KEGG   ENZYME: 2.4.1.40Help
Entry
EC 2.4.1.40                 Enzyme                                 

Name
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase;
A-transferase;
histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase);
UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase;
alpha-3-N-acetylgalactosaminyltransferase;
blood-group substance alpha-acetyltransferase;
blood-group substance A-dependent acetylgalactosaminyltransferase;
fucosylgalactose acetylgalactosaminyltransferase;
histo-blood group A acetylgalactosaminyltransferase;
histo-blood group A transferase;
UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose [RN:R04423]
Reaction(KEGG)
R04423;
(other) R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose
Product
UDP [CPD:C00015];
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose [CPD:C06483]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.40 created 1972, modified 1999
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K00709  histo-blood group ABO system transferase
Genes
HSA: 28(ABO)
PTR: 450164(ABO)
PPS: 100970130(ABO)
GGO: 101125978(ABO) 109025275
PON: 100454822(ABO)
MCC: 722252(ABO)
MCF: 102118138(ABO)
CSAB: 103239700(ABO)
RRO: 104669731(ABO)
RBB: 108512581 108513461(ABO)
CJC: 100414456(ABO)
MMU: 80908(Abo)
RNO: 100301568(Abo) 296504(Abo2) 65270(Gbgt1)
CGE: 100754666 100757742 100758032 100772592(Abo)
NGI: 103740691(Abo)
HGL: 106010599
CCAN: 109683353 109696117(Abo)
OCU: 100337847 100338543 100345312 100352380 103347352 108175433
TUP: 102470199 102471037
CFA: 100685413 491265(ABO)
AML: 100466091(ABO) 105235331
UMR: 103659300 103661988 103670246 103673989 103679813 103679933(ABO) 103681749
ORO: 101364486 101369984 101372255 101374892 101377160 101380669 101381173 101382297 105758002
FCA: 101087791 105260069
PTG: 107181109
AJU: 106989205
BTA: 515340(ABO)
BOM: 102283688(ABO)
BIU: 109565683(ABO)
PHD: 102327867
CHX: 102168916(ABO)
OAS: 101114008(ABO)
SSC: 396713(ABO)
CFR: 102523444(ABO)
CDK: 105105838(ABO)
BACU: 102997485
ECB: 102149124(ABO)
EPZ: 103542251 103542252 103547710 103565343(ABO)
EAI: 106845296 106845360
MYB: 102239108(ABO) 102250048
MYD: 102751691 102765942(ABO)
HAI: 109381041
RSS: 109445968(ABO)
LAV: 100670655(ABO)
TMU: 101341957 101344015 101351903 101353602 101353733 101356026
MDO: 100017917(ABO)
OAA: 100075215
TGU: 100223725
GFR: 102039105
FAB: 101817249
PHI: 102113787
PMAJ: 107215091
CCW: 104697784
AAM: 106488041
PSS: 102449345 102449850 102451136 102451371 102455524 102462837(ABO) 106732582
CPIC: 101943564(ABO) 101944820 101945105 101953665
GJA: 107119149(ABO) 107125123
XLA: 108698211 108698863 108699511 108699512 108699928 108714350 108715628 495825
XTR: 100488200 100491571 100491742 100491908 100492744 100492907 100497509 101734865 549437(abo) 549858 550054(abo)
NPR: 108791544 108791554 108793312 108793313 108801426 108803271
DRE: 100005704(si:dkey-110k5.10)
SRX: 107732598 107747826
SANH: 107680349 107687695 107694233
SGH: 107581033 107592359
CCAR: 109056910 109066903
ELS: 105009969
FPT: BZ13_510
NBA: CUN60_04520
HMS: HMU12050
MPRO: BJP34_10365
BOA: Bovatus_03512
SBX: CA265_12555
 » show all
Taxonomy
Reference
1  [PMID:5661629]
  Authors
Kobata A, Grollman EF, Ginsburg V.
  Title
An enzymic basis for blood type A in humans.
  Journal
Arch Biochem Biophys 124:609-12 (1968)
DOI:10.1016/0003-9861(68)90373-1
Reference
2  [PMID:2341371]
  Authors
Takeya A, Hosomi O, Ishiura M.
  Title
Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene.
  Journal
J Biochem (Tokyo) 107:360-8 (1990)
Reference
3  [PMID:6434182]
  Authors
Yates AD, Feeney J, Donald AS, Watkins WM.
  Title
Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase.
  Journal
Carbohydr Res 130:251-60 (1984)
DOI:10.1016/0008-6215(84)85283-0
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.40
IUBMB Enzyme Nomenclature: 2.4.1.40
ExPASy - ENZYME nomenclature database: 2.4.1.40
BRENDA, the Enzyme Database: 2.4.1.40
CAS: 9067-69-0

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (16)   
   KEGG COMPOUND (4)   
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Chemical reaction (8)   
   KEGG REACTION (6)   
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Gene (3895)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (151)   
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   RefGene (704)   
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Protein sequence (125)   
   UniProt (33)   
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   PDBSTR (79)   
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DNA sequence (51)   
   RefSeq(nuc) (9)   
   GenBank (21)   
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3D Structure (46)   
   PDB (46)   
All databases (4145)   

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