KEGG   ENZYME: 2.4.1.206
Entry
EC 2.4.1.206                Enzyme                                 
Name
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]
Reaction(KEGG)
R04493 R05971(G)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
History
EC 2.4.1.206 created 1992
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K03766  beta-1,3-N-acetylglucosaminyltransferase 5
Genes
HSA84002(B3GNT5)
PTR735383(B3GNT5)
PPS100978128(B3GNT5)
GGO101133247(B3GNT5)
PON100438226(B3GNT5)
NLE100600878(B3GNT5)
MCC705694(B3GNT5)
MCF102119427(B3GNT5)
CSAB103221160(B3GNT5)
CATY105598969(B3GNT5)
PANU103875470(B3GNT5)
TGE112619511(B3GNT5)
RRO104664648(B3GNT5)
RBB108521055(B3GNT5)
TFN117083796(B3GNT5)
PTEH111523207(B3GNT5)
CJC100411350(B3GNT5)
SBQ101035254(B3GNT5)
CSYR103273257(B3GNT5)
MMUR105855788(B3GNT5)
LCAT123630310(B3GNT5)
OGA100964619(B3GNT5)
MMU108105(B3gnt5)
MCAL110311880(B3gnt5)
MPAH110329546(B3gnt5)
RNO116740(B3gnt5)
MCOC116085708(B3gnt5)
MUN110564996(B3gnt5)
CGE100757919(B3gnt5)
MAUA101828920(B3gnt5)
PLEU114684261(B3gnt5)
MORG121465068(B3gnt5)
AAMP119825701(B3gnt5)
NGI103726553(B3gnt5)
HGL101723270(B3gnt5)
CPOC100721740(B3gnt5)
CCAN109700297(B3gnt5)
DORD105998376(B3gnt5)
DSP122125084(B3gnt5)
NCAR124992586
OCU100352940(B3GNT5)
OPI101531304(B3GNT5)
TUP102489196(B3GNT5)
CFA102154559(B3GNT5)
VVP112926242(B3GNT5)
VLG121477332(B3GNT5)
AML100477043(B3GNT5)
UMR103676097(B3GNT5)
UAH113254536(B3GNT5)
UAR123778960(B3GNT5)
ELK111151247
LLV125100933
MPUF101689863(B3GNT5)
ORO101385310(B3GNT5)
EJU114206948(B3GNT5)
ZCA113916714(B3GNT5)
MLX118006871(B3GNT5)
FCA101096409(B3GNT5)
PYU121034054(B3GNT5)
PBG122491684(B3GNT5)
PTG102956905(B3GNT5)
PPAD109275199(B3GNT5)
AJU106967357(B3GNT5)
HHV120238546(B3GNT5)
BTA767899(B3GNT5)
BOM102284217(B3GNT5)
BIU109557599(B3GNT5)
BBUB102402441(B3GNT5)
CHX102189161(B3GNT5)
OAS101103203(B3GNT5)
ODA120871781(B3GNT5)
CCAD122444883(B3GNT5)
SSC397599(B3GNT5)
CFR102514403(B3GNT5)
CBAI105063339(B3GNT5)
CDK105085901(B3GNT5)
VPC102545933(B3GNT5)
BACU103015740(B3GNT5)
LVE103079181(B3GNT5)
OOR101288601(B3GNT5)
DLE111173504(B3GNT5)
PCAD102979892(B3GNT5)
PSIU116752873(B3GNT5)
ECB100058694(B3GNT5)
EPZ103558196(B3GNT5)
EAI106834539(B3GNT5)
MYB102250884(B3GNT5)
MYD102773368(B3GNT5)
MMYO118676517(B3GNT5)
MLF102423549(B3GNT5)
MNA107541112(B3GNT5)
PKL118723208(B3GNT5)
HAI109396440(B3GNT5)
DRO112305059(B3GNT5)
SHON118974194(B3GNT5)
AJM119056467(B3GNT5)
PDIC114490514(B3GNT5)
PHAS123826778(B3GNT5)
MMF118617347(B3GNT5)
RFQ117031256(B3GNT5)
PALE102892817(B3GNT5)
PGIG120592877(B3GNT5)
PVP105307283(B3GNT5)
RAY107507023(B3GNT5)
MJV108397663(B3GNT5)
TOD119257330(B3GNT5)
SARA101547751(B3GNT5)
LAV100672153(B3GNT5)
