KEGG   ENZYME: 2.4.1.17Help
Entry
EC 2.4.1.17                 Enzyme                                 

Name
glucuronosyltransferase;
1-naphthol glucuronyltransferase;
1-naphthol-UDP-glucuronosyltransferase;
17beta-hydroxysteroid UDP-glucuronosyltransferase;
3alpha-hydroxysteroid UDP-glucuronosyltransferase;
4-hydroxybiphenyl UDP-glucuronosyltransferase;
4-methylumbelliferone UDP-glucuronosyltransferase;
4-nitrophenol UDP-glucuronyltransferase;
4-nitrophenol UDPGT;
17-OH steroid UDPGT;
3-OH androgenic UDPGT;
bilirubin uridine diphosphoglucuronyltransferase;
bilirubin UDP-glucuronosyltransferase;
bilirubin monoglucuronide glucuronyltransferase;
bilirubin UDPGT;
bilirubin glucuronyltransferase;
ciramadol UDP-glucuronyltransferase;
estriol UDP-glucuronosyltransferase;
estrone UDP-glucuronosyltransferase;
uridine diphosphoglucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase;
uridine diphosphoglucuronate-bilirubin glucuronosyltransferase;
uridine diphosphoglucuronate-estriol glucuronosyltransferase;
uridine diphosphoglucuronate-estradiol glucuronosyltransferase;
uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase;
uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase;
uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase;
GT;
morphine glucuronyltransferase;
p-hydroxybiphenyl UDP glucuronyltransferase;
p-nitrophenol UDP-glucuronosyltransferase;
p-nitrophenol UDP-glucuronyltransferase;
p-nitrophenylglucuronosyltransferase;
p-phenylphenol glucuronyltransferase;
phenyl-UDP-glucuronosyltransferase;
PNP-UDPGT;
UDP glucuronate-estradiol-glucuronosyltransferase;
UDP glucuronosyltransferase;
UDP glucuronate-estriol glucuronosyltransferase;
UDP glucuronic acid transferase;
UDP glucuronyltransferase;
UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase;
UDP-glucuronate-bilirubin glucuronyltransferase;
UDP-glucuronosyltransferase;
UDP-glucuronyltransferase;
UDPGA transferase;
UDPGA-glucuronyltransferase;
UDPGT;
uridine diphosphoglucuronyltransferase;
uridine diphosphate glucuronyltransferase;
uridine 5'-diphosphoglucuronyltransferase;
UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific; configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside [RN:R09428]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucuronate [CPD:C00167];
acceptor [CPD:C19645]
Product
UDP [CPD:C00015];
acceptor beta-D-glucuronoside [CPD:C19646]
Comment
This entry denotes a family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines and fatty acids. Some of the activities catalysed were previously listed separately as EC 2.4.1.42, EC 2.4.1.59, EC 2.4.1.61, EC 2.4.1.76, EC 2.4.1.77, EC 2.4.1.84, EC 2.4.1.107 and EC 2.4.1.108. A temporary nomenclature for the various forms, whose delineation is in a state of flux, is suggested in Ref. 1.
