KEGG   ENZYME: 2.4.1.275Help
Entry
EC 2.4.1.275                Enzyme                                 

Name
neolactotriaosylceramide beta-1,4-galactosyltransferase;
beta4Gal-T4;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase;
lactotriaosylceramide beta-1,4-galactosyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05977 R09755]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04845]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04922]
History
EC 2.4.1.275 created 2011, modified 2013
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 8702(B4GALT4)
PTR: 100608173(B4GALT4)
PPS: 100994562(B4GALT4)
GGO: 101146705(B4GALT4) 109026348
PON: 100443591(B4GALT4)
NLE: 100600025(B4GALT4)
MCC: 711983(B4GALT4)
MCF: 102142820(B4GALT4)
CSAB: 103228234(B4GALT4)
RRO: 104657610(B4GALT4)
RBB: 108531771(B4GALT4)
CJC: 100402903(B4GALT4)
SBQ: 101029385(B4GALT4)
MMU: 56375(B4galt4)
RNO: 303923(B4galt4)
CGE: 100689435(B4galt4)
NGI: 103741937(B4galt4)
HGL: 101723638(B4galt4)
CCAN: 109694543(B4galt4)
OCU: 100357504(B4GALT4)
TUP: 102470291(B4GALT4)
CFA: 608143(B4GALT4)
AML: 100481658(B4GALT4)
UMR: 103678795(B4GALT4)
ORO: 101385802(B4GALT4)
FCA: 101100325(B4GALT4)
PTG: 102966539(B4GALT4)
AJU: 106980243(B4GALT4)
BTA: 511328(B4GALT4)
BOM: 102279871(B4GALT4)
BIU: 109576562(B4GALT4)
PHD: 102340702(B4GALT4)
CHX: 102190262(B4GALT4)
OAS: 101104949(B4GALT4)
CFR: 102522848(B4GALT4)
CDK: 105090333(B4GALT4)
BACU: 103005928(B4GALT4)
LVE: 103084555(B4GALT4)
OOR: 101278923(B4GALT4)
ECB: 100071082(B4GALT4)
EPZ: 103547412(B4GALT4)
EAI: 106823399(B4GALT4) 106840352
MYB: 102243483(B4GALT4)
MYD: 102775104(B4GALT4)
HAI: 109386911(B4GALT4)
RSS: 109446346(B4GALT4)
PALE: 102879802(B4GALT4)
LAV: 100662008(B4GALT4)
TMU: 101352100
MDO: 100015888(B4GALT4)
SHR: 100933479(B4GALT4)
GGA: 418341(B4GALT4)
MGP: 100547867(B4GALT4)
CJO: 107320407(B4GALT4)
APLA: 101792176(B4GALT4)
ACYG: 106037583(B4GALT4)
TGU: 100230291(B4GALT4)
GFR: 102034782(B4GALT4)
FAB: 101809954(B4GALT4)
PHI: 102108146(B4GALT4)
PMAJ: 107205999(B4GALT4)
CCAE: 111939072(B4GALT4)
CCW: 104687053(B4GALT4)
FPG: 101915659(B4GALT4)
FCH: 102051115(B4GALT4)
CLV: 102093764(B4GALT4)
EGZ: 104126497(B4GALT4)
AAM: 106490705(B4GALT4)
ASN: 102370808(B4GALT4)
AMJ: 102569919(B4GALT4)
PSS: 102453780(B4GALT4)
CMY: 102946330(B4GALT4)
CPIC: 101953425(B4GALT4)
ACS: 100553568(b4galt4)
PVT: 110074021(B4GALT4)
PBI: 103068176(B4GALT4)
GJA: 107106045(B4GALT4)
XLA: 108707823(b4galt4.L) 444709(b4galt4.S)
XTR: 100488464(b4galt4)
NPR: 108797173(B4GALT4)
DRE: 492760(b4galt4)
SRX: 107719754 107752248(b4galt4)
SGH: 107557767(b4galt4) 107576632
IPU: 108260163(b4galt4)
AMEX: 103042661(b4galt4)
TRU: 101061200(b4galt4)
LCO: 104935626(b4galt4)
NCC: 104965999(b4galt4)
MZE: 101466383(b4galt4)
OLA: 101164915(b4galt4)
XMA: 102221477(b4galt4)
PRET: 103475412(b4galt4)
NFU: 107386424(b4galt4)
KMR: 108237029(b4galt4)
CSEM: 103395579
LCF: 108893526(b4galt4)
SDU: 111234517(b4galt4)
HCQ: 109517999(b4galt4)
BPEC: 110158487(b4galt4)
MALB: 109959384(b4galt4)
SASA: 106563608(b4galt4) 106603047
OTW: 112228922 112231206(b4galt4)
ELS: 105010876(b4galt4)
SFM: 108924680(b4galt4)
CMK: 103185094(b4galt4)
PRAP: 110995450
LAK: 106153459
SHX: MS3_01473
 » show all
Taxonomy
Reference
1  [PMID:9792633]
  Authors
Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett E, Clausen H
  Title
Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid  biosynthesis.
