KEGG   ENZYME: 2.4.99.9Help
Entry
EC 2.4.99.9                 Enzyme                                 

Name
lactosylceramide alpha-2,3-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase;
CMP-acetylneuraminate-lactosylceramide-sialyltransferase;
CMP-acetylneuraminic acid:lactosylceramide sialyltransferase;
CMP-sialic acid:lactosylceramide-sialyltransferase;
cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase;
ganglioside GM3 synthetase;
GM3 synthase;
GM3 synthetase;
SAT 1;
CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase;
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl(1<->1)ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Class
Transferases;
Glycosyltransferases;
Transferring other glycosyl groups
BRITE hierarchy
Sysname
CMP-N-acetylneuraminate:beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-(2->3)-N-acetylneuraminyltransferase
Reaction(IUBMB)
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R03488 R05937]
Reaction(KEGG)
R03488 R05937(G);
(other) R04630 R04647 R06003(G) R06007(G)
Show
Substrate
CMP-N-acetylneuraminate [CPD:C00128];
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C01290]
Product
CMP [CPD:C00055];
alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment
Lactose cannot act as acceptor.
History
EC 2.4.99.9 created 1984, modified 1986
Pathway
ec00604  Glycosphingolipid biosynthesis - ganglio series
ec01100  Metabolic pathways
Orthology
K03370  lactosylceramide alpha-2,3-sialyltransferase (sialyltransferase 9)
Genes
HSA: 8869(ST3GAL5)
PTR: 459371(ST3GAL5)
PPS: 100974771(ST3GAL5)
GGO: 101127197(ST3GAL5)
PON: 100458488(ST3GAL5)
NLE: 100581835(ST3GAL5)
MCC: 696842(ST3GAL5)
MCF: 102139258(ST3GAL5)
CSAB: 103219931(ST3GAL5)
RRO: 104677060(ST3GAL5)
RBB: 108518136(ST3GAL5)
CJC: 100399856(ST3GAL5)
SBQ: 101033571(ST3GAL5)
MMU: 20454(St3gal5)
RNO: 83505(St3gal5)
CGE: 100754838(St3gal5)
NGI: 103739804(St3gal5)
HGL: 101699085(St3gal5)
CCAN: 109696130(St3gal5)
OCU: 100341761(ST3GAL5)
TUP: 102502390(ST3GAL5)
CFA: 612022(ST3GAL5)
AML: 100469790(ST3GAL5)
UMR: 103671460(ST3GAL5)
ORO: 101377844(ST3GAL5)
FCA: 101092099(ST3GAL5)
PTG: 102964432(ST3GAL5)
AJU: 106978128(ST3GAL5)
BTA: 404164(ST3GAL5)
BOM: 102266477(ST3GAL5)
BIU: 109566161(ST3GAL5)
PHD: 102323243(ST3GAL5)
CHX: 102190883(ST3GAL5)
OAS: 101104977(ST3GAL5)
SSC: 100625751(ST3GAL5)
CFR: 102505366(ST3GAL5)
CDK: 105104164(ST3GAL5)
BACU: 103002546(ST3GAL5)
LVE: 103075319(ST3GAL5)
OOR: 101270788(ST3GAL5)
ECB: 100067118(ST3GAL5)
EPZ: 103556956(ST3GAL5)
EAI: 106838594(ST3GAL5)
MYB: 102245810(ST3GAL5)
MYD: 102759471(ST3GAL5)
HAI: 109371317(ST3GAL5)
RSS: 109456773(ST3GAL5)
PALE: 102879934(ST3GAL5)
LAV: 100673997(ST3GAL5)
TMU: 101361139
MDO: 100029907(ST3GAL5)
SHR: 100919035(ST3GAL5)
OAA: 100080527(ST3GAL5)
GGA: 407775(ST3GAL5)
MGP: 100547934(ST3GAL5)
CJO: 107314000(ST3GAL5)
APLA: 101803297(ST3GAL5)
ACYG: 106034105(ST3GAL5)
TGU: 100229190(ST3GAL5)
GFR: 102038355(ST3GAL5)
FAB: 101819557(ST3GAL5)
PHI: 102100405(ST3GAL5)
PMAJ: 107203387(ST3GAL5)
CCAE: 111928296(ST3GAL5)
CCW: 104690804(ST3GAL5)
FPG: 101917839(ST3GAL5)
FCH: 102058346(ST3GAL5)
CLV: 102084795(ST3GAL5)
EGZ: 104135244(ST3GAL5)
AAM: 106488111(ST3GAL5)
ASN: 102372315(ST3GAL5)
AMJ: 102562268(ST3GAL5)
PSS: 102453544(ST3GAL5)
CMY: 102933732(ST3GAL5)
CPIC: 101941756(ST3GAL5)
ACS: 100561853(st3gal5)
PVT: 110080831(ST3GAL5)
PBI: 103065629(ST3GAL5)
GJA: 107116130(ST3GAL5)
XLA: 108697625(st3gal5.L) 108706512(st3gal5.S)
XTR: 100329191(st3gal5)
NPR: 108802045(ST3GAL5)
DRE: 394230(st3gal5)
IPU: 108263616 108269097(st3gal5)
TRU: 101067907(siat5-r) 777948(st3Gal_V)
LCO: 104939171(st3gal5)
MZE: 101465565 101486925(st3gal5)
OLA: 100049379(siat9) 101156587(st3gal5)
XMA: 102216472(st3gal5) 102227685
PRET: 103471010(st3gal5) 103476912
NFU: 107375673 107390897(st3gal5)
KMR: 108234126 108240047(st3gal5)
CSEM: 103387301 103391463(st3gal5)
SDU: 111226677(st3gal5) 111235332
BPEC: 110156361(st3gal5) 110157279
MALB: 109957532(st3gal5) 109961180
SASA: 106589773 106611962(st3gal5)
ELS: 105026834(st3gal5)
SFM: 108920350(st3gal5)
LCM: 102359703
CMK: 103181477(st3gal5) 103186566
SKO: 102801588
 » show all
Taxonomy
Reference
1  [PMID:4631392]
  Authors
Basu S, Kaufman B, Roseman S.
  Title
Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 248:1388-94 (1973)
Reference
2  [PMID:4022]
  Authors
Fishman PH, Bradley RM, Henneberry RC.
  Title
Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase.
  Journal
Arch Biochem Biophys 172:618-26 (1976)
DOI:10.1016/0003-9861(76)90116-8
Reference
3  [PMID:3838172]
  Authors
Higashi H, Basu M, Basu S.
  Title
Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain.
  Journal
J Biol Chem 260:824-8 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.99.9
IUBMB Enzyme Nomenclature: 2.4.99.9
ExPASy - ENZYME nomenclature database: 2.4.99.9
BRENDA, the Enzyme Database: 2.4.99.9
CAS: 125752-90-1

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