KEGG   ENZYME: 2.4.1.40Help
Entry
EC 2.4.1.40                 Enzyme                                 

Name
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase;
A-transferase;
histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase);
UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase;
alpha-3-N-acetylgalactosaminyltransferase;
blood-group substance alpha-acetyltransferase;
blood-group substance A-dependent acetylgalactosaminyltransferase;
fucosylgalactose acetylgalactosaminyltransferase;
histo-blood group A acetylgalactosaminyltransferase;
histo-blood group A transferase;
UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose [RN:R04423]
Reaction(KEGG)
R04423;
(other) R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose
Product
UDP [CPD:C00015];
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose [CPD:C06483]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.40 created 1972, modified 1999
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K00709  histo-blood group ABO system transferase
Genes
HSA: 28(ABO)
PTR: 450164(ABO)
PPS: 100970130(ABO)
GGO: 101125978(ABO) 109025275
PON: 100454822(ABO)
MCC: 722252(ABO)
MCF: 102118138(ABO)
CSAB: 103239700(ABO)
RRO: 104669731(ABO)
RBB: 108512581 108513461(ABO)
CJC: 100414456(ABO)
MMU: 80908(Abo)
RNO: 100301568(Abo) 296504(Abo2) 65270(Gbgt1)
CGE: 100754666 100757742 100758032 100772592(Abo)
NGI: 103740691(Abo)
HGL: 106010599
CCAN: 109683353 109696117(Abo)
OCU: 100337847 100338543 100345312 100352380 103347352 108175433
TUP: 102470199 102471037
CFA: 100685413 491265(ABO)
AML: 100466091(ABO) 105235331
UMR: 103659300 103661988 103670246 103673989 103679813 103679933(ABO) 103681749
ORO: 101364486 101369984 101372255 101374892 101377160 101380669 101381173 101382297 105758002
FCA: 101087791 105260069
PTG: 107181109
AJU: 106989205(ABO)
BTA: 515340(ABO)
BOM: 102283688(ABO)
BIU: 109565683(ABO)
PHD: 102327867
CHX: 102168916(ABO)
OAS: 101114008(ABO)
SSC: 396713(ABO)
CFR: 102523444(ABO)
CDK: 105105838(ABO)
BACU: 102997485
ECB: 102149124(ABO)
EPZ: 103542251 103542252 103547710 103565343(ABO)
EAI: 106845296 106845360
MYB: 102239108(ABO) 102250048
MYD: 102751691 102765942(ABO)
HAI: 109381041
RSS: 109445968(ABO)
LAV: 100670655(ABO)
TMU: 101341957 101344015 101351903 101353602 101353733 101356026
MDO: 100017917(ABO)
OAA: 100075215
TGU: 100223725
SCAN: 103821701
GFR: 102039105
FAB: 101817249
PHI: 102113787
PMAJ: 107215091
CCAE: 111940162
CCW: 104697784
ACUN: 113484656
AAM: 106488041
PSS: 102449345 102449850 102451136 102451371 102455524 102462837(ABO) 106732582
CPIC: 101943564(ABO) 101944820 101945105 101953665
GJA: 107119149(ABO) 107125123
XLA: 108698211 108698863 108699511 108699512 108699928 108714350 108715628 495825
XTR: 100488200 100491571 100491742 100491908 100492744 100492907 100497509 101734865 549437(abo) 549858 550054(abo)
NPR: 108791544 108791554 108793312 108793313 108801426 108803271
DRE: 100005704(si:dkey-110k5.10)
SRX: 107732598 107747826
SANH: 107680349 107687695 107694233
SGH: 107581033 107592359
CCAR: 109056910 109066903
SALP: 112074307
ELS: 105009969
FPT: BZ13_510
NBA: CUN60_04520
HMS: HMU12050
MPRO: BJP34_10365
BOA: Bovatus_03512
SBX: CA265_12555
 » show all
Taxonomy
Reference
1  [PMID:5661629]
  Authors
Kobata A, Grollman EF, Ginsburg V.
  Title
An enzymic basis for blood type A in humans.
  Journal
Arch Biochem Biophys 124:609-12 (1968)
DOI:10.1016/0003-9861(68)90373-1
Reference
2  [PMID:2341371]
  Authors
Takeya A, Hosomi O, Ishiura M.
  Title
Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene.
  Journal
J Biochem (Tokyo) 107:360-8 (1990)
Reference
3  [PMID:6434182]
  Authors
Yates AD, Feeney J, Donald AS, Watkins WM.
  Title
Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase.
  Journal
Carbohydr Res 130:251-60 (1984)
DOI:10.1016/0008-6215(84)85283-0
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.40
IUBMB Enzyme Nomenclature: 2.4.1.40
ExPASy - ENZYME nomenclature database: 2.4.1.40
BRENDA, the Enzyme Database: 2.4.1.40
CAS: 9067-69-0

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (16)   
   KEGG COMPOUND (4)   
   KEGG GLYCAN (12)   
Chemical reaction (8)   
   KEGG REACTION (6)   
   KEGG RCLASS (2)   
Gene (4067)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (155)   
   KEGG MGENES (3207)   
   RefGene (704)   
Protein sequence (125)   
   UniProt (33)   
   SWISS-PROT (4)   
   RefSeq(pep) (8)   
   PDBSTR (79)   
   PMD (1)   
DNA sequence (51)   
   RefSeq(nuc) (9)   
   GenBank (21)   
   EMBL (21)   
3D Structure (46)   
   PDB (46)   
All databases (4317)   

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