KEGG   ENZYME: 2.4.99.4Help
Entry
EC 2.4.99.4                 Enzyme                                 

Name
beta-galactoside alpha-2,3-sialyltransferase;
CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactoside alpha-(2->3)-N-acetylneuraminyl-transferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [RN:R04590 R05913]
Reaction(KEGG)
R04590 R05913(G);
(other) R04648 R05116 R05942(G) R05949(G) R05957(G) R05967(G)
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Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R [CPD:C04750]
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R
Comment
The acceptor is Galbeta1,3GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. Lactose can also act as acceptor. May be identical with EC 2.4.99.2 monosialoganglioside sialyltransferase.
History
EC 2.4.99.4 created 1984, modified 1986
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec00533  Glycosaminoglycan biosynthesis - keratan sulfate
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K00780  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A)
K03368  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4B)
K03494  beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C)
Genes
HSA: 6482(ST3GAL1) 6483(ST3GAL2) 6484(ST3GAL4)
PTR: 450114(ST3GAL1) 454214(ST3GAL2) 466845(ST3GAL4)
PPS: 100973080(ST3GAL4) 100981168(ST3GAL2) 100987531(ST3GAL1)
GGO: 101130368(ST3GAL2) 101141340(ST3GAL4) 101152668(ST3GAL1)
PON: 100172032(ST3GAL4) 100438644(ST3GAL1) 100457161(ST3GAL2)
NLE: 100582142(ST3GAL2) 100605252(ST3GAL4)
MCC: 698004(ST3GAL1) 709319(ST3GAL2) 717792(ST3GAL4)
MCF: 102126028(ST3GAL4) 102127575(ST3GAL1) 102132648(ST3GAL2)
CSAB: 103233157(ST3GAL2) 103237477(ST3GAL1) 103248797(ST3GAL4)
RRO: 104653959(ST3GAL4) 104675666(ST3GAL1) 104677853(ST3GAL2)
RBB: 108527443(ST3GAL2) 108531600(ST3GAL1) 108542314(ST3GAL4)
CJC: 100400713(ST3GAL1) 100410492(ST3GAL4) 100415201(ST3GAL2)
SBQ: 101037663(ST3GAL4) 101039394(ST3GAL1) 101048291(ST3GAL2)
MMU: 20442(St3gal1) 20443(St3gal4) 20444(St3gal2)
RNO: 362924(St3gal1) 363040(St3gal4) 64442(St3gal2)
CGE: 100689440(St3gal4) 100754088(St3gal1) 100767717(St3gal2)
NGI: 103725685(St3gal2) 103728440(St3gal1) 103735380(St3gal4)
HGL: 101716004(St3gal4) 101720225(St3gal1) 101721682(St3gal2)
CCAN: 109684988(St3gal2) 109693253(St3gal1) 109698465(St3gal4)
OCU: 100008715(ST3GAL4) 100339474(ST3GAL2) 100339631(ST3GAL1)
TUP: 102469228 102472452(ST3GAL4) 102475684(ST3GAL1) 102491313(ST3GAL2)
CFA: 482050(ST3GAL1) 489714(ST3GAL2) 607094(ST3GAL4)
AML: 100467054(ST3GAL1) 100470291(ST3GAL4) 100481599(ST3GAL2)
UMR: 103656747(ST3GAL1) 103660659(ST3GAL4) 103673572(ST3GAL2)
ORO: 101370180(ST3GAL1) 101374815(ST3GAL4) 101383519(ST3GAL2)
FCA: 101087029(ST3GAL2) 101089330(ST3GAL1) 101089461(ST3GAL4)
PTG: 102950618(ST3GAL1) 102966496(ST3GAL2) 102968566(ST3GAL4)
AJU: 106971497(ST3GAL1) 106974925(ST3GAL4) 106986781(ST3GAL2)
BTA: 282351(ST3GAL1) 404163(ST3GAL4) 444879(ST3GAL2)
BOM: 102267218(ST3GAL2) 102267241(ST3GAL1) 102277759(ST3GAL4)
BIU: 109554476(ST3GAL4) 109568527(ST3GAL1) 109572479(ST3GAL2)
PHD: 102317409(ST3GAL1) 102317443(ST3GAL4) 102318541(ST3GAL2)
CHX: 102174236(ST3GAL2) 102180329(ST3GAL1) 102191019(ST3GAL4)
OAS: 100127212(ST3GAL4) 101114207(ST3GAL2) 101122606(ST3GAL1)
SSC: 100627772(ST3GAL2) 396602(ST3GAL4) 445537(ST3GAL1)
CFR: 102514165(ST3GAL2) 102516304(ST3GAL1) 102520600(ST3GAL4)
CDK: 105094266(ST3GAL4) 105096461(ST3GAL1) 105097708(ST3GAL2)
BACU: 102997215(ST3GAL2) 102998657(ST3GAL1) 103007179(ST3GAL4)
LVE: 103079143(ST3GAL4) 103084348(ST3GAL2) 103088944(ST3GAL1)
OOR: 101270756(ST3GAL1) 101280148(ST3GAL2) 101285628(ST3GAL4)
ECB: 100054889(ST3GAL2) 100069007(ST3GAL1) 100072459(ST3GAL4)
EPZ: 103549021(ST3GAL4) 103552404(ST3GAL2) 103555856(ST3GAL1)
EAI: 106823448(ST3GAL2) 106824816(ST3GAL1) 106834016(ST3GAL4)
