KEGG   ENZYME: 2.4.1.275Help
Entry
EC 2.4.1.275                Enzyme                                 

Name
neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]
History
EC 2.4.1.275 created 2011, modified 2013
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 8702(B4GALT4)
PTR: 100608173(B4GALT4)
PPS: 100994562(B4GALT4)
GGO: 101146705(B4GALT4) 109026348
PON: 100443591(B4GALT4)
NLE: 100600025(B4GALT4)
MCC: 711983(B4GALT4)
MCF: 102142820(B4GALT4)
CSAB: 103228234(B4GALT4)
RRO: 104657610(B4GALT4)
RBB: 108531771(B4GALT4)
CJC: 100402903(B4GALT4)
SBQ: 101029385(B4GALT4)
MMU: 56375(B4galt4)
RNO: 303923(B4galt4)
CGE: 100689435(B4galt4)
NGI: 103741937(B4galt4)
HGL: 101723638(B4galt4)
CCAN: 109694543(B4galt4)
OCU: 100357504(B4GALT4)
TUP: 102470291(B4GALT4)
CFA: 608143(B4GALT4)
AML: 100481658(B4GALT4)
UMR: 103678795(B4GALT4)
ORO: 101385802(B4GALT4)
FCA: 101100325(B4GALT4)
PTG: 102966539(B4GALT4)
AJU: 106980243(B4GALT4)
BTA: 511328(B4GALT4)
BOM: 102279871(B4GALT4)
BIU: 109576562(B4GALT4)
PHD: 102340702(B4GALT4)
CHX: 102190262(B4GALT4)
OAS: 101104949(B4GALT4)
CFR: 102522848(B4GALT4)
CDK: 105090333(B4GALT4)
BACU: 103005928(B4GALT4)
LVE: 103084555(B4GALT4)
OOR: 101278923(B4GALT4)
ECB: 100071082(B4GALT4)
EPZ: 103547412(B4GALT4)
EAI: 106823399(B4GALT4) 106840352
MYB: 102243483(B4GALT4)
MYD: 102775104(B4GALT4)
HAI: 109386911(B4GALT4)
RSS: 109446346(B4GALT4)
PALE: 102879802(B4GALT4)
LAV: 100662008(B4GALT4)
TMU: 101352100
MDO: 100015888(B4GALT4)
SHR: 100933479(B4GALT4)
GGA: 418341(B4GALT4)
MGP: 100547867(B4GALT4)
CJO: 107320407(B4GALT4)
APLA: 101792176(B4GALT4)
ACYG: 106037583(B4GALT4)
TGU: 100230291(B4GALT4)
GFR: 102034782(B4GALT4)
FAB: 101809954(B4GALT4)
PHI: 102108146(B4GALT4)
PMAJ: 107205999(B4GALT4)
CCAE: 111939072(B4GALT4)
CCW: 104687053(B4GALT4)
FPG: 101915659(B4GALT4)
FCH: 102051115(B4GALT4)
CLV: 102093764(B4GALT4)
EGZ: 104126497(B4GALT4)
AAM: 106490705(B4GALT4)
ASN: 102370808(B4GALT4)
AMJ: 102569919(B4GALT4)
PSS: 102453780(B4GALT4)
CMY: 102946330(B4GALT4)
CPIC: 101953425(B4GALT4)
ACS: 100553568(b4galt4)
PVT: 110074021(B4GALT4)
PBI: 103068176(B4GALT4)
GJA: 107106045(B4GALT4)
XLA: 108707823(b4galt4.L) 444709(b4galt4.S)
XTR: 100488464(b4galt4)
NPR: 108797173(B4GALT4)
DRE: 492760(b4galt4)
SRX: 107719754 107752248(b4galt4)
SGH: 107557767(b4galt4) 107576632
IPU: 108260163(b4galt4)
AMEX: 103042661(b4galt4)
TRU: 101061200(b4galt4)
LCO: 104935626(b4galt4)
NCC: 104965999(b4galt4)
MZE: 101466383(b4galt4)
OLA: 101164915(b4galt4)
XMA: 102221477(b4galt4)
PRET: 103475412(b4galt4)
NFU: 107386424(b4galt4)
KMR: 108237029(b4galt4)
CSEM: 103395579
LCF: 108893526(b4galt4)
SDU: 111234517(b4galt4)
HCQ: 109517999(b4galt4)
BPEC: 110158487(b4galt4)
MALB: 109959384(b4galt4)
SASA: 106563608(b4galt4) 106603047
OTW: 112228922 112231206(b4galt4)
ELS: 105010876(b4galt4)
SFM: 108924680(b4galt4)
CMK: 103185094(b4galt4)
PRAP: 110995450
LAK: 106153459
SHX: MS3_01473
 » show all
Taxonomy
Reference
1  [PMID:9792633]
  Authors
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H
  Title
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid  biosynthesis.
  Journal
J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331
  Sequence
[hsa:8702]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.275
IUBMB Enzyme Nomenclature: 2.4.1.275
ExPASy - ENZYME nomenclature database: 2.4.1.275
BRENDA, the Enzyme Database: 2.4.1.275

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