  Journal
J Biol Chem 273:29331-40 (1998)
DOI:10.1074/jbc.273.45.29331
  Sequence
[hsa:8702]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.275
IUBMB Enzyme Nomenclature: 2.4.1.275
ExPASy - ENZYME nomenclature database: 2.4.1.275
BRENDA, the Enzyme Database: 2.4.1.275

KEGG   ENZYME: 2.4.1.90Help
Entry
EC 2.4.1.90                 Enzyme                                 

Name
N-acetyllactosamine synthase;
UDP-galactose---N-acetylglucosamine beta-D-galactosyltransferase;
uridine diphosphogalactose-acetylglucosamine galactosyltransferase;
beta-1,4-galactosyltransferase;
acetyllactosamine synthetase;
lactosamine synthase;
lactosamine synthetase;
lactose synthetase A protein;
N-acetyllactosamine synthetase;
UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase;
UDP-galactose-acetylglucosamine galactosyltransferase;
UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase;
UDP-galactose-N-acetylglucosamine galactosyltransferase;
beta1-4-galactosyltransferase;
UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase;
beta1-4GalT;
NAL synthetase;
UDP-beta-1,4-galactosyltransferase;
Gal-T;
UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase;
UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase;
beta-N-acetylglucosaminide beta1-4-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine [RN:R01205 R06055]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-D-glucosamine [CPD:C00140]
Product
UDP [CPD:C00015];
N-acetyllactosamine [CPD:C00611]
Comment
The reaction is catalysed by a component of EC 2.4.1.22 (lactose synthase), which is identical with EC 2.4.1.38 (beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase), and by an enzyme from the Golgi apparatus of animal tissues. Formerly listed also as EC 2.4.1.98.
History
EC 2.4.1.90 created 1976 (EC 2.4.1.98 created 1980, incorporated 1984)
Orthology
K07966  beta-1,4-galactosyltransferase 1
K07967  beta-1,4-galactosyltransferase 2
K07968  beta-1,4-galactosyltransferase 3
K07969  beta-1,4-galactosyltransferase 4
Genes
HSA: 2683(B4GALT1) 8702(B4GALT4) 8703(B4GALT3) 8704(B4GALT2)
PTR: 100608173(B4GALT4) 100613700(B4GALT1) 456522(B4GALT2) 457451(B4GALT3)
PPS: 100974756(B4GALT1) 100980267(B4GALT2) 100980499(B4GALT3) 100994562(B4GALT4)
GGO: 101133326(B4GALT2) 101138982(B4GALT1) 101146705(B4GALT4) 101152694(B4GALT3) 109026348
PON: 100174763(B4GALT3) 100437696(B4GALT2) 100438031(B4GALT1) 100443591(B4GALT4)
NLE: 100597531(B4GALT1) 100598306(B4GALT2) 100600025(B4GALT4) 100600657(B4GALT3)
MCC: 703541(B4GALT1) 704038(B4GALT2) 711983(B4GALT4) 719920(B4GALT3)
MCF: 102115300(B4GALT2) 102123574(B4GALT3) 102131044(B4GALT1) 102142820(B4GALT4)
CSAB: 103219294(B4GALT1) 103223692(B4GALT3) 103224947(B4GALT2) 103228234(B4GALT4)
RRO: 104657610(B4GALT4) 104665338(B4GALT3) 104669045(B4GALT2) 104674271(B4GALT1)
