KEGG   ENZYME: 2.5.1.23Help
Entry
EC 2.5.1.23                 Enzyme                                 

Name
sym-norspermidine synthase;
S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase;
S-adenosyl 3-(methylthio)propylamine:propane-1,3-diamine 3-aminopropyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-adenosyl 3-(methylsulfanyl)propylamine:propane-1,3-diamine 3-aminopropyltransferase
Reaction(IUBMB)
S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine [RN:R03271]
Reaction(KEGG)
Substrate
S-adenosyl 3-(methylsulfanyl)propylamine [CPD:C01137];
propane-1,3-diamine [CPD:C00986]
Product
S-methyl-5'-thioadenosine [CPD:C00170];
bis(3-aminopropyl)amine [CPD:C03375]
Comment
The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase).
History
EC 2.5.1.23 created 1983, modified 2013
Reference
1  [PMID:116684]
  Authors
Aleksijevic A, Grove J, Schuber F.
  Title
Studies on polyamine biosynthesis in Euglena gracilis.
  Journal
Biochim Biophys Acta 565:199-207 (1979)
DOI:10.1016/0005-2787(79)90096-0
Reference
2
  Authors
Villanueva, V.R., Adlakha, R.C. and Calbayrac, R.
  Title
Biosynthesis of polyamines in Euglena gracilis.
  Journal
Phytochemistry 19:787-790 (1980)
Reference
3  [PMID:3096734]
  Authors
Cacciapuoti G, Porcelli M, Carteni-Farina M, Gambacorta A, Zappia V
  Title
Purification and characterization of propylamine transferase from Sulfolobus solfataricus, an extreme thermophilic archaebacterium.
  Journal
Eur J Biochem 161:263-71 (1986)
DOI:10.1111/j.1432-1033.1986.tb10442.x
  Sequence
[sso:SSO0757]
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.23
IUBMB Enzyme Nomenclature: 2.5.1.23
ExPASy - ENZYME nomenclature database: 2.5.1.23
BRENDA, the Enzyme Database: 2.5.1.23

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