KEGG   ENZYME: 2.4.1.244Help
Entry
EC 2.4.1.244                Enzyme                                 

Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase;
beta1,4-N-acetylgalactosaminyltransferase III;
beta4GalNAc-T3;
beta1,4-N-acetylgalactosaminyltransferase IV;
beta4GalNAc-T4;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Reaction(KEGG)
(other) R07610(G) R07611(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-glucosaminyl group
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
History
EC 2.4.1.244 created 2006
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09656  beta-1,4-N-acetylgalactosaminyltransferase 3
K09657  beta-1,4-N-acetylgalactosaminyltransferase 4
Genes
HSA: 283358(B4GALNT3) 338707(B4GALNT4)
PTR: 450920(B4GALNT4) 451738(B4GALNT3)
PPS: 100976376(B4GALNT4) 100989611(B4GALNT3)
GGO: 101131877(B4GALNT4) 101147545(B4GALNT3)
PON: 100435319(B4GALNT3) 100457244(B4GALNT4)
NLE: 100602613(B4GALNT4) 105738882(B4GALNT3)
MCC: 706259(B4GALNT3) 720768(B4GALNT4)
MCF: 102115389(B4GALNT4) 102145263(B4GALNT3)
CSAB: 103218358(B4GALNT3) 103239139(B4GALNT4)
RRO: 104656676(B4GALNT4) 104662541(B4GALNT3)
RBB: 108519516(B4GALNT3) 108543532(B4GALNT4)
CJC: 100407822(B4GALNT3) 100413834(B4GALNT4)
SBQ: 101037149(B4GALNT4) 101054201(B4GALNT3)
MMU: 330406(B4galnt3) 330671(B4galnt4)
RNO: 309105(B4galnt4) 500306(B4galnt3)
CGE: 100756528(B4galnt3) 100758404(B4galnt4)
NGI: 103739368(B4galnt3) 103751068(B4galnt4)
HGL: 101702463(B4galnt3) 101720559(B4galnt4)
CCAN: 109694620(B4galnt3) 109698146(B4galnt4)
OCU: 100351156(B4GALNT3)
TUP: 102476308(B4GALNT4) 102477252(B4GALNT3)
CFA: 483398(B4GALNT4) 486751(B4GALNT3)
AML: 100474848(B4GALNT4) 100481474(B4GALNT3)
UMR: 103671083(B4GALNT4) 103675765(B4GALNT3)
ORO: 101362933(B4GALNT4) 101376959(B4GALNT3)
FCA: 101086091(B4GALNT4) 101097324(B4GALNT3)
PTG: 102950331(B4GALNT4) 102953154(B4GALNT3)
AJU: 106965465(B4GALNT3) 106987942(B4GALNT4)
BTA: 100137759(B4GALNT4) 527026(B4GALNT3)
BOM: 102275891(B4GALNT3) 102283950(B4GALNT4)
BIU: 109558611(B4GALNT3)
PHD: 102317417(B4GALNT3) 102338750(B4GALNT4)
CHX: 102172522(B4GALNT3) 102188023 108634210(B4GALNT4)
OAS: 101105615(B4GALNT4) 101115274(B4GALNT3)
SSC: 100623649(B4GALNT4) 110260758(B4GALNT3)
CFR: 102522276(B4GALNT4) 102523640(B4GALNT3)
CDK: 105102955(B4GALNT3) 105106170(B4GALNT4)
BACU: 103000329(B4GALNT4) 103019272(B4GALNT3)
LVE: 103071788(B4GALNT4) 103084199(B4GALNT3)
OOR: 101269577(B4GALNT3) 101279166(B4GALNT4)
ECB: 100054676(B4GALNT4) 100056854(B4GALNT3)
EPZ: 103561349(B4GALNT4) 103565631(B4GALNT3)
EAI: 106825357(B4GALNT4) 106831525(B4GALNT3)
MYB: 102246590(B4GALNT4) 102254875(B4GALNT3)
MYD: 102756317(B4GALNT3) 102761106(B4GALNT4)
HAI: 109375626(B4GALNT4) 109388940(B4GALNT3)
RSS: 109434425(B4GALNT3) 109436291(B4GALNT4)
PALE: 102884317(B4GALNT4) 102884875(B4GALNT3)