RBB: 108518246(B4GALT1) 108521170(B4GALT3) 108531771(B4GALT4) 108535685(B4GALT2)
CJC: 100385157(B4GALT1) 100402903(B4GALT4) 100413633(B4GALT3) 100414763 100896540(B4GALT2)
SBQ: 101029385(B4GALT4) 101039415(B4GALT2) 101048901(B4GALT3) 101054125(B4GALT1)
MMU: 14595(B4galt1) 53418(B4galt2) 56375(B4galt4) 57370(B4galt3)
RNO: 24390(B4galt1) 303923(B4galt4) 313536(B4galt2) 494342(B4galt3)
CGE: 100689346(B4galt3) 100689430(B4galt1) 100689434(B4galt2) 100689435(B4galt4)
NGI: 103741594(B4galt1) 103741937(B4galt4) 103743868(B4galt2) 103745954(B4galt3)
HGL: 101698779 101702700(B4galt3) 101718811(B4galt2) 101721414(B4galt1) 101723638(B4galt4)
CCAN: 109681413 109689965 109693205(B4galt3) 109694543(B4galt4) 109695495(B4galt2)
OCU: 100345726(B4GALT1) 100351419(B4GALT2) 100357504(B4GALT4) 100358436(B4GALT3)
TUP: 102470291(B4GALT4) 102470655(B4GALT1) 102489782(B4GALT2) 102501629(B4GALT3)
CFA: 476397 481579(B4GALT1) 482527(B4GALT2) 488650(B4GALT3) 608143(B4GALT4)
AML: 100471634(B4GALT2) 100477164(B4GALT1) 100479119 100481658(B4GALT4) 100482718(B4GALT3)
UMR: 103657308 103667105(B4GALT1) 103670800(B4GALT2) 103672017(B4GALT3) 103678795(B4GALT4)
ORO: 101362571(B4GALT1) 101364688(B4GALT2) 101366805(B4GALT3) 101385802(B4GALT4)
FCA: 101084809(B4GALT2) 101089738(B4GALT3) 101100325(B4GALT4) 101100927(B4GALT1)
PTG: 102955088(B4GALT2) 102959538(B4GALT1) 102965736(B4GALT3) 102966539(B4GALT4)
AJU: 106970225(B4GALT2) 106976144(B4GALT1) 106978533(B4GALT3) 106980243(B4GALT4)
BTA: 100125390(B4GALT2) 281781(B4GALT1) 511328(B4GALT4) 515771(B4GALT3)
BOM: 102269762(B4GALT1) 102273575(B4GALT3) 102279871(B4GALT4) 102283249(B4GALT2)
BIU: 109556391(B4GALT2) 109563168(B4GALT1) 109576562(B4GALT4) 109578355(B4GALT3)
PHD: 102317609(B4GALT2) 102321948(B4GALT1) 102340702(B4GALT4) 102343232(B4GALT3)
CHX: 100860927(B4GALT1) 102190262(B4GALT4) 102191101(B4GALT2) 102191287(B4GALT3)
OAS: 100620048(B4GALT1) 101103686(B4GALT3) 101104949(B4GALT4) 101114825(B4GALT2)
SSC: 100154856(B4GALT3) 100511655(B4GALT1) 100514465 100736821(B4GALT2)
CFR: 102510375(SIGLEC6) 102516080(B4GALT2) 102517623(B4GALT1) 102522848(B4GALT4) 102523348(B4GALT3)
CDK: 105085573(B4GALT1) 105090333(B4GALT4) 105090897(B4GALT2) 105100111(B4GALT3)
BACU: 102999260(B4GALT1) 103001417(B4GALT2) 103005928(B4GALT4) 103014433(B4GALT3)
LVE: 103083911(B4GALT3) 103084555(B4GALT4) 103086401(B4GALT1) 103086978(B4GALT2)
OOR: 101278293(B4GALT3) 101278923(B4GALT4) 101285364(B4GALT1) 101285582(B4GALT2)
ECB: 100065936 100066144(B4GALT3) 100066149(B4GALT2) 100068209(B4GALT1) 100071082(B4GALT4)
EPZ: 103540622 103547412(B4GALT4) 103548278(B4GALT2) 103555031(B4GALT1) 103559988(B4GALT3)
EAI: 106822347 106823399(B4GALT4) 106827571(B4GALT3) 106840352 106841463(B4GALT1) 106847911(B4GALT2)
