KEGG   ENZYME: 2.4.2.12Help
Entry
EC 2.4.2.12                 Enzyme                                 

Name
nicotinamide phosphoribosyltransferase;
NMN pyrophosphorylase;
nicotinamide mononucleotide pyrophosphorylase;
nicotinamide mononucleotide synthetase;
NMN synthetase;
nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
nicotinamide-D-ribonucleotide:diphosphate phospho-alpha-D-ribosyltransferase
Reaction(IUBMB)
nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate [RN:R01271]
Reaction(KEGG)
Substrate
nicotinamide D-ribonucleotide [CPD:C00455];
diphosphate [CPD:C00013]
Product
nicotinamide [CPD:C00153];
5-phospho-alpha-D-ribose 1-diphosphate [CPD:C00119]
History
EC 2.4.2.12 created 1961
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
Orthology
K03462  nicotinamide phosphoribosyltransferase
Genes
HSA: 10135(NAMPT)
PTR: 463648(NAMPT)
PPS: 100978652(NAMPT)
GGO: 101151211(NAMPT)
PON: 100453575(NAMPT)
NLE: 100587413(NAMPT)
MCC: 698609(NAMPT)
MCF: 102144763(NAMPT)
CSAB: 103226706(NAMPT)
RRO: 104676004(NAMPT)
RBB: 108531301(NAMPT)
CJC: 100393546(NAMPT)
SBQ: 101047935(NAMPT)
MMU: 59027(Nampt)
RNO: 297508(Nampt)
CGE: 100767492(Nampt)
NGI: 103732185(Nampt) 103743693
HGL: 101708723(Nampt)
CCAN: 109701057(Nampt)
OCU: 100343645(NAMPT)
TUP: 102492540(NAMPT)
CFA: 100856598(NAMPT)
AML: 100475373(NAMPT)
UMR: 103674711(NAMPT)
ORO: 101364350(NAMPT)
FCA: 101081370(NAMPT)
PTG: 102960728(NAMPT)
AJU: 106987831(NAMPT)
BTA: 520472(NAMPT)
BOM: 102277699(NAMPT)
BIU: 109557381(NAMPT)
PHD: 102326145(NAMPT) 102335927
CHX: 102173810(NAMPT)
OAS: 780506(NAMPT)
SSC: 595123(NAMPT)
CFR: 102519471(NAMPT)
CDK: 105093030(NAMPT)
BACU: 103008929
LVE: 103068887(NAMPT)
OOR: 101283121(NAMPT)
ECB: 100059684(NAMPT)
EPZ: 103555664(NAMPT)
EAI: 106825180(NAMPT)
MYB: 102242336(NAMPT)
MYD: 102755142(NAMPT)
HAI: 109392065(NAMPT)
RSS: 109454593(NAMPT)
PALE: 102885557(NAMPT)
LAV: 100656670(NAMPT)
TMU: 101355029
MDO: 100019192(NAMPT)
SHR: 100925196(NAMPT)
OAA: 100077975(NAMPT)
GGA: 417707(NAMPT)
MGP: 100546626(NAMPT)
CJO: 107306334(NAMPT)
APLA: 101800925(NAMPT)
ACYG: 106042020(NAMPT)
TGU: 100223583(NAMPT)
GFR: 102036708(NAMPT)
FAB: 101808963(NAMPT)
PHI: 102107305(NAMPT)
PMAJ: 107204752(NAMPT)
CCAE: 111923293(NAMPT)
CCW: 104686924(NAMPT)
FPG: 101920910(NAMPT)
FCH: 102047445(NAMPT)
CLV: 102094757(NAMPT)
