KEGG   ENZYME: 2.4.1.222Help
Entry
EC 2.4.1.222                Enzyme                                 

Name
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase;
fringe (ambiguous)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor [RN:R09296]
Reaction(KEGG)
R09296(G)
Show
Comment
O-Fucosylpeptide 3-beta-N-acetylglucosaminyltransferases are the products of fringe genes. O-linked fucose is an unusual form of glycosylation where the fucose is attached directly to proteins through the hydroxy groups of Ser or Thr residues.
History
EC 2.4.1.222 created 2002
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K05948  fringe
Genes
HSA: 3955(LFNG) 4242(MFNG) 5986(RFNG)
PTR: 458811(MFNG) 472272(LFNG) 747153(RFNG)
PPS: 100977920(LFNG) 100980961(RFNG) 100995551(MFNG)
GGO: 101145692(LFNG) 101150690(RFNG) 101151337(MFNG)
PON: 100433262(MFNG) 100453406(RFNG) 100457821(LFNG)
NLE: 100590152(LFNG) 100599575(MFNG) 100603704(RFNG)
MCC: 100428736(LFNG) 699530(MFNG) 719330(RFNG)
MCF: 101865860 102122259(LFNG) 102132366(MFNG)
CSAB: 103223279(MFNG) 103243752(RFNG) 103246864(LFNG)
RRO: 104654981(RFNG) 104664990(LFNG) 104682508(MFNG)
RBB: 108512800(MFNG) 108534090(RFNG) 108543803(LFNG)
CJC: 100394244(RFNG) 100397083(MFNG) 100397710(LFNG)
SBQ: 101028632(MFNG) 101031267(RFNG) 101052656(LFNG)
MMU: 16848(Lfng) 17305(Mfng) 19719(Rfng)
MCAL: 110294717(Lfng) 110304960(Rfng) 110310660(Mfng)
MPAH: 110312801(Lfng) 110331255(Rfng) 110334897(Mfng)
RNO: 170905(Lfng) 315119(Mfng) 60433(Rfng)
MUN: 110548858(Rfng) 110554724(Lfng) 110558853(Mfng)
CGE: 100762397(Lfng) 100762875(Mfng) 100771257(Rfng)
NGI: 103730070(Rfng) 103748612(Mfng) 103748675(Lfng)
HGL: 101699763(Lfng) 101722987(Mfng) 101725480(Rfng)
CCAN: 109683509(Lfng) 109697229(Mfng) 109702741(Rfng)
OCU: 100355921(LFNG) 100357457(MFNG)
TUP: 102491172(LFNG) 102493487(RFNG) 102497808(MFNG)
CFA: 483376(RFNG) 489891(LFNG) 610303(MFNG)
VVP: 112920916(RFNG) 112929107(MFNG) 112929356(LFNG)
AML: 100468722(RFNG) 100470247(MFNG) 100479208(LFNG)
UMR: 103666011(RFNG) 103670070(LFNG) 103676401(MFNG)
UAH: 113241808(MFNG) 113244483(RFNG) 113247705(LFNG)
ORO: 101370080(LFNG) 101373562(RFNG) 101384739(MFNG)
FCA: 101080753(RFNG) 101092320(LFNG) 101097256(MFNG)
PTG: 102956076(RFNG) 102961069(MFNG) 102962200(LFNG)
PPAD: 109251132(LFNG) 109265536(MFNG) 109276754(RFNG)
AJU: 106984500(LFNG) 106986348(RFNG) 113602730(MFNG)
BTA: 505267(MFNG) 516209(LFNG) 532242(RFNG)
BOM: 102276513(MFNG) 102286691(RFNG) 102288229(LFNG)
BIU: 109559537(MFNG) 109573332(RFNG)
CHX: 102169449(LFNG) 102178013(RFNG) 102178708(MFNG)
OAS: 101103554(MFNG) 101106785(RFNG) 101112372(LFNG)
