KEGG   ENZYME: 2.4.1.206Help
Entry
EC 2.4.1.206                Enzyme                                 

Name
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase;
LA2 synthase;
beta1->3-N-acetylglucosaminyltransferase;
uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase;
lactosylceramide beta-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-N-acetylglucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-N-acetylglucosaminyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04493 R05971]
Reaction(KEGG)
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
UDP [CPD:C00015];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
History
EC 2.4.1.206 created 1992
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K03766  beta-1,3-N-acetylglucosaminyltransferase 5
Genes
HSA: 84002(B3GNT5)
PTR: 100614645 735383(B3GNT5)
PPS: 100978128(B3GNT5) 100983763
GGO: 101124127 101133247(B3GNT5)
PON: 100438226(B3GNT5)
NLE: 100600878(B3GNT5) 101176203
MCC: 701071 705694(B3GNT5)
MCF: 102119427(B3GNT5) 102129749
CSAB: 103219851 103221160(B3GNT5)
RRO: 104664648(B3GNT5)
RBB: 108521055(B3GNT5) 108537096
CJC: 100411350(B3GNT5)
SBQ: 101035254(B3GNT5)
MMU: 102637973(Gm34653) 108105(B3gnt5)
RNO: 103691796 116740(B3gnt5)
CGE: 100757919(B3gnt5) 103158928
NGI: 103726553(B3gnt5) 103734546
HGL: 101723270(B3gnt5) 101724191
CCAN: 109692157 109700297(B3gnt5)
OCU: 100351198 100352940(B3GNT5)
TUP: 102489196(B3GNT5)
CFA: 102154559(B3GNT5)
AML: 100477043(B3GNT5) 109489097
UMR: 103670496 103676097(B3GNT5)
ORO: 101385310(B3GNT5)
FCA: 101090150 101096409(B3GNT5)
PTG: 102956905(B3GNT5) 102962691
AJU: 106967357(B3GNT5) 106986606
BTA: 101904668 767899(B3GNT5)
BOM: 102266810 102284217(B3GNT5)
BIU: 109557599(B3GNT5) 109563403
PHD: 102327597(B3GNT5)
CHX: 102189161(B3GNT5)
OAS: 101103203(B3GNT5) 101116289
SSC: 397599(B3GNT5)
CFR: 102514403(B3GNT5)
CDK: 105085901(B3GNT5)
BACU: 103015740(B3GNT5)
LVE: 103079181(B3GNT5) 103089426
OOR: 101287888 101288601(B3GNT5)
ECB: 100058694(B3GNT5) 102150744
EPZ: 103550475 103558196(B3GNT5)
EAI: 106824184 106834539(B3GNT5)
MYB: 102245471 102250884(B3GNT5)
MYD: 102755888 102773368(B3GNT5)
HAI: 109385727 109396440(B3GNT5)
RSS: 109447140 109449494(B3GNT5)
PALE: 102885842 102892817(B3GNT5)
LAV: 100672153(B3GNT5)
MDO: 103100021(B3GNT5) 103100354
SHR: 100920203(B3GNT5) 100931269
OAA: 100092498(B3GNT5) 100681736(B3GALT4)
GGA: 417126(B3GNTL) 424960(B3GNT5)
MGP: 100544407(B3GNT5) 104913693
CJO: 107318134(B3GNT5) 107321909
APLA: 101791474(B3GNT5) 101797442(B3GALT4)
ACYG: 106032048(B3GNT5) 106040692(B3GALT4)
TGU: 100224977(B3GNT5) 100226903
GFR: 102033487(B3GNT5) 102039760(B3GALT4)
FAB: 101809205(B3GALT4) 101810058(B3GNT5)
PHI: 102108283 102111086(B3GNT5)
PMAJ: 107208796(B3GNT5) 107212218
CCAE: 111922636 111933377(B3GNT5)
CCW: 104687996(B3GNT5) 104688503
FPG: 101912901(B3GALT4) 101915210(B3GNT5)
FCH: 102047405(B3GNT5) 102053017(B3GALT4)
CLV: 102087227(B3GNT5) 102092070
EGZ: 104123298(B3GNT5) 104135232(B3GALT4)
ASN: 102377236 102383416(B3GNT5)
AMJ: 102558092(B3GNTL2) 102563242(B3GNT5)
PSS: 102451657 102462329(B3GNT5)
CMY: 102930348 102930607(B3GNT5)
CPIC: 101944344(B3GNT5) 101946415
ACS: 100560177(b3gnt5) 103281681
PVT: 110086058(B3GNT5) 110087444
PBI: 103056995(B3GNT5) 103061410
GJA: 107117663(B3GNT5) 107118787
XLA: 108698198 108700504 446540(b3gnt5.S) 496364(b3gnt5.L)
XTR: 100487553 394849(b3gnt5)
NPR: 108791305(B3GNT5) 108802047
DRE: 101883349 336526(b3gnt5a) 791470(b3gnt5b)
IPU: 100528972(b3g5a) 108267178(b3gnt5) 108278559
LCO: 104920550(b3gnt5) 104924506
NCC: 104942412(b3gnt5) 104952880
OLA: 101162144 101164751(b3gnt5)
HCQ: 109520510(b3gnt5)
LCM: 102353810(B3GALT4) 102365531 106702428(B3GNT5)
CMK: 103184652 103190749(b3galt4) 103190900(b3gnt5)
DPA: 109533212
OBI: 106878557
LAK: 106156143
ADF: 107335889
 » show all
Taxonomy
Reference
1  [PMID:1825612]
  Authors
Gottfries J, Percy AK, Mansson JE, Fredman P, Wikstrand CJ, Friedman HS, Bigner DD, Svennerholm L.
  Title
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
  Journal
Biochim Biophys Acta 1081:253-61 (1991)
DOI:10.1016/0005-2760(91)90279-Q
Reference
2  [PMID:2960671]
  Authors
Holmes EH, Hakomori S, Ostrander GK.
  Title
Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed beta 1----3N-acetylglucosaminyltransferase.
  Journal
J Biol Chem 262:15649-58 (1987)
Reference
3  [PMID:1901591]
  Authors
Percy AK, Gottfries J, Vilbergsson G, Mansson JE, Svennerholm L.
  Title
Glycosphingolipid glycosyltransferases in human fetal brain.
  Journal
J Neurochem 56:1461-5 (1991)
DOI:10.1111/j.1471-4159.1991.tb02038.x
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.206
IUBMB Enzyme Nomenclature: 2.4.1.206
ExPASy - ENZYME nomenclature database: 2.4.1.206
BRENDA, the Enzyme Database: 2.4.1.206
CAS: 83682-80-8

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