1)
RSS: 109460758(ALG1)
PALE: 102878656(ALG1)
LAV: 100667810(ALG1)
TMU: 101350793
MDO: 100026716(ALG1)
SHR: 100924461(ALG1)
GGA: 416393(ALG1)
MGP: 100548716
CJO: 107320944(ALG1)
APLA: 101797669(ALG1)
ACYG: 106046345(ALG1)
TGU: 100220687 100223607(ALG1)
GFR: 102038240(ALG1)
FAB: 101813767(ALG1)
PHI: 102110968(ALG1)
PMAJ: 107211330(ALG1)
CCAE: 111935852(ALG1)
CCW: 104684651(ALG1)
FPG: 101919558(ALG1)
FCH: 102052995(ALG1)
CLV: 102084166(ALG1)
EGZ: 104127217(ALG1)
AAM: 106500002(ALG1)
ASN: 102385977(ALG1)
AMJ: 102560208(ALG1)
PSS: 102447088(ALG1)
CMY: 102944470(ALG1)
CPIC: 101939553(ALG1)
ACS: 100561527(alg1)
PVT: 110085605(ALG1)
PBI: 103064195(ALG1)
GJA: 107114193(ALG1)
XLA: 100037043(alg1.L)
XTR: 594994(alg1)
NPR: 108802292(ALG1)
DRE: 334161(alg1)
CCAR: 109057918 109057945(alg1)
IPU: 108256341(alg1)
AMEX: 103033036(alg1)
TRU: 101075446
LCO: 104923395(alg1)
NCC: 104948568(alg1) 104961069
MZE: 101470141(alg1)
OLA: 101157620(alg1)
XMA: 102225456(alg1)
PRET: 103469070(alg1)
NFU: 107395405(alg1)
KMR: 108229762(alg1)
CSEM: 103393481(alg1)
LCF: 108888581(alg1)
SDU: 111217543(alg1)
HCQ: 109527774(alg1)
BPEC: 110154480(alg1)
MALB: 109962851(alg1)
OTW: 112240312
ELS: 105030586(alg1)
SFM: 108941805(alg1)
LCM: 102355761(ALG1)
CMK: 103178836(alg1)
CIN: 100177331
SPU: 587377
APLC: 110986124
SKO: 100370845
DME: Dmel_CG18012(CG18012)
DSI: Dsimw501_GD20206(Dsim_GD20206)
MDE: 101889251
AAG: 5577325
AME: 551379
BIM: 100742534
BTER: 100651652
SOC: 105205199
AEC: 105152616
ACEP: 105621774
PBAR: 105426120
HST: 105183269
DQU: 106743337
CFO: 105249084
LHU: 105671350
PGC: 109851867
PCF: 106793480
MDL: 103569122
TCA: 664134
DPA: 109546989
NVL: 108566490
BMOR: 101745560
PMAC: 106720740
PRAP: 111003457
HAW: 110375585
PXY: 105383608
DNX: 107162181
CLEC: 106663230
ZNE: 110837343
FCD: 110845894
CEL: CELE_T26A5.4(algn-1)
CBR: CBG19680
BMY: Bm1_57590
TSP: Tsp_00267
MYI: 110455665
OBI: 106882808
SHX: MS3_04062
EGL: EGR_04226
EPA: 110240934
ADF: 107356387
HMG: 100207677
AQU: 100640304
ATH: AT1G16570
CRB: 17899031
THJ: 104808122
CPAP: 110808818
CIT: 102618309
TCC: 18611902
GRA: 105803962
DZI: 111299750
EGR: 104448639
VRA: 106762646
VAR: 108334051
CCAJ: 109813598
CAM: 101496914
LJA: Lj3g3v2315540.1(Lj3g3v2315540.1)
ADU: 107477916
AIP: 107629906
LANG: 109340589
FVE: 101312809
PPER: 18778429
PMUM: 103325836
PAVI: 110772884
ZJU: 107423363
CMO: 103499272
MCHA: 111017980
CMAX: 111469703
CMOS: 111451822