MYB: 102240062(B4GALT1) 102243483(B4GALT4) 102245477(B4GALT3) 102248727(B4GALT2)
MYD: 102751484(B4GALT1) 102755410 102770964(B4GALT3) 102772464 102774860(B4GALT2) 102775104(B4GALT4)
HAI: 109371790(B4GALT1) 109376935(B4GALT3) 109383427(B4GALT2) 109386911(B4GALT4)
RSS: 109435224(B4GALT3) 109446346(B4GALT4) 109448661(B4GALT1) 109457878(B4GALT2)
PALE: 102878748(B4GALT1) 102879802(B4GALT4) 102884318(B4GALT2) 102897413(B4GALT3)
LAV: 100657659(B4GALT2) 100659897(B4GALT1) 100662008(B4GALT4) 100666904 100671768(B4GALT3)
MDO: 100010600(B4GALT1) 100015888(B4GALT4) 100028240 100032749(B4GALT3) 100617718(B4GALT2)
SHR: 100917085(B4GALT3) 100918732(B4GALT2) 100929465(B4GALT1) 100933479(B4GALT4) 100934965
OAA: 100075607 100075703(B4GALT1) 100092000(B4GALT2)
GGA: 396121(B4GALT1) 396122(B4GALT2) 418341(B4GALT4) 418342(B4GALT3)
MGP: 100543545(B4GALT1) 100543680(B4GALT2) 100547867(B4GALT4) 100548019
CJO: 107306674(B4GALT1) 107307393 107317480(B4GALT2) 107320407(B4GALT4) 107320437
APLA: 101792176(B4GALT4) 101792630 101792817(B4GALT1) 101802590(B4GALT2) 101803398
ACYG: 106037583(B4GALT4) 106037599(B4GALT3) 106040136(B4GALT1) 106049039(B4GALT2)
TGU: 100219809 100223650(B4GALT1) 100230291(B4GALT4) 100230857(B4GALT2)
GFR: 102034619 102034782(B4GALT4) 102035894(B4GALT3) 102036032(B4GALT2) 102041517(B4GALT1)
FAB: 101805871(B4GALT2) 101807052(B4GALT1) 101809643 101809954(B4GALT4)
PHI: 102104795(B4GALT3) 102106294(B4GALT2) 102108146(B4GALT4) 102108330 102109081(B4GALT1)
PMAJ: 107198186(B4GALT1) 107205999(B4GALT4) 107206030(B4GALT3) 107208264(B4GALT2)
CCAE: 111933140(B4GALT2) 111939072(B4GALT4) 111939118 111941228(B4GALT1)
CCW: 104687053(B4GALT4) 104687054 104689823(B4GALT1) 104695261(B4GALT2)
FPG: 101910439(B4GALT3) 101915659(B4GALT4) 101915824 101916596(B4GALT2) 101918852(B4GALT1)
FCH: 102046112(B4GALT1) 102051115(B4GALT4) 102051290 102056545(B4GALT2) 102057757(B4GALT3)
CLV: 102088289(B4GALT1) 102088677(B4GALT2) 102093764(B4GALT4) 102093948 102094059(B4GALT3)
EGZ: 104123065(B4GALT1) 104125508(B4GALT2) 104126496(B4GALT3) 104126497(B4GALT4)
AAM: 106484931(B4GALT2) 106486901(B4GALT1) 106490693 106490705(B4GALT4) 106500494(B4GALT3)
ASN: 102370415 102370808(B4GALT4) 102371026 102372956(B4GALT1) 102376584(B4GALT2) 102388067(B4GALT3)
AMJ: 102558168(B4GALT2) 102559129(B4GALT1) 102569919(B4GALT4) 102572436 102575172 106737239(B4GALT3)
PSS: 102448865(B4GALT3) 102450039 102453780(B4GALT4) 102459690(B4GALT1) 102461193
CMY: 102937222(B4GALT3) 102941460 102941864(B4GALT2) 102942662(B4GALT1) 102946330(B4GALT4)
CPIC: 101932379(B4GALT1) 101933315 101945883(B4GALT2) 101952944 101953425(B4GALT4) 101953612(B4GALT3)
ACS: 100553459 100553568(b4galt4) 100557158 100557558(b4galt2) 100558708(b4galt3) 100561064(b4galt1)
PVT: 110073738(B4GALT2) 110074017 110074021(B4GALT4) 110081027(B4GALT3) 110087350(B4GALT1) 110089672
