KEGG   ENZYME: 2.4.1.86Help
Entry
EC 2.4.1.86                 Enzyme                                 

Name
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase;
B3GALT1 (gene name);
uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase;
GalT-4;
UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-D-glucosaminyl-(1->3)-D-galactosyl-(1->4)-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide 3-beta-D-galactosyltransferase;
UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase;
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase;
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-R 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [RN:R11714]
Reaction(KEGG)
R11714;
(other) R04610 R06006(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
N-acetyl-beta-D-glucosaminyl-R [CPD:C03518]
Product
UDP [CPD:C00015];
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R [CPD:C04656]
Comment
The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta-D-glucosamine (beta-GlcNAc) residue. It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
History
EC 2.4.1.86 created 1976, modified 2017
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K07819  beta-1,3-galactosyltransferase 1
K07820  beta-1,3-galactosyltransferase 2
Genes
HSA: 8707(B3GALT2) 8708(B3GALT1)
PTR: 459710(B3GALT1) 469624(B3GALT2)
PPS: 100969537(B3GALT2) 100986605(B3GALT1)
GGO: 101126815 101127183 101153312(B3GALT1)
PON: 100173654(B3GALT2) 100451414(B3GALT1)
NLE: 100587051(B3GALT1) 100598456(B3GALT2)
MCC: 704744(B3GALT1) 712334(B3GALT2)
MCF: 101865991(B3GALT2) 102127118(B3GALT1)
CSAB: 103217238(B3GALT1) 103230393(B3GALT2)
RRO: 104655029(B3GALT1) 104655051 104671905(B3GALT2)
RBB: 108526657(B3GALT1) 108541874(B3GALT2)
CJC: 100394818(B3GALT2) 100414400(B3GALT1)
SBQ: 101033633(B3GALT1) 101045625(B3GALT2)
MMU: 26877(B3galt1) 26878(B3galt2)
RNO: 366064(B3galt1) 686081(B3galt2)
CGE: 100761765(B3galt1) 100766715(B3galt2)
NGI: 103736704(B3galt2) 103747465(B3galt1)
HGL: 101712201(B3galt1) 101726237(B3galt2)
CCAN: 109679155(B3galt1) 109682476(B3galt2)
OCU: 100338140(B3GALT1) 100348508(B3GALT2)
TUP: 102486335(B3GALT1) 102494580(B3GALT2)
CFA: 488386(B3GALT1) 607356(B3GALT2)
AML: 100473736(B3GALT1) 100484200(B3GALT2)
UMR: 103658170(B3GALT2) 103659526(B3GALT1)
ORO: 101374284(B3GALT1) 101375886(B3GALT2)
FCA: 101084131(B3GALT1) 101091170(B3GALT2)
PTG: 102949445(B3GALT1) 102959610(B3GALT2)
AJU: 106970309(B3GALT1) 106979251(B3GALT2)
BTA: 539027(B3GALT1) 539815(B3GALT2)
BOM: 102273719(B3GALT2) 102282371(B3GALT1)
BIU: 109566873(B3GALT1) 109570453(B3GALT2)
PHD: 102324103(B3GALT1) 102338524(B3GALT2)
CHX: 102177200(B3GALT1) 102190625(B3GALT2)
OAS: 101121025(B3GALT2) 101122666(B3GALT1)
SSC: 100152554(B3GALT1) 100525885(B3GALT2)
CFR: 102506488(B3GALT2) 102509415(B3GALT1)
CDK: 105091056(B3GALT1) 105097313(B3GALT2)
BACU: 103000382(B3GALT1) 103009179(B3GALT2)
LVE: 103069039(B3GALT2) 103075987(B3GALT1)
OOR: 101281564(B3GALT1) 101286633(B3GALT2)
ECB: 100051213(B3GALT2) 100052244(B3GALT1)
EPZ: 103565943(B3GALT2) 103567756(B3GALT1)
EAI: 106843408(B3GALT1) 106848631(B3GALT2)
MYB: 102245857(B3GALT1) 102257593(B3GALT2)
MYD: 102759923(B3GALT2) 102771554(B3GALT1)
HAI: 109380496(B3GALT2) 109390293(B3GALT1)
RSS: 109445189(B3GALT1) 109454945(B3GALT2)
PALE: 102895866(B3GALT1) 102898197(B3GALT2)
LAV: 100663234(B3GALT2) 100671910(B3GALT1)
OAA: 100077384(B3GALT1) 100082127(B3GALT2)
