KEGG   ENZYME: 2.4.1.187Help
Entry
EC 2.4.1.187                Enzyme                                 

Name
N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase;
uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase;
N-acetylmannosaminyltransferase;
UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase;
UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase;
UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol 4-beta-N-acetylmannosaminyltransferase;
tagA (gene name);
tarA (gene name);
UDP-N-acetyl-alpha-D-mannosamine:N-acetyl-beta-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol 4-beta-N-acetylmannosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-mannosamine:N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol 4-beta-N-acetylmannosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-mannosamine + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R05566 R06129]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-mannosamine [CPD:C01170];
N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C01289]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C04881]
Comment
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.
History
EC 2.4.1.187 created 1992, modified 2016
Orthology
K05946  N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase
Genes
XAC: XAC0046(rffM)
XCI: XCAW_00431(wecG)
XCT: J151_00158
XCJ: J158_00156
XCU: J159_00156
XCN: J169_00154
XCW: J162_00155
XCR: J163_00155
XCM: J164_00155
XCF: J172_00149
PSUW: WQ53_08555
VCH: VC0927
VCS: MS6_0725
VCE: Vch1786_I0433(cpsF)
VCI: O3Y_04310
VCO: VC0395_A0452(cpsF)
VCR: VC395_0943(cpsF)
VCM: VCM66_0884(cpsF)
VAN: VAA_01118
PMK: MDS_1409
PSOS: POS17_0810(rffM)
PSET: THL1_797
PSM: PSM_A1279
PART: PARC_a2396(tagA)
PTD: PTET_a1469(tagA)
PIN: Ping_0436
MVS: MVIS_1952
SAGA: M5M_13280
MICC: AUP74_01799(tagA)
MEJ: Q7A_1441
TIG: THII_0639
NHL: Nhal_3315
GAI: IMCC3135_12280(tagA)
SVA: SVA_1475
ENM: EBS_0659(tagA)
LHK: LHK_00833
BCEO: I35_4288
BLAT: WK25_21670
BFN: OI25_4553
BHZ: ACR54_01657(tagA)
BTRM: SAMEA390648702448(tagA)
ODI: ODI_R2603
AAA: Acav_1103
CBX: Cenrod_1356(rffM)
HAR: HEAR0725
MMS: mma_0643
HSE: Hsero_2000(epsP)
HRB: Hrubri_1887(epsP)
THI: THI_3763
RGE: RGE_10830
TCL: Tchl_0891
GEB: GM18_1587
DSF: UWK_01794
MXA: MXAN_7451
CCX: COCOR_08058(tarA)
SCL: sce6681
SAT: SYN_01098
SFD: USDA257_c10850(wecG)
RLE: pRL90144
RLG: Rleg_6229
SHZ: shn_24945
BRA: BRADO4814
BBT: BBta_1010
AOL: S58_28660
BRAD: BF49_2493
VGO: GJW-30_1_03003(wecG)
MEX: Mext_4132
MDI: METDI5126
MCH: Mchl_4500
MPO: Mpop_4614
