KEGG   ENZYME: 2.4.2.26Help
Entry
EC 2.4.2.26                 Enzyme                                 

Name
protein xylosyltransferase;
UDP-D-xylose:core protein beta-D-xylosyltransferase;
UDP-D-xylose:core protein xylosyltransferase;
UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase;
UDP-xylose-core protein beta-D-xylosyltransferase;
uridine diphosphoxylose-core protein beta-xylosyltransferase;
uridine diphosphoxylose-protein xylosyltransferase;
UDP-D-xylose:protein beta-D-xylosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-xylose:protein beta-D-xylosyltransferase (configuration-inverting)
Reaction(IUBMB)
UDP-alpha-D-xylose + [protein]-L-serine = UDP + [protein]-3-O-(beta-D-xylosyl)-L-serine [RN:R05925]
Reaction(KEGG)
R05925(G)
Show
Substrate
UDP-alpha-D-xylose [CPD:C00190];
[protein]-L-serine [CPD:C02189]
Product
UDP [CPD:C00015];
[protein]-3-O-(beta-D-xylosyl)-L-serine
Comment
Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).
History
EC 2.4.2.26 created 1976, modified 2002, modified 2016
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
ec00534  Glycosaminoglycan biosynthesis - heparan sulfate / heparin
ec01100  Metabolic pathways
Orthology
K00771  protein xylosyltransferase
Genes
HSA: 64131(XYLT1) 64132(XYLT2)
PTR: 453955(XYLT1) 455118(XYLT2)
PPS: 100970715(XYLT1) 100973069(XYLT2)
GGO: 101133399(XYLT2) 101134207(XYLT1)
PON: 100434979(XYLT1) 100459725(XYLT2)
NLE: 100596549(XYLT1) 100600245(XYLT2)
MCC: 705139(XYLT2) 718187(XYLT1)
MCF: 102133732(XYLT2) 102145035(XYLT1)
CSAB: 103228945(XYLT1) 103242938(XYLT2)
RRO: 104667853(XYLT1) 104680299(XYLT2)
RBB: 108516436(XYLT2) 108540514(XYLT1)
CJC: 100385693(XYLT2) 100404925(XYLT1)
SBQ: 101048643(XYLT2) 101052785(XYLT1)
MMU: 217119(Xylt2) 233781(Xylt1)
RNO: 64133(Xylt1) 64134(Xylt2)
NGI: 103728937(Xylt1) 103738383(Xylt2)
HGL: 101703898(Xylt2) 101726675(Xylt1)
CCAN: 109681494(Xylt2) 109701227(Xylt1)
OCU: 100342073(XYLT2) 103348571(XYLT1)
TUP: 102477995(XYLT2) 102483871(XYLT1)
CFA: 493990(XYLT2) 494008(XYLT1)
AML: 100478159(XYLT1) 100479254(XYLT2)
UMR: 103660938(XYLT2) 103668841(XYLT1)
ORO: 101368985(XYLT2) 101371971(XYLT1)
FCA: 101096940(XYLT1) 101099511(XYLT2)
PTG: 102968094(XYLT2) 102968197(XYLT1)
AJU: 106970469(XYLT1) 106985169(XYLT2)
BTA: 493989(XYLT2) 541295(XYLT1)
BOM: 102280747(XYLT2) 102281178(XYLT1)
BIU: 109573274(XYLT2) 109578118(XYLT1)
PHD: 102321893(XYLT1) 102339963(XYLT2)
CHX: 102178593(XYLT1) 102188252(XYLT2)
OAS: 101107112(XYLT2) 101111512(XYLT1)
SSC: 100514160(XYLT1) 100514793(XYLT2)
CFR: 102509305(XYLT2) 102515495(XYLT1)
CDK: 105091164(XYLT1) 105097743(XYLT2)
BACU: 103016087(XYLT1) 103016682(XYLT2)
LVE: 103071417(XYLT2) 103077954(XYLT1)
OOR: 101271334(XYLT1) 101278276(XYLT2)
ECB: 100053250(XYLT1) 100069884(XYLT2)
EPZ: 103542117 103549570(XYLT2) 103554524(XYLT1)
EAI: 106826421(XYLT2) 106828822(XYLT1)
MYB: 102241358(XYLT1) 102260510(XYLT2)
MYD: 102761761(XYLT1) 102772248(XYLT2)
HAI: 109374526(XYLT1) 109380831(XYLT2)
RSS: 109447013(XYLT2) 109458948(XYLT1)
PALE: 102887640(XYLT2) 102892920(XYLT1)
MDO: 100012411(XYLT2) 100018495(XYLT1)
SHR: 100929128(XYLT1) 100934708(XYLT2)
OAA: 100087573(XYLT1)
GGA: 414780(XYLT2) 414781(XYLT1)
MGP: 100539167(XYLT2) 100544774(XYLT1)
CJO: 107320702(XYLT1) 107322312(XYLT2)
APLA: 101801382(XYLT2) 101802041(XYLT1)
