KEGG   ENZYME: 2.4.99.3Help
Entry
EC 2.4.99.3                 Enzyme                                 

Name
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein [RN:R05911]
Reaction(KEGG)
R05911(G) > R05914(G) R06273(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein
Product
CMP [CPD:C00055];
glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein
Comment
alpha-N-Acetylgalactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
History
EC 2.4.99.3 created 1984, modified 1986
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K03479  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7A)
Genes
HSA: 55808(ST6GALNAC1)
PTR: 449516(ST6GALNAC1)
PPS: 100990954(ST6GALNAC1)
GGO: 101131564(ST6GALNAC1)
PON: 100437242(ST6GALNAC1)
NLE: 100582568(ST6GALNAC1)
MCC: 707339(ST6GALNAC1)
MCF: 102131184(ST6GALNAC1)
CSAB: 103242998(ST6GALNAC1)
RRO: 104681265(ST6GALNAC1)
RBB: 108537385(ST6GALNAC1)
CJC: 100394846(ST6GALNAC1)
SBQ: 101052905(ST6GALNAC1)
MMU: 20445(St6galnac1)
RNO: 287920(St6galnac1)
CGE: 100763224(St6galnac1) 103164123
NGI: 103732779(St6galnac1)
HGL: 101716443(St6galnac1)
CCAN: 109685592(St6galnac1)
OCU: 100357022(ST6GALNAC1)
TUP: 102502337(ST6GALNAC1)
CFA: 100049002(ST6GALNAC1)
AML: 100483351(ST6GALNAC1)
UMR: 103665769(ST6GALNAC1)
ORO: 101373308(ST6GALNAC1)
FCA: 101085418(ST6GALNAC1)
PTG: 102954578(ST6GALNAC1)
AJU: 106987766(ST6GALNAC1)
BTA: 618655(ST6GALNAC1)
BOM: 102285967(ST6GALNAC1)
BIU: 109573345(ST6GALNAC1)
PHD: 102328877(ST6GALNAC1)
CHX: 102184000(ST6GALNAC1)
OAS: 101116588(ST6GALNAC1)
SSC: 100622490(ST6GALNAC1)
CFR: 102521946(ST6GALNAC1)
CDK: 105092179(ST6GALNAC1)
BACU: 103012251(ST6GALNAC1)
LVE: 103071465(ST6GALNAC1)
OOR: 101286810(ST6GALNAC1)
ECB: 100058687(ST6GALNAC1)
EPZ: 103565524(ST6GALNAC1)
EAI: 106830340(ST6GALNAC1)
MYB: 102256773(ST6GALNAC1)
MYD: 102763652(ST6GALNAC1)
HAI: 109383649(ST6GALNAC1)
RSS: 109454665(ST6GALNAC1)
PALE: 102898342(ST6GALNAC1)
LAV: 100667338(ST6GALNAC1)
TMU: 101348933
SHR: 100913684(ST6GALNAC1)
OAA: 100076453(ST6GALNAC1)
GGA: 396168(ST6GALNAC1)
MGP: 100549131(ST6GALNAC1)
CJO: 107322110(ST6GALNAC1)
APLA: 101797291(ST6GALNAC1)
ACYG: 106034632(ST6GALNAC1)
TGU: 100227473(ST6GALNAC1)
GFR: 102044354(ST6GALNAC1)
FAB: 101816531(ST6GALNAC1)
PHI: 102104528(ST6GALNAC1)
PMAJ: 107212525(ST6GALNAC1)
CCAE: 111937266(ST6GALNAC1)
CCW: 104694336(ST6GALNAC1)
FPG: 101917973(ST6GALNAC1)
FCH: 102046634(ST6GALNAC1)
CLV: 102096307(ST6GALNAC1)
EGZ: 104125375(ST6GALNAC1)
AAM: 106485391(ST6GALNAC1)
ASN: 102380149(ST6GALNAC1)
AMJ: 102567931(ST6GALNAC1)
CMY: 102934815(ST6GALNAC1)
CPIC: 101952335(ST6GALNAC1)
ACS: 100552576(st6galnac1)
PVT: 110085897(ST6GALNAC1)
PBI: 103049161(ST6GALNAC1)
GJA: 107118138(ST6GALNAC1)
XTR: 101733431(st6galnac1)
NPR: 108786396(ST6GALNAC1)
DRE: 564336(st6galnac1.1)
LCO: 104937002(st6galnac1) 104937003
NCC: 104956443
OLA: 101164026
CSEM: 103381823(st6galnac2)
LCF: 108876231
SDU: 111219599(st6galnac1)
MALB: 109953680
ELS: 105009376
SFM: 108940103
SKO: 102803687
 » show all
Taxonomy
Reference
1  [PMID:447688]
  Authors
Sadler JE, Rearick JI, Hill RL.
  Title
Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J Biol Chem 254:5934-41 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.3
IUBMB Enzyme Nomenclature: 2.4.99.3
ExPASy - ENZYME nomenclature database: 2.4.99.3
BRENDA, the Enzyme Database: 2.4.99.3
CAS: 71124-50-0

DBGET integrated database retrieval system