KEGG   ENZYME: 2.4.1.221Help
Entry
EC 2.4.1.221                Enzyme                                 

Name
peptide-O-fucosyltransferase;
GDP-L-fucose:polypeptide fucosyltransferase;
GDP-fucose protein O-fucosyltransferase;
GDP-fucose:polypeptide fucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase
Reaction(IUBMB)
transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose to the serine hydroxy group of a protein acceptor [RN:R09295]
Reaction(KEGG)
R09295(G)
Show
Comment
Involved in the biosynthesis of O-fucosylated epidermal growth factor (EGF) and thrombospondin type 1 repeats. The attachment of O-linked fucose to serine or threonine occurs on EGF domains within the sequence Cys-Xaa-Xaa-Gly-Gly-Ser/Thr-Cys.
History
EC 2.4.1.221 created 2002
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K03691  peptide-O-fucosyltransferase
Genes
HSA: 23275(POFUT2) 23509(POFUT1)
PTR: 449504(POFUT1) 449505(POFUT2)
PPS: 100974304(POFUT1) 100982903(POFUT2)
GGO: 101147854(POFUT2) 101150837(POFUT1)
PON: 100294553(POFUT1) 100454664(POFUT2)
NLE: 100589538(POFUT1) 100590705(POFUT2)
MCC: 711966(POFUT1) 721991(POFUT2)
MCF: 101926410(POFUT1) 102145251(POFUT2)
CSAB: 103220130(POFUT2) 103248174(POFUT1)
RRO: 104653708(POFUT1) 104667612(POFUT2)
RBB: 108524134(POFUT1) 108539767(POFUT2)
CJC: 100394836(POFUT1) 100403771(POFUT2)
SBQ: 101034543(POFUT1) 101052736(POFUT2)
MMU: 140484(Pofut1) 80294(Pofut2)
RNO: 309686(Pofut2) 311551(Pofut1)
CGE: 100753417(Pofut1) 100765129(Pofut2)
NGI: 103731070(Pofut1) 103739954(Pofut2) 103740209
HGL: 101705482(Pofut2) 101707778(Pofut1)
CCAN: 109691759(Pofut1) 109694966(Pofut2)
OCU: 103346196(POFUT2) 108175392(POFUT1)
TUP: 102494095(POFUT1) 102497145(POFUT2)
CFA: 100855959(POFUT2) 609881(POFUT1)
AML: 100464828(POFUT2) 100475219(POFUT1)
UMR: 103674337(POFUT1) 103680737(POFUT2)
ORO: 101382752(POFUT2) 101384568(POFUT1)
FCA: 101086742(POFUT2) 101094335(POFUT1)
PTG: 102954403(POFUT1) 102972865(POFUT2)
AJU: 106974644(POFUT1) 106985668(POFUT2)
BTA: 360194(POFUT1) 404083(POFUT2)
BOM: 102273757(POFUT1) 102284798(POFUT2)
BIU: 109560734(POFUT2) 109567355(POFUT1)
PHD: 102334960(POFUT1) 102336641(POFUT2)
CHX: 102174438(POFUT2) 102185013(POFUT1)
OAS: 101104000(POFUT1) 101105718(POFUT2)
SSC: 100738385(POFUT2) 397627(POFUT1)
CFR: 102514788(POFUT1) 102517934(POFUT2)
BACU: 103011309(POFUT2) 103014718(POFUT1)
LVE: 103076939(POFUT1) 103085778(POFUT2)
OOR: 101270212(POFUT1) 101286585(POFUT2)
ECB: 100055890(POFUT2) 100068638(POFUT1)
EPZ: 103554276(POFUT1) 103565137(POFUT2)
EAI: 106833730(POFUT1) 106842979(POFUT2)
MYB: 102246188(POFUT1) 102252154(POFUT2)
MYD: 102763905(POFUT1) 102766539(POFUT2)
HAI: 109372103(POFUT2) 109384424(POFUT1)
RSS: 109436872(POFUT2) 109441338 109456279(POFUT1)
PALE: 102880623(POFUT2) 102890765(POFUT1)
LAV: 100659254(POFUT1) 100664414(POFUT2)
MDO: 100010283(POFUT1) 100017276(POFUT2)
SHR: 100913462(POFUT1) 100928136(POFUT2)
OAA: 100076963(POFUT2) 100088179(POFUT1)
GGA: 395070(POFUT1) 395112(POFUT2)
MGP: 100544049(POFUT1) 100547768(POFUT2)
CJO: 107316365(POFUT2) 107323075(POFUT1)
APLA: 101789419(POFUT2) 101794980(POFUT1)
ACYG: 106029351(POFUT2) 106047125(POFUT1)
TGU: 100219075(POFUT1) 100228829(POFUT2)
GFR: 102032527(POFUT2) 102038834(POFUT1)
FAB: 101806242(POFUT2) 101811220(POFUT1)
PHI: 102101164(POFUT1) 102106960(POFUT2)
PMAJ: 107207268(POFUT2) 107213290(POFUT1)
CCAE: 111931824(POFUT2) 111945082(POFUT1)
CCW: 104687842(POFUT1) 104694610(POFUT2)
FPG: 101911006(POFUT2) 101923244(POFUT1)
FCH: 102049839(POFUT1) 102058325(POFUT2)
CLV: 102089223(POFUT2) 102092521(POFUT1)
EGZ: 104125978(POFUT2) 104127624(POFUT1)
AAM: 106495242(POFUT2) 106497388(POFUT1)
ASN: 102373385(POFUT2) 102378150(POFUT1)
AMJ: 102573204(POFUT2) 102574857(POFUT1)
PSS: 102443515(POFUT1) 102455022(POFUT2)