History
EC 2.4.1.17 created 1961 (EC 2.4.1.42, EC 2.4.1.59 and EC 2.4.1.61 all created 1972, EC 2.4.1.76, EC 2.4.1.77 and EC 2.4.1.84 all created 1976, EC 2.4.1.107 and EC 2.4.1.108 both created 1983, all incorporated 1984)
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec00140  Steroid hormone biosynthesis
ec00830  Retinol metabolism
ec00860  Porphyrin and chlorophyll metabolism
ec00980  Metabolism of xenobiotics by cytochrome P450
ec00982  Drug metabolism - cytochrome P450
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00699  glucuronosyltransferase
Genes
HSA: 10720(UGT2B11) 10941(UGT2A1) 54490(UGT2B28) 54575(UGT1A10) 54576(UGT1A8) 54577(UGT1A7) 54578(UGT1A6) 54579(UGT1A5) 54600(UGT1A9) 54657(UGT1A4) 54658(UGT1A1) 54659(UGT1A3) 574537(UGT2A2) 7363(UGT2B4) 7364(UGT2B7) 7365(UGT2B10) 7366(UGT2B15) 7367(UGT2B17) 79799(UGT2A3)
PTR: 100611992 107973969 461285(UGT2B4) 461287 461289 471217 471218(UGT2B7) 471219 471220(UGT2A3) 742890(UGT2A2) 743607
PPS: 100973813(UGT2A1) 100974381(UGT2B17) 100974387(UGT2B4) 100974709 100975382 100975751(UGT1A1) 100976704(UGT2B7) 100977043 100977378 100978938 100980327 100980995 100984166(UGT2B15) 100985173 103784396
GGO: 101133016 101133387 101135156(UGT2B7) 101135980 101139531 101140249(UGT2A3) 101140616 101141374(UGT2B4) 101141727 101146584(UGT1A1) 109025837
PON: 100171521(UGT2B7) 100172533(UGT1A3) 100174202(UGT2A3) 100441531 100444573 100445423 100446313 100446928(UGT2B4) 100447782(UGT2A1) 100460599(UGT2B17) 100461334
NLE: 100591991(UGT2B15) 100592283(UGT1A7) 100595401(UGT2B17) 100595736(UGT2B10) 100596311(UGT2A3) 100596642(UGT2B7) 100597206(UGT2B28) 100598804(UGT2B4) 100599361 100599929(UGT2A1) 105738256
MCC: 100427327 574147(UGT2B33) 574210(UGT1A1) 613249(UGT2B9*2) 709132(UGT2B4) 709234(UGT2B4) 709420(UGT2A3) 710412(UGT2B15) 720405(UGT2A1)
MCF: 102118731 102121904(UGT2A1) 102122035(UGT1A1) 102123935(UGT2B19) 102124844(UGT2A3) 102125239(UGT2B23) 102126139(mfUGT2B33) 102127013(UGT2B18) 102127692(UGT2B30) 102127901(UGT2B9) 102128580(UGT2B20)
CSAB: 103218110 103218113 103235585 103235588 103235590 103235708 103235720 103235724 103247815
RRO: 104663543 104664126 104664128 104664129 104666351 104666426 104667779 104667780 104667781 104668690(UGT2A1)
CJC: 100388812(UGT2A3) 100391186 100405984(UGT1A1) 100409222(UGT2A2) 100412562(UGT2B7) 100413404 100414245(UGT2B4) 103792017
MMU: 100559(Ugt2b38) 100727(Ugt2b34) 112417(Ugt2b37) 22236(Ugt1a2) 22238(Ugt2b5) 231396(Ugt2b36) 243085(Ugt2b35) 394430(Ugt1a10) 394432(Ugt1a7c) 394433(Ugt1a5) 394434(Ugt1a9) 394435(Ugt1a6b) 394436(Ugt1a1) 552899(Ugt2a2) 71773(Ugt2b1) 72094(Ugt2a3) 94215(Ugt2a1) 94284(Ugt1a6a)