LAV: 100656658(B4GALNT4) 100665318(B4GALNT3)
MDO: 100020793(B4GALNT3)
SHR: 100918044(B4GALNT3) 100921988(B4GALNT4)
OAA: 100080104(B4GALNT3)
GGA: 418150(B4GALNT3) 770601(B4GALNT4)
MGP: 100539296(B4GALNT4) 100543657(B4GALNT3)
CJO: 107314272(B4GALNT4) 107315358(B4GALNT3)
APLA: 101794410(B4GALNT3) 101795425(B4GALNT4)
ACYG: 106031042(B4GALNT3) 106047061(B4GALNT4)
TGU: 100218099(B4GALNT4) 100221161(B4GALNT3)
GFR: 102034690(B4GALNT4) 102036024(B4GALNT3)
FAB: 101806677(B4GALNT4) 101814333(B4GALNT3)
PHI: 102109686(B4GALNT3) 102112024(B4GALNT4)
PMAJ: 107204887(B4GALNT3) 107206466(B4GALNT4)
CCW: 104684539(B4GALNT4) 104692236(B4GALNT3)
FPG: 101919553(B4GALNT4) 101920197(B4GALNT3)
FCH: 102051612(B4GALNT4) 102055264(B4GALNT3)
CLV: 102088828(B4GALNT4) 102090270(B4GALNT3)
EGZ: 104127888(B4GALNT4) 104129759(B4GALNT3)
AAM: 106488281(B4GALNT3) 106489126(B4GALNT4) 106490584
ASN: 102383192(B4GALNT3) 102384335(B4GALNT4)
AMJ: 102563895(B4GALNT3) 102569972(B4GALNT4)
PSS: 102450592(B4GALNT3) 102454912(B4GALNT4)
CMY: 102944252(B4GALNT3) 102948034(B4GALNT4)
CPIC: 101946283(B4GALNT3) 101950465(B4GALNT4)
ACS: 100552264(b4galnt3) 100568220(b4galnt4)
PVT: 110074160(B4GALNT4) 110076677(B4GALNT3)
PBI: 103050876(B4GALNT3) 103061436(B4GALNT4)
XLA: 108704576(b4galnt3.L) 108712580(b4galnt3.S) 108713824(b4galnt4.L) 108715202(b4galnt4.S)
XTR: 100036642(b4galnt4) 100488678(b4galnt3)
NPR: 108791998(B4GALNT4) 108804595(B4GALNT3)
DRE: 553524(b4galnt3b) 559305(b4galnt4b) 565184(b4galnt4a)
TRU: 101067924(b4galnt3) 101067926(b4galnt4)
LCO: 104918138(b4galnt3) 104920486(b4galnt4)
NCC: 104957600(b4galnt3) 104967977(b4galnt4)
MZE: 101471802(b4galnt4) 101485737
OLA: 101163791(b4galnt4) 101164306
XMA: 102221073(b4galnt4) 102223638
PRET: 103466150(b4galnt4) 103466673
NFU: 107388842 107389008(b4galnt4)
CSEM: 103380088 103380379(b4galnt4)
LCF: 108875136(b4galnt3) 108875398(b4galnt4)
HCQ: 109528077 109530471(b4galnt4)
BPEC: 110165926(b4galnt4) 110169192
SASA: 106560716(b4galnt4) 106561254(b4galnt3)
SFM: 108934528 108936581 108942180(b4galnt4)
LCM: 102348774(B4GALNT3) 102349555(B4GALNT4)
CMK: 103181837 103186017(b4galnt4)
HMG: 100206963
AQU: 100638711
 » show all
Taxonomy
Reference
1  [PMID:12966086]
  Authors
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
  Journal
J Biol Chem 278:47534-44 (2003)
DOI:10.1074/jbc.M308857200
  Sequence
[hsa:283358] [mmu:330406]
Reference
2  [PMID:15044014]
  Authors
Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
  Journal
FEBS Lett 562:134-40 (2004)
DOI:10.1016/S0014-5793(04)00219-4
  Sequence
[hsa:338707] [mmu:330671]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.244
IUBMB Enzyme Nomenclature: 2.4.1.244
ExPASy - ENZYME nomenclature database: 2.4.1.244
BRENDA, the Enzyme Database: 2.4.1.244

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