KEGG   ENZYME: 2.4.1.145Help
Entry
EC 2.4.1.145                Enzyme                                 

Name
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase;
N-acetylglucosaminyltransferase IV;
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV;
beta-acetylglucosaminyltransferase IV;
uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV;
alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase;
GnTIV;
UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] = UDP + beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] [RN:R05987]
Reaction(KEGG)
R05987(G);
(other) R04662
Show
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Product
UDP [CPD:C00015];
beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment
Requires Mn2+. The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus. By adding a glucosaminyl residue to biantennary N-linked glycans, it enables the synthesis of tri- and tetra-antennary complexes.
History
EC 2.4.1.145 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984), modified 2018
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00738  alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B
K13748  alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase C
Genes
HSA: 11282(MGAT4B) 11320(MGAT4A) 152586(MGAT4D) 25834(MGAT4C)
PTR: 459434(MGAT4A) 461502(MGAT4D) 467085(MGAT4C) 471774(MGAT4B)
PPS: 100981022(MGAT4B) 100992134(MGAT4C) 100994401(MGAT4D) 100996009(MGAT4A)
GGO: 101141983(MGAT4D) 101143539(MGAT4A) 101148891(MGAT4B) 101151757(MGAT4C)
PON: 100190826(MGAT4A) 100455323(MGAT4C) 100457326(MGAT4B) 100938596(MGAT4D)
NLE: 100584226(MGAT4C) 100587238(MGAT4A) 100607570(MGAT4B) 105740065(MGAT4D)
MCC: 700450(MGAT4C) 701630(MGAT4D) 705006(MGAT4B) 708094(MGAT4A)
MCF: 101866133(MGAT4A) 101866242(MGAT4C) 102143163(MGAT4B) 102146807(MGAT4D)
CSAB: 103236295(MGAT4D) 103238817(MGAT4C) 103241101(MGAT4A) 103245113(MGAT4B)
RRO: 104654329(MGAT4D) 104655963(MGAT4C) 104661480(MGAT4A) 104676225(MGAT4B)
RBB: 108523368(MGAT4B) 108529466(MGAT4A) 108530646(MGAT4D) 108535046(MGAT4C)
CJC: 100391287(MGAT4B) 100398052(MGAT4A) 100413583(MGAT4C) 103791867(MGAT4D)
SBQ: 101037371(MGAT4B) 101037806(MGAT4D) 101039237(MGAT4A) 101043109(MGAT4C)
MMU: 103534(Mgat4b) 269181(Mgat4a) 67555(Mgat4d) 67569(Mgat4c)
RNO: 299756(Mgat4c) 303100(Mgat4b) 304646(Mgat4d) 367252(Mgat4a)
CGE: 100760589(Mgat4c) 100766200(Mgat4a) 100768637(Mgat4b) 100774333(Mgat4d)
NGI: 103726602(Mgat4c) 103742396(Mgat4d) 103744157(Mgat4a) 103749373(Mgat4b)
HGL: 101716811 101722510(Mgat4a) 101723043(Mgat4b) 101725010(Mgat4c) 101726304(Mgat4d)
CCAN: 109686735(Mgat4b) 109691477(Mgat4d) 109696230(Mgat4a) 109700961(Mgat4c)
OCU: 100338722(MGAT4A) 100339976(MGAT4C) 100346059(MGAT4B) 100346813(MGAT4D)
