KEGG   ENZYME: 2.4.2.31Help
Entry
EC 2.4.2.31                 Enzyme                                 

Name
NAD+---protein-arginine ADP-ribosyltransferase;
ADP-ribosyltransferase;
mono(ADP-ribosyl)transferase;
NAD+:L-arginine ADP-D-ribosyltransferase;
NAD(P)+-arginine ADP-ribosyltransferase;
NAD(P)+:L-arginine ADP-D-ribosyltransferase;
mono-ADP-ribosyltransferase;
ART;
ART1;
ART2;
ART3;
ART4;
ART5;
ART6;
ART7;
NAD(P)+---protein-arginine ADP-ribosyltransferase;
NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase
Class
Transferases;
Glycosyltransferases;
Pentosyltransferases
BRITE hierarchy
Sysname
NAD+:protein-L-arginine ADP-D-ribosyltransferase
Reaction(IUBMB)
NAD+ + protein L-arginine = nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine [RN:R00555]
Reaction(KEGG)
Substrate
NAD+ [CPD:C00003];
protein L-arginine
Product
nicotinamide [CPD:C00153];
Nomega-(ADP-D-ribosyl)-protein-L-arginine [CPD:C16011]
Comment
Protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in the regulation of cellular activities [4]. Arginine residues in proteins act as acceptors. Free arginine, agmatine [(4-aminobutyl)guanidine], arginine methyl ester and guanidine can also do so. The enzyme from some, but not all, species can also use NADP+ as acceptor (giving rise to Nomega-[(2'-phospho-ADP)-D-ribosyl]-protein-L-arginine as the product), but more slowly [1,5]. The enzyme catalyses the NAD+-dependent activation of EC 4.6.1.1, adenylate cyclase. Some bacterial enterotoxins possess similar enzymic activities. (cf. EC 2.4.2.36 NAD+---diphthamide ADP-ribosyltransferase).
History
EC 2.4.2.31 created 1984, modified 1990, modified 2006
Orthology
K00775  ADP-ribosyltransferase 3
K06716  ADP-ribosyltransferase 1
K06717  ADP-ribosyltransferase 4
K11416  mono-ADP-ribosyltransferase sirtuin 6
K19977  ADP-ribosyltransferase 5
K19980  ADP-ribosyltransferase 2 / NAD+ glycohydrolase
Genes
HSA: 116969(ART5) 417(ART1) 419(ART3) 420(ART4) 51548(SIRT6)
PTR: 450970(ART5) 461241(ART3) 466326(ART1) 473376(ART4) 737026(SIRT6)
PPS: 100977452(ART4) 100987803(ART5) 100988371(ART1) 100992183(ART3) 100995305(SIRT6)
GGO: 101127624(SIRT6) 101134639(ART4) 101146612(ART3) 101153293(ART5) 101153661(ART1)
PON: 100172886(ART3) 100432433(ART4) 100435792(ART1) 100438048(ART5) 100441394(SIRT6)
NLE: 100592506(SIRT6) 100594753(ART5) 100595329(ART1) 100598120(ART3) 100598463(ART4)
MCC: 100424030(ART3) 574238(ART5) 699934(ART4) 714545(SIRT6) 718154(ART1)
MCF: 102134161(ART4) 102135068(ART3) 102139792(ART5) 102141535(SIRT6) 102142531(ART1)
CSAB: 103218681(ART4) 103233715(SIRT6) 103235821(ART3) 103247979(ART1) 103247980(ART5)
RRO: 104665164(ART5) 104665166(ART1) 104665427(SIRT6) 104666387(ART4) 104673155(ART3)
RBB: 108512132(SIRT6) 108530556(ART4) 108532490(ART3) 108543749(ART1) 108543751(ART5)
CJC: 100394706(SIRT6) 100398626(ART1) 100411310(ART4) 100411495(ART3) 100414071(ART5)
SBQ: 101032538(ART3) 101037109(SIRT6) 101041761(ART4) 101049965(ART1) 101051460(ART5)
MMU: 109978(Art4) 109979(Art3) 11870(Art1) 11871(Art2a-ps) 11872(Art2b) 11875(Art5) 50721(Sirt6)
RNO: 259167(Art5) 293152(Art2b) 299638(Sirt6) 305235(Art3) 308873(Art1) 312806(Art4)
NGI: 103737237(Sirt6) 103742448(Art3) 103749849 103750818(Art5) 103750820(Art1) 103752328(Art4)