TMU101342861
DNM101446264(B3GNT5)
MDO103100021(B3GNT5)
GAS123242843(B3GNT5)
SHR100920203(B3GNT5)
PCW110204756(B3GNT5)
OAA100092498(B3GNT5)
GGA424960(B3GNT5)
PCOC116235418(B3GNT5)
MGP100544407(B3GNT5)
CJO107318134(B3GNT5)
NMEL110397816(B3GNT5)
APLA101791474(B3GNT5)
ACYG106032048(B3GNT5)
AFUL116492581(B3GNT5)
TGU100224977(B3GNT5)
LSR110477686(B3GNT5)
SCAN103815322(B3GNT5)
PMOA120504286(B3GNT5)
OTC121336657(B3GNT5)
PRUF121353739(B3GNT5)
GFR102033487(B3GNT5)
FAB101810058(B3GNT5)
PHI102111086(B3GNT5)
PMAJ107208796(B3GNT5)
CCAE111933377(B3GNT5)
CCW104687996(B3GNT5)
ETL114059482(B3GNT5)
ZAB102074404(B3GNT5)
FPG101915210(B3GNT5)
FCH102047405(B3GNT5)
CLV102087227(B3GNT5)
EGZ104123298(B3GNT5)
NNI104019580(B3GNT5)
PLET104624532(B3GNT5)
ACUN113483221(B3GNT5)
TALA104359295(B3GNT5)
PADL103914981(B3GNT5)
ACHC115346758(B3GNT5)
AAM106482228(B3GNT5) 106490128
AROW112968548(B3GNT5)
NPD112952548(B3GNT5)
DNE112980139(B3GNT5)
ASN102383416(B3GNT5)
AMJ102563242(B3GNT5)
CPOO109308475(B3GNT5)
GGN109288030(B3GNT5)
PSS102462329(B3GNT5)
CMY102930607(B3GNT5)
CPIC101944344(B3GNT5)
TST117882665(B3GNT5)
CABI116838564(B3GNT5)
MRV120372157(B3GNT5)
ACS100560177(b3gnt5)
PVT110086058(B3GNT5)
SUND121925223(B3GNT5)
PBI103056995(B3GNT5)
PMUR107299948(B3GNT5)
TSR106555717(B3GNT5)
PGUT117678144(B3GNT5)
VKO123025603(B3GNT5)
PMUA114598037(B3GNT5)
ZVI118093490(B3GNT5)
GJA107117663(B3GNT5)
STOW125437770(B3GNT5)
XLA446540(b3gnt5.S) 496364(b3gnt5.L)
XTR394849(b3gnt5)
NPR108791305(B3GNT5)
RTEM120936798(B3GNT5)
BBUF120997929(B3GNT5)
BGAR122933656(B3GNT5)
DRE336526(b3gnt5a) 791470(b3gnt5b)
SRX107709072 107718888 107722519 107753797
SANH107656073 107656860 107674530 107681747
SGH107563744 107568627 107593139 107593805
CCAR109048047(b3gnt5) 109073985 109077565 109080378
CAUA113038448 113055021 113110956
PPRM120468908(b3gnt5a) 120471465(b3gnt5b)
MAMB125251550(b3gnt5b) 125256291(b3gnt5a)
IPU100528972(b3gnt5a) 108267178(b3gnt5b)
PHYP113532941 113540478
SMEO124386780(b3gnt5b) 124390966(b3gnt5a)
TFD113644057(b3gnt5b) 113657772(b3gnt5a)
AMEX103022371 103033521
EEE113568141 113570158
TRU101066739 101067076
TNGGSTEN00014965G001 GSTEN00038809G001
LCO104920550
NCC104942412(b3gnt5)
CGOB115007538 115022040
ELY117254260 117271590(b3gnt5b)
PLEP121951648(b3gnt5b) 121962675(b3gnt5a)
SLUC116046159(b3gnt5b)
ECRA117954072(b3gnt5b)
PFLV114565925(b3gnt5)
GAT120815575(b3gnt5b) 120823419(b3gnt5a)
PPUG119208572(b3gnt5b) 119216469
MSAM119901256 119902323(b3gnt5b)
CUD121512670(b3gnt5a) 121519697
ALAT119011858(b3gnt5b) 119028402(b3gnt5a)
MZE101475629(b3gnt5) 101479343
ONL100706077(b3gnt5) 102082918
OAU116309332 116320433(b3gnt5b)
OLA101164751(b3gnt5)
OML112147620