TUP: 102467784(MGAT4C) 102475912(MGAT4A) 102480932(MGAT4D) 102484580(MGAT4B)
CFA: 102153780(MGAT4D) 474562(MGAT4A) 475418(MGAT4C) 481458(MGAT4B)
AML: 100465193(MGAT4C) 100469508(MGAT4B) 100481251(MGAT4A) 105236214(MGAT4D)
UMR: 103658076(MGAT4D) 103660061(MGAT4C) 103671181(MGAT4A) 103680013(MGAT4B)
ORO: 101369336(MGAT4C) 101374303(MGAT4A) 101374424(MGAT4D) 101378211(MGAT4B)
FCA: 101088153(MGAT4A) 101095945(MGAT4B) 102900578(MGAT4D) 109501701(MGAT4C)
PTG: 102953882(MGAT4B) 102962178(MGAT4D) 102966537(MGAT4A) 102971513(MGAT4C)
AJU: 106968727(MGAT4A) 106970178(MGAT4B) 106976200(MGAT4D) 106976669(MGAT4C)
BTA: 101907024(MGAT4D) 282276(MGAT4A) 526256(MGAT4B) 539661(MGAT4C)
BOM: 102269061(MGAT4C) 102281135(MGAT4B) 102281255(MGAT4D) 102286450(MGAT4A)
BIU: 109558955(MGAT4C) 109560799(MGAT4B) 109565825(MGAT4A) 109570866(MGAT4D)
PHD: 102316698(MGAT4B) 102325642(MGAT4C) 102337122(MGAT4D) 102340515(MGAT4A)
CHX: 102169257(MGAT4C) 102173548(MGAT4B) 102177532(MGAT4A) 102191262(MGAT4D)
OAS: 101105106(MGAT4D) 101108733(MGAT4C) 101108820(MGAT4A) 101119044(MGAT4B)
SSC: 100512242(MGAT4D) 100521073(MGAT4B) 100524079(MGAT4A) 414851(MGAT4C)
CFR: 102503643(MGAT4D) 102503714(MGAT4C) 102506006(MGAT4B) 102522357(MGAT4A)
CDK: 105084877(MGAT4C) 105088873(MGAT4D) 105099131 105099793 105100632(MGAT4B)
BACU: 103004161(MGAT4C) 103010086(MGAT4A) 103011292(MGAT4B) 103018629(MGAT4D)
LVE: 103075784(MGAT4A) 103080459(MGAT4C) 103086020(MGAT4B)
OOR: 101281932(MGAT4C) 101284601(MGAT4A) 101286159(MGAT4B)
ECB: 100050964(MGAT4A) 100051064(MGAT4C) 100067257(MGAT4B) 102147352(MGAT4D)
EPZ: 103556433(MGAT4D) 103558210(MGAT4C) 103559005(MGAT4A) 103560013(MGAT4B)
EAI: 106824891 106835139(MGAT4D) 106838333(MGAT4C) 106842552 106843708(MGAT4B)
MYB: 102244266(MGAT4D) 102248905(MGAT4A) 102253362(MGAT4C) 102258316(MGAT4B)
MYD: 102760456(MGAT4D) 102762292(MGAT4A) 102769462(MGAT4C) 102770440(MGAT4B)
HAI: 109387992(MGAT4C) 109392510(MGAT4D) 109392781(MGAT4B) 109396940(MGAT4A)
RSS: 109437633(MGAT4B) 109446889(MGAT4D) 109459416(MGAT4A) 109459955(MGAT4C)
PALE: 102882602(MGAT4C) 102882798(MGAT4A) 102891025(MGAT4D) 102891973(MGAT4B)
LAV: 100654425(MGAT4A) 100654846(MGAT4C) 100675337 100675622 104845954(MGAT4D)
MDO: 100013784(MGAT4A) 100020942(MGAT4C) 100027218(MGAT4D) 100028175(MGAT4B)
SHR: 100916939 100920029(MGAT4A) 100927084 100932381(MGAT4C) 100933355(MGAT4B)
OAA: 100081053(MGAT4C) 100081934(MGAT4D) 100093525(MGAT4A)
GGA: 395415(MGAT4C) 416285(MGAT4B) 418692(MGAT4A) 422448(MGAT4D) 427873(MGAT4C)
MGP: 100538511(MGAT4A) 100541955(MGAT4C) 100542581(MGAT4D) 100543731(MGAT4B) 100550363
CJO: 107307274(MGAT4A) 107311189(MGAT4C) 107313112(MGAT4D) 107320122(MGAT4B) 107324722