EGZ: 104123787(NAMPT) 104133974
AAM: 106485277(NAMPT)
ASN: 102386190(NAMPT)
AMJ: 102559045(NAMPT)
PSS: 102458338(NAMPT)
CMY: 102946420(NAMPT)
CPIC: 101948767(NAMPT)
ACS: 100561247(nampt)
PVT: 110080948(NAMPT)
PBI: 103061771(NAMPT)
GJA: 107108984(NAMPT)
XLA: 398502(nampt.S) 735059(nampt.L)
XTR: 496856(nampt)
NPR: 108797062(NAMPT)
DRE: 100330160(nampta) 324211(namptb)
IPU: 108255025 108279799(nampt)
AMEX: 103041462 103042355(nampt)
TRU: 101069854(nampt)
LCO: 104922484 104934037(nampt)
MZE: 101463962(nampt)
OLA: 101156645 101167087(nampt)
XMA: 102220339 102232015(nampt)
PRET: 103459433(nampt) 103465472
NFU: 107384656(nampt)
KMR: 108235115(nampt) 108240353
CSEM: 103382852(nampt)
LCF: 108873533 108888920(nampt)
SDU: 111221675 111224669(nampt)
HCQ: 109513519(nampt) 109514513
BPEC: 110161662(nampt) 110165776
MALB: 109951434 109959864(nampt)
LCM: 102352973(NAMPT)
CMK: 103179768 103186243(nampt)
SPU: 577046
APLC: 110982121
SKO: 100370741
BMY: Bm1_08885
TSP: Tsp_05934
CRG: 105342526
MYI: 110460388
LAK: 106177084
SHX: MS3_08970
EGL: EGR_07009
EPA: 110251362
SMIN: v1.2.012193.t1(symbB.v1.2.012193.t1) v1.2.016825.t1(symbB.v1.2.016825.t1) v1.2.031788.t1(symbB.v1.2.031788.t1) v1.2.032601.t1(symbB.v1.2.032601.t1)
ESA: ESA_04384
CSK: ES15_0310
CTU: CTU_38680
KOX: KOX_04480
KOE: A225_5357
EBI: EbC_41490
HDU: HD_1447(nadV1) HD_1455(nadV2)
HSO: HS_0002(pncB)
HSM: HSM_1893
PMU: PM0999
PMV: PMCN06_0231(namPT)
PMP: Pmu_01630
PMUL: DR93_970
MHAT: B824_13370
MHX: MHH_c20480(nadV)
MHAE: F382_01310
MHAM: J450_00750
MHAO: J451_02040
MHAL: N220_06860
MHAQ: WC39_07120
MHAY: VK67_07120
MVG: X874_9780
AAT: D11S_1495
AAN: D7S_02006
AACN: AANUM_2319
BTO: WQG_10840
BTRE: F542_11220
BTRH: F543_12680
BTRA: F544_11210
XCC: XCC3445(pbeF)
XCB: XC_0719
XCP: XCR_3785
XCV: XCV0735
XAX: XACM_0679
XAC: XAC0674(pbeF)
XCI: XCAW_03907(pncB)
XOO: XOO3947(pbeF)
XOM: XOO3724(XOO3724)
XOP: PXO_04293
XOR: XOC_0731
XAL: XALC_0821
SML: Smlt0260
SMZ: SMD_0225
LAB: LA76x_3795(namPT)
LCP: LC55x_3802(namPT)
LGU: LG3211_1418(namPT)
LEZ: GLE_1383(pncB)
LEM: LEN_3564
VNI: VIBNI_B2141(NAMPT)
PAR: Psyc_1914
PALI: A3K91_2454
PSYC: DABAL43B_2513(pncB3)
PSYA: AOT82_2159
ACB: A1S_1780
ABM: ABSDF1962
ABY: ABAYE1790
ABN: AB57_2114
ABX: ABK1_2329
ABH: M3Q_2220
ABAD: ABD1_18010
ABAZ: P795_8170
ABAU: IX87_20340
ABAA: IX88_11080
ACI: ACIAD0963
SON: SO_1981(nadV)