CPEP: 111796158
RCU: 8271840
JCU: 105645387
HBR: 110647405
POP: 18095521
JRE: 109018722
VVI: 100247296
SLY: 101244134
SPEN: 107031903
SOT: 102587872
CANN: 107844012
NSY: 104226827
NTO: 104098177
HAN: 110889756
LSV: 111914429
CCAV: 112507769
DCR: 108215574
BVG: 104902686
SOE: 110785228
NNU: 104608625
DOSA: Os03t0180700-01(Os03g0180700) Os06t0564800-01(Os06g0564800)
OBR: 102709541
BDI: 100828564
ATS: 109736324(LOC109736324) 109753462(LOC109753462)
SBI: 8082012
SITA: 101780939
PDA: 103711321
EGU: 105060664
MUS: 103995356
DCT: 110104743
PEQ: 110022877
AOF: 109820107
ATR: 18446975
PPP: 112275208
CRE: CHLREDRAFT_108570(GTR16)
MNG: MNEG_3336
APRO: F751_2569
SCE: YBR110W(ALG1)
ERC: Ecym_3466
KMX: KLMA_80292(ALG1)
NCS: NCAS_0I01090(NCAS0I01090)
NDI: NDAI_0A07910(NDAI0A07910)
TPF: TPHA_0A03560(TPHA0A03560)
TBL: TBLA_0H01550(TBLA0H01550)
TDL: TDEL_0C05030(TDEL0C05030)
KAF: KAFR_0D02690(KAFR0D02690)
PIC: PICST_39314(ALG1)
CAL: CAALFM_C406000WA(ALG1)
CAUR: QG37_02273
SLB: AWJ20_4743(ALG1)
NCR: NCU07261
NTE: NEUTE1DRAFT121451(NEUTE1DRAFT_121451)
MGR: MGG_10494
SSCK: SPSK_09170
MAW: MAC_06369
MAJ: MAA_05105
CMT: CCM_04210
BFU: BCIN_06g07440(Bcalg1)
MBE: MBM_01584
ANI: AN5346.2
ANG: ANI_1_124054(An06g01100)
ABE: ARB_01551
TVE: TRV_02548
PTE: PTT_11774
ZTR: MYCGRDRAFT_72947(Mg84326)
SPO: SPAC23C4.14(alg1)
CNE: CNA06670
CNB: CNBA6490
LBC: LACBIDRAFT_300879(ALG1)
MRR: Moror_339
ABP: AGABI1DRAFT51041(AGABI1DRAFT_51041)
ABV: AGABI2DRAFT197784(AGABI2DRAFT_197784)
MGL: MGL_3730
DDI: DDB_G0286011(alg1)
DFA: DFA_00740(alg1)
EHI: EHI_028950(192.t00014)
CPV: cgd7_1810
SMIN: v1.2.027383.t1(symbB.v1.2.027383.t1)
SPAR: SPRG_12416
TCR: 504215.20
 » show all
Taxonomy
Reference
1  [PMID:6215245]
  Authors
Sharma CB, Lehle L, Tanner W.
  Title
Solubilization and characterization of the initial enzymes of the dolichol pathway from yeast.
  Journal
Eur J Biochem 126:319-25 (1982)
DOI:10.1111/j.1432-1033.1982.tb06781.x
Reference
2  [PMID:10704531]
  Authors
Takahashi T, Honda R, Nishikawa Y.
  Title
Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1.
  Journal
Glycobiology 10:321-7 (2000)
DOI:10.1093/glycob/10.3.321
  Sequence
[hsa:56052]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.142
IUBMB Enzyme Nomenclature: 2.4.1.142
ExPASy - ENZYME nomenclature database: 2.4.1.142
BRENDA, the Enzyme Database: 2.4.1.142
CAS: 83380-85-2

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