APLA: 101791726(MGAT4C) 101798874(MGAT4D) 101799353 101803616(MGAT4A) 101804040(MGAT4B)
ACYG: 106032813(MGAT4B) 106035707(MGAT4A) 106041520(MGAT4C) 106045877 106046674(MGAT4D)
TGU: 100218916(MGAT4A) 100220057(MGAT4D) 100224306(MGAT4B) 100228531(MGAT4C) 100232682
GFR: 102034112(MGAT4C) 102039120(MGAT4B) 102039150(MGAT4D) 102042558(MGAT4A) 102043367
FAB: 101806014(MGAT4A) 101807568(MGAT4D) 101809036(MGAT4C) 101815032 101820554(MGAT4B)
PHI: 102101535(MGAT4D) 102102354(MGAT4A) 102103698 102109899(MGAT4B) 102110314(MGAT4C)
PMAJ: 107202874(MGAT4A) 107203458(MGAT4D) 107205204(MGAT4C) 107210695(MGAT4B) 107214888
CCW: 104686044(MGAT4A) 104689699(MGAT4B) 104692465 104697272(MGAT4D) 104698425(MGAT4C)
FPG: 101913766(MGAT4D) 101914300(MGAT4C) 101916895(MGAT4B) 101916943 101918425(MGAT4A)
FCH: 102045721(MGAT4C) 102049618 102052657(MGAT4D) 102053135(MGAT4A) 102055497(MGAT4B)
CLV: 102084023(MGAT4A) 102087504(MGAT4D) 102088784(MGAT4C) 102089679 102090946(MGAT4B)
EGZ: 104121996 104123593(MGAT4B) 104125235(MGAT4A) 104131259(MGAT4D) 104132945(MGAT4C)
AAM: 106485644 106488510(MGAT4C) 106491859(MGAT4D) 106493437(MGAT4B) 106493958(MGAT4A)
ASN: 102374657(MGAT4C) 102375548(MGAT4A) 102376706 102378177 102382074(MGAT4B) 102384961(MGAT4D)
AMJ: 102560247 102563452 102564947(MGAT4A) 102568458(MGAT4B) 102570305(MGAT4D) 102575494(MGAT4C)
PSS: 102443383(MGAT4A) 102446260(MGAT4C) 102447893 102457602(MGAT4B) 102460254 102460821(MGAT4D) 102462087
CPIC: 101936161 101937266 101945192(MGAT4B) 101947319(MGAT4C) 101951561(MGAT4A) 101952278(MGAT4D)
ACS: 100552582(mgat4a) 100556708 100561638(mgat4c) 100562892 100565033(mgat4b) 100567983(mgat4d)
PVT: 110070064(MGAT4C) 110073381 110073448(MGAT4B) 110073646(MGAT4D) 110080923 110085424(MGAT4A)
GJA: 107107839 107110310(MGAT4B) 107110414(MGAT4A) 107110771(MGAT4D) 107111720 107123105(MGAT4C)
XLA: 108699587 108709721 108710250(mgat4c.L) 108713740 108715280 443870(mgat4b.L) 734354(mgat4a.S)
XTR: 100124983(mgat4b) 100145594(mgat4a) 100486336(mgat4c) 100489322(mgat4b) 100489718
NPR: 108785382(MGAT4B) 108785666 108792276(MGAT4A) 108792416(MGAT4C) 108792605(MGAT4D) 108799515
DRE: 100333333(mgat4c) 431727(mgat4b) 492796(zgc:101663) 563038(mgat4a)
IPU: 108263961(mgat4c) 108266942(mgat4a) 108268579(mgat4b) 108269056(mgat4d) 108275769
AMEX: 103026137(mgat4b) 103027198(mgat4c) 103036431 103042427(mgat4a) 103046884(mgat4d)
PRET: 103465731 103465750(mgat4c) 103466943 103470995(mgat4d) 103471906(mgat4b) 103479891(mgat4a)
CSEM: 103380004 103384716 103391069(mgat4b) 103391477(mgat4d) 103391698(mgat4a) 103398884(mgat4c)
HCQ: 109516655(mgat4b) 109528599 109530601(mgat4a) 109530880 109530900(mgat4c)
BPEC: 110155136(mgat4c) 110162118 110165504(mgat4b) 110173152(mgat4a) 110173438