RNO: 113992(Ugt1a6) 154516(Ugt1a7c) 24861(Ugt1a1) 24862(Ugt2b) 266685(Ugt2b17) 286954(Ugt2b1) 286989(Ugt2b7) 289533(Ugt2a3) 29623(Ugt2b37) 301595(Ugt1a8) 305264(Ugt2b10) 396527(Ugt1a2) 396551(Ugt1a3) 396552(Ugt1a9) 501907(RGD1559459) 574523(Ugt1a5) 63867(Ugt2a1) 83808(Ugt2b35)
FCA: 101087059 101087662 493955(UGT1A1)
PTG: 102959578(UGT1A1) 102967993 102968284(UGT2A1)
BACU: 103008324(UGT2B4) 103008900 103009971(UGT2A3) 103011957(UGT1A3)
LVE: 103071327 103078119(UGT1A1) 103078627 103081112(UGT2B4)
MDO: 100010818(UGT2A1) 100025642
OAA: 100079726 100081856(UGT2A1)
GGA: 422660(UGT2A1) 424028(UGT1A1)
APLA: 101796668(UGT2A1) 101802378
TGU: 100226418(UGT2B17) 100229734(UGT1A1)
FPG: 101913401 101923845(UGT1A1) 101924619(UGT2A1)
FCH: 102049059 102058629(UGT2A1)
AMJ: 102558477(UGT1A1) 102568629(UGT2A3)
PBI: 103057215(UGT2A2) 103068173
XLA: 100037183(ugt1a6.S) 108701409(ugt1a1.L) 108711396
XTR: 100135191(ugt1a6) 100489505(ugt1a1) 101731695 447975(ugt2a1)
DRE: 100006320(ugt2a1) 406731(ugt1ab) 553952(ugt2a2) 570913(ugt5g1) 641488(ugt1a1)
DME: Dmel_CG10178(CG10178) Dmel_CG11012(Ugt37a1) Dmel_CG11289(CG11289) Dmel_CG13270(Ugt36Ba) Dmel_CG13271 Dmel_CG15661(CG15661) Dmel_CG15902 Dmel_CG17200 Dmel_CG17322(CG17322) Dmel_CG17323(CG17323) Dmel_CG17324(CG17324) Dmel_CG17932(Ugt36Bc) Dmel_CG2788(Dot) Dmel_CG31002(CG31002) Dmel_CG3797(CG3797) Dmel_CG4302(CG4302) Dmel_CG4414(Ugt58Fa) Dmel_CG4772(Ugt86Dh) Dmel_CG5724(CG5724) Dmel_CG5999(CG5999) Dmel_CG6475(CG6475) Dmel_CG6633 Dmel_CG6644(Ugt35a) Dmel_CG6649(Ugt35b) Dmel_CG6653 Dmel_CG6658(Ugt86Di) Dmel_CG8652(Ugt37c1) Dmel_CG9481(Ugt37b1)
DSI: Dsimw501_GD12034(Dsim_GD12034) Dsimw501_GD12307(Dsim_GD12307) Dsimw501_GD16447(Dsim_GD16447) Dsimw501_GD18734(Dsim_GD18734) Dsimw501_GD18859(Dsim_GD18859) Dsimw501_GD19978(Dsim_GD19978) Dsimw501_GD20543(Dsim_GD20543) Dsimw501_GD20680(Dsim_GD20680) Dsimw501_GD20681(Dsim_GD20681) Dsimw501_GD20682(Dsim_GD20682) Dsimw501_GD20683(Dsim_GD20683) Dsimw501_GD20684(Dsim_GD20684) Dsimw501_GD20686(Dsim_GD20686) Dsimw501_GD21706(Dsim_GD21706) Dsimw501_GD23245(Dsim_GD23245) Dsimw501_GD23396(Dsim_GD23396) Dsimw501_GD23454(Dsim_GD23454) Dsimw501_GD24083(Dsim_GD24083) Dsimw501_GD24084(Dsim_GD24084) Dsimw501_GD24158(Dsim_GD24158) Dsimw501_GD24159(Dsim_GD24159) Dsimw501_GD24160(Dsim_GD24160) Dsimw501_GD25117(Dsim_GD25117) Dsimw501_GD25217(Dsim_GD25217) Dsimw501_GD25218(Dsim_GD25218) Dsimw501_GD25513(Dsim_GD25513) Dsimw501_GD27744(Dsim_GD27744) Dsimw501_GD29191(Dsim_GD29191)