FTU: FTT_1534c
FTQ: RO31_1800
FTF: FTF1534c
FTW: FTW_0395
FTT: FTV_1464
FTG: FTU_1549
FTL: FTL_0579
FTH: FTH_0579(pncB)
FTA: FTA_0613
FTS: F92_03160
FTI: FTS_0578(pncB)
FTC: DA46_104
FTV: CH67_892
FTZ: CH68_626
FTM: FTM_0364
FTN: FTN_1443
FTX: AW25_558
FTD: AS84_1059
FTY: CH70_487
FPH: Fphi_1232
FPT: BZ13_772
FPI: BF30_1479
FPM: LA56_958
FPX: KU46_80
FPZ: LA55_1678
FPJ: LA02_850
HCH: HCH_06992
OAI: OLEAN_C07600(pncB)
CVI: CV_0034(nadV)
RSO: RSp0836
RSN: RSPO_m01154(pncB)
RSE: F504_4383
RME: Rmet_5105
BVE: AK36_3514
BCN: Bcen_3480
BCJ: BCAM2079
BCEN: DM39_5719
BCEO: I35_5920
BAM: Bamb_4266
BCT: GEM_3578
BCED: DM42_5921
BDL: AK34_3608
BCON: NL30_01875
BUB: BW23_3330
BLAT: WK25_26705
BTEI: WS51_07770
BSEM: WJ12_30470
BPSL: WS57_03740
BMEC: WJ16_29025
BSTG: WT74_29575
BGO: BM43_5976
BUK: MYA_4990
BXE: Bxe_B1188
BXB: DR64_6505
BFN: OI25_6949
CFT: CFF04554_0021(nadV)
CFV: CFVI03293_0021(nadV)
CFX: CFV97608_0021(nadV)
CFZ: CSG_230
CAMP: CFT03427_0021(nadV)
CAJ: CIG1485E_0071(nadV)
CHYO: CHH_0066(nadV)
CLX: CLAN_1602(nadV)
AVI: Avi_0131
SHZ: shn_01390
CSE: Cseg_3704
SSAN: NX02_26610
MAG: amb2738
MAGN: WV31_08825
JEO: JMA_40620
LCI: LCK_01158
LKI: LKI_08835
LGS: LEGAS_0740(nadV)
CBK: CLL_A1660
CBE: Cbei_2078
CBZ: Cbs_2078
CBEI: LF65_02388
MGE: MG_037
MPN: MPN047(D09_orf451)
MPM: MPNA0470
MPJ: MPNE_0051(pncB)
MPB: C985_0047
MGA: MGA_0428
MGH: MGAH_0428(pncB)
MGF: MGF_4883(pncB)
MGZ: GCW_03475
MCHE: BB28_05075
SYN: slr0788
SYY: SYNGTS_2731(slr0788)
SYT: SYNGTI_2730(slr0788)
SYS: SYNPCCN_2729(slr0788)
SYQ: SYNPCCP_2729(slr0788)
SYC: syc1305_c
GLJ: GKIL_3232
DRA: DR_0294
MRB: Mrub_2845
LBA: Lebu_1389
SMF: Smon_0680
CPI: Cpin_0607
FLN: FLA_4720
CHU: CHU_2424(nadV)
FAE: FAES_5435
FJO: Fjoh_0745
MARM: YQ22_17990
CBAL: M667_16020
CBAT: M666_16010
NDO: DDD_0647(nadV)
TJE: TJEJU_2446(nadV)
TMAR: MARIT_0866(nadV)
MST: Msp_0764
MSI: Msm_1792
MRU: mru_1750
MEB: Abm4_0576
MMIL: sm9_1021
MEYE: TL18_04385
 » show all
Taxonomy
Reference
1  [PMID:13416279]
  Authors
PREISS J, HANDLER P.
  Title
Enzymatic synthesis of nicotinamide mononucleotide.
  Journal
J Biol Chem 225:759-70 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.12
IUBMB Enzyme Nomenclature: 2.4.2.12
ExPASy - ENZYME nomenclature database: 2.4.2.12
BRENDA, the Enzyme Database: 2.4.2.12
CAS: 9030-27-7

DBGET integrated database retrieval system