MET: M446_3405
MOR: MOC_5960
META: Y590_20595
MAQU: Maq22A_c15270(wecG)
CCS: CCNA_00094(hfsJ)
CAK: Caul_4829
MALG: MALG_03437
HBA: Hbal_1784
ANH: A6F65_00834(tagA)
GDI: GDI2548(gumM)
GDJ: Gdia_0787
GXY: GLX_27820
GXL: H845_823
KEU: S101446_03150(tagA)
RRU: Rru_A1484
RRF: F11_07665
MAG: amb1439
TXI: TH3_04430
BSU: BSU35750(tagA)
BSR: I33_3704
BSL: A7A1_1145
BSH: BSU6051_35750(tagA)
BSUT: BSUB_03808(tagA)
BSUL: BSUA_03808(tagA)
BSUS: Q433_19585
BSS: BSUW23_17555(tarA)
BST: GYO_3930(tarA)
BSO: BSNT_10219(tagA)
BSQ: B657_35750(tagA)
BSX: C663_3466(tarA)
BLI: BL02432(tagA)
BLD: BLi03819(tagA)
BLH: BaLi_c38310(tagA)
BAY: RBAM_032880(tagA)
BAQ: BACAU_3318(tagA)
BYA: BANAU_3477(tagA)
BAMP: B938_16885
BAML: BAM5036_3212(tagA)
BAMA: RBAU_3428(tagA)
BAMN: BASU_3206(tagA)
BAMB: BAPNAU_3485(tagA)
BAMT: AJ82_18565
BAMY: V529_35560(tagA)
BMP: NG74_03464(tagA)
BAO: BAMF_3414(tagA)
BAZ: BAMTA208_18090(tagA)
BQL: LL3_03709(tagA)
BXH: BAXH7_03698(tagA)
BQY: MUS_3916(tagA)
BAMI: KSO_002630
BAMC: U471_34150
BAMF: U722_17630
BAN: BA_5669
BAR: GBAA_5669
BAT: BAS5272
BCE: BC5419
BCA: BCE_5548
BCQ: BCQ_2704 BCQ_5260(tarA)
BAL: BACI_c54140(tarA)
BTL: BALH_2572(tarA) BALH_4923(tarA)
BTM: MC28_4653
BTG: BTB_c29880(tarA1) BTB_c56190(tarA2)
BWW: bwei_4362
BMYO: BG05_590
BPU: BPUM_3231
BPUM: BW16_17245
BPUS: UP12_16735
BPF: BpOF4_05795(tagA)
BMQ: BMQ_1119(tagA) BMQ_5128(tagA)
BMD: BMD_5115(tagA)
BMEG: BG04_2121
BAG: Bcoa_0676
BCOA: BF29_3017
BJS: MY9_3627
BACW: QR42_16240
BACP: SB24_12255
BACB: OY17_00120
BACO: OXB_1481
BACY: QF06_16280
BACL: BS34A_38880(tagA)
BALM: BsLM_3591
BEO: BEH_23275
BGY: BGLY_4216
GTN: GTNG_3094
GEA: GARCT_03207(tagA)
AFL: Aflv_2655(tagA)
AXL: AXY_20200(tagA)
LSP: Bsph_1039
VPN: A21D_00858(tagA)
BSE: Bsel_3063
SAU: SA0592(tagA)
SAV: SAV0636(tagA)
SAW: SAHV_0633(tagA)
SAM: MW0598(tagA)
SAS: SAS0602
SAR: SAR0646(tagA)
SAC: SACOL0693(tagA)
SAX: USA300HOU_0656(tagA)
SAA: SAUSA300_0623(tagA)
SAE: NWMN_0606(tagA)
SAD: SAAV_0599(tagA)
SUE: SAOV_0671(tagA)
SUJ: SAA6159_00591(wecG)
SUK: SAA6008_00653(wecG)
SUC: ECTR2_588
SUZ: MS7_0687(tagA)
SUX: SAEMRSA15_05620(tagA)
SUW: SATW20_07110(tagA)
SUG: SAPIG0715
SUF: SARLGA251_05700(tagA)
SAUA: SAAG_01059
SAUE: RSAU_000592(tagA)
SAUS: SA40_0577(tagA)
SAUU: SA957_0592(tagA)
SAUG: SA268_0590(tagA)
SAUZ: SAZ172_0648(tagA)
SAUT: SAI1T1_2004900(wecG)
SAUJ: SAI2T2_1004920(wecG)
SAUK: SAI3T3_1004910(wecG)
SAUQ: SAI4T8_1004900(wecG)
SAUF: X998_0684
SAB: SAB0586(tagA)
SUY: SA2981_0612(tagA)
SAUB: C248_0718(tagA)
SAUM: BN843_6380
SAUC: CA347_650
SAUR: SABB_00684(tagA)
