KEGG   ENZYME: 2.4.1.244
Entry
EC 2.4.1.244                Enzyme                                 

Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase;
beta1,4-N-acetylgalactosaminyltransferase III;
beta4GalNAc-T3;
beta1,4-N-acetylgalactosaminyltransferase IV;
beta4GalNAc-T4;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Reaction(KEGG)
(other) R07610(G) R07611(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-glucosaminyl group
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
History
EC 2.4.1.244 created 2006
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09656  beta-1,4-N-acetylgalactosaminyltransferase 3
K09657  beta-1,4-N-acetylgalactosaminyltransferase 4
Genes
HSA: 283358(B4GALNT3) 338707(B4GALNT4)
PTR: 450920(B4GALNT4) 451738(B4GALNT3)
PPS: 100976376(B4GALNT4) 100989611(B4GALNT3)
GGO: 101147545(B4GALNT3)
PON: 100435319(B4GALNT3) 100457244(B4GALNT4)
NLE: 100602613(B4GALNT4) 105738882(B4GALNT3)
MCC: 114669831(B4GALNT4) 706259(B4GALNT3) 720768
MCF: 102115389(B4GALNT4) 102145263(B4GALNT3)
CSAB: 103218358(B4GALNT3) 103239139(B4GALNT4)
CATY: 105577189(B4GALNT4) 105582943(B4GALNT3)
PANU: 101000778(B4GALNT4)
RRO: 104656676 104662541(B4GALNT3) 115893542(B4GALNT4)
RBB: 108519516(B4GALNT3) 108543532(B4GALNT4)
TFN: 117080293(B4GALNT4) 117090732(B4GALNT3)
PTEH: 111520323(B4GALNT3) 111520629(B4GALNT4)
CJC: 100407822(B4GALNT3) 100413834(B4GALNT4)
SBQ: 101037149(B4GALNT4) 101054201(B4GALNT3)
MMUR: 105862186(B4GALNT3) 105874069(B4GALNT4)
MMU: 330406(B4galnt3) 330671(B4galnt4)
MCAL: 110296670(B4galnt3) 110297886
MPAH: 110316578(B4galnt3) 110318245(B4galnt4)
RNO: 309105(B4galnt4) 500306(B4galnt3)
MCOC: 116099504(B4galnt3) 116103201(B4galnt4)
MUN: 110546049(B4galnt3) 110553927(B4galnt4)
CGE: 100756528(B4galnt3) 100758404(B4galnt4)
PLEU: 114693511(B4galnt4) 114700747(B4galnt3)
NGI: 103739368(B4galnt3) 103751068(B4galnt4)
HGL: 101702463(B4galnt3) 101720559(B4galnt4)
CCAN: 109694620(B4galnt3) 109698146(B4galnt4)
OCU: 100351156(B4GALNT3)
OPI: 101516966(B4GALNT4) 101534838(B4GALNT3)
TUP: 102476308(B4GALNT4) 102477252(B4GALNT3)
CFA: 483398(B4GALNT4) 486751(B4GALNT3)
VVP: 112914603(B4GALNT4) 112917410(B4GALNT3)
VLG: 121480290(B4GALNT3) 121501378(B4GALNT4)
AML: 100474848(B4GALNT4) 100481474(B4GALNT3)
UMR: 103671083(B4GALNT4) 103675765(B4GALNT3)
UAH: 113248774(B4GALNT4) 113258033(B4GALNT3)
ORO: 101362933(B4GALNT4) 101376959(B4GALNT3)
MPUF: 101671138(B4GALNT4) 101673160(B4GALNT3)
EJU: 114201512(B4GALNT4) 114222591(B4GALNT3)
MLX: 118015665(B4GALNT4) 118025451(B4GALNT3)
FCA: 101086091(B4GALNT4) 101097324(B4GALNT3)
PYU: 121022074(B4GALNT3) 121022812(B4GALNT4)
PBG: 122473889(B4GALNT3) 122484185(B4GALNT4)
PTG: 102950331(B4GALNT4) 102953154(B4GALNT3)
PPAD: 109259799(B4GALNT4) 109276235(B4GALNT3)
AJU: 106965465(B4GALNT3) 106987942(B4GALNT4)
HHV: 120223395(B4GALNT4) 120234496(B4GALNT3)
BTA: 100137759(B4GALNT4) 527026(B4GALNT3)
BOM: 102275891(B4GALNT3) 102283950(B4GALNT4)
BIU: 109558611(B4GALNT3)
BBUB: 102394198(B4GALNT3) 102409676(B4GALNT4)
CHX: 102172522(B4GALNT3) 102188023
OAS: 101105615(B4GALNT4) 101115274(B4GALNT3)
ODA: 120857852(B4GALNT3) 120874219(B4GALNT4)
CCAD: 122423417(B4GALNT3) 122430574(B4GALNT4)
SSC: 100623649(B4GALNT4) 110260758(B4GALNT3)
CFR: 102522276(B4GALNT4) 102523640(B4GALNT3)