MYB: 102244244(ST3GAL1) 102251231(ST3GAL4) 102252657(ST3GAL2)
MYD: 102756343(ST3GAL2) 102757000(ST3GAL1) 102759716(ST3GAL4)
HAI: 109387429(ST3GAL1) 109388875(ST3GAL2) 109391392(ST3GAL4)
RSS: 109433741(ST3GAL2) 109433897(ST3GAL4) 109443593(ST3GAL1)
PALE: 102878911(ST3GAL4) 102895580(ST3GAL2) 102898997(ST3GAL1)
LAV: 100660029(ST3GAL4) 100667581(ST3GAL1) 100669779(ST3GAL2)
MDO: 100011298(ST3GAL2) 100019589(ST3GAL4) 100032599(ST3GAL1)
SHR: 100924982(ST3GAL1) 100925774(ST3GAL4) 100932061(ST3GAL2)
OAA: 100074430(ST3GAL2) 100081042(ST3GAL1) 100089613(ST3GAL4)
GGA: 395139(ST3GAL2) 396140(ST3GAL1) 419718(ST3GAL4)
MGP: 100540561 100542452(ST3GAL4) 100543479(ST3GAL2) 100550797(ST3GAL1)
CJO: 107310569(ST3GAL1) 107319071(ST3GAL2) 107322831 107324198(ST3GAL4)
APLA: 101790636(ST3GAL1) 101792642(ST3GAL4) 101793558(ST3GAL2) 101802936
ACYG: 106033120(ST3GAL2) 106040618(ST3GAL4) 106043283(ST3GAL1) 106045430
TGU: 100224400(ST3GAL4) 100224643(ST3GAL1) 100231481(ST3GAL2)
GFR: 102033897(ST3GAL1) 102035890(ST3GAL4) 102042240(ST3GAL2)
FAB: 101811246(ST3GAL1) 101812465(ST3GAL4) 101820291(ST3GAL2)
PHI: 102102331(ST3GAL4) 102106597(ST3GAL1) 102113686(ST3GAL2)
PMAJ: 107200730(ST3GAL1) 107209855(ST3GAL2) 107213089 107214423(ST3GAL4)
CCW: 104687566(ST3GAL2) 104692148(ST3GAL4) 104692627(ST3GAL1)
FPG: 101910376(ST3GAL4) 101910682 101915219(ST3GAL1) 101916975(ST3GAL2) 101917136
FCH: 102046236(ST3GAL2) 102047460(ST3GAL4) 102049166 102052539 102059972(ST3GAL1)
CLV: 102083564(ST3GAL4) 102084549(ST3GAL1) 102084623 102092171(ST3GAL2)
EGZ: 104125426 104129203(ST3GAL4) 104130288(ST3GAL2) 104134451(ST3GAL1)
AAM: 106492726(ST3GAL2) 106496288(ST3GAL1) 106496613 106499904
ASN: 102367794(ST3GAL2) 102376781(ST3GAL1) 102382624(ST3GAL4) 102383890 112551930
AMJ: 102564632(ST3GAL4) 102568467(ST3GAL2L) 102570740(ST3GAL2) 102572981(ST3GAL1)
CMY: 102931294 102932185 102941283(ST3GAL2) 102942769(ST3GAL1) 102944986(ST3GAL4)
CPIC: 101931032 101932394(ST3GAL1) 101933140 101953037(ST3GAL4) 101953864(ST3GAL2)
ACS: 100553436(st3gal1) 100558500(st3gal2) 100563798 100565594(st3gal4)
PVT: 110073366 110081335(ST3GAL2) 110085871(ST3GAL1) 110088816(ST3GAL4)
PBI: 103053293(ST3GAL4) 103056646(ST3GAL1) 103060957 103061993(ST3GAL2)
GJA: 107106056 107107861 107117659(ST3GAL2) 107119889(ST3GAL4) 107126269(ST3GAL1)
XLA: 100126621(st3gal2.2.L) 108695455(st3gal1.S) 108697230 108697569 108715471(st3gal2.1.S) 108719427(st3gal1.L) 398747(st3Gal-II) 414465(st3gal2.1.L) 734512(st3gal4.L)
XTR: 100329190(st3gal1) 100492150(st3gal2.1) 394493(st3gal2.2) 403093(st3gal4)
DRE: 445562(st3gal2) 504044(st3gal4)
TRU: 445972(st3gal2) 445983(siat5-r) 446079(st3gal1) 780534(st3gal4)
OLA: 100049378(st3gal1) 100144348(st3gal2) 101157876(st3gal4) 101171268 101171510 101171762
NFU: 107380707(st3gal4) 107384973 107389147(st3gal2) 107395861
CSEM: 103377685(st3gal4) 103379513(st3gal2) 103386354 103394178(st3gal1)
ELS: 105012755(st3gal1) 105018508(st3gal2) 105030696
LCM: 102345200(st3gal1A) 102347188(ST3GAL2) 102358544(st3gal8) 102362202(ST3GAL4) 102363599(st3gal1B)
CIN: 445728(siat4)
SPU: 590209(st)
ADU: 107461776
AIP: 107610392
OEU: 111377827
DCT: 110114451
 » show all
Taxonomy
Reference
1  [PMID:438198]
  Authors
Rearick JI, Sadler JE, Paulson JC, Hill RL.
  Title
Enzymatic characterization of beta D-galactoside alpha2 leads to 3 sialyltransferase from porcine submaxillary gland.
  Journal
J Biol Chem 254:4444-51 (1979)
Reference
2  [PMID:438196]
  Authors
Sadler JE, Rearick JI, Paulson JC, Hill RL.
  Title
Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands.
  Journal
J Biol Chem 254:4434-42 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.4
IUBMB Enzyme Nomenclature: 2.4.99.4
ExPASy - ENZYME nomenclature database: 2.4.99.4
BRENDA, the Enzyme Database: 2.4.99.4
CAS: 71124-51-1

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