KEGG   ENZYME: 2.4.1.292Help
Entry
EC 2.4.1.292                Enzyme                                 

Name
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase;
PglH
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol 4-alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
3 UDP-N-acetyl-alpha-D-galactosamine + GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol = 3 UDP + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Product
UDP [CPD:C00015];
[GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-diNAcBac-PP-tritrans,heptacis-undecaprenol
Comment
Isolated from Campylobacter jejuni. Part of a bacterial N-linked glycosylation pathway.
History
EC 2.4.1.292 created 2012
Orthology
K17249  GalNAc-alpha-(1->4)-GalNAc-alpha-(1->3)-diNAcBac-PP-undecaprenol alpha-1,4-N-acetyl-D-galactosaminyltransferase
Genes
ABH: M3Q_293
CJE: Cj1129c(pglH)
CJB: BN148_1129c(pglH)
CJJ: CJJ81176_1146(pglH)
CJU: C8J_1069(wlaC)
CJN: ICDCCJ07001_1086
CJI: CJSA_1071(pglH)
CJM: CJM1_1107(capM)
CJS: CJS3_1175(pglH)
CJP: A911_05470
CJEJ: N564_01097
CJEU: N565_01140
CJEN: N755_01133
CJEI: N135_01166
CJER: H730_06615
CJV: MTVDSCj20_1132(pglH)
CJY: QZ67_01207(pglH)
CJQ: UC78_1086(pglH)
CJR: CJE1271(pglH)
CJD: JJD26997_0592(pglH)
CCV: CCV52592_1216(pglH1)
CCO: CCC13826_0455(pglH2)
CCOC: CCON33237_1467(pglH1) CCON33237_1468(pglH2)
CLA: Cla_1251(pglH)
CLR: UPTC16701_1234(pglH)
CLM: UPTC16712_1252(pglH)
CLQ: UPTC4110_1236(pglH)
CLN: UPTC3659_1471(pglH)
CLL: CONCH_1202(pglH)
CCQ: N149_1070
CCF: YSQ_03325
CCY: YSS_06110
CCOI: YSU_03360
CCOF: VC76_05540(pglH_1)
CCOO: ATE51_01346(pglH)
CIS: CINS_1216(pglH)
CVO: CVOL_1230(pglH)
CPEL: CPEL_1357(pglH)
CAMR: CAQ16704_1262(pglH)
CSM: CSUB8521_1438(pglH)
CSF: CSUB8523_1534(pglH)
CGRA: CGRAC_1492(pglH1) CGRAC_1494(pglH2)
CURE: CUREO_1377(pglH)
CHYO: CHH_0374 CHH_0375(pglH)
CHV: CHELV3228_0551(pglH)
CSPF: CSF_0895(pglH1) CSF_0897(pglH2)
CCUN: CCUN_1168(pglH)
CLX: CLAN_0351 CLAN_0352(pglH)
CAVI: CAV_0408(pglH)
 » show all
Taxonomy
Reference
1  [PMID:16186480]
  Authors
Glover KJ, Weerapana E, Imperiali B
  Title
In vitro assembly of the undecaprenylpyrophosphate-linked heptasaccharide for prokaryotic N-linked glycosylation.
  Journal
Proc Natl Acad Sci U S A 102:14255-9 (2005)
DOI:10.1073/pnas.0507311102
  Sequence
[cje:Cj1129c]
Reference
2  [PMID:19159314]
  Authors
Troutman JM, Imperiali B
  Title
Campylobacter jejuni PglH is a single active site processive polymerase that utilizes product inhibition to limit sequential glycosyl transfer reactions.
  Journal
Biochemistry 48:2807-16 (2009)
DOI:10.1021/bi802284d
  Sequence
[cje:Cj1129c]
Reference
3  [PMID:21606362]
  Authors
Borud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M
  Title
Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.
  Journal
Proc Natl Acad Sci U S A 108:9643-8 (2011)
DOI:10.1073/pnas.1103321108
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.292
IUBMB Enzyme Nomenclature: 2.4.1.292
ExPASy - ENZYME nomenclature database: 2.4.1.292
BRENDA, the Enzyme Database: 2.4.1.292

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