KEGG   ENZYME: 2.4.1.244
Entry
EC 2.4.1.244                Enzyme                                 

Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase;
beta1,4-N-acetylgalactosaminyltransferase III;
beta4GalNAc-T3;
beta1,4-N-acetylgalactosaminyltransferase IV;
beta4GalNAc-T4;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-glucosaminyl-group 4-beta-N-acetylgalactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Reaction(KEGG)
(other) R07610(G) R07611(G)
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-glucosaminyl group
Product
UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group
Comment
The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end. The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme-characterization experiments. Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group.
History
EC 2.4.1.244 created 2006
Pathway
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K09656  beta-1,4-N-acetylgalactosaminyltransferase 3
K09657  beta-1,4-N-acetylgalactosaminyltransferase 4
Genes
HSA: 283358(B4GALNT3) 338707(B4GALNT4)
PTR: 450920(B4GALNT4) 451738(B4GALNT3)
PPS: 100976376(B4GALNT4) 100989611(B4GALNT3)
GGO: 101147545(B4GALNT3)
PON: 100435319(B4GALNT3) 100457244(B4GALNT4)
NLE: 100602613(B4GALNT4) 105738882(B4GALNT3)
MCC: 114669831(B4GALNT4) 706259(B4GALNT3) 720768
MCF: 102115389(B4GALNT4) 102145263(B4GALNT3)
CSAB: 103218358(B4GALNT3) 103239139(B4GALNT4)
RRO: 104656676 104662541(B4GALNT3) 115893542(B4GALNT4)
RBB: 108519516(B4GALNT3) 108543532(B4GALNT4)
CJC: 100407822(B4GALNT3) 100413834(B4GALNT4)
SBQ: 101037149(B4GALNT4) 101054201(B4GALNT3)
MMU: 330406(B4galnt3) 330671(B4galnt4)
MCAL: 110296670(B4galnt3) 110297886
MPAH: 110316578(B4galnt3) 110318245(B4galnt4)
RNO: 309105(B4galnt4) 500306(B4galnt3)
MUN: 110546049(B4galnt3) 110553927(B4galnt4)
CGE: 100756528(B4galnt3) 100758404(B4galnt4)
NGI: 103739368(B4galnt3) 103751068(B4galnt4)
HGL: 101702463(B4galnt3) 101720559(B4galnt4)
CCAN: 109694620(B4galnt3) 109698146(B4galnt4)
OCU: 100351156(B4GALNT3)
TUP: 102476308(B4GALNT4) 102477252(B4GALNT3)
CFA: 483398(B4GALNT4) 486751(B4GALNT3)
VVP: 112914603(B4GALNT4) 112917410(B4GALNT3)
AML: 100474848(B4GALNT4) 100481474(B4GALNT3)
UMR: 103671083(B4GALNT4) 103675765(B4GALNT3)
UAH: 113248774(B4GALNT4) 113258033(B4GALNT3)
ORO: 101362933(B4GALNT4) 101376959(B4GALNT3)
FCA: 101086091(B4GALNT4) 101097324(B4GALNT3)
PTG: 102950331(B4GALNT4) 102953154(B4GALNT3)
PPAD: 109259799(B4GALNT4) 109276235(B4GALNT3)
AJU: 106965465(B4GALNT3) 106987942(B4GALNT4)
BTA: 100137759(B4GALNT4) 527026(B4GALNT3)
BOM: 102275891(B4GALNT3) 102283950(B4GALNT4)
