KEGG   ENZYME: 2.4.99.7Help
Entry
EC 2.4.99.7                 Enzyme                                 

Name
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase;
sialyltransferase;
cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase;
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase;
SIAT7;
ST6GALNAC;
(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase;
CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminide galactosamine-6-alpha-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [RN:R04635]
Reaction(KEGG)
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R [CPD:C04885]
Product
CMP [CPD:C00055];
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R [CPD:C04926]
Comment
Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl-galactosamine only when present in the structure of alpha-N-acetyl-neuraminyl-(2->3)-beta-galactosyl-(1->3)-N-acetylgalactosaminyl-R, where R may be protein or p-nitrophenol. Not identical with EC 2.4.99.3 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
History
EC 2.4.99.7 created 1984, modified 1986, modified 2004
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03374  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D)
Genes
HSA: 27090(ST6GALNAC4)
PTR: 450108(ST6GALNAC4)
PPS: 100995780(ST6GALNAC4)
GGO: 101151595(ST6GALNAC4)
PON: 100439613(ST6GALNAC4)
NLE: 100598104(ST6GALNAC4)
MCC: 705879(ST6GALNAC4)
MCF: 102142909(ST6GALNAC4)
CSAB: 103239817(ST6GALNAC4)
RRO: 104665870(ST6GALNAC4)
RBB: 108542735(ST6GALNAC4)
CJC: 100401438(ST6GALNAC4)
SBQ: 101037868(ST6GALNAC4)
MMU: 20448(St6galnac4)
RNO: 407764(St6galnac4)
CGE: 100759065(St6galnac4)
NGI: 103727384(St6galnac4)
HGL: 101717187(St6galnac4)
CCAN: 109686789(St6galnac4)
OCU: 100356933(ST6GALNAC4)
TUP: 102487439(ST6GALNAC4)
CFA: 609133(ST6GALNAC4)
AML: 100480565(ST6GALNAC4)
UMR: 103670294(ST6GALNAC4)
ORO: 101368864(ST6GALNAC4)
FCA: 101094459(ST6GALNAC4)
PTG: 102966320(ST6GALNAC4)
AJU: 106966292(ST6GALNAC4)
BTA: 404124(ST6GALNAC4)
BOM: 102287870(ST6GALNAC4)
PHD: 102344910(ST6GALNAC4)
CHX: 102170329(ST6GALNAC4)
OAS: 101123019(ST6GALNAC4)
SSC: 396676(ST6GALNAC4)
BACU: 103005340(ST6GALNAC4)
LVE: 103086160(ST6GALNAC4)
OOR: 101278803(ST6GALNAC4)
ECB: 100067121(ST6GALNAC4)
EPZ: 103544980(ST6GALNAC4)
EAI: 106845456(ST6GALNAC4)
MYB: 102248336 102261251(ST6GALNAC4)
MYD: 102754268(ST6GALNAC4)
HAI: 109379933(ST6GALNAC4)
RSS: 109445879(ST6GALNAC4)
PALE: 102881827(ST6GALNAC4)
LAV: 104845634(ST6GALNAC4)
TMU: 101349108
MDO: 100012077(ST6GALNAC4)
SHR: 100921479(ST6GALNAC4)
OAA: 100078837(ST6GALNAC4)
GGA: 395182(ST6GALNAC4)
MGP: 100543224(ST6GALNAC4)
CJO: 107321783(ST6GALNAC4)
APLA: 101791163(ST6GALNAC4)
ACYG: 106047277(ST6GALNAC4)
TGU: 100232134(ST6GALNAC4)
GFR: 102036471(ST6GALNAC4)
FAB: 101817162(ST6GALNAC4)
PHI: 102109129(ST6GALNAC4)
PMAJ: 107211894(ST6GALNAC4)
CCAE: 111936951(ST6GALNAC4)
CCW: 104688260(ST6GALNAC4)
FPG: 101923804(ST6GALNAC4)
FCH: 102056501(ST6GALNAC4)
CLV: 102090323(ST6GALNAC4)
EGZ: 104122368(ST6GALNAC4)
AAM: 106495296(ST6GALNAC4)
ASN: 102385694(ST6GALNAC4)
AMJ: 102575154(ST6GALNAC4)
PSS: 102443948(ST6GALNAC4)
CMY: 102932867(ST6GALNAC4)
CPIC: 101940645(ST6GALNAC4)
ACS: 100552238(st6galnac4)
PVT: 110078837(ST6GALNAC4)
PBI: 103063354(ST6GALNAC4)
GJA: 107105744(ST6GALNAC4)
XLA: 108705029
XTR: 779760(st6galnac4)
NPR: 108794466(ST6GALNAC4)
DRE: 751653(st6galnac4)
CCAR: 109062816
IPU: 108279162(st6galnac4)
AMEX: 103027742(st6galnac4)
NCC: 104946126(st6galnac4)
SDU: 111237383
BPEC: 110157454
SASA: 100196729(st6galnac4)
SFM: 108935911
LCM: 102363654(ST6GALNAC4)
ADF: 107334450
 » show all
Taxonomy
Reference
1  [PMID:6190802]
  Authors
Bergh ML, Hooghwinkel GJ, van den Eijnden DH.
  Title
Biosynthesis of the O-glycosidically linked oligosaccharide chains of fetuin. Indications for an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase with a narrow acceptor specificity in fetal calf liver.
  Journal
J Biol Chem 258:7430-6 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.7
IUBMB Enzyme Nomenclature: 2.4.99.7
ExPASy - ENZYME nomenclature database: 2.4.99.7
BRENDA, the Enzyme Database: 2.4.99.7
CAS: 129924-24-9

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