HGL: 101706114(Sirt6) 101718202(Art3) 101718884(Art4) 101722974(Art5) 101723321(Art1) 106007650
CCAN: 109678990 109687811(Sirt6) 109689052(Art4) 109699391(Art3) 109699871(Art5) 109699873(Art1)
TUP: 102475139(SIRT6) 102483009(ART1) 102484959(ART3) 102487179 102493683(ART4) 102495500(ART5)
CFA: 476821(ART1) 478434(ART3) 485045(SIRT6) 485214(ART5) 486668(ART4)
AML: 100469440(ART3) 100476510(ART5) 100476761(ART1) 100482134(ART4) 100483389(SIRT6)
UMR: 103665328(ART3) 103677779(ART4) 103678010(ART5) 103678104(ART1) 103681835(SIRT6)
ORO: 101374251(ART5) 101376010(SIRT6) 101379345(ART3) 101383793(ART4) 101386623(ART1)
FCA: 101086418(ART1) 101096491(ART4) 101096839(ART5) 101099636(ART3) 101100540(SIRT6)
PTG: 102949793(ART5) 102950272(ART1) 102956045(ART3) 102956235(SIRT6) 102960724(ART4)
AJU: 106965666(ART4) 106966015(ART5) 106966091(ART1) 106975501(SIRT6) 106981641(ART3)
PHD: 102327061(SIRT6) 102331083(ART3) 102342098 102342446(ART1) 102344135(ART4)
SSC: 100126274(SIRT6) 100152653(ART4) 100522086(ART3) 100522939(ART5) 100525416(ART1)
CFR: 102507660(ART4) 102512361(ART1) 102518432(ART5) 102519858(SIRT6) 102521392(ART3)
CDK: 105091546(ART3) 105096514(ART4) 105096600(ART5) 105098097(ART1) 105105304(SIRT6)
BACU: 103000152 103001223(ART3) 103017769(SIRT6) 103018183(ART1) 103018994(ART5) 103020109(ART4)
LVE: 103073305(ART3) 103079853(ART4) 103083699(ART5) 103083970(ART1) 103091498(SIRT6)
OOR: 101274295(ART4) 101287669(SIRT6) 101287676(ART1) 101287925(ART5) 101289023(ART3)
ECB: 100051066(ART3) 100052937(ART1) 100063125(SIRT6) 100066272(ART5) 100067242(ART4)
EPZ: 103545290(SIRT6) 103549340(ART5) 103558520(ART1) 103562218(ART3) 103565487(ART4)
EAI: 106826735(ART4) 106831645(ART1) 106831647(ART5) 106832324(SIRT6) 106846765(ART3)
MYB: 102240257(ART3) 102244974(SIRT6) 102246125(ART4) 102249629(ART5) 102252898 102259501(ART1)
MYD: 102757008(SIRT6) 102757044(ART5) 102757324(ART1) 102761825(ART4) 102771960(ART3) 102773420
HAI: 109371157(ART3) 109372401(ART5) 109372402(ART1) 109383150(ART4) 109388637(SIRT6)
RSS: 109438850(ART5) 109438856(ART1) 109440311(ART3) 109454007(SIRT6) 109454276(ART4)
PALE: 102880138(ART3) 102884668(ART4) 102893459(SIRT6) 102895427 102896718(ART5) 102896969(ART1)
LAV: 100659550(ART3) 100666872(ART5) 100670854(SIRT6) 100675697(ART1) 100677525(ART4)
MDO: 100015294 100016231(ART5) 100016271(ART1) 100022578(SIRT6) 100026013(ART3) 103098663
SHR: 100916119 100917917(SIRT6) 100922499(ART3) 100929312 100934080(ART5) 100934342(ART1)
GGA: 107052467 395661(AT2) 427879(ART4) 428123(MADPRT1) 428124(ART7B) 428332(SIRT6) 429485(ART1)
ACYG: 106044948(SIRT6) 106045748(ART4) 106048558(ART1) 106048585(ART5)
PMAJ: 107198791(ART1) 107199071 107204288(ART4) 107215472(SIRT6)
CCW: 104684214(ART1) 104696403(ART4) 104697408(SIRT6)
FPG: 101917142 101918738(ART4) 101924635(SIRT6)
FCH: 102049343(SIRT6) 102050635(ART4) 102058640
CLV: 102095862(ART4) 102096880(SIRT6) 102097697
AAM: 106488204(ART4) 106492200(SIRT6)
CMY: 102931128(SIRT6) 102944533(ART4) 102945755 102946663(ART1)
PBI: 103054029(ART1) 103062889 103068171(SIRT6)
DRE: 100317105(si:ch211-145b13.6) 100334237(si:ch211-51i16.1) 100537504 415161(sirt6)
CSEM: 103383509(art1) 103395932(sirt6)
HCQ: 109507346(sirt6) 109511505
SFM: 108921501(sirt6) 108929995
CIN: 100170015(sir2-d)