PBI: 103050267 103063173(B4GALT3) 103065477(B4GALT1) 103068003 103068176(B4GALT4) 103068203(B4GALT2)
GJA: 107106045(B4GALT4) 107106046 107110573(B4GALT1) 107120293(B4GALT2) 107121751(B4GALT3) 107122018
XLA: 100190782(b4galt2.S) 108696936 108704693 108706812(b4galt1.1.S) 108706813(b4galt1.2.S) 108707823(b4galt4.L) 108709275 108712215(b4galt1.1.L) 108712216(b4galt1.2.L) 108712940 108712957 108714282(b4galt2.L) 379106(MGC52827) 414540 444709(b4galt4.S) 446718(b4galt3.S) 496041
XTR: 100145518(b4galt1.1) 100485024 100486704 100488464(b4galt4) 100492356(b4galt2) 448369(b4galt3) 549418(b4galt1.2) 733985(b4galt3)
DRE: 100148828(b4galt2) 492760(b4galt4) 550425(b4galt1) 556544(si:dkey-199f5.8) 561756(b4galt3) 768123(b4galt1l)
IPU: 108256292 108260163(b4galt4) 108260689 108267387(b4galt2) 108276285 108277608(B4galt1)
AMEX: 103022975(b4galt3) 103028729 103031892 103033307(b4galt2) 103039461 103042661(b4galt4)
OLA: 100301598(b4galt2) 101159351(b4galt3) 101162708 101164915(b4galt4) 101171148(b4galt1)
KMR: 108235243 108237029(b4galt4) 108241697(b4galt2) 108248973(b4galt1) 108250944 108251055
SDU: 111219126 111219224(b4galt3) 111230961(b4galt2) 111233512(b4galt1) 111234517(b4galt4) 111235761 111237265
BPEC: 110158487(b4galt4) 110161009 110164179(b4galt2) 110164938 110168019(b4galt1) 110170479
CIN: 100175041
DPA: 109536817
BMOR: 101738885
PMAC: 106710215
PRAP: 110995450
PXY: 105398071
FCD: 110842915
TUT: 107361940
CEL: CELE_Y73E7A.7(bre-4)
CBR: CBG22165(Cbr-bre-4)
BMY: Bm1_02765
OBI: 106871325
ADF: 107350754
 » show all
Taxonomy
Reference
1  [PMID:99178]
  Authors
Deshmukh DS, Bear WD, Soifer D.
  Title
Isolation and characterization of an enriched Golgi fraction from rat brain.
  Journal
Biochim Biophys Acta 542:284-95 (1978)
DOI:10.1016/0304-4165(78)90024-7
Reference
2  [PMID:4631039]
  Authors
Helting T, Erbing B.
  Title
Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase.
  Journal
Biochim Biophys Acta 293:94-104 (1973)
DOI:10.1016/0005-2744(73)90379-3
Reference
3  [PMID:812340]
  Authors
Hill RL, Brew K.
  Title
Lactose synthetase.
  Journal
Adv Enzymol Relat Areas Mol Biol 43:411-90 (1975)
Reference
4  [PMID:6201486]
  Authors
Humphreys-Beher MG.
  Title
Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol.
  Journal
J Biol Chem 259:5797-802 (1984)
Reference
5  [PMID:4392041]
  Authors
Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S.
  Title
Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction.
  Journal
J Biol Chem 245:1090-100 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.90
IUBMB Enzyme Nomenclature: 2.4.1.90
ExPASy - ENZYME nomenclature database: 2.4.1.90
BRENDA, the Enzyme Database: 2.4.1.90
CAS: 9054-94-8

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