KEGG   ENZYME: 2.4.99.3
Entry
EC 2.4.99.3                 Enzyme                                 

Name
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
Sysname
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein [RN:R05911]
Reaction(KEGG)
R05911(G) > R05914(G) R06273(G)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
Product
CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Comment
alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
History
EC 2.4.99.3 created 1984, modified 1986
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03479  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
Genes
HSA: 55808(ST6GALNAC1)
PTR: 449516(ST6GALNAC1)
PPS: 100990954(ST6GALNAC1)
GGO: 101131564(ST6GALNAC1)
PON: 100437242(ST6GALNAC1)
NLE: 100582568(ST6GALNAC1)
MCC: 707339(ST6GALNAC1)
MCF: 102131184(ST6GALNAC1)
CSAB: 103242998(ST6GALNAC1)
RRO: 104681265(ST6GALNAC1)
RBB: 108537385(ST6GALNAC1)
CJC: 100394846(ST6GALNAC1)
SBQ: 101052905(ST6GALNAC1)
MMU: 20445(St6galnac1)
MCAL: 110287813 110306209(St6galnac1)
MPAH: 110331893 110332478
RNO: 287920(St6galnac1)
MUN: 110566009(St6galnac1)
CGE: 100763224 113836687
NGI: 103732779(St6galnac1)
HGL: 101716443(St6galnac1)
CCAN: 109685592(St6galnac1)
OCU: 100357022(ST6GALNAC1)
TUP: 102502337(ST6GALNAC1)
CFA: 100049002(ST6GALNAC1)
VVP: 112920614(ST6GALNAC1)
AML: 100483351(ST6GALNAC1)
UMR: 103665769(ST6GALNAC1)
UAH: 113244589(ST6GALNAC1)
ORO: 101373308(ST6GALNAC1)
ELK: 111160465
FCA: 101085418(ST6GALNAC1)
PTG: 102954578(ST6GALNAC1)
PPAD: 109276888(ST6GALNAC1)
AJU: 106987766(ST6GALNAC1)
BTA: 618655(ST6GALNAC1)
BOM: 102285967(ST6GALNAC1)
BIU: 109573345(ST6GALNAC1)
BBUB: 102415715(ST6GALNAC1)
CHX: 102184000(ST6GALNAC1)
OAS: 101116588(ST6GALNAC1)
SSC: 100622490(ST6GALNAC1)
CFR: 102521946(ST6GALNAC1)
CDK: 105092179(ST6GALNAC1)
BACU: 103012251(ST6GALNAC1)
LVE: 103071465(ST6GALNAC1)
OOR: 101286810(ST6GALNAC1)
DLE: 111182936(ST6GALNAC1)
ECB: 100058687(ST6GALNAC1)
EPZ: 103565524(ST6GALNAC1)
EAI: 106830340(ST6GALNAC1)
MYB: 102256773(ST6GALNAC1)
MYD: 102763652(ST6GALNAC1)
MNA: 107536587(ST6GALNAC1)
HAI: 109383649(ST6GALNAC1)
DRO: 112298677(ST6GALNAC1)
PALE: 102898342(ST6GALNAC1)
RAY: 107510029(ST6GALNAC1)
MJV: 108398661(ST6GALNAC1)
LAV: 100667338(ST6GALNAC1)
TMU: 101348933
SHR: 100913684(ST6GALNAC1)
OAA: 100076453(ST6GALNAC1)
GGA: 396168(ST6GALNAC1)
MGP: 100549131(ST6GALNAC1)
CJO: 107322110(ST6GALNAC1)
NMEL: 110407369(ST6GALNAC1)
APLA: 101797291(ST6GALNAC1)
ACYG: 106034632(ST6GALNAC1)
TGU: 100227473(ST6GALNAC1)
LSR: 110479610(ST6GALNAC1)
SCAN: 103820005(ST6GALNAC1)
GFR: 102044354(ST6GALNAC1)
FAB: 101816531(ST6GALNAC1)
PHI: 102104528(ST6GALNAC1)
PMAJ: 107212525(ST6GALNAC1)
CCAE: 111937266(ST6GALNAC1)
CCW: 104694336(ST6GALNAC1)
ETL: 114058601(ST6GALNAC1)
FPG: 101917973(ST6GALNAC1)