CBAI: 105062438(B4GALNT4) 105076667(B4GALNT3)
CDK: 105102955(B4GALNT3) 105106170(B4GALNT4)
BACU: 103000329(B4GALNT4) 103019272(B4GALNT3)
LVE: 103071788(B4GALNT4) 103084199(B4GALNT3)
OOR: 101269577(B4GALNT3) 101279166(B4GALNT4)
DLE: 111170320(B4GALNT4) 111176612(B4GALNT3)
PCAD: 102994651(B4GALNT4)
ECB: 100054676(B4GALNT4) 100056854(B4GALNT3)
EPZ: 103561349(B4GALNT4) 103565631(B4GALNT3)
EAI: 106825357(B4GALNT4) 106831525(B4GALNT3)
MYB: 102246590(B4GALNT4) 102254875(B4GALNT3)
MYD: 102756317(B4GALNT3)
MMYO: 118649013(B4GALNT4) 118651139(B4GALNT3)
MNA: 107542329(B4GALNT4) 107546417(B4GALNT3)
HAI: 109375626(B4GALNT4) 109388940(B4GALNT3)
DRO: 112311132(B4GALNT3) 112317448(B4GALNT4)
SHON: 118982226(B4GALNT4) 119000001(B4GALNT3)
AJM: 119045231(B4GALNT3) 119062225(B4GALNT4)
MMF: 118624292(B4GALNT3) 118643193(B4GALNT4)
PALE: 102884317(B4GALNT4) 102884875(B4GALNT3)
PGIG: 120584649(B4GALNT4) 120607341(B4GALNT3)
RAY: 107506918(B4GALNT3) 107506949(B4GALNT4)
MJV: 108386186(B4GALNT3) 108401884(B4GALNT4)
TOD: 119247842(B4GALNT3) 119248775(B4GALNT4)
LAV: 100656658(B4GALNT4) 100665318(B4GALNT3)
MDO: 100020793(B4GALNT3)
SHR: 100918044(B4GALNT3) 100921988(B4GALNT4)
PCW: 110202986(B4GALNT4) 110204330 110218701(B4GALNT3)
OAA: 100080104(B4GALNT3) 100088024(B4GALNT4)
GGA: 418150(B4GALNT3) 770601(B4GALNT4)
PCOC: 116226858(B4GALNT3) 116237913(B4GALNT4)
MGP: 100539296(B4GALNT4) 100543657(B4GALNT3)
CJO: 107314272(B4GALNT4) 107315358(B4GALNT3)
NMEL: 110395311(B4GALNT3) 110401603(B4GALNT4)
APLA: 101794410(B4GALNT3) 101795425(B4GALNT4)
ACYG: 106031042(B4GALNT3) 106047061(B4GALNT4)
TGU: 100218099(B4GALNT4) 100221161(B4GALNT3)
LSR: 110472973(B4GALNT3) 110484970(B4GALNT4)
SCAN: 103820514(B4GALNT3) 103827051(B4GALNT4)
PMOA: 120501032(B4GALNT4) 120501516(B4GALNT3)
OTC: 121332794(B4GALNT3) 121334773(B4GALNT4)
PRUF: 121352308(B4GALNT4) 121362663(B4GALNT3)
GFR: 102034690(B4GALNT4) 102036024(B4GALNT3)
FAB: 101806677(B4GALNT4) 101814333(B4GALNT3)
PHI: 102109686(B4GALNT3) 102112024(B4GALNT4)
PMAJ: 107204887(B4GALNT3) 107206466(B4GALNT4)
CCAE: 111928420(B4GALNT3) 111930586(B4GALNT4) 111944590
CCW: 104684539(B4GALNT4) 104692236(B4GALNT3)
ETL: 114063268(B4GALNT4) 114068768(B4GALNT3)
FPG: 101919553(B4GALNT4) 101920197(B4GALNT3)
FCH: 102051612(B4GALNT4) 102055264(B4GALNT3)
CLV: 102088828(B4GALNT4) 102090270(B4GALNT3)
EGZ: 104127888(B4GALNT4) 104129759(B4GALNT3)
NNI: 104011411(B4GALNT4) 104020250(B4GALNT3)
ACUN: 113481121(B4GALNT4) 113487437(B4GALNT3)
PADL: 103924499(B4GALNT3) 103925356(B4GALNT4)
AAM: 106488281(B4GALNT3) 106489126(B4GALNT4)
AROW: 112968267(B4GALNT3) 112973777(B4GALNT4)
NPD: 112948021(B4GALNT4) 112958331(B4GALNT3)
DNE: 112991580(B4GALNT4) 112993372(B4GALNT3)
ASN: 102384335(B4GALNT4)
AMJ: 102563895(B4GALNT3) 102569972(B4GALNT4)
CPOO: 109315923(B4GALNT3) 109318171(B4GALNT4)
GGN: 109296220(B4GALNT3) 109299254(B4GALNT4)
PSS: 102450592(B4GALNT3) 102454912(B4GALNT4)
CMY: 102944252(B4GALNT3) 102948034(B4GALNT4)
CPIC: 101946283(B4GALNT3) 101950465(B4GALNT4)
TST: 117877383(B4GALNT4) 117882408(B4GALNT3)
CABI: 116820558(B4GALNT4) 116834553(B4GALNT3)
ACS: 100552264(b4galnt3) 100568220(b4galnt4)
PVT: 110074160(B4GALNT4)
PBI: 103050876(B4GALNT3) 103061436(B4GALNT4)
PMUR: 107291100(B4GALNT4)
TSR: 106552382(B4GALNT4)