ACYG: 106033456(XYLT1) 106034663(XYLT2)
TGU: 100223613(XYLT2) 100228294(XYLT1)
GFR: 102035184(XYLT2) 102038830(XYLT1)
FAB: 101808039(XYLT1) 101813773(XYLT2)
PHI: 102101523(XYLT1) 102112563(XYLT2)
PMAJ: 107210973(XYLT1) 107212594(XYLT2)
CCW: 104684890(XYLT1) 104694365(XYLT2)
FPG: 101911600(XYLT2) 101922681(XYLT1)
FCH: 102051439(XYLT1) 102060281(XYLT2)
CLV: 102085335(XYLT1) 102089671(XYLT2)
EGZ: 104125342(XYLT2) 104126969(XYLT1)
AAM: 106486639(XYLT1) 106500030(XYLT2)
ASN: 102369712(XYLT2) 102382672(XYLT1)
AMJ: 102573706(XYLT1) 106737159(XYLT2)
PSS: 102453154(XYLT2) 102461402(XYLT1)
CMY: 102937617(XYLT2) 102940763
CPIC: 101942777(XYLT1) 101948787(XYLT2)
ACS: 100567768(xylt2) 103281029(xylt1)
PVT: 110083993(XYLT1) 110091236(XYLT2)
PBI: 103059572(XYLT1) 103066222(XYLT2)
GJA: 107110059(XYLT2) 107111229(XYLT1)
XLA: 108701100(xylt2.L) 108703114(xylt1.S) 444363(xylt1.L)
XTR: 100145490(xylt1) 448400(xylt2)
NPR: 108796396(XYLT2) 108799804(XYLT1)
DRE: 560951(xylt1) 563446(xylt2)
IPU: 108258104(xylt2) 108260954(xylt1)
AMEX: 103031104(xylt2) 103042681
TRU: 101063640(xylt2) 101066747 101067123(xylt1)
LCO: 104923371 104927359(xylt1) 104929516(xylt2)
PRET: 103464839(xylt1) 103469073 103469119(xylt2)
CSEM: 103384069(xylt1) 103393209(xylt2) 103393434
LCF: 108875693(xylt1) 108881037(xylt2) 108888628
BPEC: 110154460 110158203(xylt2) 110175714(xylt1)
ELS: 105012217(xylt1) 105012907(xylt2) 105030590
LCM: 102362525(XYLT1) 102363581(XYLT2)
CMK: 103175642(xylt2) 103178860(xylt1)
CIN: 619275(xt)
SPU: 585774(xylt1)
DME: Dmel_CG32300(oxt)
DPO: Dpse_GA16815(Dpse_oxt)
DAN: Dana_GF24873(Dana_oxt)
DER: Dere_GG14524(Dere_oxt)
DPE: Dper_GL24622(Dper_oxt)
DSE: Dsec_GM14129(Dsec_oxt)
DSI: Dsimw501_GD13401(Dsim_oxt)
DWI: Dwil_GK12594(Dwil_oxt)
DYA: Dyak_GE21716(Dyak_oxt)
DVI: Dvir_GJ13432(Dvir_oxt)
MDE: 101891944
AAG: 5569146
AME: 413854
BIM: 100749329
BTER: 100642262
SOC: 105207992
AEC: 105154547
ACEP: 105619481
PBAR: 105423976
HST: 105191014
CFO: 105249153
LHU: 105677546
PGC: 109857930
NVI: 100120497
TCA: 657929
DPA: 109541768
NVL: 108569283
BMOR: 101739145
PMAC: 106719105
PRAP: 110992106
PXY: 105394592
API: 100163472
DNX: 107173852
ZNE: 110833247
FCD: 110848438
TUT: 107368395
CEL: CELE_Y50D4C.4(sqv-6)
CBR: CBG17882(Cbr-sqv-6)
TSP: Tsp_08280
CRG: 105346131
MYI: 110449879
OBI: 106882818
SHX: MS3_01916
EGL: EGR_04417
EPA: 110245347
HMG: 100202092
AQU: 100635901
POP: 7490852
DFA: DFA_08183(gnt10)
SMIN: v1.2.004591.t1(symbB.v1.2.004591.t1) v1.2.020832.t1(symbB.v1.2.020832.t1)
PRI: PRIO_2973
CHZ: CHSO_3425
 » show all
Taxonomy
Reference
1  [PMID:5030630]
  Authors
Stoolmiller AC, Horwitz AL, Dorfman A.
  Title
Biosynthesis of the chondroitin sulfate proteoglycan. Purification and properties of xylosyltransferase.
  Journal
J Biol Chem 247:3525-32 (1972)
Reference
2  [PMID:11099377]
  Authors
Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K.
  Title
Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II.
  Journal
J Mol Biol 304:517-28 (2000)
DOI:10.1006/jmbi.2000.4261
  Sequence
[hsa:64131 64132] [rno:64133 64134]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.26
IUBMB Enzyme Nomenclature: 2.4.2.26
ExPASy - ENZYME nomenclature database: 2.4.2.26
BRENDA, the Enzyme Database: 2.4.2.26
CAS: 55576-38-0

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