KEGG   ENZYME: 2.4.1.267Help
Entry
EC 2.4.1.267                Enzyme                                 

Name
dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase;
ALG6;
Dol-P-Glc:Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase;
dolichyl beta-D-glucosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->6)]-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,3-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dolichyl beta-D-glucosyl phosphate:alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol 3-alpha-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06262]
Reaction(KEGG)
R06262(G)
Show
Substrate
dolichyl beta-D-glucosyl phosphate [CPD:C01246];
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol
Product
alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol;
dolichyl phosphate [CPD:C00110]
Comment
The successive addition of three glucose residues by EC 2.4.1.267, EC 2.4.1.265 (Dol-P-Glc:Glc1Man9GlcNAc2-PP-Dol alpha-1,3-glucosyltransferase) and EC 2.4.1.256 (Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase) represents the final stage of the lipid-linked oligosaccharide assembly.
History
EC 2.4.1.267 created 2011, modified 2012
Pathway
ec00510  N-Glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03848  alpha-1,3-glucosyltransferase
Genes
HSA: 29929(ALG6)
PTR: 456906(ALG6)
PPS: 100979540(ALG6)
GGO: 101136901(ALG6)
PON: 100174089(ALG6)
NLE: 100595734(ALG6)
MCC: 696323(ALG6)
MCF: 101866005(ALG6)
CSAB: 103224694(ALG6)
RRO: 104668064(ALG6)
RBB: 108532901(ALG6)
CJC: 100413929(ALG6)
SBQ: 101035312(ALG6)
MMU: 320438(Alg6)
RNO: 362547(Alg6)
CGE: 100753783(Alg6)
NGI: 103732484(Alg6)
HGL: 101713296(Alg6)
CCAN: 109681972(Alg6)
OCU: 100357591(ALG6)
TUP: 102503200(ALG6)
CFA: 609974(ALG6)
AML: 100474628(ALG6)
UMR: 103663065(ALG6)
ORO: 101381024(ALG6)
FCA: 101082423(ALG6)
PTG: 102962752(ALG6)
AJU: 106980782(ALG6)
BTA: 510138(ALG6)
BOM: 102274203(ALG6)
BIU: 109556210(ALG6)
PHD: 102329022(ALG6)
CHX: 102184686(ALG6)
OAS: 101108436(ALG6)
SSC: 100521457(ALG6)
CFR: 102521650(ALG6)
CDK: 105105724(ALG6)
BACU: 103007399(ALG6)
LVE: 103088486(ALG6)
OOR: 101272715(ALG6)
ECB: 100070118(ALG6)
EPZ: 103553697(ALG6)
EAI: 106840154(ALG6)
MYB: 102250476(ALG6)
MYD: 102753718(ALG6)
HAI: 109373931(ALG6)
RSS: 109447278(ALG6)
PALE: 102877923(ALG6)
LAV: 100667963(ALG6)
TMU: 101344260
MDO: 103106257(ALG6)
SHR: 100914646(ALG6)
OAA: 100087624(ALG6)
GGA: 395078(ALG6)
MGP: 100550656(ALG6)
CJO: 107317741(ALG6)
APLA: 101791177(ALG6)
ACYG: 106033100(ALG6)
TGU: 100225071(ALG6)
GFR: 102040783(ALG6)
FAB: 101821337(ALG6)
PHI: 102099752(ALG6)
PMAJ: 107208268(ALG6)
CCAE: 111932975(ALG6)
CCW: 104695139(ALG6)
FPG: 101921068(ALG6)
FCH: 102047964(ALG6)
CLV: 102097072(ALG6)
EGZ: 104123934(ALG6)
AAM: 106491255(ALG6)
ASN: 102369593(ALG6)
AMJ: 102560193(ALG6)
PSS: 102459075(ALG6)
CMY: 102934394(ALG6)
CPIC: 101946897(ALG6)
ACS: 100566228(alg6)
PVT: 110086655(ALG6)
PBI: 103053033(ALG6)
GJA: 107114626(ALG6)
XLA: 100049135(alg6.L) 446684(alg6.S)
XTR: 496948(alg6)
NPR: 108784909(ALG6)
DRE: 445327(alg6)
SGH: 107556552(alg6) 107591199
CCAR: 109051404(alg6)
IPU: 108272116(alg6)
AMEX: 103037923(alg6)
TRU: 101071162(alg6)
LCO: 104919026(alg6)
MZE: 101483673(alg6)
OLA: 101155182(alg6)
XMA: 102231430(alg6)
PRET: 103463050(alg6)
NFU: 107392921(alg6)
KMR: 108238379(alg6)
CSEM: 103395481(alg6)
LCF: 108897116(alg6)
SDU: 111229751(alg6)
BPEC: 110160115(alg6)
MALB: 109961726(alg6)
SASA: 106560478(alg6)
OTW: 112251366(alg6)
ELS: 105011912(alg6)
SFM: 108935514(alg6)
LCM: 102347073 102367499(ALG6)
CMK: 103188824(alg6)
CIN: 100177063
SPU: 591591
APLC: 110989378
SKO: 102806381