SAUI: AZ30_03335
SAUD: CH52_02580
SAMS: NI36_03185
SEP: SE0410
SER: SERP0295(tagA)
SEPP: SEB_00331
SEPS: DP17_1714
SHA: SH2260(tagA)
SHH: ShL2_02110(wecG)
SSP: SSP2083
SCA: SCA_0281(tagA)
SLN: SLUG_21650(tagA)
SDT: SPSE_2113(tagA)
SPAS: STP1_1722
SXO: SXYL_02213(tagA)
SHU: SHYC_10520(tagA)
SCAP: AYP1020_0003(tagA)
SSCH: LH95_10115
SSCZ: RN70_10850
SAGQ: EP23_11650
MCL: MCCL_0646(tagA)
LMO: lmo2521
LMOC: LMOSLCC5850_2525(tagA)
LMOE: BN418_2981
LMOB: BN419_2993
LMOD: LMON_2533
LMOW: AX10_06675
LMOQ: LM6179_1682(tarA)
LMOM: IJ09_12200
LMOG: BN389_24840(tarA)
LMP: MUO_12590
LMOL: LMOL312_2481(tagA)
LMOX: AX24_10545
LMQ: LMM7_2563(tagA)
LML: lmo4a_2523(tagA)
LMS: LMLG_1873
LMW: LMOSLCC2755_2527(tagA)
LMX: LMOSLCC2372_2584(tagA)
LMZ: LMOSLCC2482_2525(tagA)
LMON: LMOSLCC2376_2415(tagA)
LMOS: LMOSLCC7179_2433(tagA)
LMOO: LMOSLCC2378_2525(tagA)
LMOY: LMOSLCC2479_2584(tagA)
LMOT: LMOSLCC2540_2554(tagA)
LMOA: LMOATCC19117_2531(tagA)
LMOK: CQ02_12795
LIN: lin2665
LWE: lwe2469(tagA)
LSG: lse_2421(tagA)
LIV: LIV_2431
ESI: Exig_2890
EAN: Eab7_2701
BBE: BBR47_54210(tagA)
PPM: PPSC2_05825(tagA1) PPSC2_05935(wecG) PPSC2_23170(tagA3)
PPO: PPM_1097(tagA1) PPM_1121(wecG) PPM_4599(tagA3)
PMW: B2K_02030
PLV: ERIC2_c11610(tarA)
PSWU: SY83_10870
ASOC: CB4_00624(tagA)
AAC: Aaci_2575
AAD: TC41_2869(tagA)
BTS: Btus_3011
SIV: SSIL_3350(tagA)
JEO: JMA_29540
LLR: llh_0485
SPX: SPG_0319(cpsF)
SNT: SPT_0397
SND: MYY_0431
SPNN: T308_01760
SPV: SPH_0460
SCF: Spaf_2011(cpsFF)
SSR: SALIVB_1105(tagA)
STF: Ssal_01177(rffM)
LPL: lp_0564(tagA)
LPJ: JDM1_0461(tagA)
LPT: zj316_0709(tagA)
LPS: LPST_C0470(tagA)
LPZ: Lp16_0493
LJO: LJ_1737
LJF: FI9785_1523(tarA)
LJH: LJP_1486c
LAC: LBA0519(tagA)
LAD: LA14_0545
LAF: SD55_0542(tagA)
LSA: LCA_1571(tagA)
LSL: LSL_1262
LSI: HN6_01039
LSJ: LSJ_1243
LDB: Ldb0452
LBU: LBUL_0402
LDL: LBU_0372
LBR: LVIS_0542
LGA: LGAS_1531
LHE: lhv_0538
LHL: LBHH_1597
LHV: lhe_0535
LHH: LBH_0432
LHD: HUO_09430
LCR: LCRIS_00517(tagA)
LAM: LA2_02800
LBH: Lbuc_1495
LBN: LBUCD034_1551(tagA)
LKE: WANG_1149
LRM: LRC_03800
LAE: LBAT_1320
PPE: PEPE_1526
PPEN: T256_07540
PCE: PECL_317
EFA: EF1173
EFU: HMPREF0351_11961(wecB)
THL: TEH_16230(tagA) TEH_16350(tagA)
WKO: WKK_02760
CRN: CAR_c15750(tagA)
CML: BN424_20(tagA)
CARC: NY10_941
CPE: CPE1870
CPF: CPF_2125
CPR: CPR_0585(tagA_1) CPR_1839(tagA)
CTC: CTC_02252
CBO: CBO3092(tagA)
CBA: CLB_3121
CBH: CLC_2994
CBY: CLM_3498
CBL: CLK_2486
CBK: CLL_A2459
CBB: CLD_1448
CBI: CLJ_B3358
CBN: CbC4_1011
CBT: CLH_2227
CBF: CLI_3151
CBM: CBF_3140
CBE: Cbei_0985
CBZ: Cbs_0985
