KEGG   ENZYME: 2.4.1.260Help
Entry
EC 2.4.1.260                Enzyme                                 

Name
dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase;
ALG12;
ALG12 mannosyltransferase;
ALG12 alpha1,6mannosyltransferase;
dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase;
dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase;
EBS4;
Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase;
dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,6-mannosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-mannosyl phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 6-alpha-D-mannosyltransferase (configuration-inverting)
Reaction(IUBMB)
dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06260]
Reaction(KEGG)
R06260(G)
Show
Substrate
dolichyl beta-D-mannosyl phosphate [CPD:C03862];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-beta-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
alpha-D-Man-alpha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate. Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9Glc-NAc2-PP-Dol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
History
EC 2.4.1.260 created 1976 as EC 2.4.1.130, part transferred 2011 to EC 2.4.1.160, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec00513  Various types of N-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03847  alpha-1,6-mannosyltransferase
Genes
HSA: 79087(ALG12)
PTR: 470247(ALG12)
PPS: 100977641(ALG12)
GGO: 101126908(ALG12)
PON: 100431368(ALG12)
NLE: 100588258(ALG12)
MCC: 715172(ALG12)
MCF: 102117563(ALG12)
CSAB: 103223543(ALG12)
RRO: 104670360(ALG12)
RBB: 108516534(ALG12)
CJC: 100392255(ALG12)
SBQ: 101036432(ALG12)
MMU: 223774(Alg12)
RNO: 315212(Alg12)
CGE: 100770096(Alg12)
NGI: 103735462(Alg12)
HGL: 101715432(Alg12)
CCAN: 109697709(Alg12)
OCU: 100346344(ALG12)
TUP: 102492059(ALG12)
CFA: 481196(ALG12)
AML: 100477708(ALG12)
UMR: 103674123(ALG12)
ORO: 101363058(ALG12)
FCA: 101099567(ALG12)
AJU: 106987628(ALG12)
BTA: 100125314(ALG12)
BOM: 102281651(ALG12)
PHD: 102330821(ALG12)
CHX: 102181760(ALG12)
OAS: 101112896(ALG12)
SSC: 100520494(ALG12)
CFR: 102524349(ALG12)
CDK: 105090366(ALG12)
BACU: 103004635(ALG12)
LVE: 103079764(ALG12)
OOR: 101285549(ALG12)
ECB: 100146652(ALG12)
EPZ: 103565594(ALG12)
EAI: 106845994(ALG12)
MYB: 102251651(ALG12)
MYD: 102767133(ALG12)
HAI: 109396645(ALG12)
RSS: 109434905(ALG12)
PALE: 102883747(ALG12)
LAV: 100661791(ALG12)
TMU: 101345042
SHR: 100920134(ALG12)
OAA: 100073873(ALG12)
GGA: 417733(ALG12)
MGP: 100538714(ALG12)
CJO: 107308331(ALG12)
APLA: 101790290(ALG12)
ACYG: 106040489(ALG12)
TGU: 100228059(ALG12)
GFR: 102041702(ALG12)
FAB: 101811748(ALG12)
PHI: 102108073(ALG12)
PMAJ: 107204336(ALG12)
CCW: 104686842(ALG12)
FPG: 101921937(ALG12)
FCH: 102049527(ALG12)
CLV: 102086330(ALG12)
EGZ: 104134412(ALG12)
AAM: 106495380(ALG12)
ASN: 102370274(ALG12)
AMJ: 102563831(ALG12)
PSS: 102447329(ALG12)
CMY: 102931282(ALG12)
CPIC: 101946366(ALG12)
ACS: 100560474(alg12)
PVT: 110076228(ALG12)
PBI: 103051026(ALG12)
GJA: 107112025(ALG12)
XLA: 108711164(alg12.L)
XTR: 548874(alg12)
NPR: 108796727(ALG12)
DRE: 569494(alg12)
SRX: 107730685(alg12)
SANH: 107699370(alg12)
SGH: 107601012(alg12)
IPU: 108279802(alg12)
AMEX: 103044448(alg12)
TRU: 101076670(alg12)
LCO: 104926575(alg12)
NCC: 104953716(alg12)
MZE: 101476903(alg12)
OLA: 101171875(alg12)
XMA: 102222592(alg12)
PRET: 108165888(alg12)
NFU: 107383916(alg12)
CSEM: 103382918(alg12)
LCF: 108899853(alg12)
HCQ: 109523664(alg12)
BPEC: 110161826(alg12)
SASA: 100195409(alg12) 106609155
ELS: 105020252(alg12)
SFM: 108931614(alg12)
LCM: 102363795(ALG12)
CMK: 103177032(alg12)
CIN: 100177471
SPU: 591306
APLC: 110974150
SKO: 100374699
DME: Dmel_CG8412(CG8412)
DSI: Dsimw501_GD18643(Dsim_GD18643)
MDE: 101900007
AAG: 5564018
AME: 724431
BIM: 105680192
BTER: 105665616
SOC: 105198677
