KEGG   ENZYME: 2.4.1.274Help
Entry
EC 2.4.1.274                Enzyme                                 

Name
glucosylceramide beta-1,4-galactosyltransferase;
lactosylceramide synthase;
uridine diphosphate-galactose:glucosyl ceramide beta 1-4 galactosyltransferase;
UDP-Gal:glucosylceramide beta1->4galactosyltransferase;
GalT-2 (misleading);
UDP-galactose:beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03354 R06276]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-glucosyl-(1<->1)-ceramide [CPD:C01190]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Comment
Involved in the synthesis of several different major classes of glycosphingolipids.
History
EC 2.4.1.274 created 2011
Pathway
ec00600  Sphingolipid metabolism
ec01100  Metabolic pathways
Orthology
K07553  beta-1,4-galactosyltransferase 6
Genes
HSA: 9331(B4GALT6)
PTR: 468512(B4GALT6)
PPS: 100993210(B4GALT6)
GGO: 101152268(B4GALT6)
PON: 100455489(B4GALT6)
NLE: 100589590(B4GALT6)
MCC: 706068(B4GALT6)
MCF: 102126845(B4GALT6)
CSAB: 103222574(B4GALT6)
RRO: 104676080(B4GALT6)
RBB: 108519203(B4GALT6)
CJC: 100415155(B4GALT6)
SBQ: 101033869(B4GALT6)
MMU: 56386(B4galt6)
RNO: 65196(B4galt6)
CGE: 100689438(B4galt6)
NGI: 103730564(B4galt6)
HGL: 101726172(B4galt6)
CCAN: 109701903(B4galt6)
OCU: 100348067(B4GALT6)
TUP: 102469566(B4GALT6)
CFA: 490499(B4GALT6)
AML: 100474316(B4GALT6)
UMR: 103663257(B4GALT6)
ORO: 101384375(B4GALT6)
FCA: 101088368(B4GALT6)
PTG: 102972031(B4GALT6)
AJU: 106983835(B4GALT6)
BTA: 524460(B4GALT6)
BOM: 102267802(B4GALT6)
BIU: 109577926(B4GALT6)
PHD: 102340540(B4GALT6)
CHX: 102182084(B4GALT6)
OAS: 101114836(B4GALT6)
SSC: 100517222(B4GALT6)
CFR: 102503599(B4GALT6)
CDK: 105086692(B4GALT6)
BACU: 103020724(B4GALT6)
LVE: 103088100(B4GALT6)
OOR: 101289247(B4GALT6)
ECB: 100052209(B4GALT6)
EPZ: 103561393(B4GALT6)
EAI: 106833968(B4GALT6)
MYB: 102262835(B4GALT6)
MYD: 102754818(B4GALT6)
HAI: 109375981(B4GALT6)
RSS: 109452383(B4GALT6)
PALE: 102890757(B4GALT6)
LAV: 100675072(B4GALT6)
TMU: 101348467
MDO: 100024039(B4GALT6)
SHR: 100919571(B4GALT6)
OAA: 100084861(B4GALT6)
GGA: 421092(B4GALT6)
MGP: 100544705(B4GALT6)
CJO: 107310112(B4GALT6)
APLA: 101801239(B4GALT6)
ACYG: 106037605(B4GALT6)
TGU: 100224001(B4GALT6)
GFR: 102041264(B4GALT6)
FAB: 101811130(B4GALT6)
PHI: 102111801(B4GALT6)
PMAJ: 107200037(B4GALT6)
CCW: 104690421(B4GALT6)
FPG: 101914158(B4GALT6)
FCH: 102051198(B4GALT6)
CLV: 102095761(B4GALT6)
EGZ: 104126868(B4GALT6)
AAM: 106484570(B4GALT6)
ASN: 102368658(B4GALT6)
AMJ: 102558728(B4GALT6)
PSS: 102452701(B4GALT6)
CMY: 102935373(B4GALT6)
CPIC: 101947429(B4GALT6)
ACS: 100564858(b4galt6)
PVT: 110077648(B4GALT6)
PBI: 103051698(B4GALT6)
XLA: 108695277 779435(b4galt5.L)
XTR: 548965(b4galt5)
NPR: 108786088(B4GALT6)
DRE: 393912(b4galt6)
SGH: 107588895
IPU: 108258006(b4galt6)
AMEX: 103035788(b4galt6)
TRU: 101067520
LCO: 104925469
NCC: 104953137
MZE: 101483448
OLA: 101160972
CSEM: 103399846(b4galt6)
LCF: 108900672
BPEC: 110161219
ELS: 105011876(b4galt6)
LCM: 102348772(B4GALT6)
CMK: 103179660(b4galt6)
CIN: 100184389
SPU: 576438
SKO: 102808999
BMOR: 101738741
 » show all
Taxonomy
Reference
1  [PMID:3099851]
  Authors
Chatterjee S, Castiglione E
  Title
UDPgalactose:glucosylceramide beta 1----4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes.
  Journal
Biochim Biophys Acta 923:136-42 (1987)
DOI:10.1016/0304-4165(87)90136-X
  Sequence
[hsa:9331]
Reference
2  [PMID:1900430]
  Authors
Trinchera M, Fiorilli A, Ghidoni R
  Title
Localization in the Golgi apparatus of rat liver UDP-Gal:glucosylceramide beta 1----4galactosyltransferase.
  Journal
Biochemistry 30:2719-24 (1991)
Reference
3  [PMID:1551920]
  Authors
Chatterjee S, Ghosh N, Khurana S
  Title
Purification of uridine diphosphate-galactose:glucosyl ceramide, beta 1-4 galactosyltransferase from human kidney.
  Journal
J Biol Chem 267:7148-53 (1992)
  Sequence
[hsa:9331]
Reference
4  [PMID:9593693]
  Authors
Nomura T, Takizawa M, Aoki J, Arai H, Inoue K, Wakisaka E, Yoshizuka N, Imokawa G, Dohmae N, Takio K, Hattori M, Matsuo N
  Title
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.
  Journal
J Biol Chem 273:13570-7 (1998)
DOI:10.1074/jbc.273.22.13570
  Sequence
[rno:65196]
Reference
5  [PMID:10320813]
  Authors
Takizawa M, Nomura T, Wakisaka E, Yoshizuka N, Aoki J, Arai H, Inoue K, Hattori M, Matsuo N
  Title
cDNA cloning and expression of human lactosylceramide synthase.
  Journal
Biochim Biophys Acta 1438:301-4 (1999)
DOI:10.1016/S1388-1981(99)00051-7
  Sequence
[hsa:9331]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.274
IUBMB Enzyme Nomenclature: 2.4.1.274
ExPASy - ENZYME nomenclature database: 2.4.1.274
BRENDA, the Enzyme Database: 2.4.1.274

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