FCH: 102046634(ST6GALNAC1)
CLV: 102096307(ST6GALNAC1)
EGZ: 104125375(ST6GALNAC1)
NNI: 104022870(ST6GALNAC1)
ACUN: 113486705(ST6GALNAC1)
PADL: 103921018(ST6GALNAC1)
AAM: 106485391(ST6GALNAC1)
ASN: 102380149(ST6GALNAC1)
AMJ: 102567931(ST6GALNAC1)
CMY: 102934815(ST6GALNAC1)
CPIC: 101952335(ST6GALNAC1)
ACS: 100552576(st6galnac1)
PVT: 110085897(ST6GALNAC1)
PBI: 103049161(ST6GALNAC1)
PMUR: 107300765(ST6GALNAC1)
TSR: 106546339
PMUA: 114590659(ST6GALNAC1)
GJA: 107118138(ST6GALNAC1)
XLA: 108701136 108702827
XTR: 101733431(st6galnac1)
NPR: 108786396(ST6GALNAC1)
DRE: 564336(st6galnac1.1) 799868(st6galnac1.2)
SRX: 107721981 107721986 107734167 107734198
SANH: 107660869 107660870 107692092 107692094
SGH: 107577723 107584072 107584073
CCAR: 109100113 109110781
IPU: 108273438
PHYP: 113527221(st6galnac1)
AMEX: 103028114 111196612
EEE: 113572794 113582980
LCO: 104937002 104937003
NCC: 104956443
MZE: 101474318 101474872 101475163 101481664 112430022
ONL: 100691443 100691711 100691981 100692518 100698116 100708495 100708765 100709034 106097985 109203140 112847711
OLA: 101164026
XMA: 102225407 102225672 102230432
XCO: 114151667 114152135 114152366
PRET: 103481510 103481511 103481513
CVG: 107088933 107089181 107089188
NFU: 107387721 107387723 107387725
KMR: 108246104 108246110 108249294
ALIM: 106516657 106516659 106516660
AOCE: 111583259
CSEM: 103381823(st6galnac2)
POV: 109643035
LCF: 108876231
SDU: 111219599(st6galnac1)
SLAL: 111673497(st6galnac1)
HCQ: 109516217 109516279
BPEC: 110165448 110166304
MALB: 109953680
SASA: 106570212 106589847
OTW: 112229175 112229683
SALP: 111968151
ELS: 105009376
SFM: 108940103
PKI: 111848248
BFO: 118406423 118407349 118410756 118411095 118414746 118424170 118430484 118431407
SPU: 105437315 115929913 581003
APLC: 110973336 110973337 110973339 110973340 110973577 110973580 110982145 110983162
SKO: 102803687 102808553
 » show all
Reference
1  [PMID:447688]
  Authors
Sadler JE, Rearick JI, Hill RL.
  Title
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J Biol Chem 254:5934-41 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.3
IUBMB Enzyme Nomenclature: 2.4.99.3
ExPASy - ENZYME nomenclature database: 2.4.99.3
BRENDA, the Enzyme Database: 2.4.99.3
CAS: 71124-50-0

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (10)   
   KEGG GLYCAN (10)   
Chemical reaction (3)   
   KEGG REACTION (3)   
Gene (331)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (207)   
   KEGG MGENES (68)   
   RefGene (55)   
Protein sequence (26)   
   UniProt (9)   
   SWISS-PROT (6)   
   RefSeq(pep) (11)   
DNA sequence (21)   
   RefSeq(nuc) (12)   
   GenBank (5)   
   EMBL (4)   
Protein domain (3)   
   InterPro (3)   
All databases (398)   

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