SSC: 100524978(LFNG) 102161832(MFNG) 110255925(RFNG)
CFR: 102506111 102506937(LFNG) 102509192(RFNG) 102518312(MFNG)
CDK: 105091974(MFNG) 105102217(RFNG) 105105769(LFNG) 105105996
BACU: 103005287(MFNG) 103009108(LFNG) 103019781(RFNG)
LVE: 103075553(MFNG) 103076301(RFNG) 103089921(LFNG)
OOR: 101270479(MFNG) 101278665(RFNG) 101282067(LFNG)
DLE: 111169357(LFNG) 111182674(RFNG) 111186217(MFNG)
PCAD: 102977711(RFNG) 102989837(MFNG) 102990636(LFNG)
ECB: 100057395(RFNG) 100069766(MFNG) 100147464(LFNG)
EPZ: 103551123(RFNG) 103566953(LFNG) 103567118(MFNG)
EAI: 106834776(LFNG) 106837591(MFNG) 106846141(RFNG)
MYB: 102238965(MFNG) 102261162(LFNG)
MYD: 102761145(RFNG) 102764930(LFNG) 102767457(MFNG)
MNA: 107537047(LFNG) 107539057(RFNG) 107545234(MFNG)
HAI: 109380238(LFNG) 109393064(RFNG) 109394533(MFNG)
DRO: 112298814(RFNG) 112319527(LFNG) 112321833(MFNG)
PALE: 102879652(RFNG) 102885010(MFNG) 102892443(LFNG)
RAY: 107519247(MFNG) 107520206(RFNG) 107521424(LFNG)
MJV: 108392670(MFNG) 108395246(RFNG) 108398746(LFNG)
LAV: 100655946(LFNG) 100669607(MFNG)
TMU: 101356202
MDO: 100012518(LFNG) 100025532(MFNG) 100029839(RFNG)
PCW: 110200103(LFNG) 110205752(MFNG) 110218311(RFNG)
OAA: 100078922(LFNG) 100088145(RFNG) 100093244(MFNG)
GGA: 395789(RFNG) 395790(LFNG) 418042(MFNG)
MGP: 100539077(MFNG) 100544514(RFNG) 100549739(LFNG)
CJO: 107313900(MFNG) 107320761(LFNG) 107322080(RFNG)
NMEL: 110393122(MFNG) 110405902(LFNG)
APLA: 101790022(MFNG) 101797427(LFNG) 101800803(RFNG)
ACYG: 106033576(LFNG) 106035911(MFNG) 106046760(RFNG)
TGU: 100218383(LFNG) 100232033(MFNG) 100232663(RFNG)
LSR: 110472408(RFNG) 110475488(LFNG) 110483830(MFNG)
SCAN: 103813595(MFNG) 103817861(LFNG) 103819909(RFNG)
GFR: 102032502(MFNG) 102045456(LFNG) 102045657(RFNG)
FAB: 101808008(MFNG) 101818865(LFNG) 101819642(RFNG)
PHI: 102103333(RFNG) 102104211(LFNG) 102107617(MFNG)
PMAJ: 107205151(MFNG) 107211349(LFNG) 107212318(RFNG)
CCAE: 111931257 111936281(LFNG) 111937595(RFNG)
CCW: 104685032(LFNG) 104696299(MFNG) 104698221(RFNG)
ETL: 114055408(MFNG) 114060198(LFNG) 114060327(RFNG)
FPG: 101914835(RFNG) 101916406(MFNG) 101916735(LFNG)
FCH: 102047108(LFNG) 102054672(RFNG) 102059881(MFNG)
CLV: 102084027(LFNG) 102092690(MFNG) 102094918(RFNG)
EGZ: 104131255(RFNG) 104132617(LFNG) 104134305(MFNG)
NNI: 104014390(RFNG) 104015089(LFNG) 104021594(MFNG)
ACUN: 113485767(LFNG) 113486842(RFNG) 113491499(MFNG)
PADL: 103912340 103913573(LFNG) 103917468(RFNG) 103924151(MFNG)
AAM: 106487094(RFNG) 106488480(MFNG) 106496125
ASN: 102381094(LFNG) 102386399(RFNG) 102388348(MFNG)
AMJ: 102566885(LFNG) 102567014(MFNG) 102571352(RFNG)
PSS: 102443867(LFNG) 102455692 102458358(MFNG)
CMY: 102931854 102932974(RFNG) 102935387(MFNG)
