KEGG   ENZYME: 2.4.1.87Help
Entry
EC 2.4.1.87                 Enzyme                                 

Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)
Show
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736  alpha-1,3-galactosyltransferase 2
Genes
HSA: 127550(A3GALT2)
PTR: 104007284(A3GALT2)
PPS: 100975171(A3GALT2)
GGO: 101137879(A3GALT2)
PON: 100431438(A3GALT2) 100433669(GGTA1P)
NLE: 100586880(A3GALT2)
MCC: 711045(A3GALT2)
MCF: 102136396(A3GALT2)
CSAB: 103225947(A3GALT2)
RRO: 104655865 104677306(A3GALT2)
RBB: 108537074 108537279(A3GALT2)
CJC: 100390928(GGTA1P) 100414894(A3GALT2)
SBQ: 101033629(A3GALT2) 101038827
MMU: 14594(Ggta1) 215493(A3galt2)
RNO: 171553(A3galt2) 246766(Ggta1)
CGE: 100754535(Ggta1) 100774283(A3galt2)
NGI: 103730905(A3galt2) 103734487
HGL: 101699219(A3galt2) 101705531
CCAN: 109686855(A3galt2) 109692479
OCU: 100339429(A3GALT2) 100348435
TUP: 102483559(A3GALT2) 102502371
CFA: 487298(A3GALT2) 491357(GGTA1P)
AML: 100479995(A3GALT2) 100482234
UMR: 103670365
ORO: 101365724(A3GALT2) 101367788
FCA: 101084042(A3GALT2) 493877(GGTA1)
PTG: 102965067 107180570(A3GALT2)
AJU: 106973174(A3GALT2) 106986621
BTA: 281780(GGTA1) 617693(A3GALT2)
BOM: 102276118(A3GALT2) 102282898
BIU: 109566417 109575981(A3GALT2)
PHD: 102317168 102327203(A3GALT2)
CHX: 102168270 108637492(A3GALT2)
OAS: 101103704(A3GALT2) 443282(GGTA2P)
SSC: 100739829(A3GALT2) 396733(GGTA1P)
CFR: 102516495(A3GALT2) 102516521
CDK: 105104406
BACU: 103004808(A3GALT2) 103006673
LVE: 103079826(A3GALT2) 103089836
OOR: 101277096(GLT6D1) 101279702(A3GALT2)
ECB: 100067589 106782783(A3GALT2)
EPZ: 103555510 103557792(A3GALT2)
EAI: 106824198 106829012(A3GALT2)
MYB: 102261921 106728178(A3GALT2)
MYD: 102751930 102753567(A3GALT2)
HAI: 109385732 109390838(A3GALT2)
RSS: 109446559(A3GALT2) 109447168
PALE: 102885392(A3GALT2) 102892029
LAV: 100655343 100671107(A3GALT2)
TMU: 101352341
MDO: 100016105
SHR: 100933356
OAA: 100089476(GLT6D1)
PSS: 102447976(A3GALT2)
CMY: 102941601(A3GALT2)
ACS: 103281997
PVT: 110078804
PBI: 103058654
GJA: 107118477
NPR: 108793736
TRU: 101078261
LCO: 104919360
MZE: 101476245(a3galt2)
XMA: 102225862(a3galt2)
PRET: 103462901 103464476(a3galt2)
BPEC: 110168737
ELS: 105017413
SFM: 108918234(a3galt2) 108924914
LCM: 102357128
CMK: 103181344(a3galt2)
AAE: aq_516(mtfC)
AFU: AF_1728
 » show all
Taxonomy
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 248:1700-6 (1973)
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
IUBMB Enzyme Nomenclature: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
BRENDA, the Enzyme Database: 2.4.1.87
CAS: 128449-51-4

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