KEGG   ENZYME: 2.5.1.102Help
Entry
EC 2.5.1.102                Enzyme                                 

Name
geranyl-pyrophosphate---olivetolic acid geranyltransferase;
GOT (ambiguous)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:olivetolate geranyltransferase
Reaction(IUBMB)
geranyl diphosphate + 2,4-dihydroxy-6-pentylbenzoate = diphosphate + cannabigerolate [RN:R10176]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:C00341];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Product
diphosphate [CPD:C00013];
cannabigerolate [CPD:C20406]
Comment
Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also use neryl diphosphate as substrate, forming cannabinerolate.
History
EC 2.5.1.102 created 2012
Pathway
ec00999  Biosynthesis of secondary metabolites - unclassified
Reference
1  [PMID:9607329]
  Authors
Fellermeier M, Zenk MH
  Title
Prenylation of olivetolate by a hemp transferase yields cannabigerolic acid, the  precursor of tetrahydrocannabinol.
  Journal
FEBS Lett 427:283-5 (1998)
DOI:10.1016/S0014-5793(98)00450-5
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.102
IUBMB Enzyme Nomenclature: 2.5.1.102
ExPASy - ENZYME nomenclature database: 2.5.1.102
BRENDA, the Enzyme Database: 2.5.1.102

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