XMA102225193(b3gnt5) 102236464
XCO114146530 114150713
XHE116721599(b3gnt5) 116726057
PRET103464035 103479067(b3gnt5)
PFOR103132032 103139965(b3gnt5)
PLAI106940453 106961899(b3gnt5)
PMEI106908586 106920602(b3gnt5)
GAF122838839(b3gnt5a) 122840609
CVG107082590(b3gnt5)
CTUL119782555
GMU124870190(b3gnt5b) 124873601(b3gnt5a)
NFU107384478 107387353
KMR108238228(b3gnt5b) 108250604(b3gnt5a)
ALIM106517288 106530178
NWH119414521(b3gnt5b) 119430697
AOCE111581474(b3gnt5) 111588986
CSEM103396140 103399979
POV109625816 109639539
SSEN122765522 122781213(b3gnt5a)
HHIP117760676(b3gnt5a) 117778636
HSP118117812 118120602(b3gnt5a)
LCF108883761(b3gnt5) 108896980
SDU111228747(b3gnt5) 111231897
SLAL111661239 111662612
XGL120790841(b3gnt5a) 120798536(b3gnt5b)
HCQ109520510(b3gnt5)
BPEC110161218 110173517 110173522
MALB109951382 109951962
BSPL114845185(b3gnt5b) 114854589
SASA106568751 106584309 106598820(b3gnt5)
OTW112227140 112248383 112251035 112260200
OMY110509000 110521586 110524457 110530057
OGO123996930 124010129 124037789 124042082
ONE115101832 115108447 115114145 115145031
SALP111957280 111972226(b3gnt5) 111975851 111979664
SNH120052528 120054870 120055482
ELS105011704 105028915
SFM108921630 108937393
PKI111854663(b3gnt5) 111860520
AANG118226264 118229676
LOC102683403(b3gnt5)
PSPA121322922 121327006
ARUT117417154 117422989
LCM106702428(B3GNT5)
CMK103190900(b3gnt5a)
RTP109915865(b3gnt5)
BFO118432074
BBEL109461543
CIN104265549
SCLV120341604
OTU111415023 111419006
DMK116919378 116922449 116929466 116932905 116933809 116933909 116936133 123477442
RSAN119376234 119392791 119392862 119393728
RMP119162044
SDM118181413
BGT106054985 106068978
GAE121384290 121384451
PMAX117324988 117326304 117333008 117342140 117342628 117342690 117343021
OSN115224368
 » show all
Reference
1  [PMID:1825612]
  Authors
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.
  Title
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
  Journal
Biochim Biophys Acta 1081:253-61 (1991)
DOI:10.1016/0005-2760(91)90279-Q
Reference
2  [PMID:2960671]
  Authors
Holmes EH, Hakomori S, Ostrander GK.
  Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 262:15649-58 (1987)
Reference
3  [PMID:1901591]
  Authors
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
  Title
Glycosphingolipid glycosyltransferases in human fetal brain.
  Journal
J Neurochem 56:1461-5 (1991)
DOI:10.1111/j.1471-4159.1991.tb02038.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.206
IUBMB Enzyme Nomenclature: 2.4.1.206
ExPASy - ENZYME nomenclature database: 2.4.1.206
BRENDA, the Enzyme Database: 2.4.1.206
CAS: 83682-80-8

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