KEGG   ENZYME: 2.4.1.53Help
Entry
EC 2.4.1.53                 Enzyme                                 

Name
poly(ribitol-phosphate) beta-glucosyltransferase;
TarQ;
UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase;
uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase;
UDP-D-glucose polyribitol phosphate glucosyl transferase;
UDP-D-glucose:polyribitol phosphate glucosyl transferase;
UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol beta-D-glucosyltransferase (configuration-inverting)
Reaction(IUBMB)
n UDP-alpha-D-glucose + 4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n UDP + 4-O-[(2-beta-D-glucosyl-1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R12036]
Reaction(KEGG)
R12036;
(other) R02716 R06181(G)
Show
Substrate
UDP-alpha-D-glucose [CPD:C00029];
4-O-[(1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21504]
Product
UDP [CPD:C00015];
4-O-[(2-beta-D-glucosyl-1-D-ribitylphospho)n-(1-D-ribitylphospho)-(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21869]
Comment
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Bacillus subtilis W23. This enzyme adds a beta-D-glucose to the hydroxyl group at the 2 position of the ribitol phosphate units.
History
EC 2.4.1.53 created 1972, modified 2018
Orthology
K22709  poly(ribitol-phosphate) beta-glucosyltransferase
Genes
BSY: I653_17345
BSUS: Q433_19495
BSS: BSUW23_17465(tarQ)
BST: GYO_3914
BSX: C663_3447(tarQ)
BJS: MY9_3611
BACY: QF06_16200
BGI: BGM20_11945
Taxonomy
Reference
1  [PMID:4960203]
  Authors
Chin T, Burger MM, Glaser L.
  Title
Synthesis of teichoic acids. VI. The formation of multiple wall polymers in Bacillus subtilis W-23.
  Journal
Arch Biochem Biophys 116:358-67 (1966)
Reference
2  [PMID:23027967]
  Authors
Brown S, Xia G, Luhachack LG, Campbell J, Meredith TC, Chen C, Winstel V, Gekeler C, Irazoqui JE, Peschel A, Walker S
  Title
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
  Journal
Proc Natl Acad Sci U S A 109:18909-14 (2012)
DOI:10.1073/pnas.1209126109
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.53
IUBMB Enzyme Nomenclature: 2.4.1.53
ExPASy - ENZYME nomenclature database: 2.4.1.53
BRENDA, the Enzyme Database: 2.4.1.53
CAS: 37277-61-5

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