KEGG   ENZYME: 2.4.1.62Help
Entry
EC 2.4.1.62                 Enzyme                                 

Name
ganglioside galactosyltransferase;
UDP-galactose---ceramide galactosyltransferase;
uridine diphosphogalactose-ceramide galactosyltransferase;
UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase;
UDP-galactose-GM2 galactosyltransferase;
uridine diphosphogalactose-GM2 galactosyltransferase;
uridine diphosphate D-galactose:glycolipid galactosyltransferase;
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase;
UDP-galactose-GM2 ganglioside galactosyltransferase;
GM1-synthase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04631 R05941]
Reaction(KEGG)
R04631 R05941(G);
(other) R05110 R05111 R05948(G) R05953(G) R05956(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
The substrate is also known as gangloside GM2, the product as gangloside GM1a
History
EC 2.4.1.62 created 1972, modified 2013
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K00715  ganglioside galactosyltransferase
Genes
HSA: 8705(B3GALT4)
PTR: 746800(B3GALT4)
PPS: 100990558(B3GALT4)
GGO: 101147230(B3GALT4)
PON: 100431810(B3GALT4)
NLE: 100581961(B3GALT4)
MCC: 718178(B3GALT4)
MCF: 101867339(B3GALT4)
CSAB: 103221668(B3GALT4)
RRO: 104657975(B3GALT4)
RBB: 108540279(B3GALT4)
CJC: 100386867(B3GALT4)
SBQ: 101045208(B3GALT4)
MMU: 54218(B3galt4)
RNO: 171079(B3galt4)
CGE: 100751197(B3galt4)
NGI: 103739707(B3galt4)
HGL: 101722054(B3galt4)
CCAN: 109686699(B3galt4)
OCU: 100353929(B3GALT4)
TUP: 102493328(B3GALT4)
CFA: 481737(B3GALT4)
AML: 100474436(B3GALT4)
UMR: 103665497(B3GALT4)
ORO: 101375875(B3GALT4)
FCA: 101087480 111556175(B3GALT4)
PTG: 102968511(B3GALT4)
AJU: 106976084(B3GALT4)
BTA: 768038(B3GALT4)
BOM: 102287503(B3GALT4)
BIU: 109576550(B3GALT4)
PHD: 102317916(B3GALT4)
CHX: 102182551(B3GALT4)
OAS: 101111585(B3GALT4)
SSC: 100155431(B3GALT4)
CFR: 102504152(B3GALT4)
CDK: 105101388(B3GALT4)
BACU: 103004913(B3GALT4)
LVE: 103073598(B3GALT4)
OOR: 101285679(B3GALT4)
ECB: 100052704(B3GALT4)
EPZ: 103567107(B3GALT4)
EAI: 106834597(B3GALT4)
MYB: 102253194(B3GALT4)
MYD: 102766372(B3GALT4)
HAI: 109392428(B3GALT4)
RSS: 109450928(B3GALT4)
PALE: 102882787(B3GALT4)
LAV: 100662423(B3GALT4)
TMU: 101340682
MDO: 100618101(B3GALT4)
SHR: 100932392 105750445(B3GALT4)
PHI: 102110936
ASN: 102386365(B3GALT4)
AMJ: 106737709(B3GALT4)
CPIC: 101953116(B3GALT4)
PVT: 110091025(B3GALT4)
GJA: 107115678(B3GALT4)
XLA: 108698545(b3galt4.L)
XTR: 100489366(b3galt4)
NPR: 108788356(B3GALT4)
DRE: 101886595(b3galt4)
SRX: 107706538
SANH: 107667941
SGH: 107549558
IPU: 108265547(b3galt4)
AMEX: 103044102
TRU: 101065804(b3galt4)
LCO: 104938595(b3galt4)
NCC: 104957801
MZE: 101480560(b3galt4)
OLA: 101168709(b3galt4)
XMA: 102221914
PRET: 103467526(b3galt4)
NFU: 107391227(b3galt4)
KMR: 108231973
CSEM: 103385519
LCF: 108898093
SDU: 111217361
HCQ: 109528392
BPEC: 110156371 110158064(b3galt4)
MALB: 109966040(b3galt4)
SASA: 106571873
ELS: 105024940(b3galt4)
SFM: 108940259(b3galt4)
 » show all
Taxonomy
Reference
1  [PMID:5842076]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase.
  Journal
J Biol Chem 240:4115-7 (1965)
Reference
2  [PMID:4987145]
  Authors
Yip GB, Dain JA.
  Title
The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
  Journal
Biochim Biophys Acta 206:252-60 (1970)
DOI:10.1016/0005-2744(70)90108-7
Reference
3  [PMID:5484669]
  Authors
Yip MC, Dain JA.
  Title
Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceram ide galactosyltransferase.
  Journal
Biochem J 118:247-52 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.62
IUBMB Enzyme Nomenclature: 2.4.1.62
ExPASy - ENZYME nomenclature database: 2.4.1.62
BRENDA, the Enzyme Database: 2.4.1.62
CAS: 37217-28-0

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