CMY: 102940672(POFUT1) 102946661(POFUT2)
CPIC: 101939997(POFUT2) 101947437(POFUT1)
ACS: 100557912(pofut1) 100562354(pofut2)
PVT: 110086713(POFUT1) 110087483(POFUT2)
PBI: 103049826(POFUT2) 103056988(POFUT1)
GJA: 107117607(POFUT2) 107123014(POFUT1)
XLA: 108701431 108703041 398423(pofut1.L)
XTR: 496411(pofut1) 779585(pofut2)
NPR: 108786997(POFUT1) 108800907(POFUT2)
DRE: 403029(pofut1) 777668(pofut2)
IPU: 108267012(pofut2) 108276463(pofut1)
AMEX: 103028255(pofut2) 103035639(pofut1)
TRU: 445894(pofut2) 445971(pofut1)
LCO: 104928587(pofut2) 104933738(pofut1)
MZE: 101476334(pofut2) 101485169(pofut1)
OLA: 100125467(pofut1) 100125468(pofut2)
XMA: 102217431(pofut1) 102230718(pofut2)
PRET: 103461626(pofut2) 103466930(pofut1)
NFU: 107373963 107390151(pofut2) 107396519(pofut1)
KMR: 108240390(pofut2) 108250037(pofut1)
CSEM: 103384760(pofut1) 103392214(pofut2)
LCF: 108880458(pofut2) 108885091(pofut1)
SDU: 111218475(pofut2) 111236989(pofut1)
HCQ: 109514103(pofut1) 109531252(pofut2)
BPEC: 110156071(pofut2) 110164916(pofut1)
MALB: 109964368(pofut2) 109969994(pofut1)
ELS: 105023776(pofut1) 105029224(pofut2)
SFM: 108925598(pofut1) 108928892(pofut2)
LCM: 102348539(POFUT2) 102355355(POFUT1)
CMK: 103176848(pofut2)
CIN: 100181584 445727(fut13)
SPU: 578163 585387 589493(pofut1)
DME: Dmel_CG12366(O-fut1) Dmel_CG14789(O-fut2)
DPO: Dpse_GA11584(Dpse_O-fut1) Dpse_GA13247
DSI: Dsimw501_GD11022(Dsim_GD11022) Dsimw501_GD24636(Dsim_GD24636)
DYA: Dyak_GE13556(Dyak_O-fut1) Dyak_GE16526(Dyak_O-fut2)
AME: 551457
NVI: 100118147
BMOR: 692614(pofut1) 692681(pofut2)
TUT: 107363333
CEL: CELE_C15C7.7(C15C7.7) CELE_K10G9.3(pad-2)
CBR: CBG14147 CBG24618(Cbr-pad-2)
EGL: EGR_02572
CPAP: 110818367
CIT: 102617227
TCC: 18596324
CAM: 101496484
LJA: Lj6g3v1089070.1(Lj6g3v1089070.1)
FVE: 101299396
PPER: 18782455
PMUM: 103327543
PAVI: 110761675
ZJU: 107434277
RCU: 8273041
JCU: 105631313
POP: 7461959
VVI: 100254979
SOT: 102584575(fut13) 102602087
HAN: 110880311
LSV: 111915318
DCR: 108192920
BVG: 104899667
SOE: 110787192
NNU: 104609241
OSA: 4343677
DOSA: Os07t0572600-01(Os07g0572600)
OBR: 102711445
BDI: 100825796
ATS: 109752045
SBI: 8055669
ZMA: 100384812
SITA: 101783584
PEQ: 110031360
ATR: 18432553
SMO: SELMODRAFT_94197(GT68A1)
PPP: 112277890
PYO: PY17X_0813700(PY03133)
PCB: PCHAS_081070(PC000119.05.0)
CPV: cgd1_2440
SMIN: v1.2.005444.t1(symbB.v1.2.005444.t1) v1.2.010142.t1(symbB.v1.2.010142.t1)
 » show all
Taxonomy
Reference
1  [PMID:9525914]
  Authors
Wang Y, Spellman MW.
  Title
Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells.
  Journal
J Biol Chem 273:8112-8 (1998)
DOI:10.1074/jbc.273.14.8112
  Sequence
[cge:100753417]
Reference
2  [PMID:11524432]
  Authors
Wang Y, Shao L, Shi S, Harris RJ, Spellman MW, Stanley P, Haltiwanger RS.
  Title
Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
  Journal
J Biol Chem 276:40338-45 (2001)
DOI:10.1074/jbc.M107849200
  Sequence
[hsa:23509] [mmu:140484] [cel:CELE_C15C7.7] [dme:Dmel_CG12366]
Reference
3  [PMID:9023546]
  Authors
Wang Y, Lee GF, Kelley RF, Spellman MW.
  Title
Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains.
  Journal
Glycobiology 6:837-42 (1996)
DOI:10.1093/glycob/6.8.837
  Sequence
[rno:311551] [cge:100753417]
Reference
4  [PMID:11067851]
  Authors
Hofsteenge J, Huwiler KG, Macek B, Hess D, Lawler J, Mosher DF, Peter-Katalinic J.
  Title
C-mannosylation and O-fucosylation of the thrombospondin type 1 module.
  Journal
J Biol Chem 276:6485-98 (2001)
DOI:10.1074/jbc.M008073200
  Sequence
[hsa:23275]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.221
IUBMB Enzyme Nomenclature: 2.4.1.221
ExPASy - ENZYME nomenclature database: 2.4.1.221
BRENDA, the Enzyme Database: 2.4.1.221
CAS: 9033-08-3

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