CKL: CKL_3160
CKR: CKR_2798
CSR: Cspa_c10700(tarA)
CPAS: Clopa_3029
CPAT: CLPA_c17140(tagA)
CPAE: CPAST_c17140(tagA)
CSB: CLSA_c12310(tagA)
CSQ: CSCA_4801
CLD: CLSPO_c27560(tarA) CLSPO_c31880(tagA)
CACE: CACET_c33140(tagA)
CTYK: CTK_C08800
AMT: Amet_4139
AOE: Clos_2269
ASF: SFBM_0923
CTH: Cthe_2701
HSC: HVS_14215(tagA)
CCE: Ccel_2921
CSS: Cst_c25080(tagA)
CSD: Clst_2401
CCEL: CCDG5_1026
BHU: bhn_I0495
CSO: CLS_25560
CPRO: CPRO_26240(tagA)
ERT: EUR_03310
ERA: ERE_22770
EAC: EAL2_c04040(tarA)
STH: STH138
SWO: Swol_2372
SLP: Slip_2273
DSY: DSY4885
DHD: Dhaf_4762
DRM: Dred_3113
DAE: Dtox_4123
PTH: PTH_2780(WecG)
DAU: Daud_2098
SGY: Sgly_3264
HMO: HM1_1123
EHL: EHLA_0602
OVA: OBV_21420
TMR: Tmar_0638
TTE: TTE2163(WecG)
TIT: Thit_1850
TKI: TKV_c18860(tagA)
TAE: TepiRe1_1800(tarA)
MTA: Moth_2365
ADG: Adeg_0101
TPZ: Tph_c28170(tarA)
CSC: Csac_1349
ATE: Athe_2062
TOC: Toce_1704
TTM: Tthe_0543
TSH: Tsac_1146
TACI: TDSAC_0288
PED: ING2D1G_0332(tagA)
CAD: Curi_c20770(tagA)
VPR: Vpar_1053
VRM: 44547418_01066(tagA)
MED: MELS_0022
SRI: SELR_20930(tagA)
MHG: MHY_23190
PUF: UFO1_2363
PFT: JBW_02255
AIN: Acin_1159
LPIL: LIP_2942
MSTE: MSTE_02558
RER: RER_13090
REY: O5Y_06210
RRT: 4535765_00197(tagA)
SLAU: SLA_0654
ARX: ARZXY2_1085(tagA) ARZXY2_524(rffM)
ACH: Achl_2349
DCO: SAMEA4475696_0962(tagA)
KFL: Kfla_2744
TCU: Tcur_1019
AMI: Amir_1752
SESP: BN6_25460
KAL: KALB_8421
ACAD: UA74_28765
AMS: AMIS_7300
ACTN: L083_1061
AFS: AFR_05165
SNA: Snas_1484
CWO: Cwoe_5504
ELE: Elen_2443
SYN: slr1118(rffM) slr1271(rffM)
SYZ: MYO_117150(rffM) MYO_1560(rffM)
SYY: SYNGTS_0056(rffM) SYNGTS_1697(rffM)
SYT: SYNGTI_0056(rffM) SYNGTI_1697(rffM)
SYS: SYNPCCN_0056(rffM) SYNPCCN_1696(rffM)
SYQ: SYNPCCP_0056(rffM) SYNPCCP_1696(rffM)
SYJ: D082_18190(rffM) D082_33480(rffM)
SYW: SYNW0242(rffM)
SYC: syc2435_c(rffM)
SYG: sync_0282(rffM)
SYP: SYNPCC7002_A1117(rffM)
CYA: CYA_0146
CYB: CYB_1888
SYNR: KR49_10145
SYND: KR52_01305
SYH: Syncc8109_0233(rffM)
TEL: tll0454
THN: NK55_02620(rffM-1) NK55_07105(rffM-2)
CYI: CBM981_2002(rffM)
LET: O77CONTIG1_00965(tagA_1) O77CONTIG1_01368(tagA_2) O77CONTIG1_02144(tagA_3)
HHG: XM38_001940(tarA_1) XM38_024020(wecG_1) XM38_048160(tarA_2)
PMT: PMT_1864
PMF: P9303_24921(rffM)
MAR: MAE_24220
MPK: VL20_4006
CYL: AA637_06570(tagA)
CYT: cce_0374(rffM)
TER: Tery_3422
GVI: gll0650
GLJ: GKIL_0451 GKIL_1279(rffM)
ANA: alr1705(rffM)
NAZ: Aazo_1204
NSP: BMF81_01139(tagA)
CEO: ETSB_0766(rffM)
RCA: Rcas_3785
CAU: Caur_2361
CAG: Cagg_3031
HAU: Haur_2744
TRO: trd_1541
STI: Sthe_1747
ATM: ANT_24600
CAP: CLDAP_26490(tagA)
