KEGG   ENZYME: 2.4.1.46Help
Entry
EC 2.4.1.46                 Enzyme                                 

Name
monogalactosyldiacylglycerol synthase;
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose:diacylglycerol galactosyltransferase;
MGDG synthase;
UDP galactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose-diacylglyceride galactosyltransferase;
UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase;
1beta-MGDG;
1,2-diacylglycerol 3-beta-galactosyltransferase;
UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol [RN:R02691]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
UDP [CPD:C00015];
1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
Comment
This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].
History
EC 2.4.1.46 created 1972, modified 2003, modified 2005
Pathway
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K03715  1,2-diacylglycerol 3-beta-galactosyltransferase
Genes
ATH: AT2G11810(MGDC) AT4G31780(MGD1) AT5G20410(MGD2)
ALY: ARALYDRAFT_488950 ARALYDRAFT_899522 ARALYDRAFT_913288
CRB: 17878480 17882958 17892650
CSAT: 104700063 104706388 104717012 104721659 104730134 104736117 104748635 104767934 104770420
EUS: EUTSA_v10013431mg EUTSA_v10022676mg EUTSA_v10024883mg
BRP: 103837651 103851349 103851545 103862083
BNA: 106354743 106366315 106368692 106372755 106375399 106392218 106420497 106423395 106425766 111204520
BOE: 106301258 106316128 106316193 106325403
THJ: 104808956 104811011 104819949
CPAP: 110808254 110826136
LJA: Lj0g3v0327859.1(Lj0g3v0327859.1) Lj4g3v1935530.1(Lj4g3v1935530.1)
CSV: 101209030(CsMGD1) 101215352
DOSA: Os02t0802700-01(Os02g0802700) Os08t0299400-01(Os08g0299400) Os09t0423600-01(Os09g0423600)
ATS: 109741872(LOC109741872) 109755152(LOC109755152) 109768828(LOC109768828) 109769532(LOC109769532)
ZMA: 100274282 100281388(si660066d07) 100383973
MNG: MNEG_3776
OLU: OSTLU_119506(mgdA)
BPG: Bathy14g01530(MGDG)
MIS: MICPUN_107335(MGDA)
APRO: F751_2604
SMIN: v1.2.024400.t1(symbB.v1.2.024400.t1)
NGD: NGA_0081800(MGD)
AJS: Ajs_1204
BVR: BVIR_951
 » show all
Taxonomy
Reference
1  [PMID:4838219]
  Authors
Veerkamp JH.
  Title
Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.
  Journal
Biochim Biophys Acta 348:23-34 (1974)
DOI:10.1016/0005-2760(74)90089-7
Reference
2  [PMID:5681471]
  Authors
Wenger DA, Petitpas JW, Pieringer RA.
  Title
The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.
  Journal
Biochemistry 7:3700-7 (1968)
Reference
3  [PMID:10518794]
  Authors
Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R, Joyard J.
  Title
Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.
  Journal
Eur J Biochem 265:990-1001 (1999)
DOI:10.1046/j.1432-1327.1999.00801.x
  Sequence
Reference
4  [PMID:15590685]
  Authors
Benning C, Ohta H.
  Title
Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.
  Journal
J Biol Chem 280:2397-400 (2005)
DOI:10.1074/jbc.R400032200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.46
IUBMB Enzyme Nomenclature: 2.4.1.46
ExPASy - ENZYME nomenclature database: 2.4.1.46
BRENDA, the Enzyme Database: 2.4.1.46
CAS: 37277-55-7

DBGET integrated database retrieval system