KEGG   ENZYME: 2.4.1.152Help
Entry
EC 2.4.1.152                Enzyme                                 

Name
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase;
Lewis-negative alpha-3-fucosyltransferase;
plasma alpha-3-fucosyltransferase;
guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase;
galactoside 3-fucosyltransferase;
GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase;
GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase
Reaction(IUBMB)
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R [RN:R03519]
Reaction(KEGG)
R03519 > R05904(G) R06025(G) R06038(G) R06039(G);
(other) R06075(G) R06076(G) R06095(G)
Show
Substrate
GDP-beta-L-fucose [CPD:C00325];
(1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
Product
GDP [CPD:C00035];
(1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R
Comment
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
History
EC 2.4.1.152 created 1984, modified 2002
Pathway
ec00515  Mannose type O-glycan biosynthesis
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K03663  4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase
K20151  alpha(1,3/1,4) fucosyltransferase
Genes
HSA: 10690(FUT9)
PTR: 449500(FUT9)
PPS: 100995687(FUT9)
GGO: 101149404(FUT9)
PON: 100452333(FUT9)
NLE: 100598858(FUT9)
MCC: 708361(FUT9)
MCF: 102130080(FUT9)
CSAB: 103240132(FUT9)
RRO: 104659030(FUT9)
RBB: 108538590(FUT9)
CJC: 100405706(FUT9)
SBQ: 101042637(FUT9)
MMU: 14348(Fut9)
RNO: 84597(Fut9)
CGE: 100689036(Fut9)
NGI: 103739272(Fut9)
HGL: 101722848(Fut9)
CCAN: 109692033(Fut9)
OCU: 103349852(FUT9)
TUP: 102469465(FUT9)
CFA: 449027(FUT9)
AML: 100482132(FUT9)
UMR: 103675890(FUT9)
ORO: 101373062(FUT9)
FCA: 101080384(FUT9)
PTG: 102953801(FUT9)
AJU: 106980088(FUT9)
BTA: 282853(FUT9)
BOM: 102265797(FUT9)
BIU: 109563638(FUT9)
PHD: 102325045(FUT9)
CHX: 102190604(FUT9)
OAS: 106990120(FUT9)
SSC: 102160171(FUT9)
CFR: 102504781(FUT9)
CDK: 105092259(FUT9)
BACU: 103013395(FUT9)
LVE: 103076056(FUT9)
OOR: 101282525(FUT9)
ECB: 100071396(FUT9)
EPZ: 103548330(FUT9)
EAI: 106832465(FUT9)
MYB: 102244048(FUT9)
MYD: 102761474(FUT9)
HAI: 109373534(FUT9)
RSS: 109453596(FUT9)
PALE: 102880999(FUT9)
LAV: 100666316(FUT9)
TMU: 101343680
MDO: 100020278(FUT9)
SHR: 100925710(FUT9)
OAA: 100075626(FUT9)
GGA: 771133(FUT9)
MGP: 100538515(FUT9)
CJO: 107311931(FUT9)
APLA: 101799797(FUT9)
ACYG: 106035417(FUT9)
TGU: 100230065(FUT9)
GFR: 102034715(FUT9)
FAB: 101814999(FUT9)
PHI: 102108313(FUT9)
PMAJ: 107202583(FUT9)
CCAE: 111925714(FUT9)
CCW: 104692122(FUT9)
FPG: 101916872(FUT9)
FCH: 102057900(FUT9)
CLV: 102090826(FUT9)
EGZ: 104135407(FUT9)
AAM: 106489650(FUT9)
ASN: 102381575(FUT9)
AMJ: 102560865(FUT9)
PSS: 102445061(FUT9)
CMY: 102943905(FUT9)
CPIC: 101939838(FUT9)
ACS: 100565195(fut9)
PVT: 110074019(FUT9)
PBI: 103053931
GJA: 107121221(FUT9)
XLA: 100337597(fut9.S) 108716340(fut9.L)
XTR: 548391(fut9)
NPR: 108788910(FUT9)
DRE: 796410(fut9a)
TRU: 101073723 101074839 445968(fut9b) 445969(fut9c) 446062(fut9a)
MZE: 101475990
OLA: 100302422(fut9a) 100302423(fut9b) 100302424(fut9c)
NFU: 107392154 107392156(fut9)
KMR: 108233304 108237367(fut9)
HCQ: 109517458(fut9)
MALB: 109968070(fut9)
LCM: 102347013(FUT9)
CIN: 100183411
BPSI: IX83_03990
HPJ: jhp_0596(fucT) jhp_1002(fucU)
HPB: HELPY_0720(futB) HELPY_1046(futA)
HPL: HPB8_427(fucT1) HPB8_428(fucT3) HPB8_853(fucT5) HPB8_854(fucT7)
HPI: hp908_0664(fucT) hp908_1067(fucU)
HPQ: hp2017_0641(fucT)
HPW: hp2018_0642(fucT)
HEF: HPF16_0660(fucT) HPF16_1018(fucT)
HPF: HPF30_0312(fucT) HPF30_0677(fucT)
HEQ: HPF32_0329(fucT) HPF32_0668(fucT)
HEX: HPF57_0674(fucT) HPF57_1038(fucT)
HPD: KHP_0670(fucTa) KHP_0977(fucTb)
HPYI: K750_05570
HAC: Hac_1063(fuc)
MAGX: XM1_1803
MAGN: WV31_16795
AGL: PYTT_1437
 » show all
Taxonomy
Reference
1  [PMID:7295318]
  Authors
Johnson PH, Yates AD, Watkins WM.
  Title
Human salivary fucosyltransferases : evidence for two distinct alpha-3-L-fucosyltransferase activities one or which is associated with the Lewis blood group Le gene.
  Journal
Biochem Biophys Res Commun 100:1611-8 (1981)
DOI:10.1016/0006-291X(81)90703-8
Reference
2  [PMID:6366476]
  Authors
Schachter H, Narasimhan S, Gleeson P, Vella G.
  Title
Glycosyltransferases involved in elongation of N-glycosidically linked oligosaccharides of the complex or N-acetyllactosamine type.
  Journal
Methods Enzymol 98:98-134 (1983)
Reference
3  [PMID:12676935]
  Authors
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE.
  Title
C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer.
  Journal
J Biol Chem 278:21893-900 (2003)
DOI:10.1074/jbc.M301704200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.152
IUBMB Enzyme Nomenclature: 2.4.1.152
ExPASy - ENZYME nomenclature database: 2.4.1.152
BRENDA, the Enzyme Database: 2.4.1.152
CAS: 39279-34-0

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