BIU: 109558611(B4GALNT3)
BBUB: 102394198(B4GALNT3) 102409676(B4GALNT4)
CHX: 102172522(B4GALNT3) 102188023
OAS: 101105615(B4GALNT4) 101115274(B4GALNT3)
SSC: 100623649(B4GALNT4) 110260758(B4GALNT3)
CFR: 102522276(B4GALNT4) 102523640(B4GALNT3)
CDK: 105102955(B4GALNT3) 105106170(B4GALNT4)
BACU: 103000329(B4GALNT4) 103019272(B4GALNT3)
LVE: 103071788(B4GALNT4) 103084199(B4GALNT3)
OOR: 101269577(B4GALNT3) 101279166(B4GALNT4)
DLE: 111170320(B4GALNT4) 111176612(B4GALNT3)
PCAD: 102994651(B4GALNT4)
ECB: 100054676(B4GALNT4) 100056854(B4GALNT3)
EPZ: 103561349(B4GALNT4) 103565631(B4GALNT3)
EAI: 106825357(B4GALNT4) 106831525(B4GALNT3)
MYB: 102246590(B4GALNT4) 102254875(B4GALNT3)
MYD: 102756317(B4GALNT3)
MNA: 107542329(B4GALNT4) 107546417(B4GALNT3)
HAI: 109375626(B4GALNT4) 109388940(B4GALNT3)
DRO: 112311132(B4GALNT3) 112317448(B4GALNT4)
PALE: 102884317(B4GALNT4) 102884875(B4GALNT3)
RAY: 107506918(B4GALNT3) 107506949(B4GALNT4)
MJV: 108386186(B4GALNT3) 108401884(B4GALNT4)
LAV: 100656658(B4GALNT4) 100665318(B4GALNT3)
MDO: 100020793(B4GALNT3)
SHR: 100918044(B4GALNT3) 100921988(B4GALNT4)
PCW: 110202986(B4GALNT4) 110204330 110218701(B4GALNT3)
OAA: 100080104(B4GALNT3) 100088024(B4GALNT4)
GGA: 418150(B4GALNT3) 770601(B4GALNT4)
MGP: 100539296(B4GALNT4) 100543657(B4GALNT3)
CJO: 107314272(B4GALNT4) 107315358(B4GALNT3)
NMEL: 110395311(B4GALNT3) 110401603(B4GALNT4)
APLA: 101794410(B4GALNT3) 101795425(B4GALNT4)
ACYG: 106031042(B4GALNT3) 106047061(B4GALNT4)
TGU: 100218099(B4GALNT4) 100221161(B4GALNT3)
LSR: 110472973(B4GALNT3) 110484970(B4GALNT4)
SCAN: 103820514(B4GALNT3) 103827051(B4GALNT4)
GFR: 102034690(B4GALNT4) 102036024(B4GALNT3)
FAB: 101806677(B4GALNT4) 101814333(B4GALNT3)
PHI: 102109686(B4GALNT3) 102112024(B4GALNT4)
PMAJ: 107204887(B4GALNT3) 107206466(B4GALNT4)
CCAE: 111928420(B4GALNT3) 111930586(B4GALNT4) 111944590
CCW: 104684539(B4GALNT4) 104692236(B4GALNT3)
ETL: 114063268(B4GALNT4) 114068768(B4GALNT3)
FPG: 101919553(B4GALNT4) 101920197(B4GALNT3)
FCH: 102051612(B4GALNT4) 102055264(B4GALNT3)
CLV: 102088828(B4GALNT4) 102090270(B4GALNT3)
EGZ: 104127888(B4GALNT4) 104129759(B4GALNT3)
NNI: 104011411(B4GALNT4) 104020250(B4GALNT3)
ACUN: 113481121(B4GALNT4) 113487437(B4GALNT3)
PADL: 103924499(B4GALNT3) 103925356(B4GALNT4)
AAM: 106488281(B4GALNT3) 106489126(B4GALNT4)
ASN: 102384335(B4GALNT4)
AMJ: 102563895(B4GALNT3) 102569972(B4GALNT4)
PSS: 102450592(B4GALNT3) 102454912(B4GALNT4)
CMY: 102944252(B4GALNT3) 102948034(B4GALNT4)
CPIC: 101946283(B4GALNT3) 101950465(B4GALNT4)
ACS: 100552264(b4galnt3) 100568220(b4galnt4)
PVT: 110074160(B4GALNT4)
PBI: 103050876(B4GALNT3) 103061436(B4GALNT4)