PGUT: 117655634(B4GALNT3) 117665151(B4GALNT4)
PMUA: 114600280(B4GALNT4) 114605389(B4GALNT3)
ZVI: 118090793(B4GALNT3)
GJA: 107108372
XLA: 108704576(b4galnt3.L) 108712580(b4galnt3.S) 108713824(b4galnt4.L) 108715202(b4galnt4.S)
XTR: 100036642(b4galnt4) 100488678(b4galnt3)
NPR: 108791998(B4GALNT4)
DRE: 553524(b4galnt3b) 559305(b4galnt4b) 565184(b4galnt4a)
IPU: 108259196 108264151 108275076(b4galnt4)
PHYP: 113529844(b4galnt4) 113540814
AMEX: 103022890 103037724(b4galnt4) 103040627
EEE: 113570817 113579684 113581322(b4galnt4)
TRU: 101067924 101067926(b4galnt4)
LCO: 104918138 104920486(b4galnt4)
NCC: 104957600(b4galnt3) 104967977(b4galnt4)
CGOB: 115009853(b4galnt4) 115010263
ELY: 117262120(b4galnt3b) 117262290(b4galnt4a)
PLEP: 121949667(b4galnt4a) 121950026(b4galnt3b)
SLUC: 116038542(b4galnt4a) 116045686(b4galnt3b)
ECRA: 117949490(b4galnt4a) 117949521(b4galnt3b)
PFLV: 114559669(b4galnt4) 114560215
GAT: 120808958 120809787(b4galnt3b) 120812247
PPUG: 119195585(b4galnt4a) 119196592(b4galnt3b)
MSAM: 119893562(b4galnt3b) 119894206(b4galnt4a)
CUD: 121514681(b4galnt3b) 121515700(b4galnt4a)
MZE: 101471802(b4galnt4) 101485737
ONL: 100704589(b4galnt4) 100709042
OAU: 116313492(b4galnt3b) 116333275(b4galnt4a)
OLA: 101163791(b4galnt4) 101164306
OML: 112151753(b4galnt4a) 112152134(b4galnt3b)
XMA: 102221073(b4galnt4) 102223638
XHE: 116734070(b4galnt4) 116735786
PRET: 103466150(b4galnt4) 103466673
CVG: 107085425(b4galnt4) 107090556
CTUL: 119772420(b4galnt3b) 119776920(b4galnt4a)
NFU: 107388842 107389008(b4galnt4)
KMR: 108230205(b4galnt3b) 108239976(b4galnt4a)
ALIM: 106514300(b4galnt3) 106515656(b4galnt4)
CSEM: 103380088 103380379(b4galnt4)
POV: 109638984
LCF: 108875136(b4galnt3) 108875398(b4galnt4)
SDU: 111228500 111228650(b4galnt4)
SLAL: 111653356 111661820(b4galnt4)
XGL: 120792688(b4galnt3b) 120793655(b4galnt4a)
HCQ: 109528077 109530471(b4galnt4)
BPEC: 110165926(b4galnt4)
SASA: 106560716(b4galnt4) 106561254(b4galnt3)
OTW: 112219203(b4galnt4a) 112252461
OMY: 110490617(b4galnt4a) 110496319 110521711
SALP: 111961981(b4galnt4) 111962535
SNH: 120065861(b4galnt3b) 120066544(b4galnt4a)
ELS: 105006820(b4galnt4) 105022210
SFM: 108934528 108936581 108942180(b4galnt4)
PKI: 111841532 111859463(b4galnt4)
AANG: 118215602(b4galnt4a) 118219072(b4galnt3b) 118228416 118231854
LOC: 102683937(b4galnt3) 102689842(b4galnt4)
ARUT: 117416081 117420048(b4galnt3b) 117432458
LCM: 102348774(B4GALNT3) 102349555(B4GALNT4)
CMK: 103181837(b4galnt3b) 103186017
AQU: 100638711
 » show all
Reference
1  [PMID:12966086]
  Authors
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H
  Title
Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
  Journal
J Biol Chem 278:47534-44 (2003)
DOI:10.1074/jbc.M308857200
  Sequence
[hsa:283358] [mmu:330406]
Reference
2  [PMID:15044014]
  Authors
Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H
  Title
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
  Journal
FEBS Lett 562:134-40 (2004)
DOI:10.1016/S0014-5793(04)00219-4
  Sequence
[hsa:338707] [mmu:330671]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.244
IUBMB Enzyme Nomenclature: 2.4.1.244
ExPASy - ENZYME nomenclature database: 2.4.1.244
BRENDA, the Enzyme Database: 2.4.1.244

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