CPIC: 101934811(MFNG) 101940585(RFNG) 101950276(LFNG)
ACS: 100561637(mfng) 100565009(lfng) 100567901(rfng)
PVT: 110075969(MFNG) 110090776(RFNG) 110091685(LFNG)
PBI: 103060821 103063742(RFNG)
PMUR: 107288860(RFNG) 107290633(LFNG)
TSR: 106551147(RFNG)
PMUA: 114584152(LFNG) 114589787(RFNG) 114605544(MFNG)
GJA: 107105918(MFNG) 107118125(RFNG) 107122012(LFNG)
XLA: 100036937(lfng.L) 394282(rfng.L) 397855(lfng.S) 397979(xfringe2)
XTR: 100486895(rfng) 549805(lfng)
NPR: 108786198(LFNG) 108791320(RFNG)
DRE: 30158(lfng) 414848(rfng) 493633(mfng)
IPU: 108257411(lfng) 108259517 108273644(rfng)
PHYP: 113524273 113527078(rfng) 113536168(lfng)
AMEX: 103025168(lfng) 103035856(mfng) 103037421(rfng)
NCC: 104940897 104964482(lfng)
XMA: 102219280(rfng) 102225648 102230356(lfng)
XCO: 114145337 114150882(rfng) 114160037(lfng)
PRET: 103468664(lfng) 103480636 103482187(rfng)
BPEC: 110154327(rfng) 110165650 110167656(lfng)
LCM: 102347945(LFNG) 102350505(MFNG) 102362901(RFNG)
CMK: 103175474(rfng) 103186827(lfng) 103189782
CIN: 778622
SPU: 578181
SKO: 100653401(fng)
DME: Dmel_CG10580(fng)
DER: 6546161
DSI: Dsimw501_GD28062(Dsim_GD28062)
DSR: 110189997
DPE: 6604426
DAZ: 108614550
DNV: 108650377
DHE: 111592962
MDE: 101890371
LCQ: 111676980
AAG: 5574115
AALB: 109623129
AME: 551501
BIM: 100741335
BTER: 100648290
CCAL: 108624015
OBB: 114878915
SOC: 105201656
MPHA: 105832301
AEC: 105145067
ACEP: 105624750
PBAR: 105422509
VEM: 105562750
HST: 105185424
DQU: 106741484
CFO: 105251037
LHU: 105675165
PGC: 109851939
OBO: 105276314
PCF: 106790982
NVI: 100678242
CSOL: 105361405
TCA: 100141773
DPA: 109540120
ATD: 109598146
BMOR: 100144549(Fng)
PMAC: 106718445
PRAP: 110995650
HAW: 110371554
TNL: 113504560
API: 100160830
DNX: 107164992
AGS: 114126629
RMD: 113553865
BTAB: 109037881
CLEC: 106661495
ZNE: 110830882
FCD: 110847136
PVM: 113813153
TUT: 107360014
DPTE: 113793628
PTEP: 107441830
BMY: Bm1_29470
PCAN: 112561686
CRG: 105321777
MYI: 110453003
OBI: 106871323
LAK: 106168328
EPA: 110237675
ADF: 107346687
PDAM: 113678576
SPIS: 111340325
 » show all
Taxonomy
Reference
1  [PMID:10935626]
  Authors
Moloney DJ, Panin VM, Johnston SH, Chen J, Shao L, Wilson R, Wang Y, Stanley P, Irvine KD, Haltiwanger RS, Vogt TF.
  Title
Fringe is a glycosyltransferase that modifies Notch.
  Journal
Nature 406:369-75 (2000)
DOI:10.1038/35019000
  Sequence
[dme:Dmel_CG10580] [hsa:4242]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.222
IUBMB Enzyme Nomenclature: 2.4.1.222
ExPASy - ENZYME nomenclature database: 2.4.1.222
BRENDA, the Enzyme Database: 2.4.1.222
CAS: 299203-70-6

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