DRA: DR_1645
DGE: Dgeo_1066
DGO: DGo_CA1420(wecG)
TRA: Trad_1378
TTH: TT_C0054
TTJ: TTHA0422
MRB: Mrub_2133
TTR: Tter_1397
PUV: PUV_04240
OBG: Verru16b_01670(tagA)
CAA: Caka_0405
AGL: PYTT_1548
RBA: RB1367
PIR: VN12_20530(tagA_2)
PLH: VT85_26035(tagA)
TTF: THTE_2838
PBU: L21SP3_00743(tagA)
PBP: STSP1_00214(tagA)
VBL: L21SP4_01789(tagA_1) L21SP4_02278(tagA_2)
TPW: TPANIC_0275(wecG)
TPU: TPADAL_0275(wecG)
TPO: TPAMA_0275(wecG)
TPC: TPECDC2_0275(wecG)
TPG: TPEGAU_0275(wecG)
TPM: TPESAMD_0275(wecG)
TPB: TPFB_0275(wecG)
TDE: TDE1876
TPL: TPCCA_0275(wecG)
TPED: TPE_1678
LIL: LA_1992(wecG)
LIE: LIF_A1609(wecG)
LIC: LIC_11914(wecG)
LIS: LIL_12035(wecG)
LBJ: LBJ_1525
LBL: LBL_1749
LBF: LBF_2861
LST: LSS_12392
BHY: BHWA1_02458(wecG)
BRM: Bmur_2361
BIP: Bint_0683(wecG)
ACA: ACP_3383
TAI: Taci_1005
TLI: Tlie_0904
FSC: FSU_1409
GBA: J421_0140
BFR: BF2926
BVU: BVU_3924
BXY: BXY_03160
BOA: Bovatus_00250(tagA_1)
PMUC: ING2E5A_2043(tagA1) ING2E5A_2832(tagA3)
PSAC: PSM36_1703
DORI: FH5T_18615
MBAS: ALGA_0491
RMR: Rmar_0895
SMIZ: 4412673_02150(tagA)
FAE: FAES_0810
HSW: Hsw_2797
MARM: YQ22_10310
CBAT: M666_03485
MPW: MPR_3637
CLI: Clim_1834
PPH: Ppha_1019
MRO: MROS_2060
TMA: TM0818
TMW: THMA_0838
TMQ: THMB_0838
TMX: THMC_0838
TPT: Tpet_0109
TRQ: TRQ2_0108
TNA: CTN_1758
TNP: Tnap_0109
TLE: Tlet_0730
TME: Tmel_1334
TAF: THA_1676
THER: Y592_07535
FNO: Fnod_1777
PMO: Pmob_1709
MARN: LN42_08155
DTN: DTL3_1451
KOL: Kole_2045
CEX: CSE_07560
DTU: Dtur_1407
NJA: NSJP_3450
IIS: EYM_00270
 » show all
Taxonomy
Reference
1  [PMID:2977387]
  Authors
Murazumi N, Kumita K, Araki Y, Ito E.
  Title
Partial purification and properties of UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase from Bacillus subtilis.
  Journal
J Biochem (Tokyo) 104:980-4 (1988)
  Sequence
[bsu:BSU35750]
Reference
2  [PMID:17163636]
  Authors
Ginsberg C, Zhang YH, Yuan Y, Walker S
  Title
In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis.
  Journal
ACS Chem Biol 1:25-8 (2006)
DOI:10.1021/cb0500041
  Sequence
[bsu:BSU35750]
Reference
3  [PMID:16953575]
  Authors
Zhang YH, Ginsberg C, Yuan Y, Walker S
  Title
Acceptor substrate selectivity and kinetic mechanism of Bacillus subtilis TagA.
  Journal
Biochemistry 45:10895-904 (2006)
DOI:10.1021/bi060872z
  Sequence
[bsu:BSU35750]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.187
IUBMB Enzyme Nomenclature: 2.4.1.187
ExPASy - ENZYME nomenclature database: 2.4.1.187
BRENDA, the Enzyme Database: 2.4.1.187
CAS: 118731-82-1

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