BMOR: 100174975(Ugt2) 100216349(Ugt) 100313492(Ugt3) 100500754(UGT10286) 100500755(UGT10287A) 100500757(UGT10289B) 100500758(UGT10100) 100500763(UGT10288) 100862802(UGT33D2) 100862803(UGT33D3) 100862804(UGT33D6) 100862805(UGT33K1) 100862806(UGT33N1) 100862807(UGT33Q1) 100862808(UGT33R1) 100862809(UGT340C1) 100862810(UGT340C2) 100862811(UGT39C1) 100862812(UGT40B1) 100862815(UGT41A2) 100862816(UGT41A3) 100862817(UGT42A1) 100862818(UGT42A2) 100862819(UGT43B1) 100862820(UGT44A1) 100862821(UGT46A2) 100862822(UGT46C2) 100862823(UGT47A1) 100862828(UGT013830) 100862830(UGT39B1) 100862832(UGT46A1) 100862841(UGT33D7) 100862842(UGT33R2) 100862843(UGT41A1) 100862845(UGT33D5) 101739741(UGT42B1) 692593(UGT40A1) 732962(UGT33D4)
CEL: CELE_B0310.5(ugt-46) CELE_C17G1.3(ugt-23) CELE_C18C4.3(ugt-48) CELE_C44H9.1(ugt-15) CELE_F35H8.6(ugt-58) CELE_F39G3.1(ugt-61) CELE_M88.1(ugt-62) CELE_T04H1.7(ugt-55) CELE_T04H1.8(ugt-56) CELE_T07C5.1(ugt-50) CELE_ZC443.5(ugt-18) CELE_ZC455.4(ugt-6)
CBR: CBG00090(Cbr-ugt-50) CBG00954(Cbr-ugt-58) CBG01959(Cbr-ugt-23) CBG09373(Cbr-ugt-48) CBG17190(Cbr-ugt-46) CBG17629(Cbr-ugt-54) CBG18047(Cbr-ugt-62) CBG23424(Cbr-ugt-56) CBG24724
BMY: Bm1_13480
GMX: 100798391
VRA: 106778516
SLY: 101262190
SPEN: 107013955
DCR: 108226135
SMIN: v1.2.023601.t1(symbB.v1.2.023601.t1)
TCR: 510761.76
 » show all
Taxonomy
Reference
1  [PMID:6404284]
  Authors
Bock KW, Burchell B, Dutton GJ, Hanninen O, Mulder GJ, Owens IS, Siest G, Tephly TR.
  Title
UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions.
  Journal
Biochem Pharmacol 32:953-5 (1983)
DOI:10.1016/0006-2952(83)90610-X
Reference
2  [PMID:111930]
  Authors
Bock KW, Josting D, Lilienblum W, Pfeil H.
  Title
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital.
  Journal
Eur J Biochem 98:19-26 (1979)
DOI:10.1111/j.1432-1033.1979.tb13155.x
Reference
3
  Authors
Burchell, B.
  Title
Identification and purification of multiple forms of UDP-glucuronosyltransferase.
  Journal
Rev Biochem Toxicol 3:1-32 (1981)
Reference
4
  Authors
Dutton, G.J.
  Title
Glucuronidation of Drugs and Other Compounds, C.R.C. Press, Boca Raton, Florida, 1980.
Reference
5  [PMID:3931633]
  Authors
Green MD, Falany CN, Kirkpatrick RB, Tephly TR.
  Title
Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.
  Journal
Biochem J 230:403-9 (1985)
Reference
6
  Authors
Jansen, P.L.M.
  Title
The enzyme-catalyzed formation of bilirubin diglucuronide by a solublized preparation from cat liver microsomes.
  Journal
Biochim Biophys Acta 338:170-182 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.17
IUBMB Enzyme Nomenclature: 2.4.1.17
ExPASy - ENZYME nomenclature database: 2.4.1.17
BRENDA, the Enzyme Database: 2.4.1.17
CAS: 9030-08-4

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