KEGG   ENZYME: 2.5.1.22Help
Entry
EC 2.5.1.22                 Enzyme                                 

Name
spermine synthase;
spermidine aminopropyltransferase;
spermine synthetase;
S-adenosylmethioninamine:spermidine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5'-thioadenosine + spermine [RN:R02869]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
spermidine [CPD:C00315]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
spermine [CPD:C00750]
Comment
The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase).
History
EC 2.5.1.22 created 1982, modified 2013
Pathway
ec00270  Cysteine and methionine metabolism
ec00330  Arginine and proline metabolism
ec00410  beta-Alanine metabolism
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00802  spermine synthase
Genes
HSA: 6611(SMS)
PTR: 107966193(SMS) 739762
PPS: 100974711 100989256(SMS)
GGO: 101136287(SMS)
PON: 100447565 100455032(SMS)
NLE: 100592294(SMS)
MCC: 698179(SMS)
MCF: 102139114(SMS)
CSAB: 103231701(SMS)
RRO: 104676688(SMS)
RBB: 108512250
CJC: 100411404(SMS)
SBQ: 101037456(SMS)
MMU: 20603(Sms)
RNO: 363469(Sms)
CGE: 100753198(Sms) 100769680
NGI: 103730144(Sms)
HGL: 101696715(Sms) 101718865
CCAN: 109685258(Sms) 109685259
OCU: 100340020(SMS)
CFA: 480861(SMS)
AML: 100469558(SMS)
UMR: 103668176(SMS)
ORO: 101364730(SMS) 101371201
FCA: 101090842(SMS)
PTG: 102954471(SMS)
AJU: 106968260(SMS)
BTA: 615950(SMS)
BOM: 102270205 102283485(SMS)
BIU: 109554942(SMS) 109559006
PHD: 102340705(SMS)
CHX: 102190676(SMS)
OAS: 101107419(SMS) 101112287
SSC: 100153052(SMS)
CFR: 102512656(SMS)
CDK: 105105052(SMS)
BACU: 103019290(SMS)
LVE: 103068984
OOR: 101272903(SMS)
ECB: 100051857(SMS)
EPZ: 103566846(SMS)
EAI: 106835513(SMS)
MYB: 102251500 102257010(SMS)
MYD: 102760281(SMS)
HAI: 109395813(SMS)
RSS: 109436201(SMS)
PALE: 102896435(SMS)
LAV: 100658418(SMS)
TMU: 101354696
MDO: 100012760(SMS)
SHR: 100928879(SMS)
OAA: 100083114(SMS)
GGA: 418602(SMS)
MGP: 100549711(SMS)
CJO: 107324967(SMS)
APLA: 101791698(SMS)
ACYG: 106037821(SMS)
TGU: 100228014(SMS)
GFR: 102034236(SMS)
FAB: 101806851(SMS)
PHI: 102114400(SMS)
PMAJ: 107201826(SMS)
CCW: 104686193(SMS)
FPG: 101922863(SMS)
FCH: 102049429(SMS)
CLV: 102096362(SMS)
EGZ: 104135174(SMS)
AAM: 106492122(SMS)
ASN: 102388291(SMS)
AMJ: 102559699(SMS)
PSS: 102445830(SMS)
CMY: 102933684(SMS)
CPIC: 101931607(SMS)
ACS: 100552713(sms) 100561005
PVT: 110076724(SMS)
PBI: 103049999(SMS)
GJA: 107120288(SMS)
XLA: 108708014(sms.L)
XTR: 100497747(sms)
NPR: 108791842(SMS)
DRE: 80872(sms)
IPU: 108279239(sms)
AMEX: 103023143(sms)
TRU: 101072716(sms)
LCO: 104924594(sms)
NCC: 104965977(sms)
MZE: 101475695(sms)
OLA: 101166897(sms)
XMA: 102233412(sms)
PRET: 103475438(sms)
NFU: 107386402(sms)
CSEM: 103395717(sms)
LCF: 108893544(sms)
HCQ: 109517965(sms)
BPEC: 110158443(sms)
SASA: 100195133(spsy) 106603082
ELS: 105010858(sms)
SFM: 108939723(sms)
LCM: 102363084(SMS)
CMK: 103189993(sms)
CIN: 100184953
SPU: 584264
APLC: 110984481
DME: Dmel_CG4300(CG4300)
DSI: Dsimw501_GD12732(Dsim_GD12732)
MDE: 101896722
AAG: 5570348
AME: 410080
BIM: 100742708
BTER: 100647449
SOC: 105201107
AEC: 105145851
ACEP: 105618948
PBAR: 105434139
HST: 105184220
CFO: 105258881
LHU: 105667455
PGC: 109857572
NVI: 100116075
TCA: 656524
DPA: 109542993
NVL: 108563491
BMOR: 101742636
PMAC: 106710981
PRAP: 110997871
ZNE: 110837290
TUT: 107372126
MYI: 110453256
SCE: YLR146C(SPE4)
KMX: KLMA_50519(SPE4)
NCS: NCAS_0C03110(NCAS0C03110)
NDI: NDAI_0G02420(NDAI0G02420)
TPF: TPHA_0A01420(TPHA0A01420)
TBL: TBLA_0A04140(TBLA0A04140)
TDL: TDEL_0F04780(TDEL0F04780)
KAF: KAFR_0H02120(KAFR0H02120)
AEH: Mlg_0336
HHA: Hhal_0951
 » show all
Taxonomy
Reference
1  [PMID:7396856]
  Authors
Hibasami H, Borchardt RT, Chen SY, Coward JK, Pegg AE.
  Title
Studies of inhibition of rat spermidine synthase and spermine synthase.
  Journal
Biochem J 187:419-28 (1980)
Reference
2  [PMID:520313]
  Authors
Pajula RL, Raina A, Eloranta T.
  Title
Polyamine synthesis in mammalian tissues. Isolation and characterization of spermine synthase from bovine brain.
  Journal
Eur J Biochem 101:619-26 (1979)
DOI:10.1111/j.1432-1033.1979.tb19756.x
Reference
3  [PMID:6798961]
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.22
IUBMB Enzyme Nomenclature: 2.5.1.22
ExPASy - ENZYME nomenclature database: 2.5.1.22
BRENDA, the Enzyme Database: 2.5.1.22
CAS: 74812-43-4

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