KEGG   ENZYME: 2.4.1.251Help
Entry
EC 2.4.1.251                Enzyme                                 

Name
GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase;
GumI
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
GDP-mannose:GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol 4-beta-mannosyltransferase
Reaction(IUBMB)
GDP-mannose + GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol = GDP + D-Man-beta-(1->4)- GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol [RN:R09734]
Reaction(KEGG)
Substrate
GDP-mannose [CPD:C00096];
GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol
Product
GDP [CPD:C00035];
D-Man-beta-(1->4)- GlcA-beta-(1->2)-D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol
Comment
The enzyme is involved in the biosynthesis of the exopolysaccharide xanthan.
History
EC 2.4.1.251 created 2011
Orthology
K13658  beta-1,4-mannosyltransferase
Genes
XCC: XCC2447(gumI)
XCB: XC_1665
XCA: xcc-b100_1719(gumI)
XCP: XCR_2760(gumI)
XCV: XCV2780(gumI)
XAX: XACM_2560(gumI)
XAC: XAC2578(gumI)
XCI: XCAW_02259(gumI)
XCT: J151_02759
XCJ: J158_02746
XFU: XFF4834R_chr26150(gumI)
XOO: XOO3172(gumI)
XOM: XOO3012(XOO3012)
XOP: PXO_01399(gumI)
XOR: XOC_1874(gumI)
PSD: DSC_06250
AZA: AZKH_0950(gumI)
 » show all
Taxonomy
Reference
1  [PMID:9537354]
  Authors
Katzen F, Ferreiro DU, Oddo CG, Ielmini MV, Becker A, Puhler A, Ielpi L
  Title
Xanthomonas campestris pv. campestris gum mutants: effects on xanthan biosynthesis and plant virulence.
  Journal
J Bacteriol 180:1607-17 (1998)
  Sequence
[xcc:XCC2447]
Reference
2  [PMID:7683019]
  Authors
Ielpi L, Couso RO, Dankert MA
  Title
Sequential assembly and polymerization of the polyprenol-linked pentasaccharide repeating unit of the xanthan polysaccharide in Xanthomonas campestris.
  Journal
J Bacteriol 175:2490-500 (1993)
DOI:10.1128/JB.175.9.2490-2500.1993
Reference
3  [PMID:18854951]
  Authors
Kim SY, Kim JG, Lee BM, Cho JY
  Title
Mutational analysis of the gum gene cluster required for xanthan biosynthesis in  Xanthomonas oryzae pv oryzae.
  Journal
Biotechnol Lett 31:265-70 (2009)
DOI:10.1007/s10529-008-9858-3
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.251
IUBMB Enzyme Nomenclature: 2.4.1.251
ExPASy - ENZYME nomenclature database: 2.4.1.251
BRENDA, the Enzyme Database: 2.4.1.251

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