SPU: 581757
APLC: 110982236
SKO: 100375279
DME: Dmel_CG6284(Sirt6)
DSI: Dsimw501_GD20725(Dsim_GD20725)
MDE: 101900605
AAG: 5574867
AME: 412846
BIM: 100744880
BTER: 100644478
SOC: 105202123
AEC: 105146195
ACEP: 105623031
PBAR: 105429144
HST: 105180671
DQU: 106746422
CFO: 105254211
LHU: 105677754
PGC: 109855690
PCF: 106783629
NVI: 100113582
MDL: 103570912
TCA: 661871
NVL: 108560095
BMOR: 101745097
PMAC: 106710047
PRAP: 111003182
HAW: 110384243
PXY: 105382799
API: 100164943
DNX: 107166705
CLEC: 106663838
ZNE: 110830967
TUT: 107372288
CEL: CELE_C06A5.11(sir-2.4)
CBR: CBG03922(Cbr-sir-2.4)
BMY: Bm1_16975
OBI: 106880845
SHX: MS3_09429
EGL: EGR_00437
HMG: 100202497
ATH: AT5G55760(SRT1)
CRB: 17876100
BRP: 103856967
BOE: 106331719
THJ: 104811666
CPAP: 110820822
TCC: 18593282
GRA: 105783377
GHI: 107920273
EGR: 104449123
VRA: 106779609
VAR: 108343079
CCAJ: 109813136
CAM: 101496418
LJA: Lj6g3v0738970.1(Lj6g3v0738970.1) Lj6g3v0738970.2(Lj6g3v0738970.2) Lj6g3v0738970.3(Lj6g3v0738970.3)
ADU: 107461365
AIP: 107616234
LANG: 109350303
FVE: 101302617
PPER: 18780136
PMUM: 103326700
PAVI: 110760652
ZJU: 107433598
CSV: 101212255
CMO: 103501252
MCHA: 111010606
CMAX: 111476427
CMOS: 111443095
CPEP: 111797655
RCU: 8286827
JCU: 105633083
POP: 7485113
VVI: 100261752(SRT1)
SLY: 101251202
SPEN: 107024387
SOT: 102582619
CANN: 107878802
NSY: 104216832
NTO: 104085710
INI: 109190739
SIND: 105174967
OEU: 111374179
DCR: 108222889
SOE: 110782746
NNU: 104594254
OSA: 4335342
DOSA: Os04t0271000-01(Os04g0271000)
OBR: 102713539
BDI: 100826316
ATS: 109752574(LOC109752574)
SBI: 110436344
ZMA: 542568(cl3393_1)
SITA: 101769948
PDA: 103713295
MUS: 103996363
DCT: 110114495
PEQ: 110018182
AOF: 109840236
ATR: 18433910
MNG: MNEG_8254
NHE: NECHADRAFT_106479(SRT2103)
SMIN: v1.2.026788.t1(symbB.v1.2.026788.t1) v1.2.026788.t2(symbB.v1.2.026788.t2) v1.2.034465.t1(symbB.v1.2.034465.t1)
SPAR: SPRG_18837
 » show all
Taxonomy
Reference
1  [PMID:225315]
  Authors
Moss J, Stanley SJ, Oppenheimer NJ.
  Title
Substrate specificity and partial purification of a stereospecific NAD- and guanidine-dependent ADP-ribosyltransferase from avian erythrocytes.
  Journal
J Biol Chem 254:8891-4 (1979)
Reference
2  [PMID:6247348]
  Authors
Moss J, Stanley SJ, Watkins PA.
  Title
Isolation and properties of an NAD- and guanidine-dependent ADP-ribosyltransferase from turkey erythrocytes.
  Journal
J Biol Chem 255:5838-40 (1980)
Reference
3  [PMID:3927821]
  Authors
Ueda K, Hayaishi O.
  Title
ADP-ribosylation.
  Journal
Annu Rev Biochem 54:73-100 (1985)
DOI:10.1146/annurev.bi.54.070185.000445
Reference
4  [PMID:12727863]
  Authors
Corda D, Di Girolamo M.
  Title
Functional aspects of protein mono-ADP-ribosylation.
  Journal
EMBO J 22:1953-8 (2003)
DOI:10.1093/emboj/cdg209
Reference
5  [PMID:16627471]
  Authors
Paone G, Stevens LA, Levine RL, Bourgeois C, Steagall WK, Gochuico BR, Moss J
  Title
ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
  Journal
J Biol Chem 281:17054-60 (2006)
DOI:10.1074/jbc.M603042200
  Sequence
[hsa:417]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.2.31
IUBMB Enzyme Nomenclature: 2.4.2.31
ExPASy - ENZYME nomenclature database: 2.4.2.31
BRENDA, the Enzyme Database: 2.4.2.31
CAS: 81457-93-4

DBGET integrated database retrieval system