AEC: 105151528
PBAR: 105425633
HST: 105191684
CFO: 105250907
LHU: 105677564
PGC: 109854174
NVI: 100120808
TCA: 660266
DPA: 109534052
NVL: 108569886
BMOR: 101745504
PMAC: 106721445
PRAP: 110993073
PXY: 105392967
API: 100160697
DNX: 107171945
ZNE: 110831686
FCD: 110842961
TUT: 107359154
CEL: CELE_ZC513.5(ZC513.5)
CBR: CBG11382
BMY: Bm1_50775
TSP: Tsp_15122
CRG: 105322567
MYI: 110454805
OBI: 106867594
LAK: 106178263
EPA: 110245274
ADF: 107341875
HMG: 100214068
AQU: 100640861
ATH: AT1G02145(ALG12)
CRB: 17897192
THJ: 104814061
CPAP: 110816214
CIT: 102622888
TCC: 18614505
GRA: 105791709
DZI: 111313726
EGR: 104444420
VRA: 106774197
VAR: 108347728
CCAJ: 109818826
CAM: 101509278
LJA: Lj0g3v0165139.1(Lj0g3v0165139.1) Lj0g3v0165139.2(Lj0g3v0165139.2) Lj3g3v0594260.1(Lj3g3v0594260.1) Lj3g3v0594260.2(Lj3g3v0594260.2)
ADU: 107464448
AIP: 107618752
LANG: 109352550
FVE: 101300391
PPER: 109947168
PMUM: 103331526
PAVI: 110745699
MDM: 103438967
PXB: 103964190
ZJU: 107421766
CSV: 101222209
CMO: 103498998
MCHA: 111022781
CMAX: 111499003
CMOS: 111460074
CPEP: 111807199
RCU: 8263298
JCU: 105643234
HBR: 110635799
POP: 7483803
VVI: 100253051
SLY: 101253423
SPEN: 107028308
SOT: 102579208
CANN: 107844599
NSY: 104216946
NTO: 104098178
INI: 109155587
SIND: 105169914
OEU: 111383370
HAN: 110922314
LSV: 111885666
DCR: 108202471
BVG: 104905254
SOE: 110803939
NNU: 104589452
OSA: 4336560
DOSA: Os04t0544900-01(Os04g0544900)
OBR: 102708889
BDI: 100830072
ATS: 109740842(LOC109740842)
SBI: 8055942
ZMA: 100282442
SITA: 101755068
PDA: 103704603
EGU: 105053932
MUS: 103970072
DCT: 110107771
ATR: 18429228
SMO: SELMODRAFT_91475(GT22A3)
PPP: 112295252
APRO: F751_2283
SCE: YNR030W(ALG12)
ERC: Ecym_2496
KMX: KLMA_70199(ALG12)
NCS: NCAS_0A05360(NCAS0A05360)
NDI: NDAI_0K02210(NDAI0K02210)
TPF: TPHA_0M01820(TPHA0M01820)
TBL: TBLA_0F04110(TBLA0F04110)
TDL: TDEL_0A07530(TDEL0A07530)
KAF: KAFR_0C04580(KAFR0C04580)
PIC: PICST_31100(ECM39)
CAL: CAALFM_C702970WA(ECM39)
CAUR: QG37_01592
SLB: AWJ20_3629(ALG12)
NCR: NCU07472
NTE: NEUTE1DRAFT88888(NEUTE1DRAFT_88888)
MGR: MGG_09909
SSCK: SPSK_08732
MAW: MAC_00572
MAJ: MAA_07235
CMT: CCM_06927
MBE: MBM_02529
ANI: AN3588.2
ANG: ANI_1_1126014(An01g08460)
ABE: ARB_00142
TVE: TRV_01650
PTE: PTT_15141
SPO: SPBC1734.12c(alg12)
CNE: CNC03430
CNB: CNBC3790
LBC: LACBIDRAFT_302539(ALG12)
ABP: AGABI1DRAFT75475(AGABI1DRAFT_75475)
ABV: AGABI2DRAFT184199(AGABI2DRAFT_184199)
MGL: MGL_2261
DDI: DDB_G0267884(alg12)
DFA: DFA_08503(alg12)
 » show all
Taxonomy
Reference
1  [PMID:15987956]
  Authors
Frank CG, Aebi M
  Title
ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis.
  Journal
Glycobiology 15:1156-63 (2005)
DOI:10.1093/glycob/cwj002
  Sequence
[sce:YNR030W]
Reference
2  [PMID:20023196]
  Authors
Hong Z, Jin H, Fitchette AC, Xia Y, Monk AM, Faye L, Li J
  Title
Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis.
  Journal
Plant Cell 21:3792-802 (2009)
DOI:10.1105/tpc.109.070284
  Sequence
[ath:AT1G02145]
Reference
3  [PMID:12460943]
  Authors
Cipollo JF, Trimble RB
  Title
The Saccharomyces cerevisiae alg12delta mutant reveals a role for the middle-arm  alpha1,2Man- and upper-arm alpha1,2Manalpha1,6Man- residues of Glc3Man9GlcNAc2-PP-Dol in regulating glycoprotein glycan processing in the endoplasmic reticulum and Golgi apparatus.
  Journal
Glycobiology 12:749-62 (2002)
Reference
4  [PMID:12217961]
  Authors
Grubenmann CE, Frank CG, Kjaergaard S, Berger EG, Aebi M, Hennet T
  Title
ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg.
  Journal
Hum Mol Genet 11:2331-9 (2002)
DOI:10.1093/hmg/11.19.2331
  Sequence
[hsa:79087]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.260
IUBMB Enzyme Nomenclature: 2.4.1.260
ExPASy - ENZYME nomenclature database: 2.4.1.260
BRENDA, the Enzyme Database: 2.4.1.260

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