CMK: 103175065 103177135(mgat4a) 103179072 103181292(mgat4d) 103185333(mgat4c) 103188228(mgat4b)
DME: Dmel_CG17173(CG17173) Dmel_CG9384(CG9384)
DSI: Dsimw501_GD12602(Dsim_GD12602) Dsimw501_GD14502(Dsim_GD14502)
MDE: 101891834
AAG: 5578895
AME: 412423
BIM: 100747322
BTER: 100648137
SOC: 105202928
AEC: 105150554
ACEP: 105623910
PBAR: 105426519
HST: 105190955
CFO: 105257764
LHU: 105672071
PGC: 109858308
NVI: 100121669
TCA: 654917
DPA: 109543002
NVL: 108561500
BMOR: 101740839
PRAP: 111003402
ZNE: 110837930
TUT: 107361964
BMY: Bm1_37290
TSP: Tsp_06598
OBI: 106871368
HMG: 100200548
SMIN: v1.2.033022.t1(symbB.v1.2.033022.t1)
 » show all
Taxonomy
Reference
1  [PMID:6222042]
  Authors
Gleeson PA, Schachter H.
  Title
Control of glycoprotein synthesis.
  Journal
J Biol Chem 258:6162-73 (1983)
Reference
2  [PMID:9278430]
  Authors
Oguri S, Minowa MT, Ihara Y, Taniguchi N, Ikenaga H, Takeuchi M
  Title
Purification and characterization of UDP-N-acetylglucosamine: alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase-IV) from bovine small intestine.
  Journal
J Biol Chem 272:22721-7 (1997)
DOI:10.1074/jbc.272.36.22721
  Sequence
[bta:282276]
Reference
3  [PMID:9565571]
  Authors
Minowa MT, Oguri S, Yoshida A, Hara T, Iwamatsu A, Ikenaga H, Takeuchi M
  Title
cDNA cloning and expression of bovine UDP-N-acetylglucosamine: alpha1, 3-D-mannoside beta1,4-N-acetylglucosaminyltransferase IV.
  Journal
J Biol Chem 273:11556-62 (1998)
DOI:10.1074/jbc.273.19.11556
  Sequence
[bta:282276]
Reference
4  [PMID:10024668]
  Authors
Yoshida A, Minowa MT, Takamatsu S, Hara T, Oguri S, Ikenaga H, Takeuchi M
  Title
Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase.
  Journal
Glycobiology 9:303-10 (1999)
DOI:10.1093/glycob/9.3.303
  Sequence
[hsa:11320]
Reference
5  [PMID:10372966]
  Authors
Yoshida A, Minowa MT, Takamatsu S, Hara T, Ikenaga H, Takeuchi M
  Title
A novel second isoenzyme of the human UDP-N-acetylglucosamine:alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase family: cDNA cloning, expression, and chromosomal assignment.
  Journal
Glycoconj J 15:1115-23 (1998)
  Sequence
[hsa:11282]
Reference
6  [PMID:20015870]
  Authors
Takamatsu S, Antonopoulos A, Ohtsubo K, Ditto D, Chiba Y, Le DT, Morris HR, Haslam SM, Dell A, Marth JD, Taniguchi N
  Title
Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.
  Journal
Glycobiology 20:485-97 (2010)
DOI:10.1093/glycob/cwp200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.145
IUBMB Enzyme Nomenclature: 2.4.1.145
ExPASy - ENZYME nomenclature database: 2.4.1.145
BRENDA, the Enzyme Database: 2.4.1.145
CAS: 86498-16-0

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