GGA: 429027(B3GALT1) 769122(B3GALT2)
MGP: 100543629(B3GALT2) 100544560(B3GALT1)
CJO: 107316755(B3GALT1) 107317132(B3GALT2)
APLA: 101797838(B3GALT1) 101802460(B3GALT2)
ACYG: 106029956(B3GALT1) 106041600(B3GALT2)
TGU: 100218797(B3GALT1) 100220053(B3GALT2)
GFR: 102036759(B3GALT2) 102042546(B3GALT1) 102043072 102045170
FAB: 101807086 101818309(B3GALT1) 101819026 101819490(B3GALT2)
PHI: 102103706 102109748(B3GALT2) 102111511(B3GALT1)
PMAJ: 107207453(B3GALT1) 107207931(B3GALT2)
CCAE: 111932126(B3GALT1) 111932694(B3GALT2)
FPG: 101915951(B3GALT2) 101920291(B3GALT1) 106112240
FCH: 102046778(B3GALT1) 102050143 102051968(B3GALT2)
CLV: 102089471 102092086(B3GALT2) 102093422(B3GALT1)
EGZ: 104125251 104127613(B3GALT2) 104127618 104128034(B3GALT1)
AAM: 106492232 106492233 106499290(B3GALT1) 106499716(B3GALT2)
ASN: 102372302 102373214(B3GALT2) 102374304 102380022(B3GALT1)
AMJ: 102560847(B3GALT2) 102565358 102565495 102568197(B3GALT1)
PSS: 102444287 102458854(B3GALT2) 102459753(B3GALT1) 106731581
ACS: 100556689 100562203(b3galt1) 100562695(b3galt2)
PVT: 110076874(B3GALT1) 110077421(B3GALT2) 110077942
PBI: 103051546(B3GALT2) 103054338(B3GALT1)
GJA: 107108379 107119638(B3GALT1) 107123228(B3GALT2)
DRE: 100003996(si:ch73-195i19.3) 100331460 100333524 404633(b3galt2) 559521(b3galt1a) 565422 571003(b3galt1b) 798349(zgc:194330)
CMK: 103176378(b3galt1) 103180052(b3galt2)
SPU: 574982
DME: Dmel_CG30036(CG30036) Dmel_CG30037(CG30037) Dmel_CG33145(GalT1)
DPE: 6602080
DSI: Dsimw501_GD25871(Dsim_GD25871) Dsimw501_GD25872(Dsim_GD25872)
DWI: 6643236
AAG: 5568339
AME: 552398
BIM: 100748146
BTER: 100647992
SOC: 105201622
AEC: 105143964
ACEP: 105622322
PBAR: 105422909
HST: 105182267
DQU: 106747347
CFO: 105247810
LHU: 105676308
PGC: 109852403
PCF: 106788159
NVI: 100118799
MDL: 103576367
DPA: 109546560
NVL: 108556461
PMAC: 106714171
CLEC: 106673665
CEL: CELE_B0024.15(B0024.15)
CBR: CBG09575
MAW: MAC_04394
 » show all
Taxonomy
Reference
1  [PMID:4335001]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 247:1489-95 (1972)
Reference
2  [PMID:291963]
  Authors
Basu M, Presper KA, Basu S, Hoffman LM, Brooks SE.
  Title
Differential activities of glycolipid glycosyltransferases in Tay-Sachs disease: studies in cultured cells from cerebrum.
  Journal
Proc Natl Acad Sci U S A 76:4270-4 (1979)
DOI:10.1073/pnas.76.9.4270
Reference
3  [PMID:9582303]
  Authors
Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H
  Title
A family of human beta3-galactosyltransferases. Characterization of four members  of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.
  Journal
J Biol Chem 273:12770-8 (1998)
DOI:10.1074/jbc.273.21.12770
  Sequence
[hsa:8708 8707]
Reference
4  [PMID:10580128]
  Authors
Amado M, Almeida R, Schwientek T, Clausen H
  Title
Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.
  Journal
Biochim Biophys Acta 1473:35-53 (1999)
DOI:10.1016/S0304-4165(99)00168-3
Reference
5  [PMID:10356986]
  Authors
Bardoni A, Valli M, Trinchera M
  Title
Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.
  Journal
FEBS Lett 451:75-80 (1999)
DOI:10.1016/S0014-5793(99)00547-5
  Sequence
[hsa:8708]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.86
IUBMB Enzyme Nomenclature: 2.4.1.86
ExPASy - ENZYME nomenclature database: 2.4.1.86
BRENDA, the Enzyme Database: 2.4.1.86
CAS: 9073-46-5

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