PMUR: 107291100(B4GALNT4)
TSR: 106552382(B4GALNT4)
PMUA: 114600280(B4GALNT4) 114605389(B4GALNT3)
GJA: 107108372
XLA: 108704576(b4galnt3.L) 108712580(b4galnt3.S) 108713824(b4galnt4.L) 108715202(b4galnt4.S)
XTR: 100036642(b4galnt4) 100488678(b4galnt3)
NPR: 108791998(B4GALNT4)
DRE: 553524(b4galnt3b) 559305(b4galnt4b) 565184(b4galnt4a)
IPU: 108259196 108264151 108275076(b4galnt4)
PHYP: 113529844(b4galnt4) 113540814
AMEX: 103022890 103037724(b4galnt4) 103040627
EEE: 113570817 113579684 113581322(b4galnt4)
TRU: 101067924 101067926(b4galnt4)
LCO: 104918138 104920486(b4galnt4)
NCC: 104957600(b4galnt3) 104967977(b4galnt4)
MZE: 101471802(b4galnt4) 101485737
ONL: 100704589(b4galnt4) 100709042
OLA: 101163791(b4galnt4) 101164306
XMA: 102221073(b4galnt4) 102223638
PRET: 103466150(b4galnt4) 103466673
CVG: 107085425(b4galnt4) 107090556
NFU: 107388842 107389008(b4galnt4)
KMR: 108230205 108239976(b4galnt4)
ALIM: 106514300(b4galnt3) 106515656(b4galnt4)
CSEM: 103380088 103380379(b4galnt4)
POV: 109638984
LCF: 108875136(b4galnt3) 108875398(b4galnt4)
SDU: 111228500 111228650(b4galnt4)
SLAL: 111653356 111661820(b4galnt4)
HCQ: 109528077 109530471(b4galnt4)
BPEC: 110165926(b4galnt4)
SASA: 106560716(b4galnt4) 106561254(b4galnt3)
OTW: 112219203(b4galnt4) 112245132 112252461
SALP: 111961981(b4galnt4) 111962535
ELS: 105006820(b4galnt4) 105022210
SFM: 108934528 108936581 108942180(b4galnt4)
PKI: 111841532 111859463(b4galnt4)
LCM: 102348774(B4GALNT3) 102349555(B4GALNT4)
CMK: 103181837 103186017(b4galnt4)
AQU: 100638711
 » show all
Reference
1  [PMID:12966086]
  Authors
Sato T, Gotoh M, Kiyohara K, Kameyama A, Kubota T, Kikuchi N, Ishizuka Y, Iwasaki H, Togayachi A, Kudo T, Ohkura T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel human beta 1,4-N-acetylgalactosaminyltransferase, beta 4GalNAc-T3, responsible for the synthesis of N,N'-diacetyllactosediamine, galNAc beta 1-4GlcNAc.
  Journal
J Biol Chem 278:47534-44 (2003)
DOI:10.1074/jbc.M308857200
  Sequence
[hsa:283358] [mmu:330406]
Reference
2  [PMID:15044014]
  Authors
Gotoh M, Sato T, Kiyohara K, Kameyama A, Kikuchi N, Kwon YD, Ishizuka Y, Iwai T, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of beta1,4-N-acetylgalactosaminyltransferases IV synthesizing N,N'-diacetyllactosediamine.
  Journal
FEBS Lett 562:134-40 (2004)
DOI:10.1016/S0014-5793(04)00219-4
  Sequence
[hsa:338707] [mmu:330671]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.244
IUBMB Enzyme Nomenclature: 2.4.1.244
ExPASy - ENZYME nomenclature database: 2.4.1.244
BRENDA, the Enzyme Database: 2.4.1.244

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