KEGG   ENZYME: 2.4.1.206
Entry
EC 2.4.1.206                Enzyme                                 

Name
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]
Reaction(KEGG)
R04493 R05971(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
History
EC 2.4.1.206 created 1992
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K03766  beta-1,3-N-acetylglucosaminyltransferase 5
Genes
HSA: 84002(B3GNT5)
PTR: 100614645 735383(B3GNT5)
PPS: 100978128(B3GNT5) 100983763
GGO: 101124127 101133247(B3GNT5)
PON: 100438226(B3GNT5) 112134936
NLE: 100600878(B3GNT5) 101176203
MCC: 701071 705694(B3GNT5)
MCF: 102119427(B3GNT5) 102129749
CSAB: 103219851 103221160(B3GNT5)
RRO: 104664648(B3GNT5) 115893932
RBB: 108521055(B3GNT5) 108537096
CJC: 100411350(B3GNT5)
SBQ: 101035254(B3GNT5)
MMU: 102637973(Gm34653) 108105(B3gnt5)
MCAL: 110290334 110311880(B3gnt5)
MPAH: 110317537 110329546(B3gnt5)
RNO: 103691796 116740(B3gnt5)
MUN: 110563756 110564996(B3gnt5)
CGE: 100757919(B3gnt5)
NGI: 103726553(B3gnt5) 103734546
HGL: 101723270(B3gnt5) 101724191
CCAN: 109692157 109700297(B3gnt5)
OCU: 100351198 100352940(B3GNT5)
TUP: 102489196(B3GNT5)
CFA: 102154559(B3GNT5)
VVP: 112926242(B3GNT5)
AML: 100477043(B3GNT5) 109489097
UMR: 103670496 103676097(B3GNT5)
UAH: 113254536(B3GNT5) 113266260
ORO: 101385310(B3GNT5)
FCA: 101090150 101096409(B3GNT5)
PTG: 102956905(B3GNT5) 102962691
PPAD: 109269820 109275199(B3GNT5)
AJU: 106967357(B3GNT5) 106986606
BTA: 101904668 767899(B3GNT5)
BOM: 102266810 102284217(B3GNT5)
BIU: 109557599(B3GNT5) 109563403
BBUB: 102402441(B3GNT5) 102410041
CHX: 102189161(B3GNT5)
OAS: 101103203(B3GNT5) 101116289
SSC: 397599(B3GNT5)
CFR: 102514403(B3GNT5) 116663373
CDK: 105085901(B3GNT5) 116152531
BACU: 103015740(B3GNT5)
LVE: 103079181(B3GNT5) 103089426
OOR: 101287888 101288601(B3GNT5)
DLE: 111173504(B3GNT5) 111176920
PCAD: 102979892(B3GNT5) 112065518
ECB: 100058694(B3GNT5) 102150744
EPZ: 103550475 103558196(B3GNT5)
EAI: 106824184 106834539(B3GNT5)
MYB: 102245471 102250884(B3GNT5)
MYD: 102755888 102773368(B3GNT5)
MNA: 107537617 107541112(B3GNT5)
HAI: 109385727 109396440(B3GNT5)
DRO: 112305059(B3GNT5) 112306510
PALE: 102885842 102892817(B3GNT5)
RAY: 107507023(B3GNT5) 107516299
MJV: 108397663(B3GNT5)
LAV: 100672153(B3GNT5)
MDO: 103100021(B3GNT5) 103100354
SHR: 100920203(B3GNT5) 100931269
PCW: 110204756(B3GNT5) 110211348
OAA: 100092498(B3GNT5) 100681736
GGA: 417126(B3GNTL) 424960(B3GNT5)
MGP: 100544407(B3GNT5) 104913693
CJO: 107318134(B3GNT5) 107321909
NMEL: 110397816(B3GNT5) 110406886
APLA: 101791474(B3GNT5) 101797442
ACYG: 106032048(B3GNT5) 106040692(B3GALT4)
TGU: 100224977(B3GNT5) 100226903
LSR: 110477686(B3GNT5) 110477709
SCAN: 103815322(B3GNT5) 103819117
GFR: 102033487(B3GNT5) 102039760(B3GALT4)
FAB: 101809205(B3GALT4) 101810058(B3GNT5)
PHI: 102108283 102111086(B3GNT5)
PMAJ: 107208796(B3GNT5) 107212218
CCAE: 111922636 111933377(B3GNT5)
CCW: 104687996(B3GNT5) 104688503
ETL: 114058488 114059482(B3GNT5)
FPG: 101912901(B3GALT4) 101915210(B3GNT5)
FCH: 102047405(B3GNT5) 102053017
CLV: 102087227(B3GNT5) 102092070
EGZ: 104123298(B3GNT5) 104135232(B3GALT4)
NNI: 104019580(B3GNT5) 104023306
ACUN: 113483221(B3GNT5) 113486465
PADL: 103914981(B3GNT5) 103915328(B3GALT4)
ASN: 102377236 102383416(B3GNT5)
AMJ: 102558092(B3GNTL2) 102563242(B3GNT5)
PSS: 102451657 102462329(B3GNT5)
CMY: 102930348 102930607(B3GNT5)
CPIC: 101944344(B3GNT5) 101946415
ACS: 100560177(b3gnt5) 103281681
PVT: 110086058(B3GNT5) 110087444
PBI: 103056995(B3GNT5) 103061410
PMUR: 107297713 107299948(B3GNT5)
TSR: 106553968 106555717(B3GNT5)
PMUA: 114589406 114598037(B3GNT5)
GJA: 107117663(B3GNT5) 107118787
XLA: 108698198 108700504 446540(b3gnt5.S) 496364(b3gnt5.L)
XTR: 100487553(b3gnt10) 394849(b3gnt5)
NPR: 108791305(B3GNT5) 108802047
DRE: 101883349 336526(b3gnt5a) 791470(b3gnt5b)
IPU: 100528972(b3g5a) 108267178(b3gnt5) 108278559
NCC: 104942412(b3gnt5) 104952880
OLA: 101162144 101164751(b3gnt5)
CVG: 107082590(b3gnt5) 107089760
HCQ: 109520510(b3gnt5)
LCM: 102353810(B3GALT4) 102365531 106702428(B3GNT5)
CMK: 103184652 103190749(b3galt4) 103190900(b3gnt5)
RTP: 109915865(b3gnt5) 109918071
AME: 724947
LHU: 105675448
MDL: 103569714
ATD: 109597558
BMAN: 114252194
PRAP: 111001359
API: 100162029
DNX: 107171251
AGS: 114127226
RMD: 113555874
FCD: 110852431
DPTE: 113794195
MYI: 110442288
OBI: 106878557
ADF: 107335889
PDAM: 113685965
SPIS: 111327675
HMG: 100199193
 » show all
Reference
1  [PMID:1825612]
  Authors
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.
  Title
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
  Journal
Biochim Biophys Acta 1081:253-61 (1991)
DOI:10.1016/0005-2760(91)90279-Q
Reference
2  [PMID:2960671]
  Authors
Holmes EH, Hakomori S, Ostrander GK.
  Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 262:15649-58 (1987)
Reference
3  [PMID:1901591]
  Authors
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
  Title
Glycosphingolipid glycosyltransferases in human fetal brain.
  Journal
J Neurochem 56:1461-5 (1991)
DOI:10.1111/j.1471-4159.1991.tb02038.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.206
IUBMB Enzyme Nomenclature: 2.4.1.206
ExPASy - ENZYME nomenclature database: 2.4.1.206
BRENDA, the Enzyme Database: 2.4.1.206
CAS: 83682-80-8

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