KEGG   ENZYME: 2.4.1.66Help
Entry
EC 2.4.1.66                 Enzyme                                 

Name
procollagen glucosyltransferase;
galactosylhydroxylysine glucosyltransferase;
collagen glucosyltransferase;
collagen hydroxylysyl glucosyltransferase;
galactosylhydroxylysyl glucosyltransferase;
UDP-glucose-collagenglucosyltransferase;
uridine diphosphoglucose-collagen glucosyltransferase;
UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase;
UDP-glucose:(2S,5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine-[procollagen] D-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-glucose:[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine 2-alpha-D-glucosyltransferase (configuration-retaining)
Reaction(IUBMB)
UDP-alpha-D-glucose + [procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine = UDP + [procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine [RN:R04491]
Reaction(KEGG)
Substrate
UDP-alpha-D-glucose [CPD:C00029];
[procollagen]-(5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysine
Product
UDP [CPD:C00015];
[procollagen]-(5R)-5-O-[alpha-D-glucosyl-(1->2)-beta-D-galactosyl]-5-hydroxy-L-lysine
Comment
Involved in the synthesis of carbohydrate units in the complement system (cf. EC 2.4.1.50 procollagen galactosyltransferase).
History
EC 2.4.1.66 created 1972
Pathway
ec00514  Other types of O-glycan biosynthesis
Orthology
K13646  lysyl hydroxylase/galactosyltransferase/glucosyltransferase
Genes
HSA: 8985(PLOD3)
PTR: 463618(PLOD3)
PPS: 100968399(PLOD3)
GGO: 101151570(PLOD3)
PON: 100189797(PLOD3)
NLE: 100597272(PLOD3)
MCC: 714283(PLOD3)
MCF: 101867014(PLOD3)
CSAB: 103246688(PLOD3)
RRO: 104681188(PLOD3)
RBB: 108518931(PLOD3)
CJC: 100390092(PLOD3)
SBQ: 101043341(PLOD3)
MMU: 26433(Plod3)
RNO: 288583(Plod3)
NGI: 103733492(Plod3)
HGL: 101701075(Plod3)
CCAN: 109692822(Plod3)
OCU: 103345704
TUP: 102476916(PLOD3)
CFA: 479730(PLOD3)
AML: 100484476(PLOD3)
UMR: 103670197(PLOD3)
ORO: 101383290(PLOD3)
FCA: 101089668(PLOD3)
PTG: 102950927(PLOD3)
AJU: 106988106(PLOD3)
BTA: 514996(PLOD3)
BOM: 102276636(PLOD3)
BIU: 109578633(PLOD3)
PHD: 102321876(PLOD3)
CHX: 100861039(PLOD3)
OAS: 101121738(PLOD3)
SSC: 100624420(PLOD3)
CFR: 102505707(PLOD3)
CDK: 105092397(PLOD3)
BACU: 103018042(PLOD3)
LVE: 103090807(PLOD3)
OOR: 101272678(PLOD3)
ECB: 100059479(PLOD3)
EPZ: 103566973(PLOD3)
EAI: 106839342(PLOD3)
MYB: 102249872(PLOD3)
MYD: 102755224(PLOD3)
HAI: 109385048(PLOD3)
RSS: 109458817(PLOD3)
PALE: 102879015(PLOD3)
LAV: 100675876(PLOD3)
TMU: 101349481
MDO: 100017782(PLOD3)
SHR: 100921874(PLOD3)
OAA: 100086224(PLOD3)
ASN: 102379166
AMJ: 102561107(PLOD3)
PSS: 102444474(PLOD3)
CPIC: 101943910(PLOD3)
ACS: 100558042(plod3)
PVT: 110087641(PLOD3)
PBI: 103051832(PLOD3) 103067401
GJA: 107118151(PLOD3)
XLA: 380138(plod3.L) 495489
XTR: 734090(plod3)
NPR: 108800474(PLOD3)
DRE: 556077(plod3)
IPU: 108275691(plod3)
AMEX: 103037645
TRU: 100101242(plod3)
MZE: 101473400
OLA: 101154842(plod3)
XMA: 102223949
PRET: 103460325
KMR: 108229759
CSEM: 103389255
SDU: 111239991
HCQ: 109518414(plod3)
BPEC: 110174873
MALB: 109952454(plod3) 109954107
SASA: 100196315(plod3)
OTW: 112235044
ELS: 105008588
SFM: 108920367(plod3) 108923182
LCM: 102347396(PLOD3)
CIN: 100178986
TSP: Tsp_03029
EPA: 110241798
ADF: 107346845
 » show all
Taxonomy
Reference
1  [PMID:5637038]
  Authors
Bosmann HB, Eylar EH.
  Title
Attachment of carbohydrate to collagen. Isolation, purification and properties of the glucosyl transferase.
  Journal
Biochem Biophys Res Commun 30:89-94 (1968)
DOI:10.1016/0006-291X(68)90717-1
Reference
2  [PMID:4968368]
  Authors
Bosmann HB, Eylar EH.
  Title
Collagen-glucosyl transferase in fibriblasts transformed by oncogenic viruses.
  Journal
Nature 218:582-3 (1968)
Reference
3  [PMID:4288358]
  Authors
Butler WT, Cunningham LW.
  Title
Evidence for the linkage of a disaccharide to hydroxylysine in tropocollagen.
  Journal
J Biol Chem 241:3882-8 (1966)
Reference
4
  Authors
Kivirikko, K.I. and Myllyla, R.
  Title
In: Hall, D.A. and Jackson, D.S. (Eds.), International Review of Connective Tissue Research, vol. 8, Academic Press, New York, 1979, p. 23.
Reference
5  [PMID:21220425]
  Authors
Sricholpech M, Perdivara I, Nagaoka H, Yokoyama M, Tomer KB, Yamauchi M
  Title
Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture.
  Journal
J Biol Chem 286:8846-56 (2011)
DOI:10.1074/jbc.M110.178509
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.66
IUBMB Enzyme Nomenclature: 2.4.1.66
ExPASy - ENZYME nomenclature database: 2.4.1.66
BRENDA, the Enzyme Database: 2.4.1.66
CAS: 9028-08-4

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