DME: Dmel_CG5091(gny)
DSI: Dsimw501_GD23688(Dsim_GD23688)
MDE: 101901798
AAG: 5567997
BTER: 105666302
SOC: 105208187
AEC: 105145883
ACEP: 105618921
PBAR: 105432721
HST: 105184276
DQU: 106745142
CFO: 109609714
LHU: 105678272
PGC: 109862366
PCF: 106785522
NVI: 107980453
MDL: 106694031
TCA: 660992
DPA: 109546787
NVL: 108569629
BMOR: 101739034
PMAC: 106714609
PRAP: 110996587
HAW: 110370956
PXY: 105382225
DNX: 107161902
CLEC: 106672624
ZNE: 110837011
FCD: 110847940
CEL: CELE_C08B11.8(C08B11.8)
CBR: CBG13345
CRG: 105344039
MYI: 110461575
OBI: 106876492
SHX: MS3_09591
EGL: EGR_03476
EPA: 110241901
HMG: 100212807
AQU: 100637175
ATH: AT5G38460
CRB: 17879686
BRP: 103863785
BOE: 106336946
THJ: 104823863
CIT: 102614354
TCC: 18602064
GRA: 105800443
DZI: 111307727
EGR: 104449421
GMX: 100809881
VRA: 106779287
VAR: 108338929
CCAJ: 109807934
CAM: 101508658
LJA: Lj2g3v0178240.1(Lj2g3v0178240.1)
ADU: 107496977
LANG: 109347413
FVE: 101299480
PPER: 18792310
PMUM: 103319131
PAVI: 110764879
PXB: 103933347
ZJU: 107434554
CSV: 101213368
MCHA: 111016925
CMAX: 111482205
CMOS: 111441865
CPEP: 111790566
RCU: 8261177
JCU: 105638725
HBR: 110661109
JRE: 109013415
VVI: 100241202
SLY: 101245516
SPEN: 107009207
SOT: 102604261
NSY: 104233050
NTO: 104093727
INI: 109177503
SIND: 105178349
OEU: 111382797
HAN: 110889422
LSV: 111917918
CCAV: 112519850
DCR: 108193203
BVG: 104905946
SOE: 110799005
NNU: 104612640
OSA: 4342475
DOSA: Os07t0164500-01(Os07g0164500)
OBR: 102718344
BDI: 100834235
ATS: 109761484(LOC109761484)
SBI: 110429710
SITA: 101773240
MUS: 103984187
DCT: 110098774
PEQ: 110039375
AOF: 109843181
ATR: 18437952
SMO: SELMODRAFT_452924(GT57A1)
PPP: 112295718
CRE: CHLREDRAFT_36194(GTR21)
MNG: MNEG_5112
APRO: F751_3706
SCE: YOR002W(ALG6)
ERC: Ecym_3027
KMX: KLMA_80037(ALG6)
NCS: NCAS_0D02160(NCAS0D02160)
NDI: NDAI_0C02630(NDAI0C02630)
TPF: TPHA_0J00350(TPHA0J00350)
TBL: TBLA_0G00970(TBLA0G00970)
TDL: TDEL_0G04470(TDEL0G04470)
KAF: KAFR_0A05070(KAFR0A05070)
PIC: PICST_29880(ALG6)
CAL: CAALFM_CR06900CA(ALG6)
SLB: AWJ20_2484(ALG6)
NCR: NCU03317
NTE: NEUTE1DRAFT114446(NEUTE1DRAFT_114446)
MGR: MGG_09310
SSCK: SPSK_01578
MAW: MAC_09329
MAJ: MAA_03384
CMT: CCM_07273
BFU: BCIN_15g01740(Bcalg6)
MBE: MBM_00132
ANI: AN4864.2
ANG: ANI_1_1736024(An02g12630)
ABE: ARB_06600
TVE: TRV_04803
PTE: PTT_11965
SPO: SPBC342.01c(alg6)
LBC: LACBIDRAFT_399393(ALG6)
ABP: AGABI1DRAFT74153(AGABI1DRAFT_74153)
ABV: AGABI2DRAFT206973(AGABI2DRAFT_206973)
MGL: MGL_2343
DDI: DDB_G0283841(alg6)
CPV: cgd4_3120
SMIN: v1.2.013301.t1(symbB.v1.2.013301.t1)
SPAR: SPRG_04930
EHX: EMIHUDRAFT_521937(ALG6-2) EMIHUDRAFT_521942(ALG6-1)
 » show all
Taxonomy
Reference
1  [PMID:8877369]
  Authors
Reiss G, te Heesen S, Zimmerman J, Robbins PW, Aebi M
  Title
Isolation of the ALG6 locus of Saccharomyces cerevisiae required for glucosylation in the N-linked glycosylation pathway.
  Journal
Glycobiology 6:493-8 (1996)
DOI:10.1093/glycob/6.5.493
  Sequence
[sce:YOR002W]
Reference
2  [PMID:6423630]
  Authors
Runge KW, Huffaker TC, Robbins PW
  Title
Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway.
  Journal
J Biol Chem 259:412-7 (1984)
Reference
3  [PMID:14517965]
  Authors
Westphal V, Xiao M, Kwok PY, Freeze HH
  Title
Identification of a frequent variant in ALG6, the cause of Congenital Disorder of Glycosylation-Ic.
  Journal
Hum Mutat 22:420-1 (2003)
DOI:10.1002/humu.9195
  Sequence
[hsa:29929]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.267
IUBMB Enzyme Nomenclature: 2.4.1.267
ExPASy - ENZYME nomenclature database: 2.4.1.267
BRENDA, the Enzyme Database: 2.4.1.267

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